scholarly journals Comparison of some indicators of the thyroid gland functional activity in simultaneous testing of capillary and venous blood

2017 ◽  
Vol 13 (2) ◽  
pp. 39-44 ◽  
Author(s):  
Andrey Yu. Olkhovik ◽  
Pavel S. Sadovnikov ◽  
Anton V. Vasiliev ◽  
Dmitriy G. Denisov ◽  
Vladimir L. Emanuel
Keyword(s):  
Thyroid Gland ◽  
Functional Activity ◽  
Venous Blood ◽  
Simultaneous Testing ◽  
Roche Cobas

Обоснование. В клинической практике регулярно встречаются ситуации, при которых невозможно взять кровь из периферических вен для проведения лабораторных анализов. При этом проблема сравнительной оценки показателей венозной и капиллярной крови остается недостаточно изученной. Цель. Провести сравнительную оценку 5 лабораторных показателей функции щитовидной железы – свободного Т3 (св.Т3), свободного Т4 (св.Т4), антител к тиреоглобулину (АТ-ТГ), антител к тиреопероксидазе (АТ-ТПО), тиреотропного гормона (ТТГ) – для выявления характера отклонений рассматриваемых параметров капиллярной крови от аналогичных показателей венозной. Методы. В исследование были включены 22 клинически здоровых добровольца обоих полов, единовременно сдавших для обследования образцы капиллярной и венозной крови с соблюдением правил преаналитики. Выполнение исследований производили в течение трех часов после взятия биоматериала на анализаторе Roche Cobas e601. Для всех показателей рассчитывали средние значения с 95% доверительным интервалом (ДИ), вычисленным процедурой бутстрепа. В парах значений показателей венозной и капиллярной крови рассчитывали их разность, которую выражали в относительных (в %) единицах. Для сравнения зависимых выборок также использовали критерий Уилкоксона для разностей пар и корреляционный анализ. Результаты. Для св.Т3 (среднее отклонение 3,11%; p < 0,001), св.Т4 (3,89%; p < 0,001), АТ-ТГ (2,73%; p = 0,041) и АТ-ТПО (6,75%; p < 0,001) продемонстрировано статистически значимое увеличение, а для ТТГ (-4,3%; p < 0,001) – снижение значений для образцов капиллярной крови по сравнению с аналогичными показателями венозной. Отклонение в пределах 5% в подавляющем большинстве случаев не имеет клинического значения при постановке диагноза и выборе терапии для пациента. Все рассмотренные показатели капиллярной крови обладают сильной корреляцией (r > 0,75) с аналогичными показателями венозной крови: для св.Т3 r = 0,971; св.Т4 – r = 0,993; АТ-ТГ – r = 0,958; АТ-ТПО – r = 0,836; ТТГ – r = 0,995. Заключение. Таким образом, показатели св.Т3, св.Т4 и ТТГ можно определять в капиллярной крови без какого-либо ущерба для точности клинической оценки при строгом соблюдении преаналитических правил, при этом для таких показателей как АТ-ТГ, АТ-ТПО данные отклонения могут иметь значение только при результатах, находящихся на верхней границе референсных интервалов.

THE EXTERIORIZATION OF THE THYROID GLAND AND MEASUREMENT OF ITS FUNCTION

1963 ◽  
Vol 26 (2) ◽  
pp. 241-247 ◽  
Author(s):  
I. R. FALCONER
Keyword(s):  
Thyroid Gland ◽  
Carotid Artery ◽  
Histological Examination ◽  
Jugular Vein ◽  
Venous Blood ◽  
New Method ◽  
Secretory Function

SUMMARY A new method for obtaining thyroid venous blood from an essentially undisturbed ewe has been developed. A lobe of the thyroid gland is transferred to the outside of the neck, in a carotid artery—jugular vein loop. The remaining lobe is removed. The secretory function of the exteriorized lobe has been shown to be normal by 131I studies, measurement of protein bound iodine, response to T.S.H. and histological examination. Cannulation of the jugular vein near the thyroid vein allows continuous or interrupted sampling of thyroid venous blood, the jugular flow being occluded by pressure.

scholarly journals Chronic Electrical Stimulation of the Superior Laryngeal Nerve in the Rat: A Potential Therapeutic Approach for Postmenopausal Osteoporosis

Biomedicines ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 369
Author(s):  
Kaori Iimura ◽  
Nobuhiro Watanabe ◽  
Philip Milliken ◽  
Yee-Hsee Hsieh ◽  
Stephen J. Lewis ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Thyroid Gland ◽  
Venous Blood ◽  
Disease Model ◽  
Superior Laryngeal Nerve ◽  
Laryngeal Nerve ◽  
Mineral Density ◽  
Ovx Rats ◽  
Chronic Electrical Stimulation ◽  
Stimulation Of

Electrical stimulation of myelinated afferent fibers of the superior laryngeal nerve (SLN) facilitates calcitonin secretion from the thyroid gland in anesthetized rats. In this study, we aimed to quantify the electrical SLN stimulation-induced systemic calcitonin release in conscious rats and to then clarify effects of chronic SLN stimulation on bone mineral density (BMD) in a rat ovariectomized disease model of osteoporosis. Cuff electrodes were implanted bilaterally on SLNs and after two weeks recovery were stimulated (0.5 ms, 90 microampere) repetitively at 40 Hz for 8 min. Immunoreactive calcitonin release was initially measured and quantified in systemic venous blood plasma samples from conscious healthy rats. For chronic SLN stimulation, stimuli were applied intermittently for 3–4 weeks, starting at five weeks after ovariectomy (OVX). After the end of the stimulation period, BMD of the femur and tibia was measured. SLN stimulation increased plasma immunoreactive calcitonin concentration by 13.3 ± 17.3 pg/mL (mean ± SD). BMD in proximal metaphysis of tibia (p = 0.0324) and in distal metaphysis of femur (p = 0.0510) in chronically SLN-stimulated rats was 4–5% higher than that in sham rats. Our findings demonstrate chronic electrical stimulation of the SLNs produced enhanced calcitonin release from the thyroid gland and partially improved bone loss in OVX rats.

scholarly journals HISTOLOGICAL STUDY OF THYROID STATE IN ADMINISTRATION OF AQUEOUS EXTRACT FROM LEMNA MINOR FROND IN EXPERIMENTAL HYPOTHYROIDISM

2016 ◽  
Author(s):  
A. H. H. Kononenko ◽  
V. M. Kravchenko
Keyword(s):  
Thyroid Gland ◽  
Aqueous Extract ◽  
Functional Activity ◽  
Lemna Minor ◽  
Histological Study ◽  
Morphological Structure ◽  
Practical Significance ◽  
Outer Diameter ◽  
Experimental Conditions ◽  
Thyroid State

The influence of aqueous extract from Lemna minor frond on morphological status of the thyroid gland in the experimental conditions of hypothyroidism in rats induced by administration of merkazolilum solution instead of drinking water for 30 days was studied. Thyreostatic merkazolilum resulted in changes of morphological structure of the thyroid gland, accompanied by manifestations of hyperplastic tissue proliferation and corresponds with hypofunctional state.The introduction of aqueous extract from Lemna minor frond resulted in positive influence on the restructuring of the thyroid gland in rats with hypothyroidism, increasing its functional activity. There was a decrease of proliferative processes of the epithelium and extrafollicular thyrocytes in follicles. The outer diameter of the follicles are not different from intact control, height follicular thyrocytes decreased compared with pathology by 41.08%. Iodomarin and L-thyroxine increased functional activity of the thyroid gland, but to a lesser degree than the aqueous extract from Lemna minor frond. L-thyroxine is not increased pharmacological effect of the studied extract. The results have practical significance for drugs development with thyroid-stimulating action.

scholarly journals ONTOGENETIC, BREED, AND SEASONAL FEATURES OF THE SYNTHESIS OF THYROXIN AND CORTISOL IN DOGS AND CATS

2022 ◽  
pp. 19-24
Author(s):  
N. V. Efanova ◽  
S. V. Batalova ◽  
L. M. Osina ◽  
Е. D. Naumova
Keyword(s):  
Thyroid Gland ◽  
Seasonal Dynamics ◽  
Functional Activity ◽  
Seasonal Characteristics ◽  
Research Period

   The article presents data on the breed and seasonal characteristics of the synthesis of thyroxine and cortisol in dogs of different breeds and cats that do not have a breed. It has been shown that the synthesis of thyroxine in dogs and cats depends on the breed, age and season. The functional activity of the thyroid gland in dogs decreases by 10-12, and in cats by 9-13 years of age. The highest level of thyroxine production throughout the entire research period belongs to the Griffon Petit-Brabancons. The synthesis of cortisol in dogs and cats is stable and does not undergo statistically significant changes. Seasonal dynamics of thyroxine is observed in dogs, but absent in cats. No sea-sonal dependence of cortisol synthesis has been reported in dogs and cats.

CHANGES IN THYROID FUNCTION INDUCED BY SHIFTS OF HYDROGEN ISO-TOPES RATIO

2021 ◽  
Author(s):  
Nataliya Yaglova ◽  
◽  
Sergey Obernikhin ◽  
Ekaterina Timokhina ◽  
◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Functional Activity ◽  
Short Term

Impact of short-term shift in deuterium body content on thyroid function was studied. In-creased functional activity of the thyroid gland, but without raise in rate of thyroxine to triiodothyronine conversion was found both after depletion and enrichment of deuterium body co

Lipid spectrum of breast milk and blood serum in women with different functional activity of the thyroid gland

1982 ◽  
Vol 63 (4) ◽  
pp. 42-43
Author(s):  
L. Ya. Salimova ◽  
N. N. Chukanin
Keyword(s):  
Breast Milk ◽  
Thyroid Gland ◽  
Blood Serum ◽  
Thyroid Function ◽  
Lipid Composition ◽  
Functional Activity ◽  
Lipid Fractions ◽  
Altered Thyroid ◽  
Lipid Spectrum

The paper presents the results of a study of the lipid spectrum of breast milk and blood serum in 48 women with different functional activity of the thyroid gland. A decrease in certain lipid fractions in blood serum and in breast milk in women with altered thyroid function was established. A definite regulating effect of the thyroid gland on the lipid composition of breast milk and blood serum was established.

Iodine deficiency diseases in children and adolescents (plenary lecture)

2019 ◽  
Vol 43 (3) ◽  
pp. 3-7 ◽  
Author(s):  
E. P. Kasatkina
Keyword(s):  
Thyroid Gland ◽  
Adverse Effects ◽  
Children And Adolescents ◽  
Human Health ◽  
Iodine Deficiency ◽  
Functional Activity ◽  
Endemic Goiter ◽  
Plenary Lecture ◽  
Long Time ◽  
Deficiency Diseases

The main consequence of iodine deficiency in the environment is the development of goiter in people living in iodine-deficient regions (endemic goiter). In this regard, for a long time it was considered that goiter is the only manifestation of this condition. It has now been proven that, in addition to goiter, iodine deficiency also has other adverse effects on human health. In 1983, the term "endemic goiter" was replaced by the term  "iodine deficiency diseases" (IDD). These diseases are caused by a decrease in the functional activity of the thyroid gland in response to iodine deficiency.

SECRETION OF THYROXINE, 3,5,3′-TRIIODOTHYRONINE AND 3,3′5′-TRIIODOTHYRONINE IN EUTHYROID MAN

1977 ◽  
Vol 84 (2) ◽  
pp. 281-289 ◽  
Author(s):  
U. Westgren ◽  
A. Melander ◽  
S. Ingemansson ◽  
A. Burger ◽  
S. Tibblin ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Venous Blood ◽  
Human Thyroid ◽  
Acute Administration ◽  
Peripheral Venous Blood ◽  
Before And After ◽  
Normal Human ◽  
Pre Treatment ◽  
Almost All ◽  
Secretion Rates

ABSTRACT The secretion of iodothyronines from the normal human thyroid gland was assessed by radioimmunoassay analyses of the concentrations of thyroxine (T4), 3,5,3′-triiodothyronine (T3) and 3,3′,5′-triiodothyronine (reverse T3, rT3) in thyroid venous and peripheral venous blood. The subjects studied were euthyroid patients undergoing parathyroid surgery. Measurements were carried out both under apparently normal conditions, following peroral T3 pre-treatment, and before and after acute administration of TSH into a thyroid artery. In the control subjects, significant gradients between thyroid venous and peripheral venous concentrations were recorded both for T4, T3 and rT3, suggesting that all three iodothyronines are secreted by the normal human thyroid. T3 pre-treatment seemed to reduce this secretion, and acute administration of TSH promoted rapid, marked, and concomitant increments in the thyroid venous concentrations of all three iodothyronines. Hence, it appears that not only T4 but also T3 and rT3 are secreted by the normal human thyroid gland, and that TSH stimulates the secretion of all three iodothyronines. On the other hand, calculations of the relative secretion rates yielded the relation T4:T3:rT3 as 85:9:1. This indicates that, in euthyroid subjects, most of T3, and almost all of rT3, is produced by extrathyroidal conversion of T4 and not by direct thyroidal secretion.

scholarly journals INFLUENCE OF ALIMENTARY DEPRIVATION ON MORPHOLOGICAL CHANGES OF RAT'S THYROID GLAND

2021 ◽  
Vol 26 (2(49)) ◽  
pp. 89-97
Author(s):  
R. V. Yanko
Keyword(s):  
Thyroid Gland ◽  
Functional Activity ◽  
Morphological Changes ◽  
Thyroid Tissue ◽  
Digital Camera ◽  
The Body ◽  
Standard Diet ◽  
Thyroid Cells ◽  
Experimental Animals ◽  
The Impact

Introduction: Despite the well-studied effect of alimentary deprivation on the body, the literature data on its effect on functional activity and, in particular, on morphological changes in the thyroid gland are single and often contradictory, which does not allow unambiguous conclusions. All this requires a more detailed study of the role and mechanisms of the impact of restricted nutrition on the thyroid gland. Aim: To investigate the effect of alimentary deprivation on morphological changes in the thyroid gland of young rats. Methods: The study was conducted on 24 male Wistar rats aged 3 months. Rats of all groups were in uniform conditions, on a standard diet. Animals of the experimental group, for 28 days, received a diet reduced by 30 %. Work with rats was carried out in accordance with the principles of the Declaration of Helsinki. Histological preparations were made from the central areas of the thyroid tissue according to the standard method. Using a digital camera, the micropreparations were photographed under a Nikon Eclipse E 100 microscope (Japan). Morphometry was performed using a computer program "Image J". Results: Histological analysis of the rat's thyroid gland affected by alimentary deprivation revealed that it had an unchanged physiological structure. The follicles were mostly of oval shape and of various sizes. Colloid in the follicles of experimental animals is of moderate density and contains numerous resorption vacuoles. Thyroid cells are of prismatic and cubic shape. It was found that in the thyroid gland of experimental rats the area of ​​follicles, colloid, their inner diameter decreases, the height of thyrocytes increases, the stereological resorption index increases and the colloid accumulation index decreases, the number of interfollicular islands increases. Also in experimental animals there was a decrease in the width of the interlobar and interfollicular connective tissue. Conclusion: In rats fed on a reduced diet, morphological signs of increased functional activity of the thyroid gland were found.

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