scholarly journals Comparative safety profiles of two enrofloxacin generics after repeated intracrop administration to broilers

2016 ◽  
Vol 4 (2) ◽  
pp. 170
Author(s):  
Nasser Ehmeza ◽  
Abdelrazzag Elmajdoub ◽  
Abdurazzag Abusnina ◽  
Emad Bennour ◽  
Giuma Elhafi Giuma Elhafi ◽  
...  
Keyword(s):  
Dose Regimen ◽  
Broiler Chickens ◽  
Histopathological Examination ◽  
Hematological Parameters ◽  
Repeated Administration ◽  
Control Group ◽  
Bolus Administration ◽  
Plasma Urea ◽  
Comparative Safety ◽  
Plasma Creatine Kinase

Clinicochemical, haematological and histopathological alterations were demonstrated in broiler chickens following repeated oral bolus administration of two different enrofloxacin generic preparations, formulated as 10% oral solutions, given at a dose regimen of 10 mg/Kg body weight for 5 consecutive days. The two tested preparations were Enrol® (Medmac®, Jordan), referred thereafter as ENRO-A; and Syvaquinol® (Syva®, Spain), which referred thereafter as ENRO-B. Eighteen broilers chickens, aging 40 days old, divided equally and randomly into three groups, have been used in the present study. ENRO-A or ENRO-B was given via intra-crop route of administration at the above-mentioned dose regimen to birds of the 2nd and the 3rd groups, respectively; where those of the 1st group were given water instead and kept as control. Blood samples were collected from all birds via the wing and metatarsal veins on the 5th day for clinicochemical and haematological examinations. Birds were then humanely sacrificed and liver, kidneys and heart were dissected out for histopathological examination. Results revealed that ENRO-A induced a significant (p<0.05) increase of the activity of alkaline phosphatase compared to ENRO-B as well as control group. Both ENRO-A and ENRO-B caused significant increases in the levels of plasma urea and creatinine concentrations compared to control (p<0.05), with higher significance in case of ENRO-A. Activity of plasma creatine kinase significantly (p<0.05) increased after ENRO-A compared to control and ENRO-B-treated groups. ENRO-A and ENRO-B significantly (p<0.05) increased blood glucose and triglyceride levels compared to that of control. Cholesterol level was increased significantly (p<0.05) only after ENRO-B repeated administration. However, other metabolic parameters showed insignificant changes. Parallel inflammatory and degenerative histopathological changes in the affected organs, except kidneys, have been observed. Nevertheless, administration of either ENRO-A or ENRO-B caused insignificant changes in hematological parameters of the treated chicken groups. Data of the present study may indicate that enrofloxacin may cause organ dysfunction in broilers during the course of therapy based on clinicochemical and histopathological reasons. The data may also indicate that the pharmaceutical technology may be a detrimental factor in safety profiles of generic products based on the differences recorded between the two tested brands.

scholarly journals Safety profile of clarithromycin in broilers after repeated oral administration

2016 ◽  
Vol 4 (2) ◽  
pp. 263
Author(s):  
Hanady Awadallah ◽  
Shaban Awidat ◽  
Emad Bennour ◽  
Giuma Elhafi ◽  
Abubakr El-Mahmoudy
Keyword(s):  
Oral Administration ◽  
Broiler Chickens ◽  
Histopathological Examination ◽  
Hematological Parameters ◽  
Repeated Administration ◽  
Blood Parameters ◽  
Parallel Study ◽  
Chemical Parameters ◽  
Liver And Kidney ◽  
Lipid Parameters

The effects of repeated oral administration of clarithromycin (7.5 mg/Kg B.W., daily for 5 consecutive days) on blood parameters, clinico-chemical parameters and vital organ histology were evaluated in Ross broiler chickens. Twelve clinically healthy birds have been used in a parallel study design, where they have been randomly divided into two groups. The 1st group received a dose of 7.5 mg clarithromycin/Kg as intracrop bolus daily for 5 consecutive days after 6 h fasting; while the 2nd group received iso-saline and was kept as control. Blood samples were collected from all birds via the wing and metatarsal vein punctures on the 5th day for clinico-chemical and haematological examinations; and liver, kidneys and heart were dissected out for histopathological examination. Results revealed that repeated administration of clarithromycin caused significant increases in ALP, AST, ALT, CK, urea and creatinine levels, compared to those of control. Metabolic parameters exhibited significant decrease in albumin with consequent decrease in total protein and decreased albumin/globulin ratio. Lipid parameters remained unchanged, compared to control. Leuckogram revealed that total leuckocytic count was decreased as a result of the decreased number of lymphocytes and mid-sized cells. On the other hand, granulocytes number exhibited significant increase (granulocytosis) together with increased number of platelets (thrombocytosis); while erythrogram remained insignifi-cantly affected. Liver and kidney showed inflammatory cellular infiltrations associated with degenerative changes and haemorrhages. Although heart did not show inflammatory cellular infiltrations, yet breakage in some bundles was noted. These data indicate that although clarithromycin did not cause any clinical serious manifestations on the treated birds, yet laboratory analysis revealed some adverse effects on some organs as liver, kidney and heart as well as alterations in some clinic-chemical and hematological parameters; these findings should be taken in consideration during therapy with clarithromycin.

scholarly journals Influence of Bacterial Organic Selenium on Blood Parameters, Immune Response, Selenium Retention and Intestinal Morphology of Broiler Chickens

2020 ◽  
Author(s):  
A. M. Dalia ◽  
T. C. Loh ◽  
A. Q. Sazili ◽  
Anjas Asmara Samsudin
Keyword(s):  
Broiler Chickens ◽  
Hematological Parameters ◽  
Basal Diet ◽  
Blood Parameters ◽  
Intestinal Morphology ◽  
Control Group ◽  
Villus Height ◽  
Organic Selenium ◽  
Significant Difference ◽  
Immunity Response

Abstract Background: Several studies indicated that dietary organic selenium (Se) usually absorbed better than an inorganic source, with high retention and bioavailability. Dietary Se as an antioxidant element affects the immune system and hematological status in animals. Therefore, the aim of this study was to evaluate the effect of dietary supplementation of bacterial selenium as an organic source on hematology, immunity response, selenium retention, and gut morphology in broiler chickens. Results: The present results revealed that supplementation of inorganic Se was associated with the lowest level of RBC, HB, and PCV with significant difference than ADS18-Se. In the starter stage, both T2 and T5 were associated with the significantly highest IgG level compared to the basal diet, while all supplemented groups showed higher IgM levels compared to the control group. In the finisher phase, all Se supplemented groups showed significant (P ˂ 0.05) increases in IgG, IgA, and IgM levels compared to T1. Birds fed bacterial-Se showed high intestinal villus height and better Se retention more than sodium selenite. The organic selenium of ADS18 had a superior action in improving Se retention compared to ADS1 and ADS2 bacterial Se. Conclusion: Bacterial organic Se had a beneficial effect on the villus height of small intestine led to high Se absorption and retention. Thus, it caused a better effect of Se on hematological parameters and immunity response.

scholarly journals EVALUATION OF EFFICIENCY OF APPLICATION OF FEED ADDITIVE ON BROILER CHICKENS

2020 ◽  
Vol 21 (2) ◽  
pp. 90-95
Author(s):  
T. R. Levytskyі
Keyword(s):  
Broiler Chickens ◽  
Hematological Parameters ◽  
Average Daily Gain ◽  
Live Weight ◽  
Feed Additives ◽  
Poultry Meat ◽  
Feed Additive ◽  
Control Group ◽  
Feed Conversion ◽  
Experimental Group

A study of the effectiveness of the use of feed additive Liaform in relation to its effect on the growth and development of broiler chickens. For research, 2 groups of broiler chickens of 55 heads (control and experimental) from 8 days of age were formed on the principle of analogues. Feeding of the control group was carried out with standard complete feed. Feeding of the experimental group was carried out with standard complete feed, in which the feed additive Liaform was added at the rate of 2 g / kg. During the experiment, the general condition of the bird, the safety of the bird, zootechnical and hematological parameters were monitored. It is established that the studied feed additive has a positive effect on the productivity of broiler chickens, improves feed absorption. As a result of the use of feed additive Liaform live weight of broiler chickens in the experimental group was 4.3 % higher compared to the control. The average daily gain of chickens in the experimental group exceeded this figure of chickens in the control group by 4,1 %. The use of feed additives helped to increase feed conversion. The use of Liaform feed increased the protein level in poultry meat

scholarly journals Effect of discriminate and indiscriminate use of oxytetracycline on residual status in broiler soft tissues

2020 ◽  
Vol 13 (1) ◽  
pp. 61-67
Author(s):  
Most. Rifat Ara Ferdous ◽  
Md. Raju Ahmed ◽  
Sayekul Hasan Khan ◽  
Mufsana Akter Mukta ◽  
Tasnia Tabassum Anika ◽  
...  
Keyword(s):  
Drinking Water ◽  
Thermal Effect ◽  
Broiler Chickens ◽  
Soft Tissues ◽  
Hematological Parameters ◽  
Volume Estimation ◽  
Control Group ◽  
Withdrawal Period ◽  
Cooking Method ◽  
Hematological Analysis

Aim: This study aimed to evaluate the effects of discriminate and indiscriminate use of oxytetracycline on hematological parameters, residual status in soft tissue of broiler and of thermal effect on oxytetracycline residual status. Materials and Methods: Eighteen, day-old male broiler chickens were purchased and were divided into three different groups (control group, discriminate group, and indiscriminate group). The control group received no antibiotics. The discriminate group received oxytetracycline 1 g/L drinking water for 5 consecutive days, and 10 days' withdrawal period was maintained before sacrifice. The indiscriminate group received oxytetracycline 1 g/L drinking water till the sacrificed day. Blood samples were collected before sacrificing for hematological analysis. After sacrificing liver, kidney, spleen, and muscle samples were collected for analysis of oxytetracycline residues in raw soft tissues. Since meat is used to cook by traditional method in Bangladesh before consumption that is why positive meat samples were cooked by traditional cooking method to evaluate the thermal effect on oxytetracycline residual status as well. Thin-layer chromatography (TLC) was done for screening of oxytetracycline residues in soft tissues. Results: Mean differences of total erythrocyte count (million/mm3), hemoglobin estimation (gm%), and packed cell volume (%) estimation were not statistically significant among the groups. TLC analysis of raw samples showed 100% positive results of all samples collected from the indiscriminate group. In contrast, samples collected from the discriminate group were negative for oxytetracycline residues. In the control group, all samples were negative for oxytetracycline residue. There was a significant (p<0.05) relationship of oxytetracycline residues among three different groups for liver, kidney, spleen, and muscle samples. Positive liver and muscle samples from the indiscriminate group were subjected to thermal treatment by traditional cooking method of Bangladesh. Oxytetracycline residues had found in cooked meat, liver, and juice part, suggesting that antibiotic residues disseminated to juice part from flesh part after cooking. Conclusion: Evidence suggests that proper maintenance of withdrawal period would minimize oxytetracycline residues in broiler soft tissues, whereas antibiotics retained in soft tissues of broiler in case of indiscriminate use. Traditional cooking does not change oxytetracycline residual status in edible tissues. Therefore, awareness regarding the proper maintenance of withdrawal period after antibiotic treatment of broiler is one of the best strategies which may positively reduce the risk of antimicrobial drugs residue in meat.

scholarly journals Influence of Bacterial Organic Selenium on Blood Parameters, Immune Response, Selenium Retention and Intestinal Morphology of Broiler Chickens

2020 ◽  
Author(s):  
A. M. Dalia ◽  
T. C. Loh ◽  
A. Q. Sazili ◽  
Anjas Asmara Samsudin
Keyword(s):  
Broiler Chickens ◽  
Hematological Parameters ◽  
Basal Diet ◽  
Blood Parameters ◽  
Intestinal Morphology ◽  
Control Group ◽  
Villus Height ◽  
Organic Selenium ◽  
Significant Difference ◽  
Immunity Response

Abstract Background: Several studies indicated that dietary organic selenium (Se) usually absorbed better than an inorganic source, with high retention and bioavailability. Dietary Se as an antioxidant element affects the immune system and hematological status in animals. Therefore, the aim of this study was to evaluate the effect of dietary supplementation of bacterial selenium as an organic source on hematology, immunity response, selenium retention, and gut morphology in broiler chickens. Results: The present results revealed that supplementation of inorganic Se was associated with the lowest level of RBC, HB, and PCV with significant difference than ADS18-Se. In the starter stage, both T2 and T5 were associated with the significantly highest IgG level compared to the basal diet, while all supplemented groups showed higher IgM levels compared to the control group. In the finisher phase, all Se supplemented groups showed significant (P ˂ 0.05) increases in IgG, IgA, and IgM levels compared to T1. Birds fed bacterial-Se showed high intestinal villus height and better Se retention more than sodium selenite. The organic selenium of ADS18 had a superior action in improving Se retention compared to ADS1 and ADS2 bacterial Se. Conclusion: Bacterial organic Se had a beneficial effect on the villus height of small intestine led to high Se absorption and retention. Thus, it caused a better effect of Se on hematological parameters and immunity response.

Chicken proventricular necrosis virus related transmissible viral proventriculitis in broiler chickens in Poland

2020 ◽  
Author(s):  
Marcin Śmiałek ◽  
Michał Gesek ◽  
Daria Dziwulska ◽  
Jowita Samanta-Niczyporuk ◽  
Andrzej Koncicki
Keyword(s):  
Body Weight ◽  
Broiler Chickens ◽  
Histopathological Examination ◽  
Cross Reactivity ◽  
Control Group ◽  
Feed Conversion ◽  
Necrosis Virus ◽  
Group A ◽  
Potential Factor ◽  
Antibody Levels

Abstract Background. Transmissible viral proventriculitis (TVP) is an infectious disease reported in all production types of chickens. TVP is manifested in decreased body weight gains, wide weight diversity of birds in the flock and poor feed conversion. Histopathological examination seems to be the most reliable method for confirming the disease. Although TVP etiology has not been explicitly defined, a novel virus identified as a member of the Birnaviridae family, named chicken proventricular necrosis virus (CPNV) has been isolated from clinical cases of TVP and it is now considered as a potential factor of a disease. The study was undertaken in order to reproduce the disease under laboratory conditions and to evaluate the etiology of first described Polish case of TVP. Results. Anatomopathological and histopathological evaluation reveled that we've succeeded to reproduce TVP in broiler chickens. Within 14 days after infection birds gained approximately 30,38% less body weight in comparison to Control group. In TVP infected group a seroconversion against FAdV and IBDV was recorded 14 days post infection (dpi). 14 dpi CPNV was detected in proventriculi, while FAdV in spleens and livers of infected birds. Conclusions. We have demonstrated that CPNV was involved in the development of the disease. We did not record the presence of IBDV in the TVP or control birds, despite our recording a strong seroconversion against IBDV in the birds from the TVP group. CPNV belongs to the same family as IBDV, which allows us to assume serological cross-reactivity between them. This possibility of CPNV infections affecting IBDV antibody levels detected by commonly available ELISAs should be taken into account under poultry field conditions and diagnosis. The role of FAdV in the development of TVP needs further evaluation.

THE EFFECT OF MICRONUTRIENT AND PROBIOTIC FOR HEMATOLOGICAL PARAMETERS OF BIRDS

2016 ◽  
Vol 1 (4) ◽  
pp. 71-74
Author(s):  
Колесникова ◽  
Irina Kolesnikova ◽  
Никулин ◽  
Vladimir Nikulin
Keyword(s):  
Potassium Iodide ◽  
Broiler Chickens ◽  
Hematological Parameters ◽  
Experimental Studies ◽  
Control Treatment ◽  
Maximum Effect ◽  
Control Group ◽  
Hemoglobin Content ◽  
Basic Diet ◽  
Experimental Group

The purpose of research is improving physiological and biochemical status and productive qualities of broiler chickens by including basic diet lactoamilovorin and potassium iodide. For experimental studies experimental and control groups formed randomly on the 35 day-old chicks, which were grown in Techa-of 42 days at the cellular content. It was found that the number of red blood cells in the blood of studied groups broiler chickens in the whole investigated period increased. leukocyte concentration was lower in broilers of the experimental group by 2.6%, compared to the control. The hemoglobin content increased in those chenie the entire period of study in a group of birds fed the probiotic and potassium iodide. Statistically significant differences in hematological parameters relative to those of the control group of birds observed in the integrated use of iodine preparations and probiotics in the period from 14 th to 42 th day. At 14, 21, 35 and 42 day old chicks advantage over the control treatment groups on the hemoglobin content amounted to 14.03, respectively; 10.40; 9.79 and 12.28%.Analyzing the morphological indicators of blood of experimental groups, it should be noted that they were within the physiological norm. The maximum effect is the physiological norm was observed in broiler chickens III experimental group, which in addition to the basic diet fed potassium iodide and lactoamilovorin.

scholarly journals Influence of bacterial organic selenium on blood parameters, immune response, selenium retention and intestinal morphology of broiler chickens

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
A. M. Dalia ◽  
T. C. Loh ◽  
A. Q. Sazili ◽  
A. A. Samsudin
Keyword(s):  
Broiler Chickens ◽  
Hematological Parameters ◽  
Basal Diet ◽  
Blood Parameters ◽  
Intestinal Morphology ◽  
Control Group ◽  
Villus Height ◽  
Organic Selenium ◽  
Significant Difference ◽  
Immunity Response

Abstract Background Several studies indicated that dietary organic selenium (Se) usually absorbed better than an inorganic source, with high retention and bioavailability. Dietary Se as an antioxidant element affects the immune system and hematological status in animals. Therefore, the aim of this study was to evaluate the effect of dietary supplementation of bacterial selenium as an organic source on hematology, immunity response, selenium retention, and gut morphology in broiler chickens. Results The present results revealed that supplementation of inorganic Se was associated with the lowest level of RBC, HB, and PCV with significant difference than ADS18-Se. In the starter stage, both T2 and T5 were associated with the significantly highest IgG level compared to the basal diet, while all supplemented groups showed higher IgM levels compared to the control group. In the finisher phase, all Se supplemented groups showed significant (P ˂ 0.05) increases in IgG, IgA, and IgM levels compared to T1. Birds fed bacterial-Se showed high intestinal villus height and better Se retention more than sodium selenite. The organic selenium of ADS18 had a superior action in improving Se retention compared to ADS1 and ADS2 bacterial Se. Conclusions Bacterial organic Se had a beneficial effect on the villus height of small intestine led to high Se absorption and retention. Thus, it caused a better effect of Se on hematological parameters and immunity response.

scholarly journals Influence of Bacterial Organic Selenium on Blood Parameters, Immune Response, Selenium Retention and Intestinal Morphology of Broiler Chickens

2020 ◽  
Author(s):  
A. M. Dalia ◽  
T. C. Loh ◽  
A. Q. Sazili ◽  
Anjas Asmara Samsudin
Keyword(s):  
Broiler Chickens ◽  
Hematological Parameters ◽  
Basal Diet ◽  
Blood Parameters ◽  
Intestinal Morphology ◽  
Control Group ◽  
Villus Height ◽  
Organic Selenium ◽  
Significant Difference ◽  
Immunity Response

Abstract Background Several studies indicated that dietary organic Se usually absorbed better than inorganic Se with high retention and bioavailability. Dietary Se as an antioxidant element affects the immune system and hematological status in animals. Therefore, the aim of this study was to evaluate the effect of dietary supplementation of bacterial selenium as organic source on hematology, immunity response, selenium retention and gut morphology in broiler chickens.Results The present results revealed that supplementation of inorganic Se was associated with the lowest level of RBC, HB, and PCV with significant difference than ADS18-Se. In the starter stage, both T2 and T5 were associated with the significantly highest IgG level compared to the basal diet, while all supplemented groups showed higher IgM level compared to control group. In the finisher phase, all Se supplemented groups showed significant (P ˂ 0.05) increases in IgG, IgA and IgM levels compared to T1. Birds fed bacterial-Se showed high intestinal villus height and better Se retention more than sodium selenite. Selenium of ADS18 had a superior action in improving Se retention compared to ADS1 and ADS2 bacterial Se.Conclusion Bacterial organic Se had a beneficial effect on villus height of small intestine led to high Se absorption and retention. Thus, caused better effect of Se on hematological parameters and immunity response.

scholarly journals THE IMPACT OF PROBIOTIC “PROPIONOVYY” ON THE PRODUCTIVITY AND HEMATOLOGICAL FEATURES OF BROILERS

2019 ◽  
pp. 98-104
Author(s):  
T. N. Orlova
Keyword(s):  
Broiler Chickens ◽  
Hematological Parameters ◽  
Average Daily Gain ◽  
Live Weight ◽  
Cholesterol Concentration ◽  
Control Group ◽  
Livestock Farming ◽  
Siberian Research Institute ◽  
Feed Costs ◽  
The Impact

The paper demonstrates the results of applying some doses of probiotic specimen “Propionovyy” when feeding broilers. Propionovyy specimen was developed by the staff of the Laboratory of Microbiology of the department “Siberian Research Institute of Chemistry” of Federal Altai Center of Agricultural Biotechnologies. It includes multi strain propionate of Propionibacterium freudenreichii type taken from the Siberian collection of microorganisms. The scientific and economic experiment was conducted at the poultry farm of LLC Kuzbass Broiler in the Kemerovo region. The researchers arranged four groups of broiler chickens; each group contained 198 broilers. The control group received a basic diet without probiotics. In the experimental groups, different dosages of Propionovyy specimen were added to the main diet instead of feed antibiotic. The experiment explores the effect of “Propionovyy” specimen on livestock farming and physiological parameters of broiler chickens. The following indicators were considered: live weight, absolute and average daily gain of live weight, poultry liveability, feed costs per 1 kg of gain, morphological and biochemical indicators of blood at the age of 28 and 39 days. The researchers observed the chickens of experimental groups who received probiotic specimen “Propionovyy” and found out an increase in live weight by 0.49-1.94%, an absolute and average daily increase of up to 2.00%. The safety of the chickens receiving the probiotic was increased by 1.00-2.02% compared to the control group. Hematological parameters of blood in chickens of all groups varied within the limits of physiological standard that testifies to the healthy physiological condition of the poultry. The authors found out the decrease of glucose and cholesterol concentration in blood serum in the experimental groups. According to the research results the authors elaborated the appropriate and efficient dosage of “Propionovyy” specimen, rendering the greatest positive effect on productive qualities of poultry and reducing expenses of forages on 1 kg of growth on 0,05 kg.

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