scholarly journals Loneliness and Cardiovascular Disease

2021 ◽  
Vol 9 (1) ◽  
pp. 40
Author(s):  
Shashi K. Agarwal
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Significant Role ◽  
Financial Burden ◽  
Poor Compliance ◽  
Healthy Lifestyles ◽  
Molecular Effect ◽  
The Us

Loneliness is a silent social epidemic that affects more than one third of the US population. Cardiovascular diseases impart a huge morbidity, mortality, and financial burden on our society. The detrimental role of loneliness in cardiovascular diseases is being increasingly recognized. Besides having a direct molecular effect on cardiovascular diseases, loneliness also encourages poor compliance with healthy lifestyles, that play a significant role in preventing and improving cardiovascular diseases. This brief review highlights the ominous effects of loneliness on cardiovascular diseases.

The Evolving Role of Angiotensin Receptor Blockers in Heart Failure

2002 ◽  
Vol 37 (5) ◽  
pp. 474-482
Author(s):  
Patricia A. Howard
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Angiotensin Receptor Blockers ◽  
Angiotensin Receptor ◽  
Cardiovascular Pharmacotherapy ◽  
The Us ◽  
Prevention And Treatment ◽  
Recent Developments ◽  
Receptor Blockers

This continuing feature will update readers on recent developments in cardiovascular pharmacotherapy. Cardiovascular disease remains the number one killer in the US, and more clinical outcome trials have been conducted in cardiology than in any other field of medicine. Given this rapidly expanding knowledge base, pharmacists can have a significant impact on the prevention and treatment of cardiovascular disease—if they keep current with developments in drug therapy.

scholarly journals The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular Diseases

2020 ◽  
Vol 21 (11) ◽  
pp. 4006
Author(s):  
Levi W. Evans ◽  
Maheshi Athukorala ◽  
Kristina Martinez-Guryn ◽  
Bradley S. Ferguson
Keyword(s):  
Cardiovascular Diseases ◽  
Histone Acetylation ◽  
Fruits And Vegetables ◽  
Financial Burden ◽  
Epigallocatechin Gallate ◽  
Mechanisms Of Action ◽  
Global Changes ◽  
Treatment And Prevention ◽  
The Impact

Cardiovascular diseases (CVD) are the main cause of death worldwide and create a substantial financial burden. Emerging studies have begun to focus on epigenetic targets and re-establishing healthy gut microbes as therapeutic options for the treatment and prevention of CVD. Phytochemicals, commonly found in fruits and vegetables, have been shown to exert a protective effect against CVD, though their mechanisms of action remain incompletely understood. Of interest, phytochemicals such as curcumin, resveratrol and epigallocatechin gallate (EGCG) have been shown to regulate both histone acetylation and microbiome re-composition. The purpose of this review is to highlight the microbiome–epigenome axis as a therapeutic target for food bioactives in the prevention and/or treatment of CVD. Specifically, we will discuss studies that highlight how the three phytochemicals above alter histone acetylation leading to global changes in gene expression and CVD protection. Then, we will expand upon these phytochemicals to discuss the impact of phytochemical–microbiome–histone acetylation interaction in CVD.

scholarly journals Association between faecal haemoglobin concentration and the risk of cardiovascular diseases among Taiwanese adults in a community-based screening cohort

BMJ Open ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. e032633 ◽  
Author(s):  
Kuo-Liong Chien ◽  
Ting-Yu Lin ◽  
Chen-Yang Hsu ◽  
Chang-Chuan Chan ◽  
Tony Hsiu-Hsi Chen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Cardiovascular Events ◽  
Reference Group ◽  
Haemoglobin Concentration ◽  
Population Based ◽  
Trend Test ◽  
Cohort Study Design

ObjectivesThe role of faecal haemoglobin as a colorectal cancer screening tool has been demonstrated. However, the association between the faecal haemoglobin concentration and the risk of cardiovascular disease events and deaths is still unclear.DesignCohort study design.SettingPopulation-based organised integrated service screening in Keelung City, TaiwanParticipantsA total of 33 355 healthy individuals aged over 40 years who were free of cardiovascular disease at study entry were followed up.Main outcomes and measuresNewly diagnosed cardiovascular disease events and deaths.ResultsAfter a median follow-up of 2.39 years, a total of 2768 participants developed cardiovascular events, and after a median follow-up of 8.43 years, 317 cases of cardiovascular deaths occurred. The risk of cardiovascular disease increased with baseline faecal haemoglobin in a dose–response manner, yielding a significant elevated risk of cardiovascular disease in parallel with the incremental concentration of faecal haemoglobin (adjusted HRs=1.04, 1.10, 1.40 and 1.23 for faecal haemoglobin concentrations of 1–19, 20–49, 50–99 and ≥100 ng/mL, trend test, p<0.0001, as compared with the reference group with undetectable faecal haemoglobin concentrations). A similar pattern was observed for the risk of cardiovascular disease deaths. In addition, the faecal haemoglobin improved the prediction performance of the model for the risk of cardiovascular diseases; the integrated discrimination improvement was 0.3% (p<0.001) for cardiovascular events and 0.1% (p=0.020) for cardiovascular deaths.ConclusionsOur data support that faecal haemoglobin concentrations may be associated with the risk of cardiovascular diseases. The biological mechanisms underlying the role of faecal haemoglobin as health outcomes should be investigated.

Hypothyroidism and cardiovascular system

2016 ◽  
Vol 94 (7) ◽  
pp. 497-503 ◽  
Author(s):  
A. F. Verbovoy ◽  
Lyudmila A. Sharonova ◽  
O. V. Kosareva ◽  
N. I. Verbovaya ◽  
Yu. A. Dolgikh
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Vitamin D3 ◽  
Thyroid Dysfunction ◽  
Myocardial Remodeling ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

The article presents data on the relationship between thyroid dysfunction and cardiovascular diseases. The role of dyslipidemia, adipokines (adiponectin, leptin, resistin), C-reactive protein, deficiency of vitamin D3 in the development of cardiovascular disease in hypothyroidism is discussed. The article describes characteristics of myocardial remodeling, its dysfunction and their correlation with risk factors of cardiovascular diseases in patients with hypothyroidism.

The significant role of the Golgi apparatus in cardiovascular diseases

2017 ◽  
Vol 233 (4) ◽  
pp. 2911-2919 ◽  
Author(s):  
Liqun Lu ◽  
Qun Zhou ◽  
Zhe Chen ◽  
Linxi Chen
Keyword(s):  
Cardiovascular Diseases ◽  
Golgi Apparatus ◽  
Significant Role

scholarly journals microRNAs in the onset and development of cardiovascular disease

2013 ◽  
Vol 126 (3) ◽  
pp. 183-194 ◽  
Author(s):  
Kasey C. Vickers ◽  
Kerry-Anne Rye ◽  
Fatiha Tabet
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Present Review ◽  
Novel Therapies ◽  
Regulatory Processes ◽  
Gene Regulatory

Physiological and pathological roles for small non-encoding miRNAs (microRNAs) in the cardiovascular system have recently emerged and are now widely studied. The discovery of widespread functions of miRNAs has increased the complexity of gene-regulatory processes and networks in both the cardiovascular system and cardiovascular diseases. Indeed, it has recently been shown that miRNAs are implicated in the regulation of many of the steps leading to the development of cardiovascular disease. These findings represent novel aspects in miRNA biology and, therefore, our understanding of the role of these miRNAs during the pathogenesis of cardiovascular disease is critical for the development of novel therapies and diagnostic interventions. The present review will focus on understanding how miRNAs are involved in the onset and development of cardiovascular diseases.

scholarly journals Redefining the Scope of Ayurveda in Cardiology

2018 ◽  
Vol 6 (5) ◽  
pp. 56-59
Author(s):  
Jithesh Madhavan
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Medicinal Plants ◽  
World Health Organization ◽  
Dietary Supplements ◽  
Significant Role ◽  
World Health ◽  
Preventive Cardiology ◽  
The World ◽  
Health Organization

Cardiovascular diseases (CVDs) have now become the leading cause of mortality or even morbidity in India. According to the World Health Organization, cardiovascular disease causes 12 million deaths in the world each year. Even with all the advancements in medicine, the management of CVD’s are yet to be redefined. Ayurveda proposes a different understanding to etiopathogenesis of such conditions and subsequent healthcare, in the context of hrdroga. Latest researches in Ayurveda have given a new hope in CVDs, the curative as well as preventive aspects. With the emergence of increasing number of cardiac problems from the young age itself, it is the time to explore various options available in the alternative areas of medicine. Herbs and dietary supplements can have significant role in preventive cardiology as well as per published studies. Equivalent is the management of associative psychological contributors. In this article, research works of medicinal plants useful in cardiology are described with special emphasis on rasona, arjuna, guggulu, amalaki and gokshura. This work emphasises the scope of such practice so as to popularize the options available in Ayurvedic literature.

scholarly journals Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities

2021 ◽  
Author(s):  
Hongyang Shu ◽  
Yizhong Peng ◽  
Weijian Hang ◽  
Ning Zhou ◽  
Dao Wen Wang
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Reperfusion Injury ◽  
Cardiovascular System ◽  
Molecular Mechanisms ◽  
Ischemia Reperfusion Injury ◽  
Therapeutic Potential ◽  
Ischemia Reperfusion ◽  
Heart Research

Valosin-containing protein (VCP/p97) is a member of the conserved type II AAA+ (ATPases associated with diverse cellular activities) family of proteins with multiple biological functions, especially in protein homeostasis. Mutations in VCP/p97 are reportedly related to unique autosomal dominant diseases, which may worsen cardiac function. Although the structure of VCP/p97 has been clearly characterized, with reports of high abundance in the heart, research focusing on the molecular mechanisms underpinning the roles of VCP/p97 in the cardiovascular system has been recently undertaken over the past decades. Recent studies have shown that VCP/p97 deficiency affects myocardial fibers and induces heart failure, while overexpression of VCP/p97 eliminates ischemia/reperfusion injury and relieves pathological cardiac hypertrophy caused by cardiac pressure overload, which is related to changes in the mitochondria and calcium overload. However, certain studies have drawn opposing conclusions, including the mitigation of ischemia/reperfusion injury via inhibition of VCP/p97 ATPase activity. Nevertheless, these emerging studies shed light on the role of VCP/p97 and its therapeutic potential in cardiovascular diseases. In other words, VCP/p97 may be involved in the development of cardiovascular disease, and is anticipated to be a new therapeutic target. This review summarizes current findings regarding VCP/p97 in the cardiovascular system for the first time, and discusses the role of VCP/p97 in cardiovascular disease.

scholarly journals Role of Serum Amyloid A in Abdominal Aortic Aneurysm and Related Cardiovascular Diseases

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1883
Author(s):  
Preetha Shridas ◽  
Avery C. Patrick ◽  
Lisa R. Tannock
Keyword(s):  
Cardiovascular Disease ◽  
Abdominal Aortic Aneurysm ◽  
Cardiovascular Diseases ◽  
Aortic Aneurysm ◽  
Serum Amyloid A ◽  
Epidemiological Data ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Abdominal Aortic

Epidemiological data positively correlate plasma serum amyloid A (SAA) levels with cardiovascular disease severity and mortality. Studies by several investigators have indicated a causal role for SAA in the development of atherosclerosis in animal models. Suppression of SAA attenuates the development of angiotensin II (AngII)-induced abdominal aortic aneurysm (AAA) formation in mice. Thus, SAA is not just a marker for cardiovascular disease (CVD) development, but it is a key player. However, to consider SAA as a therapeutic target for these diseases, the pathway leading to its involvement needs to be understood. This review provides a brief description of the pathobiological significance of this enigmatic molecule. The purpose of this review is to summarize the data relevant to its role in the development of CVD, the pitfalls in SAA research, and unanswered questions in the field.

Cardiomegaly found in the 2019 Novel Coronavirus Disease (COVID-19): Analysis of 115 Patients

2020 ◽  
Author(s):  
Zeinab Shankayi ◽  
Farideh Bahrami ◽  
Tahereh Mohammadzadeh ◽  
Amineh Ghafari Anvar ◽  
Hosein Amini ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Ct Scan ◽  
Respiratory Illness ◽  
Mortality And Morbidity ◽  
Study Results ◽  
Novel Coronavirus ◽  
Optimum Management ◽  
Chest Ct Scan

Abstract Objectives There is much evidence showing that most of the mortality and morbidity cases are observed in COVID-19 patients with cardiovascular diseases. Thus, the study on COVID 19 patients with cardiovascular diseases is required for their optimum management. The present study presents a preliminary report on the cardiomegaly of laboratory and CT findings of COVID-19 pneumonia in Iran. A total of 115 Patients with COVID-19 pneumonia hospitalized in (confirmed by CT scan and RT-PCR) Baghiyatallah hospital participated in the present study. Results Thirty-three of these patients (26.8%) had cardiomegaly detected by chest CT scan. Creatinine, Urea and CRP levels of patients significantly increased based on cardiovascular disease detection. In contrast, Sodium levels reduced to below the normal in patients with cardiomegaly. Despite respiratory illness as the first symptom of COVID-19, the role of other diseases such as cardiovascular disease requires further investigation.

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