Epitopes on the Meningococcal Class 1 Protein.

1991 ◽  
pp. 153-158
Author(s):  
E. Wedege ◽  
D.A. Caugant ◽  
L.O. Frøholm
Keyword(s):  
Class 1

Nonspecific Chronic Back Pain: Sixth Edition Approaches

2019 ◽  
Vol 24 (5) ◽  
pp. 14-15
Author(s):  
Jay Blaisdell ◽  
James B. Talmage
Keyword(s):  
Back Pain ◽  
Chronic Back Pain ◽  
Intervertebral Disk ◽  
Key Factors ◽  
Sixth Edition ◽  
Whole Person ◽  
Class 1 ◽  
A Cell ◽  
Intervertebral Disk Herniation ◽  
The Individual

Abstract Ratings for “non-specific chronic, or chronic reoccurring, back pain” are based on the diagnosis-based impairment method whereby an impairment class, usually representing a range of impairment values within a cell of a grid, is selected by diagnosis and “specific criteria” (key factors). Within the impairment class, the default impairment value then can be modified using non-key factors or “grade modifiers” such as functional history, physical examination, and clinical studies using the net adjustment formula. The diagnosis of “nonspecific chronic, or chronic reoccurring, back pain” can be rated in class 0 and 1; the former has a default value of 0%, and the latter has a default value of 2% before any modifications. The key concept here is that the physician believes that the patient is experiencing pain, yet there are no related objective findings, most notably radiculopathy as distinguished from “nonverifiable radicular complaints.” If the individual is found not to have radiculopathy and the medical record shows that the patient has never had clinically verifiable radiculopathy, then the diagnosis of “intervertebral disk herniation and/or AOMSI [alteration of motion segment integrity] cannot be used.” If the patient is asymptomatic at maximum medical improvement, then impairment Class 0 should be chosen, not Class 1; a final whole person impairment rating of 1% indicates incorrect use of the methodology.

ЖУРНАЛІСТСЬКІ ПРОФЕСІЇ НА РАДІО В ЕПОХУ КОНВЕРҐЕНТНОСТІ МОВЛЕННЯ

2020 ◽  
pp. 48
Author(s):  
V. Kostiuk ◽  
Yu. Kostiuk ◽  
O. Usmanova
Keyword(s):  
Web Sites ◽  
Technology Development ◽  
Media Management ◽  
Radio Stations ◽  
Evolution And Development ◽  
Top Managers ◽  
Class 1 ◽  
E Mail ◽  
Business Media ◽  
Marketing Director

<div><p class="1"><em>The article’s research used the analysis scientific-sources base on a select question, web-sites of the stations (media concern TAVR Media and Internet-station </em><em>SKOVORODA), monitoring.</em></p></div><p><em>Broadcast relieve some periods of improvement, evolution and development, based on it’s features. One of the progress’ reason is technology development connected with radio. The end of last century and twenty years of current one characterise by universalism and convergence, that let media, beyond broadcast, had got the characteristics it never had before: watch the radio, fast connection between audience representers, communication with station’s journalists.</em></p><p><em>It made some influence and changes on the principles of formatting and functioning journalists professions at the radio. First, media concerns started to appeared, which have some stations in their structure, that have same top managers, almost similar department, close principles of airing. Second, Internet-stations let their audience the possibility to observe the air.</em></p><p><em>During the research, we defined, the administration of TAVR Media has the managers on each direction: manager of radio group, financial manager, commercial one (responsible for the sale), marketing director, (pr and image), general producer (manage musician direction), the station’s director.</em></p><p><em>Today, station has to work in active way and communicate with their audience, using messengers, profiles in social media. As a result, radio stations have in their arsenal person or group of persons which responsible for that activity. For example, web-radio SKOVORODA has a man, who manage </em><em><br /> </em><em>IT-work. Main duties of him: work with social medias, site content, deal with e-mail. Station’s of</em><em> </em><em>TAVR Media group (Melodiya FM, Relax, Radio Rocks, Russkoye Radio v Ukrayini, KISS FM, ХІТ FM) also have representers of modern professions: the head of digital department, traffic manager, system admin, etc.</em></p><p><em>Comparative analysis of the professions at radio, which include in the concern TAVR Media and web-station SKOVORODA did in the articleIn.</em></p><p><em>The research results can be used during the further study of radio journalism, teaching of one’s subject during the process of study students at faculture journalism, business media, management, etc.</em></p><p><strong><em>Key words:</em></strong><em> fm-broadcast, web-radio, journalist professions, media concern, radio presenter.</em><em></em></p>

METODE PEMBELAJARAN SAS UNTUK MENINGKATKAN KETERAMPILAN MEMBACA SISWA KELAS I SD NEGERI 021 SITORAJO KARI KECAMATAN KUANTAN TENGAH KABUPATEN KUANTAN SINGINGI

2018 ◽  
Vol 2 (5) ◽  
pp. 659
Author(s):  
Emgusnadi Emgusnadi
Keyword(s):  
Learning Outcomes ◽  
Reading Skills ◽  
Class I ◽  
Low Grade ◽  
Observation Data ◽  
School Students ◽  
Class 1 ◽  
Reading Study ◽  
Student Observation ◽  
Daily Test

Reading learning in the low grade class 1, which is often done in the early stages of learning which is calledpreliminary reading, has been done in various ways so that students read smoothly, but the numbers of studentswho cannot read in grade 1 are high. Therefore, researchers conducted research to improve reading skills ingrade 1 elementary school students by using the SAS learning method. . The research class study is improvementstudying process to solve problem that can be happen by a teacher in the class. Data on gain after research toteacher activity in cycle I meeting 1 with percentage 58%, meeting 2 with percentage 70,5%, in cycle II meeting3 percentage in the amount of 84%, and meeting 4 percentage obtained 97%. The student observation data inthis research obtained percentage in cycle I meeting 1 in the amount 51,5%, meeting 2 in the amount 66,5%, inthe cycle II meeting 3 in the amount 89%, and inthe meeting 4 obtained percentage in the amount 94% this isprove if the student activity is rise experience. Data increase learning outcomes in the class I SDN 021 SitorajoKari kecamatan Kuantan Tengah in the data early obtained average 60,5, in the daily test 1 obtained average inthe amount 74, and in the daily test 2 obtained average in the amount 83 this prove using the method of SAS theefective reading study used in class I.

IMPLEMENTASI MANAJEMEN PEMBELAJARAN TAHFIDZUL QUR’AN DI MI ISTIQOMAH SAMBAS PURBALINGGA

2018 ◽  
Vol 19 (2) ◽  
pp. 104-120
Author(s):  
Maulana Khusen
Keyword(s):  
Decision Making ◽  
Teacher Performance ◽  
Learning Program ◽  
Target Class ◽  
Class 1 ◽  
Second Year ◽  
Learning Management ◽  
Coordination Meeting

Abstract: The results of the study show that: (1) Tahfidzul Qur'an learning planning is done through the preparation of memorization targets and the determination of effective weeks and days in each semester; (2) Organizing is carried out through the division of tasks and responsibilities as well as the construction of the structure of the tutoring teacher; (3) The mobilization is carried out through the coordination meeting of the Tahfidz coordinator as a shering forum for decision making and direction of the Tahfidzul Qur'an learning program and the implementation of learning is carried out every Monday-Friday; and (4) Supervision is carried out through assessing teacher performance at the end of December and June. The highest achievement target for the second year of the implementation of the Tahfidzul Qur'an's 2017/2018 year program is juz 29 and 30, the lowest target for class 1 is juz 30 to Surat al Ghosyiyyah. For class 1, 85% of the target is achieved and 11% of students exceed the target. Class 2 targets reached 19%. Class 3, 10.86% reached the target and 0.35% of students exceeded the target. Class 4 tarjet reached 12.44%. Class 5 targets reached 4.24%, and the last grade 6 target reached 13.79% and 1.5% of students exceeded the target. Keywords: Learning Management, Tahfidzul Qur'an.

Antigens HLA class 1 in patients with anterior uveitis with and without spondyloarthritis

2020 ◽  
pp. 195-196
Author(s):  
I.Y. Razumova ◽  
◽  
A.A. Godzenko ◽  
I.A. Guseva ◽  
◽  
...  
Keyword(s):  
Anterior Uveitis ◽  
Class 1 ◽  
Hla Class 1

Mechanisms of Drug Solubilization by Polar Lipids in Biorelevant Media

2020 ◽  
Author(s):  
Vladimir Katev ◽  
Zahari Vinarov ◽  
Slavka S. Tcholakova
Keyword(s):  
Chain Length ◽  
Acyl Chain ◽  
Polar Lipids ◽  
Superior Performance ◽  
Head Group ◽  
Formulation Development ◽  
Biorelevant Media ◽  
Drug Solubilization ◽  
Colloidal Aggregates ◽  
Class 1

Despite the widespread use of lipid excipients in both academic research and oral formulation development, rational selection guidelines are still missing. In the current study, we aimed to establish a link between the molecular structure of commonly used polar lipids and drug solubilization in biorelevant media. We studied the effect of 26 polar lipids of the fatty acid, phospholipid or monoglyceride type on the solubilization of fenofibrate in a two-stage <i>in vitro</i> GI tract model. The main trends were checked also with progesterone and danazol.<br>Based on their fenofibrate solubilization efficiency, the polar lipids can be grouped in 3 main classes. Class 1 substances (n = 5) provide biggest enhancement of drug solubilization (>10-fold) and are composed only by unsaturated compounds. Class 2 materials (n = 10) have an intermediate effect (3-10 fold increase) and are composed primarily (80 %) of saturated compounds. Class 3 materials (n = 11) have very low or no effect on drug solubilization and are entirely composed of saturated compounds.<br>The observed behaviour of the polar lipids was rationalized by using two classical physicochemical parameters: the acyl chain phase transition temperature (<i>T</i><sub>m</sub>) and the critical micellar concentration (CMC). Hence, the superior performance of class 1 polar lipids was explained by the double bonds in their acyl chains, which: (1) significantly decrease <i>T</i><sub>m</sub>, allowing these C18 lipids to form colloidal aggregates and (2) prevent tight packing of the molecules in the aggregates, resulting in bigger volume available for drug solubilization. Long-chain (C18) saturated polar lipids had no significant effect on drug solubilization because their <i>T</i><sub>m</sub> was much higher than the temperature of the experiment (<i>T</i> = 37 C) and, therefore, their association in colloidal aggregates was limited. On the other end of the spectrum, the short chain octanoic acid manifested a high CMC (50 mM), which had to be exceeded in order to enhance drug solubilization. When these two parameters were satisfied (C > CMC, <i>T</i><sub>m</sub> < <i>T</i><sub>exp</sub>), the increase of the polar lipid chain length increased the drug solubilization capacity (similarly to classical surfactants), due to the decreased CMC and bigger volume available for solubilization.<br>The hydrophilic head group also has a dramatic impact on the drug solubilization enhancement, with polar lipids performance decreasing in the order: choline phospholipids > monoglycerides > fatty acids.<br>As both the acyl chain length and the head group type are structural features of the polar lipids, and not of the solubilized drugs, the impact of <i>T</i><sub>m</sub> and CMC on solubilization by polar lipids should hold true for a wide variety of hydrophobic molecules. The obtained mechanistic insights can guide rational drug formulation development and thus support modern drug discovery pipelines.<br>

Mechanisms of Drug Solubilization by Polar Lipids in Biorelevant Media

2020 ◽  
Author(s):  
Vladimir Katev ◽  
Zahari Vinarov ◽  
Slavka S. Tcholakova
Keyword(s):  
Chain Length ◽  
Acyl Chain ◽  
Polar Lipids ◽  
Superior Performance ◽  
Head Group ◽  
Formulation Development ◽  
Biorelevant Media ◽  
Drug Solubilization ◽  
Colloidal Aggregates ◽  
Class 1

Despite the widespread use of lipid excipients in both academic research and oral formulation development, rational selection guidelines are still missing. In the current study, we aimed to establish a link between the molecular structure of commonly used polar lipids and drug solubilization in biorelevant media. We studied the effect of 26 polar lipids of the fatty acid, phospholipid or monoglyceride type on the solubilization of fenofibrate in a two-stage <i>in vitro</i> GI tract model. The main trends were checked also with progesterone and danazol.<br>Based on their fenofibrate solubilization efficiency, the polar lipids can be grouped in 3 main classes. Class 1 substances (n = 5) provide biggest enhancement of drug solubilization (>10-fold) and are composed only by unsaturated compounds. Class 2 materials (n = 10) have an intermediate effect (3-10 fold increase) and are composed primarily (80 %) of saturated compounds. Class 3 materials (n = 11) have very low or no effect on drug solubilization and are entirely composed of saturated compounds.<br>The observed behaviour of the polar lipids was rationalized by using two classical physicochemical parameters: the acyl chain phase transition temperature (<i>T</i><sub>m</sub>) and the critical micellar concentration (CMC). Hence, the superior performance of class 1 polar lipids was explained by the double bonds in their acyl chains, which: (1) significantly decrease <i>T</i><sub>m</sub>, allowing these C18 lipids to form colloidal aggregates and (2) prevent tight packing of the molecules in the aggregates, resulting in bigger volume available for drug solubilization. Long-chain (C18) saturated polar lipids had no significant effect on drug solubilization because their <i>T</i><sub>m</sub> was much higher than the temperature of the experiment (<i>T</i> = 37 C) and, therefore, their association in colloidal aggregates was limited. On the other end of the spectrum, the short chain octanoic acid manifested a high CMC (50 mM), which had to be exceeded in order to enhance drug solubilization. When these two parameters were satisfied (C > CMC, <i>T</i><sub>m</sub> < <i>T</i><sub>exp</sub>), the increase of the polar lipid chain length increased the drug solubilization capacity (similarly to classical surfactants), due to the decreased CMC and bigger volume available for solubilization.<br>The hydrophilic head group also has a dramatic impact on the drug solubilization enhancement, with polar lipids performance decreasing in the order: choline phospholipids > monoglycerides > fatty acids.<br>As both the acyl chain length and the head group type are structural features of the polar lipids, and not of the solubilized drugs, the impact of <i>T</i><sub>m</sub> and CMC on solubilization by polar lipids should hold true for a wide variety of hydrophobic molecules. The obtained mechanistic insights can guide rational drug formulation development and thus support modern drug discovery pipelines.<br>

ADAPTIVE CAPACITY OF EINKORN HUSKLESS IN THE SECOND, THIRD AND SEVENTH RUSSIAN FEDERATION REGIONS

1970 ◽  
pp. 34-38
Author(s):  
S. K. Temirbekova ◽  
M. Sh. Begeulov ◽  
Yu. V. Afanaseva ◽  
I. M. Kulikov ◽  
N. E. Ionova
Keyword(s):  
Amino Acids ◽  
Biochemical Analysis ◽  
Chemical Properties ◽  
First Grade ◽  
Essential Amino Acids ◽  
Wheat Grain ◽  
Volume Yield ◽  
Class 1 ◽  
Group B ◽  
Field And Laboratory Conditions

Biochemical, immunological and physico-chemical properties of an ancient wheat grain – hulless spelt cultivar Gremme are investigated. Biochemical analysis of grain revealed a high content of protein, fiber, macro-and microelements, a rich composition of essential amino acids, which is characteristic of ancient wheat species. Evaluated milling and baking properties of spelt flour. Physical and chemical parameters of spelt grain met the requirements for soft wheat grain class 1: the mass fraction of gluten-38.7 %, the nature of the grain-795 g / l, the number of drops-416 C, the total vitreousness-70 %. However, gluten had an increased stickiness, which is obviously due to the increased content of fiber and gliadin fraction. Grinding of spelt grain was carried out on the aggregate mill installation "Miller 100 Lux" to obtain baking flour of various cultivars. The overall yield of flour of the first grinding was 59.7 %. The highest volume yield (359 cm3) and the best organoleptic properties (total baking score – 3.6 points) were observed in a sample of bread baked from spelt flour that meets the requirements for wheat baking flour of the first grade. Studies have confirmed the possibility of using flour produced from the spelt grain of the Gremme variety for the production of bakery products of increased biological, therapeutic and prophylactic, nutritional value and with a high organoleptic rating. Cereals and flour are very rich in trace elements-manganese, selenium, zinc, potassium, iron, phosphorus, vitamins from group B and B, essential amino acids (biochemical analysis was carried out by the Cherkizovo Center). The cultivar is resistant to drought, heat, excessive moisture. Proved immunological properties to several diseases in the field and laboratory conditions-resistant to enzyme-mycotic seed depletion (EMIS), various types of rust, powdery mildew.

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