scholarly journals Resveratrol and Its Analogues – Is It a New Strategy of Anticancer Therapy?

2017 ◽  
Vol 5 (1) ◽  
pp. 32-42 ◽  
Author(s):  
Sylwia Borys ◽  
Ronza Khozmi ◽  
Wiesława Kranc ◽  
Artur Bryja ◽  
Michal Jeseta ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Neurodegenerative Diseases ◽  
Antiproliferative Activity ◽  
Anticancer Therapy ◽  
Modern World ◽  
Grape Skin ◽  
Research Teams ◽  
Pharmacokinetic Properties ◽  
New Strategy ◽  
Number Of Publications

SummaryResveratrol (RSV) is one of the polyphenols - metabolites common in plants,however it does not occur in animals. It occurs mainly in grape skin (Vitisvinifera), peanuts (Arachis hypogeal) and in the roots of (Polygonumcupidatum) a traditional Chinese curative plant.RSV has a preventive property against the most serious diseases of modern world such as cancer, neurodegenerative diseases and cardiovascular diseases. Due to pleiotropy, RSV is currently the main object of many research teams′ interest, which is shown by the significant number of publications devoted to this subject.Animal and human conducted studies have shown very low bioavailability of RSV (approx. 2%), which is the result of rapid biotransformation to sulphate and to a lesser extent, to the glucuronide conjugates as well. The studies on the improvement of RSV bioavailability, which have beencarried out for many years, have contributed to the synthesis of the analogues of more chemopreventive and more desirable pharmacokinetic properties. In order to enhance antiproliferative activity and RSV bioavailability, series of methyl analogues were synthesized and this will be described later in more detail. An example of such a derivative is DMU-212 (3,4,4’5-tetramethoxystilbene).

scholarly journals Effect of Antioxidant Therapy on Oxidative Stress In Vivo

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 344
Author(s):  
Anna Maria Fratta Pasini ◽  
Luciano Cominacini
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Neurodegenerative Diseases ◽  
Antioxidant Therapy ◽  
Potential Benefits

Over the last few decades, many efforts have been put into fields that explore the potential benefits of antioxidants, especially with regards to aging, cancer, cardiovascular diseases, and neurodegenerative diseases. [...]

scholarly journals Synthesis of New Molecules Based on 1-pyrindane Ring as a New Strategy in the Neurodegenerative Diseases Treatment

2012 ◽  
Author(s):  
José Rodriguez-Borges ◽  
Cidália Pereira ◽  
Fabio Rizzo-Aguiar ◽  
Xerardo García-Mera
Keyword(s):  
Neurodegenerative Diseases ◽  
New Strategy

Design of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy

2013 ◽  
Vol 85 (3) ◽  
pp. 862-872 ◽  
Author(s):  
Régis Delatouche ◽  
Iza Denis ◽  
Marion Grinda ◽  
Fatima El Bahhaj ◽  
Estelle Baucher ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Anticancer Therapy ◽  
Ph Responsive ◽  
New Strategy

scholarly journals Cardioprotective effects and pharmacokinetic properties of a controlled release formulation of a novel hydrogen sulfide donor in rats with acute myocardial infarction

2015 ◽  
Vol 35 (3) ◽  
Author(s):  
Ba Hieu Tran ◽  
Chengrong Huang ◽  
Qiuyan Zhang ◽  
Xu Liu ◽  
Shizhou Lin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Hydrogen Sulfide ◽  
Controlled Release ◽  
Cardiovascular Diseases ◽  
Release Formulation ◽  
Controlled Release Formulation ◽  
Pharmacokinetic Properties ◽  
Cardioprotective Effects

The present study confirms that CR-SPRC is stable, effective and is thus an alternative candidate for hydrogen sulfide-mediated long-term prevention of cardiovascular diseases.

scholarly journals Graphic Novels in the Repertoire of Modern Russian Publishers

2020 ◽  
pp. 156-172
Author(s):  
Olga Yu. Panferova ◽  
◽  
Elena L. Mzhelskaya ◽  
Keyword(s):  
Graphic Novels ◽  
Publishing House ◽  
Modern Society ◽  
Modern World ◽  
Book Market ◽  
Contemporary Culture ◽  
Processing Information ◽  
Publishing Houses ◽  
Number Of Publications ◽  
Selection Of

The article summarizes the practice of Russian publishers in the formation of the repertoire of graphic novels. In the modern world, visual perception of information is becoming an increasingly common way of obtaining and processing information. Graphic novels are forming an important part of contemporary culture in general and literature in particular, occupying a larger niche in the contemporary literary market. Publishers are trying to meet the needs of readers and include more and more series with graphic novels in their repertoire. The most successful projects in the publishing houses Bubble, Jellyfish Jam, Zodiac, 42!, Komil’fo, AST, specializing in graphic novels, are analyzed. The expansion of this book segment is continuous and quite fast. Summarizing the repertoire policy of Russian publishers, it can be asserted that graphic novels come to play an increasingly important role in modern society and in the modern book market, and they will be equal in importance to classical book editions in the future. Every year the number of graphic novels by Russian authors in the book market is growing. The repertoire of Russian publishers engaged in the production of graphic novels is quite diverse. Specialized publishers pay more attention to the projects produced, due to which there are fewer errors in the production of graphic novels in these publishers. The number of publications produced per year in specialized publishing houses is small, compared with large universal publishers. Projects of specialized publishers are more carefully selected, are often original or little-known in Russia. Each project of graphic novels by foreign authors is unique for a certain publishing house, and is not released in other publishing houses. The spread of circulations in specialized publishing houses is quite wide and often depends on the features of the project, the author’s fame, the features of the publication, as well as the niche of the publishing house. Large universal publishers mainly focus on graphic novels of widespread popularity, as a rule, within the Marvel, DC universes. All publishers considered in the study have a clear principle of development of their repertoire; in specialized publishers, the selection of projects is much more thoughtful, and each project is given more attention.

Thomas Paine

2018 ◽  
Author(s):  
J. C. D. Clark
Keyword(s):  
Class Action ◽  
Modern World ◽  
Thomas Paine ◽  
Political Discourses ◽  
Large Numbers ◽  
Obvious Association ◽  
Number Of Publications ◽  
Ideological Change ◽  
The Impact

Thomas Paine (1737–1809) was England’s greatest revolutionary: no other reformer was as actively involved in events of the scale of the American and French Revolutions, and none wrote such best-selling texts with the impact of Common Sense and Rights of Man. None combined his roles as activist and theorist, or did so in the ‘age of revolutions’, fundamental as it was to the emergence of the ‘modern world’. But his fame meant that he was taken up and reinterpreted for current use by successive later commentators and politicians, so that the ‘historic Paine’ was too often obscured by the ‘usable Paine’. This book attempts to explain Paine against a revised background of early and mid-eighteenth-century England. It argues that he knew and learned less about events in America and France than was once thought. It de-attributes a number of publications, and passages, hitherto assumed to have been his own, and detaches him from a number of causes (including anti-slavery, women’s emancipation, and class action) with which he was once associated. And it argues that his formerly obvious association with the early origin and long-term triumph of natural rights, republicanism, and democracy needs to be rethought. As a result, it offers a picture of radical and reforming movements as more indebted to the initiatives of large numbers of men and women in fast-evolving situations than to the writings of a few individuals who framed lasting, and eventually triumphant, political discourses. Delivering ideological change was much harder than used to be supposed.

Pivotal Role Of The Interaction Between Herbal Medicines And Gut Microbiota On Disease Treatment

2020 ◽  
Vol 21 ◽  
Author(s):  
Tingting Zhao ◽  
Zhe Wang ◽  
Zhilong Liu ◽  
Youhua Xu
Keyword(s):  
Cardiovascular Diseases ◽  
Gut Microbiota ◽  
Neurodegenerative Diseases ◽  
Disease Progression ◽  
Herbal Medicines ◽  
Underlying Mechanism ◽  
Disease Treatment ◽  
Endocrine Diseases ◽  
Health And Disease

: With the recognition of the important role of gut microbiota in both health and disease progression, attempts to modulate its composition as well as its co-metabolism with the organism have attracted special attention. Abundant studies have demonstrated that dysfunction or imbalance of gut microbiota is closely with disease including endocrine diseases, neurodegenerative diseases, tumors, cardiovascular diseases, et al. Herbal medicines have been applied for preventing and treating disease worldwide for hundreds of years. Although the underlying mechanism seems to be complex, one of the important one is through modulating gut microbiota. In this review, co-metabolism between herbal medicines and microbiota, as well as the potential pathways are summarized from most recent published papers.

Current Prospects of Nutraceuticals: A Review

2020 ◽  
Vol 21 (10) ◽  
pp. 884-896 ◽  
Author(s):  
Vedant Sachdeva ◽  
Arpita Roy ◽  
Navneeta Bharadvaja
Keyword(s):  
Quality Of Life ◽  
Cardiovascular Diseases ◽  
Medicinal Plants ◽  
Neurodegenerative Diseases ◽  
Dietary Supplements ◽  
Human Body ◽  
Global Market ◽  
Optimal Health ◽  
Bioactive Ingredients

Nutraceuticals are dietary supplements, utilized to ameliorate health, delay senescence, prevent diseases, and support the proper functioning of the human body. Currently, nutraceuticals are gaining substantial attention due to nutrition and therapeutic potentials. Based on their sources, they are categorized as dietary supplements and herbal bioactive compounds. The global market for nutraceutical is huge i.e. approximately USD 117 billion. Herbal nutraceutical helps in maintaining health and promoting optimal health, longevity, and quality of life. Studies have shown promising results of nutraceuticals to treat several diseases, such as cancer, neurodegenerative diseases, cardiovascular diseases, etc. In the present review, an overview of various bioactive ingredients that act as nutraceuticals (carbohydrates, lipids, edible flowers, alkaloids, medicinal plants, etc.) and their role in health benefits, has been discussed. Further application of nutraceuticals in the prevention of various diseases has also been discussed.

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