Bioglass at 50 – A look at Larry Hench’s legacy and bioactive materials

2019 ◽  
Vol 5 (1) ◽  
pp. 178-184 ◽  
Author(s):  
David Greenspan
Keyword(s):  
Bioactive Glass ◽  
The Body ◽  
Inorganic Materials ◽  
Bioactive Glasses ◽  
Bioactive Materials ◽  
Bone Replacement Material ◽  
Bone Replacement ◽  
Young Professor

Abstract In 1969, fifty years ago, a young professor of ceramic engineering created a 4-component glass to be used as a bone replacement material. That material became known as “Bioglass” and more generally as a class of materials known as bioactive glass. Those first experiments conducted by Dr. Larry Hench completely shifted the paradigm of how the biomaterials and medical communities look at the interactions between inorganic materials and tissues in the body. This article will touch on just a few highlights of the development of bioactive glasses and relate those to the concepts of bioactivity and tissue bonding.

scholarly journals Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review

2021 ◽  
Vol 14 (2) ◽  
pp. 75
Author(s):  
Nuha Al-Harbi ◽  
Hiba Mohammed ◽  
Yas Al-Hadeethi ◽  
Ahmed Samir Bakry ◽  
Ahmad Umar ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Tissue Regeneration ◽  
The Body ◽  
Bone Tissue Regeneration ◽  
Hard Tissue ◽  
Bioactive Glasses ◽  
Bioactive Materials ◽  
Glass Forming ◽  
Content Ratio ◽  
Implant Coatings

Regenerative medicine is a field that aims to influence and improvise the processes of tissue repair and restoration and to assist the body to heal and recover. In the field of hard tissue regeneration, bio-inert materials are being predominantly used, and there is a necessity to use bioactive materials that can help in better tissue–implant interactions and facilitate the healing and regeneration process. One such bioactive material that is being focused upon and studied extensively in the past few decades is bioactive glass (BG). The original bioactive glass (45S5) is composed of silicon dioxide, sodium dioxide, calcium oxide, and phosphorus pentoxide and is mainly referred to by its commercial name Bioglass. BG is mainly used for bone tissue regeneration due to its osteoconductivity and osteostimulation properties. The bioactivity of BG, however, is highly dependent on the compositional ratio of certain glass-forming system content. The manipulation of content ratio and the element compositional flexibility of BG-forming network developed other types of bioactive glasses with controllable chemical durability and chemical affinity with bone and bioactivity. This review article mainly discusses the basic information about silica-based bioactive glasses, including their composition, processing, and properties, as well as their medical applications such as in bone regeneration, as bone grafts, and as dental implant coatings.

The Obliteration of Noncritical Size Bone Defects With Bone Dust or Bone Replacement Material (Bioactive Glass S53P4)

2019 ◽  
Vol 40 (4) ◽  
pp. e415-e423 ◽  
Author(s):  
Anne Kluge ◽  
Marcus Neudert ◽  
Christiane Kunert-Keil ◽  
Susen Lailach ◽  
Thomas Zahnert ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Defects ◽  
Bone Replacement Material ◽  
Bone Replacement

Biomorphic Silicon Carbide Ceramics Coated with Bioactive Glass for Medical Applications

2006 ◽  
Vol 514-516 ◽  
pp. 970-974 ◽  
Author(s):  
Jacinto P. Borrajo ◽  
Pio González ◽  
Julia Serra ◽  
Sara Liste ◽  
Stefano Chiussi ◽  
...  
Keyword(s):  
Silicon Carbide ◽  
Bioactive Glass ◽  
The Body ◽  
Bioactive Materials ◽  
Bioactive Coatings ◽  
Metallic Substrates ◽  
New Material ◽  
Carbide Ceramics ◽  
Silicon Carbide Ceramics

There is a need to develop new tough bioactive materials capable to withstand high loads when implanted in the body and with improved fixation, which led to the production of bioactive coatings on metallic substrates. A new approach, which consists of biomorphic silicon carbide (SiC) coated with bioactive glass, was recently presented. This new material joins the high mechanical strength, lightness and porosity of biomorphic SiC, and the bioactive properties of PLD glass films. In this work, a multiple evaluation in terms of biocompatibility of this new material was carried out starting from the biomorphic SiC morphology and porosity, following with the bioactivity of the coatings in simulated body fluid, and ending with a deep biocompatibility study with MG-63 cells. Different ranges of porosity and pore size were offered by the biomorphic SiC depending on the starting wood. The PLD glassy coatings had a high bioactivity in vitro and both the biomorphic SiC coated and uncoated presented high levels of biocompatibility.

A Comparative Investigation on a Novel Bioactive Glass Synthesized via Sol-Gel Processing

2014 ◽  
Vol 631 ◽  
pp. 25-29
Author(s):  
S.S. Seyedmomeni ◽  
M. Naeimi ◽  
Majid Raz ◽  
J. Aghazadeh Mohandesi ◽  
F. Moztarzadeh
Keyword(s):  
Bioactive Glass ◽  
Sol Gel ◽  
Bone Substitutes ◽  
Comparative Investigation ◽  
X Ray Diffraction ◽  
Bioactive Glasses ◽  
Bioactive Materials ◽  
Proliferation And Differentiation ◽  
Crystalline Domains ◽  
Gel Processing

Various kinds of bioactive materials are developed as bone substitutes. Bioactive materials may affect attachment, proliferation and differentiation of cells and the subsequent integration in a host tissue. In this research 21%CaO–5%P2O5–64%SiO2–5%ZnO-5%B2O3and 16%CaO–5%P2O5–64%SiO2–5%ZnO-10%B2O3bioactive glasses were successfully synthesized by the sol–gel technique. Then the prepared bioactive glasses were soaked into simulated body fluid. Then the prepared samples were characterized using X-ray diffraction (XRD) and Scanning electron microscopy (SEM). It was seen that addition of boron to the structure remarkably enhances the formation of hydroxyapatite on the surface of the bioactive glass and subsequently improves the bioactivity. The obtained results from SEM and XRD were in good agreement with each other. Besides, effect of boron on atomic arrangement of the prepared bioactive glass was studies and compared with previous researches. It was shown that by increasing the boron content, more crystalline domains would be observed.

scholarly journals Bioactive Glass Applications in Dentistry

2019 ◽  
Vol 20 (23) ◽  
pp. 5960 ◽  
Author(s):  
Hans Erling Skallevold ◽  
Dinesh Rokaya ◽  
Zohaib Khurshid ◽  
Muhammad Sohail Zafar
Keyword(s):  
Soft Tissue ◽  
Bioactive Glass ◽  
The Body ◽  
Ground Substance ◽  
Air Abrasion ◽  
Bioactive Glasses ◽  
Bioactive Ingredients ◽  
Soft Tissue Engineering ◽  
Tissue Restoration ◽  
Dental Restorative

At present, researchers in the field of biomaterials are focusing on the oral hard and soft tissue engineering with bioactive ingredients by activating body immune cells or different proteins of the body. By doing this natural ground substance, tissue component and long-lasting tissues grow. One of the current biomaterials is known as bioactive glass (BAG). The bioactive properties make BAG applicable to several clinical applications involving the regeneration of hard tissues in medicine and dentistry. In dentistry, its uses include dental restorative materials, mineralizing agents, as a coating material for dental implants, pulp capping, root canal treatment, and air-abrasion, and in medicine it has its applications from orthopedics to soft-tissue restoration. This review aims to provide an overview of promising and current uses of bioactive glasses in dentistry.

Fabrication of Zn-Sr–doped laser-spinning glass nanofibers with antibacterial properties

2016 ◽  
Vol 31 (6) ◽  
pp. 819-831 ◽  
Author(s):  
María Magdalena Echezarreta-López ◽  
Trinidad de Miguel ◽  
Félix Quintero ◽  
Juan Pou ◽  
Mariana Landín
Keyword(s):  
Antibacterial Activity ◽  
Bioactive Glass ◽  
Antibacterial Properties ◽  
Growth Index ◽  
Bactericidal Effect ◽  
Bioactive Glasses ◽  
Bioactive Materials ◽  
Nanofibrous Structure ◽  
The Media ◽  
45S5 Bioglass

The morphology and dimensions of bioactive materials are essential attributes to promote tissue culture. Bioactive materials with nanofibrous structure have excellent potential to be used as bone-defect fillers, since they mimic the collagen in the extracellular matrix. On the other hand, bioactive glasses with applications in regenerative medicine may present antibacterial properties, which depend on glass composition, concentration and the microorganisms tested. Likewise, their morphology may influence their antibacterial activity too. In the present work, the laser-spinning technique was used to produce bioactive glass nanofibers of two different compositions: 45S5 Bioglass® and ICIE16M, bioactive glass doped with zinc and strontium. Their antibacterial activity against Staphylococcus aureus was tested by culturing them in dynamic conditions. Bacterial growth index profiles during the first days of experiment can be explained by the variations in the pH values of the media. The bactericidal effect of the doped nanofibers at longer times is justified by the release of zinc and strontium ions. Cytotoxicity was analyzed by means of cell viability tests performed with BALB/3T3 cell line.

scholarly journals Novel Hydrogels of Chitosan and Poly (vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass

Polymers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 691
Author(s):  
O. Sánchez-Aguinagalde ◽  
Ainhoa Lejardi ◽  
Emilio Meaurio ◽  
Rebeca Hernández ◽  
Carmen Mijangos ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Release ◽  
Bioactive Glass ◽  
Vinyl Alcohol ◽  
Release Kinetics ◽  
The Body ◽  
Poly Vinyl Alcohol ◽  
X Ray Diffraction ◽  
Inorganic Particles ◽  
Release Studies

Chitosan (CS) and poly (vinyl alcohol) (PVA) hydrogels, a polymeric system that shows a broad potential in biomedical applications, were developed. Despite the advantages they present, their mechanical properties are insufficient to support the loads that appear on the body. Thus, it was proposed to reinforce these gels with inorganic glass particles (BG) in order to improve mechanical properties and bioactivity and to see how this reinforcement affects levofloxacin drug release kinetics. Scanning electron microscopy (SEM), X-ray diffraction (XRD), swelling tests, rheology and drug release studies characterized the resulting hydrogels. The experimental results verified the bioactivity of these gels, showed an improvement of the mechanical properties and proved that the added bioactive glass does affect the release kinetics.

Study of the Bioactive Behavior of Thermally Treated Modified 58S Bioactive Glass

2008 ◽  
Vol 396-398 ◽  
pp. 131-134 ◽  
Author(s):  
Ourania Menti Goudouri ◽  
Xanthippi Chatzistavrou ◽  
Eleana Kontonasaki ◽  
Nikolaos Kantiranis ◽  
Lambrini Papadopoulou ◽  
...  
Keyword(s):  
Thermal Treatment ◽  
Bioactive Glass ◽  
Sol Gel ◽  
Bioactive Glasses ◽  
X Ray ◽  
Characteristic Temperatures ◽  
Calcium Silicates ◽  
Crystal Phases ◽  
Thermally Treated

Thermal treatment of bioactive glasses can affect their microstructure and thus their bioactivity. The aim of this study was the characterization of the thermally treated sol-gel-derived bioactive glass 58S at characteristic temperatures and the dependence of its bioactive behavior on the specific thermal treatment. The thermal behavior of the bioactive glass was studied by thermal analysis (TG/DTA). Fourier Transform Infrared Spectroscopy (FTIR) and X-ray Diffractometry (XRD) were used for the characterization of the bioactive glass. The bioactive behavior in Simulated Body Fluid (SBF) was examined by Scanning Electron Microscopy (SEM-EDS) and FTIR. The major crystal phases after thermal treatment were Calcium Silicates, Wollastonite and Pseudowollastonite, while all thermally treated samples developed apatite after 48 hours in SBF. A slight enhancement of bioactivity was observed for the samples heated at the temperature range 910-970oC.

scholarly journals Aging of Bioactive Glass-Based Foams: Effects on Structure, Properties, and Bioactivity

Materials ◽  
2019 ◽  
Vol 12 (9) ◽  
pp. 1485 ◽  
Author(s):  
Pier Francesco Menci ◽  
Andrea Mari ◽  
Cindy Charbonneau ◽  
Louis-Philippe Lefebvre ◽  
Luigi De Nardo
Keyword(s):  
Bioactive Glass ◽  
Chemical Species ◽  
Accelerated Tests ◽  
Aging Effects ◽  
Bioactive Glasses ◽  
Structural Support ◽  
Dental Procedures ◽  
Recent Advancement ◽  
Aging Mechanisms ◽  
Structure Properties

Bioactive glasses (BG) possess significant bone-bonding and osteogenic properties that support their use for bone defects repair in orthopaedic and dental procedures. Recent advancement enables the manufacturing of BG-based scaffolds providing structural support during bone regeneration. Despite the wide number of studies on BG and BG-based materials, little information on their aging mechanisms and shelf life is available in the literature. In this study, the evolution of chemical species on BG-based foams was investigated via accelerated tests in the presence of CO2 and humidity. The aging process led to the formation of carbonates (Na2CO3 and CaCO3) and hydrocarbonates (NaHCO3). The amount and composition of nucleated species evolved with time, affecting the structure, properties, and bioactivity of the scaffolds. This study provides a first structured report of aging effects on the structure and chemico-physical properties of bioactive glass-based scaffolds, offering an insight about the importance of their storage and packaging.

scholarly journals A thermodynamic discourse on the dissolution behavior of bioactive glasses

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Barbara Pföss ◽  
Reinhard Conradt
Keyword(s):  
Bioactive Glass ◽  
Body Fluid ◽  
Solid Material ◽  
Aqueous System ◽  
Dissolution Behavior ◽  
Glassy Material ◽  
Bioactive Glasses ◽  
Gibbs Energies ◽  
The Impact ◽  
Glass Compositions

AbstractThe interaction between bioactive glass and body fluid is crucial for the special properties of this material, therefore a large number of experimental data is available in literature. However, a frame for systematic interpretation of these results in terms of understanding the mechanisms at the interface between glass and body medium and the relation between glass composition and dissolution behavior is still missing. For two multicomponent bioactive glasses, 45S5 and 13-93, the Gibbs energies of the glassy material on one side and their aqueous system on the other side were calculated individually. The difference between solid material and aqueous system further constitutes the pH dependent Gibbs energy of hydration, ∆Ghydr. The impact of glass compositions and glassy or crystalline state on ∆Ghydr is demonstrated referring to chemical durability. Along considerations regarding the aqueous system, the thermodynamic calculations proof the precipitation of hydroxyapatite inwater and simulated body fluid for a systemcontaining P2O5 and Ca2+. In the course of deriving the Gibbs energies for bioactive glass compositions via constitutional compounds, bioactive behavior is discussed from the point of coexisting equilibrium phases in the system of Na2O-CaO-SiO2.

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