scholarly journals Generation of a Simplified Brain Geometry for the Calculation of Local Cerebral Temperature using a 1D Hemodynamic Model

2019 ◽  
Vol 5 (1) ◽  
pp. 529-532
Author(s):  
Rosa Daschner ◽  
Lorena Krames ◽  
Yannick Lutz ◽  
Axel Loewe ◽  
Olaf Dössel ◽  
...  
Keyword(s):  
Neuroprotective Effect ◽  
Extensive Literature ◽  
Invasive Procedures ◽  
Permanent Disability ◽  
Literature Research ◽  
The Third ◽  
Temperature Calculation ◽  
Cooling Method ◽  
Hemodynamic Model ◽  
The Brain

AbstractIn Western countries, stroke is the third-most cause of death; 35- 55% of the survivors experience permanent disability. Mild therapeutic hypothermia (TH) showed neuroprotective effect in patients returning from cardiac arrest and is therefore assumed to decrease stroke induced cerebral damage. Recently, an intracarotid cooling sheath was developed to induce local TH in the penumbra using the cooling effect of cerebral blood flow via collaterals. Computational modeling provides unique opportunities to predict the resulting cerebral temperature without invasive procedures. In this work, we generated a simplified brain model to establish a cerebral temperature calculation using Pennes’ bio-heat equation and a 1D hemodynamics model of the cranial artery tree. In this context, we performed an extensive literature research to assign the terminal segments of the latter to the corresponding perfused tissue. Using the intracarotid cooling method, we simulated the treatment with TH for different degrees of stenosis in the middle cerebral artery (MCA) and analyzed the resulting temperature spatialtemporal distributions of the brain and the systemic body considering the influence of the collaterals on the effect of cooling.

Right-handedness and Left-handedness. (Journ. Anth. Inst., July—Dec., 1902.) Cunningham, D. J.

1903 ◽  
Vol 49 (206) ◽  
pp. 547-547
Author(s):  
Havelock Ellis
Keyword(s):  
Natural Selection ◽  
Good Reason ◽  
Cerebral Hemispheres ◽  
Memorial Lecture ◽  
Extensive Literature ◽  
The Third ◽  
Left Handedness ◽  
Left Handed ◽  
Thoracic And Abdominal ◽  
The Brain

This subject was chosen by Professor Cunningham for the third Huxley Memorial Lecture of the Anthropological Institute. He deals with it in a thorough manner and with wide knowledge of the extensive literature. He regards right-handedness as an organic acquirement of early man, due to natural selection. There is no good reason to show that monkeys are right-handed, and evidence obtained from Dr. Taylor, at the Darenth Asylum, showed that microcephalic idiots tend to be ambidextrous (five right-handed, four ambidextrous, one left-handed) The functional pre-eminence of the brain is the cause, and not the result, of right-handedness. Left-handedness may be regarded as due “probably to a transposition of the two cerebral hemispheres in the same way that transposition, either partial or complete, of the thoracic and abdominal viscera occurs.” It is noteworthy that there is a large proportion of left-handedness in those showing transposition of the viscera.

ADRENOCORTICAL FUNCTION IN PATIENTS WITH ACUTE SEVERE BRAIN AND PITUITARY LESION

1962 ◽  
Vol 40 (2) ◽  
pp. 254-262 ◽  
Author(s):  
H. H. Bassøe ◽  
R. Emberland ◽  
E. Glück ◽  
K. F. Støa
Keyword(s):  
Pituitary Gland ◽  
Adrenal Cortex ◽  
Artificial Ventilation ◽  
Practical Significance ◽  
Adrenocortical Function ◽  
The Third ◽  
Low Levels ◽  
Pituitary Lesion ◽  
Steroid Excretion ◽  
The Brain

ABSTRACT The steroid excretion and the plasma corticosteroids were investigated in three patients with necrosis of the brain and of the pituitary gland. The patients were kept alive by artificial ventilation. In two of the patients the neutral 17-ketosteroids and the 17-hydrocorticosteroids fell to extremely low levels. At the same time, the number of eosinophil cells showed a tendency to increase. Corticotrophin administered intravenously twice to the third patient had a stimulating effect on the adrenal cortex. The theoretical and practical significance of these findings is discussed.

Neuromyelitis optica spectrum: novel concept of pathogenesis, diagnosis and treatment of Devic’s disease

2009 ◽  
Vol 150 (46) ◽  
pp. 2101-2109 ◽  
Author(s):  
Péter Csécsei ◽  
Anita Trauninger ◽  
Sámuel Komoly ◽  
Zsolt Illés
Keyword(s):  
Neuromyelitis Optica ◽  
Water Channel ◽  
Diagnostic Procedures ◽  
Diagnosis And Treatment ◽  
Clinical Settings ◽  
Permanent Disability ◽  
Therapeutic Decisions ◽  
Novel Concept ◽  
The Brain

The identification of autoantibodies generated against the brain isoform water channel aquaporin4 in the sera of patients, changed the current diagnostic guidelines and concept of neuromyelitis optica (NMO). In a number of cases, clinical manifestation is spatially limited to myelitis or relapsing optic neuritis creating a diverse. NMO spectrum. Since prevention of relapses provides the only possibility to reduce permanent disability, early diagnosis and treatment is mandatory. In the present study, we discuss the potential role of neuroimaging and laboratory tests in differentiating the NMO spectrum from other diseases, as well as the diagnostic procedures and therapeutic options. We also present clinical cases, to provide examples of different clinical settings, diagnostic procedures and therapeutic decisions.

RAS in the Central Nervous System: Potential Role in Neuropsychiatric Disorders

2018 ◽  
Vol 25 (28) ◽  
pp. 3333-3352 ◽  
Author(s):  
Natalia Pessoa Rocha ◽  
Ana Cristina Simoes e Silva ◽  
Thiago Ruiz Rodrigues Prestes ◽  
Victor Feracin ◽  
Caroline Amaral Machado ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Central Nervous System ◽  
Nervous System ◽  
Therapeutic Potential ◽  
Neuropsychiatric Disorders ◽  
Extensive Literature ◽  
Ang Ii ◽  
Mas Receptor ◽  
The Central Nervous System ◽  
The Brain

Background: The Renin-Angiotensin System (RAS) is a key regulator of cardiovascular and renal homeostasis, but also plays important roles in mediating physiological functions in the central nervous system (CNS). The effects of the RAS were classically described as mediated by angiotensin (Ang) II via angiotensin type 1 (AT1) receptors. However, another arm of the RAS formed by the angiotensin converting enzyme 2 (ACE2), Ang-(1-7) and the Mas receptor has been a matter of investigation due to its important physiological roles, usually counterbalancing the classical effects exerted by Ang II. Objective: We aim to provide an overview of effects elicited by the RAS, especially Ang-(1-7), in the brain. We also aim to discuss the therapeutic potential for neuropsychiatric disorders for the modulation of RAS. Method: We carried out an extensive literature search in PubMed central. Results: Within the brain, Ang-(1-7) contributes to the regulation of blood pressure by acting at regions that control cardiovascular functions. In contrast with Ang II, Ang-(1-7) improves baroreflex sensitivity and plays an inhibitory role in hypothalamic noradrenergic neurotransmission. Ang-(1-7) not only exerts effects related to blood pressure regulation, but also acts as a neuroprotective component of the RAS, for instance, by reducing cerebral infarct size, inflammation, oxidative stress and neuronal apoptosis. Conclusion: Pre-clinical evidence supports a relevant role for ACE2/Ang-(1-7)/Mas receptor axis in several neuropsychiatric conditions, including stress-related and mood disorders, cerebrovascular ischemic and hemorrhagic lesions and neurodegenerative diseases. However, very few data are available regarding the ACE2/Ang-(1-7)/Mas receptor axis in human CNS.

Stroke Lesion Segmentation and Analysis using Entropy/Otsu’s Function – A Study with Social Group Optimization

2019 ◽  
Vol 14 (4) ◽  
pp. 305-313 ◽  
Author(s):  
Suresh Chandra Satapathy ◽  
Steven Lawrence Fernandes ◽  
Hong Lin
Keyword(s):  
Social Group ◽  
Research Work ◽  
Lesion Segmentation ◽  
Permanent Disability ◽  
Brain Abnormality ◽  
Inspection Process ◽  
Stroke Lesion ◽  
Social Group Optimization ◽  
The Brain ◽  
Otsu’S Function

Background: Stroke is one of the major causes for the momentary/permanent disability in the human community. Usually, stroke will originate in the brain section because of the neurological deficit and this kind of brain abnormality can be predicted by scrutinizing the periphery of brain region. Magnetic Resonance Image (MRI) is the extensively considered imaging procedure to record the interior sections of the brain to support visual inspection process. Objective: In the proposed work, a semi-automated examination procedure is proposed to inspect the province and the severity of the stroke lesion using the MRI. associations while known disease-lncRNA associations are required only. Method: Recently discovered heuristic approach called the Social Group Optimization (SGO) algorithm is considered to pre-process the test image based on a chosen image multi-thresholding procedure. Later, a chosen segmentation procedure is considered in the post-processing section to mine the stroke lesion from the pre-processed image. Results: In this paper, the pre-processing work is executed with the well known thresholding approaches, such as Shannon’s entropy, Kapur’s entropy and Otsu’s function. Similarly, the postprocessing task is executed using most successful procedures, such as level set, active contour and watershed algorithm. Conclusion: The proposed procedure is experimentally inspected using the benchmark brain stroke database known as Ischemic Stroke Lesion Segmentation (ISLES 2015) challenge database. The results of this experimental work authenticates that, Shannon’s approach along with the LS segmentation offers superior average values compared with the other approaches considered in this research work.</P>

The Meditations

2017 ◽  
Author(s):  
Walter Ott
Keyword(s):  
Perceptual Experience ◽  
Developmental Reading ◽  
Basic Structure ◽  
Brain Image ◽  
The Real ◽  
The Third ◽  
Real Work ◽  
Sensible Qualities ◽  
The Brain

Despite its difference in aspiration, the Meditations preserves the basic structure of perceptual experience outlined in Descartes’s earliest works. The chapter explores Descartes’s notion of an idea and uses a developmental reading to clear up the mystery surrounding material falsity. In the third Meditation, our protagonist does not yet know enough about extension in order to be able to tell whether her idea of cold is an idea of a real feature of bodies or merely the idea of a sensation. By the time she reaches the end of her reflections, she has learned that sensible qualities are at most sensations. As in his earliest stages, Descartes believes that the real work of perceiving the geometrical qualities of bodies is done by the brain image, which he persists in calling an ‘idea,’ at least when it is the object of mental awareness.

scholarly journals The Potential Effects of Phytoestrogens: The Role in Neuroprotection

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2954
Author(s):  
Justyna Gorzkiewicz ◽  
Grzegorz Bartosz ◽  
Izabela Sadowska-Bartosz
Keyword(s):  
Neuroprotective Effect ◽  
Antioxidant Properties ◽  
Estrogen Therapy ◽  
Neuroprotective Effects ◽  
Potential Health ◽  
Naturally Occurring ◽  
Epigenetic Effects ◽  
Estrogen Synthesis ◽  
Health Promoting ◽  
The Brain

Phytoestrogens are naturally occurring non-steroidal phenolic plant compounds. Their structure is similar to 17-β-estradiol, the main female sex hormone. This review offers a concise summary of the current literature on several potential health benefits of phytoestrogens, mainly their neuroprotective effect. Phytoestrogens lower the risk of menopausal symptoms and osteoporosis, as well as cardiovascular disease. They also reduce the risk of brain disease. The effects of phytoestrogens and their derivatives on cancer are mainly due to the inhibition of estrogen synthesis and metabolism, leading to antiangiogenic, antimetastatic, and epigenetic effects. The brain controls the secretion of estrogen (hypothalamus-pituitary-gonads axis). However, it has not been unequivocally established whether estrogen therapy has a neuroprotective effect on brain function. The neuroprotective effects of phytoestrogens seem to be related to both their antioxidant properties and interaction with the estrogen receptor. The possible effects of phytoestrogens on the thyroid cause some concern; nevertheless, generally, no serious side effects have been reported, and these compounds can be recommended as health-promoting food components or supplements.

The effect of hypophysectomy on physiological color change in Fundulus heteroclitus

1971 ◽  
Vol 49 (1) ◽  
pp. 129-131 ◽  
Author(s):  
F. S. Abbott ◽  
M. B. Favreau
Keyword(s):  
Histological Examination ◽  
Fundulus Heteroclitus ◽  
Color Change ◽  
The Third ◽  
The Brain

Thirty-eight Fundulus heteroclitus were tested for ability to adapt to white and black backgrounds. They were then hypophysectomized and distributed individually to white and black containers. Their ability to adapt to background was determined for periods up to 2 weeks. Sixteen operated fish retained their preoperative ability to adapt; 8 became dark temporarily; 14 became persistently dark. Histological examination confirmed the result of the operation. In the third group of fish the persistent darkness was not associated with damage to specific areas of the brain although damage was more widespread in this group. It is concluded that hypophysectomy does not interfere with physiological color change in F. heteroclitus. The location of the central relays in the melanophore system could not be determined.

scholarly journals Zingiber officinaleMitigates Brain Damage and Improves Memory Impairment in Focal Cerebral Ischemic Rat

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Jintanaporn Wattanathorn ◽  
Jinatta Jittiwat ◽  
Terdthai Tongun ◽  
Supaporn Muchimapura ◽  
Kornkanok Ingkaninan
Keyword(s):  
Cognitive Function ◽  
Cerebral Ischemia ◽  
Brain Damage ◽  
Focal Cerebral Ischemia ◽  
Infarct Volume ◽  
Neuroprotective Effect ◽  
Morris Water Maze Test ◽  
Brain Infarct ◽  
Ginger Rhizome ◽  
The Brain

Cerebral ischemia is known to produce brain damage and related behavioral deficits including memory. Recently, accumulating lines of evidence showed that dietary enrichment with nutritional antioxidants could reduce brain damage and improve cognitive function. In this study, possible protective effect ofZingiber officinale, a medicinal plant reputed for neuroprotective effect against oxidative stress-related brain damage, on brain damage and memory deficit induced by focal cerebral ischemia was elucidated. Male adult Wistar rats were administrated an alcoholic extract of ginger rhizome orally 14 days before and 21 days after the permanent occlusion of right middle cerebral artery (MCAO). Cognitive function assessment was performed at 7, 14, and 21 days after MCAO using the Morris water maze test. The brain infarct volume and density of neurons in hippocampus were also determined. Furthermore, the level of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in cerebral cortex, striatum, and hippocampus was also quantified at the end of experiment. The results showed that cognitive function and neurons density in hippocampus of rats receiving ginger rhizome extract were improved while the brain infarct volume was decreased. The cognitive enhancing effect and neuroprotective effect occurred partly via the antioxidant activity of the extract. In conclusion, our study demonstrated the beneficial effect of ginger rhizome to protect against focal cerebral ischemia.

Sign in / Sign up

Export Citation Format

Share Document