Comparison of chemical composition and biological activities of Seseli rigidum fruit essential oils from Serbia

AbstractPlants from genus Seseli, have been widely used in European traditional medicine, exhibiting antibacterial, antifungal, insect repellent, emmenogogue, antiflatulence, anti-inflammatory, antinociceptive, anti-tumor, antirheumatic activities and protective effect on human lymphocytes DNA. They usually grow on mountain rocky terrains. Part of their habitat on Vidlic Mountain, located in South-east Serbia, was struck with a large wildfire. Seseli rigidum fruit essential oils (from post fire and control areas) compositions were analyzed by GC and GC-MS, identifying monoterpenes α-pinene and sabinene as most abundant. Statistical tests showed a non-significant difference in chemical composition of these two oils, but a significant difference in comparison with the herb from a geographically different origin. Antimicrobial tests showed strong activities of the oils against tested bacteria, thus confirming its administration in various inflammation processes as a quite effective remedy. Applying DPPH. and ABTS+. radical scavenging and total reducing Fe(III) to Fe(II) power assays, antioxidant characteristics of both studied essential oils were estimated as weak, though of close values. Seseli rigidum fruit essential oil was proven as a potent inhibitor of human and horse serum cholinesterase, recognizing its possible application as neural protective agent

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Chemical Composition and Biological Activities of Essential Oils from the Leaves, Stems, and Roots of Kadsura coccinea

Molecules ◽

10.3390/molecules26206259 ◽

2021 ◽

Vol 26 (20) ◽

pp. 6259

Author(s):

Tianming Zhao ◽

Chao Ma ◽

Guofei Zhu

Keyword(s):

Gas Chromatography ◽

Chemical Composition ◽

Essential Oils ◽

Antioxidant Activities ◽

Biological Activities ◽

Radical Scavenging ◽

Cholinesterase Inhibition ◽

Pharmaceutical Industries ◽

Kadsura Coccinea ◽

Radical Scavenging Assay

The chemical composition and biological activities of the essential oils from the leaves, stems, and roots of Kadsura coccinea (K. coccinea) were investigated. The essential oils were extracted by hydro distillation and analyzed by gas chromatography mass spectrometry (GC-MS) and gas chromatography with flame ionization detector (GC-FID). Antioxidant activities of the essential oils were examined with DPPH radical scavenging assay, ABTS cation radical scavenging assay, and ferric reducing antioxidant power assay. Antimicrobial activities were evaluated by determining minimum inhibitory concentrations (MIC) and minimum microbiocidal concentrations (MMC). Acetylcholinesterase and butyrylcholinesterase inhibitory activity of the essential oils were also tested. A total of 46, 44, and 47 components were identified in the leaf, stem, and root oils, representing 95.66%, 97.35%, and 92.72% of total composition, respectively. The major compounds of three essential oils were α-pinene (16.60–42.02%), β-pinene (10.03–18.82%), camphene (1.56–10.95%), borneol (0.50–7.71%), δ-cadinene (1.52–7.06%), and β-elemene (1.86–4.45%). The essential oils were found to have weak antioxidant activities and cholinesterase inhibition activities. The essential oils showed more inhibitory effects against Staphylococcus aureus (S. aureus) than those of other strains. The highest antimicrobial activity was observed in the root oil against S. aureus, with MIC of 0.78 mg/mL. Therefore, K. coccinea essential oils might be considered as a natural antibacterial agent against S. aureus with potential application in food and pharmaceutical industries.

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Chemical composition, biological activities, and toxicity study of Carduncellus pinnatus essential oil from west Algeria

Current Bioactive Compounds ◽

10.2174/1573407217666210802113423 ◽

2021 ◽

Vol 17 ◽

Author(s):

Mohammed Semaoui ◽

Mohammed El Amine Dib ◽

Nassim Djabou ◽

Jean Costa ◽

Alain Muselli

Keyword(s):

Gas Chromatography ◽

Chemical Composition ◽

Essential Oil ◽

Essential Oils ◽

Biological Activities ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Bacterial Strains ◽

Biological Potential ◽

New Findings

Background: Many species have already been examined regarding their biological activities but there are nevertheless many more which merits examination, among them Carduncellus pinnatus (Desf), that is one of the less abundant and the less frequent aromatic plants of Asteraceae species, it is one species widely distributed in the Mediterranean region. In the present investigation, chemical composition of essential oils of Carduncellus pinnatus and their antioxidant, antimicrobial and antifungal activities were investigated for the first time. Methods: The chemical composition of the essential oils of Carduncellus pinnatus was analyzed by gas chromatography (GC) and gas chromatography mass spectroscopy (GC/MS) during its vegetative cycle. The antioxidant properties were evaluated by DPPH-radical scavenging and FRAP methods. The essential oil was tested on two-gram positive bacteria, three-gram negative bacteria, two filamentous fungi and one yeast. The toxicity of this essential oil was evaluated from several experiments on five mice tested in the laboratory. Results: The chemical composition of essential oils studied by GC and GC-MS showed a total of Twenty-seven compounds constituted mainly by Aplotaxene. Harvest time affected quantitatively but not qualitatively the chemical composition of essential oils. The results showed that Carduncellus pinnatus presented interesting antioxidant property. In order to assess the biological activities of Carduncellus pinnatus, all essential oil samples were combined together to produce a collective essential oil (Coll EO). The Coll EO showed activity on all tested bacterial strains based on the inhibition diameters obtained. The most interesting antimicrobial activity has been observed against Salmonella typhi, Escherichia coli and Staphylococcus aureus with IC50s 0.4, 1.2 and 1.2 g/L, but which remains weak compared to the Gentamicin control, respectively). Regarding antifungal activity, largest inhibition was observed against Fusarium solani (IC50= 0.8 g/L). On the other hand, the toxicity test of Coll EO showed no mortality rate to the concentration of 1g/kg injected to the mice. Conclusion: The results presented here constitutes new findings in the field of the chemical characterization and biological potential of Carduncellus pinnatus.

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Chemical Composition and Biological Activities of Oregano and Lavender Essential Oils

Applied Sciences ◽

10.3390/app11125688 ◽

2021 ◽

Vol 11 (12) ◽

pp. 5688

Author(s):

Benbrahim Chahla ◽

Barka Mohammed Salih ◽

Basile Adriana ◽

Maresca Viviana ◽

Flamini Guido ◽

...

Keyword(s):

Chemical Composition ◽

Essential Oils ◽

Biological Activities ◽

Human Lymphocytes ◽

Folk Medicine ◽

Multidrug Resistant ◽

Major Constituent ◽

Antioxidant Agents ◽

Ultrastructural Damage ◽

Cellular Components

Folk medicine uses wild herbs, especially from the Lamiaceae family, such as oregano and lavender, in the treatment of many diseases. In the present study, we investigated the antibacterial activity of the essential oils of Origanum glandulosum Desf. and Lavandula dentata L. against multidrug-resistant Klebsiella pneumoniae strains. The chemical composition of essential oils and their effect on the ultrastructure of the tested bacteria and on the release of cellular components that absorb at 260 nm were studied. Furthermore, the cytotoxicity and the production of reactive oxygen species in human lymphocytes treated with essential oils were evaluated. Thymol (33.2%) was the major constituent in O. glandulosum, and β-pinene (17.3%) was the major constituent in L. dentata. We observed ultrastructural damage in bacteria and increased release of cellular material. Furthermore, ROS production in human lymphocytes treated with essential oils was lower than in untreated lymphocytes and no cytotoxicity was observed. Therefore, the essential oils of lavender and oregano could be used as a source of natural antibacterial and antioxidant agents with potential pharmacological applications.

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Chemical Composition, Antibacterial, Insecticidal and Anti-Oxidant Activities of Three Acantholimon Species (A. atropatanum, A. gilliatii and A. tragacanthium)

The Natural Products Journal ◽

10.2174/2210315509666190117153456 ◽

2020 ◽

Vol 10 (3) ◽

pp. 272-278

Author(s):

Ardalan Pasdaran ◽

Satyajit D. Sarker ◽

Lutfun Nahar ◽

Azadeh Hamedi

Keyword(s):

Antibacterial Activity ◽

Chemical Composition ◽

Essential Oil ◽

Essential Oils ◽

Radical Scavenging Activity ◽

Radical Scavenging ◽

Main Compound ◽

Aerial Parts ◽

Anti Oxidant ◽

Gas Chromatography Mass Spectroscopy

Background: The essential oil from the Acantholimon genus have been an integral part of the traditional food additive in Middle East. Most of the plants in Acantholimon genus have not been studied scientifically. The aim of this study is to investigate the chemical composition, antibacterial, insecticidal and anti-oxidant activities of three Acantholimon species including Acantholimon atropatanum, A. gilliatii and A. tragacanthium. Method: The essential oils of the aerial parts were extracted by hydrodistillation. Chemical constitutions were identified by gas chromatography- mass spectroscopy technique, also their toxicities were assessed against the two important grain products pests, Oryzeaphilus mercator and Tribolium castaneum. Antibacterial activity was assessed against the three foodborne bacteria that include Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus based on the disc diffusion assay. Free-radical-scavenging property was identified based on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Results: 2-hexahydrofarnesyl acetone was the main compound in A. gilliatii and A. tragacanthium, whilst farnesyl acetone, heptacosane and germacrene D were the principal components of A. atropatanum essential oil. These oils exhibited 40-90% mortality of O. mercator and/or T. castaneum at a dose of 12 μl/l air after 48h of exposure, and exhibited significant free-radicalscavenging property (RC50 = 3.7 × 10-3 - 8.3 × 10-3 mg/ml). The oils of A. tragacanthium and A. gilliatii showed a weaker antibacterial activity compared to A. atropatanum. Conclusion: A. atropatanum, A. gilliatii and A. tragacanthium essential oils had significant insecticidal and anti-oxidant properties. They also showed week to moderate antibacterial activity against P. aeruginosa and S. aureus.

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Chemical Composition and Biological Activities of Two Angelica Essential Oils from China

Planta Medica ◽

10.1055/s-2009-1216468 ◽

2009 ◽

Vol 75 (04) ◽

Author(s):

DE Wedge ◽

Z Gao ◽

N Tabanca ◽

B Demirci ◽

KHC Baser ◽

...

Keyword(s):

Chemical Composition ◽

Essential Oils ◽

Biological Activities

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Chemical composition and biological activities of the essential oils of Psidium guajava leaf

Journal of King Saud University - Science ◽

10.1016/j.jksus.2018.07.021 ◽

2019 ◽

Vol 31 (4) ◽

pp. 993-998 ◽

Cited By ~ 4

Author(s):

Afaf Weli ◽

Amna Al-Kaabi ◽

Jamal Al-Sabahi ◽

Sadri Said ◽

Mohammad Amzad Hossain ◽

...

Keyword(s):

Chemical Composition ◽

Essential Oils ◽

Biological Activities ◽

Psidium Guajava

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Chemical composition, antimicrobial, antioxidative and anticholinesterase activity of Satureja Montana L. ssp montana essential oil

Open Life Sciences ◽

10.2478/s11535-014-0298-x ◽

2014 ◽

Vol 9 (7) ◽

pp. 668-677 ◽

Cited By ~ 5

Author(s):

Tatjana Mihajilov-Krstev ◽

Dragan Radnović ◽

Dušanka Kitić ◽

Vesna Jovanović ◽

Violeta Mitić ◽

...

Keyword(s):

Essential Oil ◽

Essential Oils ◽

Human Serum ◽

Biological Activities ◽

Serum Cholinesterase ◽

Health Improvement ◽

Chemical Compositions ◽

Bacterial Strains ◽

Antimicrobial Potential ◽

Satureja Montana

AbstractThe present study investigates the chemical compositions of three Satureja montana L. ssp montana essential oils and correlates chemical variability with biological activities. GC/MS analysis showed that with an increase in altitude (100–500–800 m), a higher content of linalool, terpinen-4-ol and cis-sabinene hydrate was found, while the percentage of phenolic compounds, thymol and carvacrol decreased. Antimicrobial activity of the essential oils was tested against 7 fungal and 23 bacterial strains. The essential oil characterized by the highest content of phenols and alcohols exhibited the highest antimicrobial potential. The correlation analysis showed that the major carriers of the obtained antioxidant activity are oxygenated monoterpenes. All essential oils inhibited human serum cholinesterase activity. High antimicrobial potential, together with moderate antioxidant capacity and strong inhibition of human serum cholinesterase, classifies S. montana essential oil as a natural source of compounds that can be used in the treatment of foodborne and neurological diseases, wound and other infections, as well as for general health improvement.

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Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

Pharmaceuticals ◽

10.3390/ph14111145 ◽

2021 ◽

Vol 14 (11) ◽

pp. 1145

Author(s):

Chabaco Armijos ◽

Jorge Ramírez ◽

Melissa Salinas ◽

Giovanni Vidari ◽

Alírica I. Suárez

Keyword(s):

Chemical Composition ◽

Medicinal Plants ◽

Secondary Metabolites ◽

Essential Oils ◽

Volatile Compounds ◽

Biological Activities ◽

Indigenous Communities ◽

Therapeutic Agents ◽

Practical Applications ◽

Pharmacological Studies

The use of plants as therapeutic agents is part of the traditional medicine that is practiced by many indigenous communities in Ecuador. The aim of this study was to update a review published in 2016 by including the studies that were carried out in the period 2016–July 2021 on about 120 Ecuadorian medicinal plants. Relevant data on raw extracts and isolated secondary metabolites were retrieved from different databases, resulting in 104 references. They included phytochemical and pharmacological studies on several non-volatile compounds, as well as the chemical composition of essential oils (EOs). The tested biological activities are also reported. The potential of Ecuadorian plants as sources of products for practical applications in different fields, as well the perspectives of future investigations, are discussed in the last part of the review.

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Chemical Composition and Pharmacological Activities of Plantago major L. in Vietnam

Asian Journal of Chemistry ◽

10.14233/ajchem.2021.22976 ◽

2021 ◽

Vol 33 (2) ◽

pp. 314-318

Author(s):

DO THI VIET HUONG ◽

PHAN MINH GIANG ◽

DO HUY HOANG ◽

NGUYEN ANH PHUONG ◽

TRIEU ANH TRUNG

Keyword(s):

Chemical Composition ◽

Biological Activities ◽

Radical Scavenging Activity ◽

Radical Scavenging ◽

Postprandial Glucose ◽

Biologically Active ◽

Plantago Major ◽

Pharmacological Activities ◽

Glucose Levels ◽

Ic50 Values

Plantago major L. in Vietnam was investigated for its chemical composition and also evaluated the biological activities against enzyme α- glucosidase and free radicals activities. The powder mixture of dried leave and roots of this species was extracted separately by three solvents: dichloromethane, water, water:alcohol (50:50, v:v). The chemical composition of dichloromethane extract was analyzed by GC-MS system to identify eighteen components, out of which eight biologically active compounds viz. 5-hydroxymethylfurfural, n-hecxadecanoic acid, 9,12-octadecadienoic acid (Z,Z)-methyl ester, allogibberic acid, β-tocopherol, campesterol, γ-sitosterol, lup-20(29)-en-3-ol and friedenlan-3-one were presented. The concentration of radical scavenging activity DPPH expressed by IC50 for water, water:alcohol (50:50, v:v) and dichloromethane with 208.7, 89.3 and 62.05 μg/mL, respectively. The dichloromethane, water and water:alcohol (50:50, v:v) extract of Plantago major exhibited α-glucosidase inhibitory activity with IC50 values of 116.4, 302.7, 195.9 μg/mL, respectively, which was comparable with acarbose (98.4 μg/mL). Plantago major L. in Vietnam may be effective inhibitors as the antidiabetic candidate and helpful to reduce the postprandial glucose levels.

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