COVID-19-associated coagulopathy

Diagnosis ◽  
2020 ◽  
Vol 7 (4) ◽  
pp. 357-363 ◽  
Author(s):  
Massimo Franchini ◽  
Giuseppe Marano ◽  
Mario Cruciani ◽  
Carlo Mengoli ◽  
Ilaria Pati ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Molecular Mechanisms ◽  
Respiratory Illness ◽  
Current Understanding ◽  
Prothrombotic State ◽  
Close Link ◽  
Thrombotic Risk ◽  
Laboratory Features ◽  
Systemic Disorder ◽  
Viral Respiratory

AbstractCoronavirus disease 2019 (COVID-19), a viral respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been recently recognized as a systemic disorder inducing a prothrombotic state. The molecular mechanisms underlying the hypercoagulable state seen in patients with COVID-19 is still incompletely understood, although it presumably involves the close link between inflammatory and hemostatic systems. The laboratory coagulation monitoring of severely ill COVID-19 patients is mandatory to identify those patients at increased thrombotic risk and to modulate thromboprophylaxis accordingly. In this review, we summarize the current understanding on the pathogenesis, epidemiology, clinical and laboratory features and management of coagulopathy associated with COVID-19.

scholarly journals A case report on Severe Acute Respiratory Infection

2021 ◽  
pp. 206-210
Author(s):  
Shiva Bawane ◽  
Manjusha Mahakalkar ◽  
Ruchira Ankar
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Case Fatality ◽  
Respiratory Illness ◽  
Virus Species ◽  
Corona Virus ◽  
Appropriate Treatment ◽  
Severe Acute Respiratory Infection ◽  
Wbc Count ◽  
Percent Case ◽  
Viral Respiratory

Introduction: Severe Acute Respiratory Syndrome is a zootoxic viral respiratory illness caused by the severe acute respiratory syndrome corona virus (SARS-CoV or SARS-The syndrome was the cause of the Severe Acute Respiratory Syndrome outbreak in 2002–2004. The virus was traced back to cave-dwelling horseshoe bats via Asian palm civets in late 2017 by Chinese scientists in Xizang Yi Ethnic Township, Yunnan. SARS was a rare illness; there were 8,422 cases at the end of the pandemic in June 2003, with an 11 percent case fatality rate (CFR) (CoV-1), the initial strain of the SARS corona virus species (SARSr-CoV). Clinical Finding: Swelling over Right. Half of face, Breathlessness. Diagnostic Evaluation: Blood test: Hb – 9.2gm%, Total RBC count- 3.22 millions/cu.mm, HCT- 26.6%, Total WBC count – 6600/cu.mm, Monocytes-02%, granulocytes-85%, lymphocytes-10000 /mcl. HRCT Scan OF Thorax: Multiple ill defined patchy ground glass opacities with consolidation and sepal thickening in bilateral lungs filled s/o infective etiology possibility of atypical viral pneumonia. View of covid positive PCR test; imagine grading corad-6 with CT severity score – 03\25 (Mild). Therapeutic Intervention: Inj.Amphotericin-B 500mg IV, Inj.Piptaz 4.4gm IV x TDS, Inj.levoflox 500 mg x OD, Inj.Clindamycin 300mg x BD, Inj.pantaprazol 40 mg x OD, Inj.Emset 4mg x TDS, Tab. limcee 500 mg x BD. Outcome: After Treatment, the patient shows improvement. His swelling over face decrease, and breathlessness decrease. Conclusion: My patient was admitted in SARI-HDU, AVBRH with complaint of swelling over face Right side, and breathlessness. After getting appropriate treatment his condition was improved.

scholarly journals The Myriad of Clinical Presentations of COVID-19: a Short Review

2020 ◽  
Vol 3 (1) ◽  
pp. 313-316
Author(s):  
Richa Nepal
Keyword(s):  
Abdominal Pain ◽  
Severe Acute Respiratory Syndrome ◽  
Healthcare Workers ◽  
Respiratory Illness ◽  
Short Review ◽  
Clinical Implications ◽  
Clinical Presentations ◽  
Atypical Presentations ◽  
Respiratory Complaints ◽  
Viral Respiratory

The ongoing pandemic of Coronavirus disease- 2019 is yet to be defeated. It is primarily a viral respiratory illness, with a myriad of clinical presentations being reported, since it was first identified towards the end of 2019 in China. Apart from the classical symptoms of fever, cough, and dyspnea, atypical presentations in COVID-19 patients, have puzzled healthcare workers worldwide. Patients with isolated non- respiratory complaints like diarrhea, vomiting, abdominal pain, skin rash, and confusion, have tested positive for severe acute respiratory syndrome coronavirus-2. The symptoms of olfactory and gustatory dysfunction have recently been added to the list for screening suspected cases after their prevalence was found to be high among COVID-19 patients. This article elaborates on the system-wise manifestations of COVID-19 and discusses the clinical implications of these aberrant presentations to healthcare workers.

scholarly journals In search of feasible interventions for the prevention and cure of novel Coronavirus disease 2019

2020 ◽  
Author(s):  
Sunil Verma
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Traditional Medicine ◽  
Molecular Mechanisms ◽  
Treatment Options ◽  
Public Health Emergency ◽  
Current Understanding ◽  
Naturally Occurring ◽  
Novel Coronavirus ◽  
Prevention And Cure

COVID-19 (coronavirus disease 2019) is a public health emergency of international concern caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As of this time, there is no known effective pharmaceutical, phytopharmaceutical or traditional medicine for cure or prevention of COVID-19, although it is urgently needed. Based on the current understanding of the disease molecular mechanisms from the closest relatives of SARS-CoV-2 as well as novel Coronavirus SARS-CoV-2, I attempt to translate this knowledge into identifying some naturally occurring plant based substances and Ayurvedic medicinal herbs that could feasibly be used as preventive as well as treatment options for COVID-19.

scholarly journals Circadian Blood Pressure Rhythm in Cardiovascular and Renal Health and Disease

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 868
Author(s):  
Jiayang Zhang ◽  
Ruoyu Sun ◽  
Tingting Jiang ◽  
Guangrui Yang ◽  
Lihong Chen
Keyword(s):  
Blood Pressure ◽  
Circadian Rhythm ◽  
Molecular Mechanisms ◽  
Current Understanding ◽  
Renal Outcomes ◽  
Circadian Blood Pressure ◽  
Health And Disease ◽  
The Relationship

Blood pressure (BP) follows a circadian rhythm, it increases on waking in the morning and decreases during sleeping at night. Disruption of the circadian BP rhythm has been reported to be associated with worsened cardiovascular and renal outcomes, however the underlying molecular mechanisms are still not clear. In this review, we briefly summarized the current understanding of the circadian BP regulation and provided therapeutic overview of the relationship between circadian BP rhythm and cardiovascular and renal health and disease.

scholarly journals Vestibular neuritis caused by severe acute respiratory syndrome coronavirus 2 infection diagnosed by serology: Case report

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110132
Author(s):  
Alexandra Halalau ◽  
Madalina Halalau ◽  
Christopher Carpenter ◽  
Amr E Abbas ◽  
Matthew Sims
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Medical History ◽  
Cranial Nerve ◽  
Respiratory Illness ◽  
Vestibular Neuritis ◽  
Past Medical History ◽  
Significant Past Medical History ◽  
Eighth Cranial Nerve ◽  
Male Physician

Vestibular neuritis is a disorder selectively affecting the vestibular portion of the eighth cranial nerve generally considered to be inflammatory in nature. There have been no reports of severe acute respiratory syndrome coronavirus 2 causing vestibular neuritis. We present the case of a 42-year-old Caucasian male physician, providing care to COVID-19 patients, with no significant past medical history, who developed acute vestibular neuritis, 2 weeks following a mild respiratory illness, later diagnosed as COVID-19. Physicians should keep severe acute respiratory syndrome coronavirus 2 high on the list as a possible etiology when suspecting vestibular neuritis, given the extent and implications of the current pandemic and the high contagiousness potential.

Modern concepts of etiology, pathogenesis and risk factors for preeclampsia

2021 ◽  
Vol 70 (5) ◽  
pp. 105-116
Author(s):  
Maria Yu. Abramova ◽  
Mikhail I. Churnosov
Keyword(s):  
Risk Factors ◽  
Social Issue ◽  
Chronic Diseases ◽  
Molecular Mechanisms ◽  
Current Understanding ◽  
Morbidity And Mortality ◽  
Perinatal Morbidity ◽  
Distant Future

Preeclampsia is a serious complication of pregnancy and complicates its course in 2-8% of all cases. According to the literature, the disease is associated with an increase in maternal and perinatal morbidity and mortality, and is a predictor of the development of chronic diseases in the distant future, which is an important medical and social issue. Of particular interest is the study of the molecular mechanisms of etiopathogenesis and risk factors for preeclampsia, which, unfortunately, are currently poorly studied and understood, thus dictating the need for further study of this complication of pregnancy. This article discusses the current understanding of the etiology, pathogenesis and risk factors for preeclampsia.

Sign in / Sign up

Export Citation Format

Share Document