scholarly journals A case report on Severe Acute Respiratory Infection

2021 ◽  
pp. 206-210
Author(s):  
Shiva Bawane ◽  
Manjusha Mahakalkar ◽  
Ruchira Ankar
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Case Fatality ◽  
Respiratory Illness ◽  
Virus Species ◽  
Corona Virus ◽  
Appropriate Treatment ◽  
Severe Acute Respiratory Infection ◽  
Wbc Count ◽  
Percent Case ◽  
Viral Respiratory

Introduction: Severe Acute Respiratory Syndrome is a zootoxic viral respiratory illness caused by the severe acute respiratory syndrome corona virus (SARS-CoV or SARS-The syndrome was the cause of the Severe Acute Respiratory Syndrome outbreak in 2002–2004. The virus was traced back to cave-dwelling horseshoe bats via Asian palm civets in late 2017 by Chinese scientists in Xizang Yi Ethnic Township, Yunnan. SARS was a rare illness; there were 8,422 cases at the end of the pandemic in June 2003, with an 11 percent case fatality rate (CFR) (CoV-1), the initial strain of the SARS corona virus species (SARSr-CoV). Clinical Finding: Swelling over Right. Half of face, Breathlessness. Diagnostic Evaluation: Blood test: Hb – 9.2gm%, Total RBC count- 3.22 millions/cu.mm, HCT- 26.6%, Total WBC count – 6600/cu.mm, Monocytes-02%, granulocytes-85%, lymphocytes-10000 /mcl. HRCT Scan OF Thorax: Multiple ill defined patchy ground glass opacities with consolidation and sepal thickening in bilateral lungs filled s/o infective etiology possibility of atypical viral pneumonia. View of covid positive PCR test; imagine grading corad-6 with CT severity score – 03\25 (Mild). Therapeutic Intervention: Inj.Amphotericin-B 500mg IV, Inj.Piptaz 4.4gm IV x TDS, Inj.levoflox 500 mg x OD, Inj.Clindamycin 300mg x BD, Inj.pantaprazol 40 mg x OD, Inj.Emset 4mg x TDS, Tab. limcee 500 mg x BD. Outcome: After Treatment, the patient shows improvement. His swelling over face decrease, and breathlessness decrease. Conclusion: My patient was admitted in SARI-HDU, AVBRH with complaint of swelling over face Right side, and breathlessness. After getting appropriate treatment his condition was improved.

COVID-19-associated coagulopathy

Diagnosis ◽  
2020 ◽  
Vol 7 (4) ◽  
pp. 357-363 ◽  
Author(s):  
Massimo Franchini ◽  
Giuseppe Marano ◽  
Mario Cruciani ◽  
Carlo Mengoli ◽  
Ilaria Pati ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Molecular Mechanisms ◽  
Respiratory Illness ◽  
Current Understanding ◽  
Prothrombotic State ◽  
Close Link ◽  
Thrombotic Risk ◽  
Laboratory Features ◽  
Systemic Disorder ◽  
Viral Respiratory

AbstractCoronavirus disease 2019 (COVID-19), a viral respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been recently recognized as a systemic disorder inducing a prothrombotic state. The molecular mechanisms underlying the hypercoagulable state seen in patients with COVID-19 is still incompletely understood, although it presumably involves the close link between inflammatory and hemostatic systems. The laboratory coagulation monitoring of severely ill COVID-19 patients is mandatory to identify those patients at increased thrombotic risk and to modulate thromboprophylaxis accordingly. In this review, we summarize the current understanding on the pathogenesis, epidemiology, clinical and laboratory features and management of coagulopathy associated with COVID-19.

scholarly journals The Myriad of Clinical Presentations of COVID-19: a Short Review

2020 ◽  
Vol 3 (1) ◽  
pp. 313-316
Author(s):  
Richa Nepal
Keyword(s):  
Abdominal Pain ◽  
Severe Acute Respiratory Syndrome ◽  
Healthcare Workers ◽  
Respiratory Illness ◽  
Short Review ◽  
Clinical Implications ◽  
Clinical Presentations ◽  
Atypical Presentations ◽  
Respiratory Complaints ◽  
Viral Respiratory

The ongoing pandemic of Coronavirus disease- 2019 is yet to be defeated. It is primarily a viral respiratory illness, with a myriad of clinical presentations being reported, since it was first identified towards the end of 2019 in China. Apart from the classical symptoms of fever, cough, and dyspnea, atypical presentations in COVID-19 patients, have puzzled healthcare workers worldwide. Patients with isolated non- respiratory complaints like diarrhea, vomiting, abdominal pain, skin rash, and confusion, have tested positive for severe acute respiratory syndrome coronavirus-2. The symptoms of olfactory and gustatory dysfunction have recently been added to the list for screening suspected cases after their prevalence was found to be high among COVID-19 patients. This article elaborates on the system-wise manifestations of COVID-19 and discusses the clinical implications of these aberrant presentations to healthcare workers.

COVID-19

2022 ◽  
pp. 1-16
Author(s):  
Soraia El Baz ◽  
My Abdelmonaim El Hidan ◽  
Nadia Zouhairi ◽  
Abdelmohcine Aimrane ◽  
Redouane Chatoui ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Current Knowledge ◽  
Virus Disease ◽  
Case Fatality ◽  
Unknown Etiology ◽  
Human Coronavirus ◽  
Corona Virus ◽  
The World ◽  
Human Coronaviruses

Since December 2019, a pneumonia outbreak with unknown etiology occurred in Wuhan, China. Later, the pathogen was identified as novel human coronavirus and named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease was named corona virus disease 2019 (COVID-19) and caused a pandemic. As of 23 June 2020, the global COVID-19 pandemic has battered the world. More than 1.5 million people have died with over 80 million people confirmed infected. This outbreak is spreading in approximately 216 countries and regions as of 22 July 2020. Comparing the three human coronavirus, SARS and MERS have significantly higher case fatality rates than COVID-19, but COVID-19 is more infectious and spreads more easily among people. Therefore, in this chapter, the authors summarize the most fatal pandemic in recorded history. Also, they collected all information about the current knowledge about COVID-19 pandemic including similarity and differences with other human coronaviruses.

scholarly journals DETAILED INFORMATION ON FAVIPIRAVIR: DRUG FOR TREATMENT OF SARS-COV-2

2020 ◽  
pp. 13-17
Author(s):  
MONAJI SANJANA REDDY
Keyword(s):  
Clinical Trials ◽  
Side Effects ◽  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
Respiratory Illness ◽  
World Health ◽  
Genetic Mutations ◽  
Corona Virus ◽  
The World ◽  
Health Organization

Severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) is another name given to pandemic disease COVID-19 that is caused by a newly discovered coronavirus. People infected with coronavirus will experience mild-to-moderate respiratory illness, and it can be seen in a serious stage when comorbidities include along with it. This is now creating a huge pandemic situation all over the world with a huge rate of sufferers, that is, around 9.06 million around the world and about 440 k in India till today according to the World Health Organization. This is a serious condition that should be solved with vaccine only as coronavirus is undergoing mutation it makes difficult to invent a vaccine for it. So far, about 200 genetic mutations have been discovered across the world also in these 198 mutations appeared independently more than once. Due to this pandemic situation, there are so many clinical trials going on in discovering vaccines. Recently, after many trails conducting favipiravir are found to be the most successful in treating any stage of SARS-CoV-2. This article focuses completely on this area, along with its mechanism, side effects, uses, and contraindications.

scholarly journals Comparison of Five Serological Assays for the Detection of SARS-CoV-2 Antibodies

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 78
Author(s):  
Anja Dörschug ◽  
Julian Schwanbeck ◽  
Andreas Hahn ◽  
Anke Hillebrecht ◽  
Sabine Blaschke ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Blood Donor ◽  
Immunoglobulin G ◽  
The Other ◽  
Specific Antibodies ◽  
Diagnostic Assays ◽  
Immunoglobulin Class ◽  
Corona Virus ◽  
Immunoglobulin Subclass

Serological assays can contribute to the estimation of population proportions with previous immunologically relevant contact with the Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) virus. In this study, we compared five commercially available diagnostic assays for the diagnostic identification of SARS-CoV-2-specific antibodies. Depending on the assessed immunoglobulin subclass, recorded sensitivity ranged from 17.0% to 81.9% with best results for immunoglobulin G. Specificity with blood donor sera ranged from 90.2% to 100%, with sera from EBV patients it ranged from 84.3% to 100%. Agreement from fair to nearly perfect was recorded depending on the immunoglobulin class between the assays, the with best results being found for immunoglobulin G. Only for this immunoglobulin class was the association between later sample acquisition times (about three weeks after first positive PCR results) and positive serological results in COVID-19 patients confirmed. In conclusion, acceptable and comparable reliability for the assessed immunoglobulin G-specific assays could be shown, while there is still room for improvement regarding the reliability of the assays targeting the other immunoglobulin classes.

scholarly journals Klebsiella spp. cause severe and fatal disease in Mozambican children: antimicrobial resistance profile and molecular characterization

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Arsénia J. Massinga ◽  
Marcelino Garrine ◽  
Augusto Messa ◽  
Nélio A. Nobela ◽  
Nadia Boisen ◽  
...  
Keyword(s):  
Antimicrobial Susceptibility ◽  
Case Fatality ◽  
Multidrug Resistant ◽  
Childhood Mortality ◽  
Fatal Disease ◽  
Appropriate Treatment ◽  
Antimicrobial Resistance Profile ◽  
Postmortem Blood ◽  
Postmortem Studies ◽  
Klebsiella Spp

Abstract Background Klebsiella spp. are important pathogens associated with bacteremia among admitted children and is among the leading cause of death in children < 5 years in postmortem studies, supporting a larger role than previously considered in childhood mortality. Herein, we compared the antimicrobial susceptibility, mechanisms of resistance, and the virulence profile of Klebsiella spp. from admitted and postmortem children. Methods Antimicrobial susceptibility and virulence factors of Klebsiella spp. recovered from blood samples collected upon admission to the hospital (n = 88) and postmortem blood (n = 23) from children < 5 years were assessed by disk diffusion and multiplex PCR. Results Klebsiella isolates from postmortem blood were likely to be ceftriaxone resistant (69.6%, 16/23 vs. 48.9%, 43/88, p = 0.045) or extended-spectrum β-lactamase (ESBL) producers (60.9%, 14/23 vs. 25%, 22/88, p = 0.001) compared to those from admitted children. blaCTX-M-15 was the most frequent ESBL gene: 65.3%, 9/14 in postmortem isolates and 22.7% (5/22) from admitted children. We found higher frequency of genes associated with hypermucoviscosity phenotype and invasin in postmortem isolates than those from admitted children: rmpA (30.4%; 7/23 vs. 9.1%, 8/88, p = 0.011), wzi-K1 (34.7%; 8/23 vs. 8%; 7/88, p = 0.002) and traT (60.8%; 14/23 vs. 10.2%; 9/88, p < 0.0001), respectively. Additionally, serine protease auto-transporters of Enterobacteriaceae were detected from 1.8% (pic) to 12.6% (pet) among all isolates. Klebsiella case fatality rate was 30.7% (23/75). Conclusion Multidrug resistant Klebsiella spp. harboring genes associated with hypermucoviscosity phenotype has emerged in Mozambique causing invasive fatal disease in children; highlighting the urgent need for prompt diagnosis, appropriate treatment and effective preventive measures for infection control.

scholarly journals Vestibular neuritis caused by severe acute respiratory syndrome coronavirus 2 infection diagnosed by serology: Case report

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110132
Author(s):  
Alexandra Halalau ◽  
Madalina Halalau ◽  
Christopher Carpenter ◽  
Amr E Abbas ◽  
Matthew Sims
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Medical History ◽  
Cranial Nerve ◽  
Respiratory Illness ◽  
Vestibular Neuritis ◽  
Past Medical History ◽  
Significant Past Medical History ◽  
Eighth Cranial Nerve ◽  
Male Physician

Vestibular neuritis is a disorder selectively affecting the vestibular portion of the eighth cranial nerve generally considered to be inflammatory in nature. There have been no reports of severe acute respiratory syndrome coronavirus 2 causing vestibular neuritis. We present the case of a 42-year-old Caucasian male physician, providing care to COVID-19 patients, with no significant past medical history, who developed acute vestibular neuritis, 2 weeks following a mild respiratory illness, later diagnosed as COVID-19. Physicians should keep severe acute respiratory syndrome coronavirus 2 high on the list as a possible etiology when suspecting vestibular neuritis, given the extent and implications of the current pandemic and the high contagiousness potential.

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