Usefulness of hematological parameters for differential diagnosis of endometriomas in adolescents/young adults and older women

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Berna Seckin ◽  
Mete Can Ates ◽  
Ayse Kirbas ◽  
Huseyin Yesilyurt
Keyword(s):  
Young Adults ◽  
Differential Diagnosis ◽  
Platelet Count ◽  
Older Women ◽  
Hematological Parameters ◽  
Reproductive Age ◽  
Ca 125 ◽  
Control Group ◽  
Platelet Indices ◽  
Lymphocyte Ratio

Abstract Background Inflammatory processes have been considered to be involved in the pathogenesis of endometriosis. However, the predictive role of inflammatory hematological parameters in endometriosis is not clear. The aim of this study was to analyze the clinical value of hematologic markers in the differential diagnosis of endometriomas in younger and older reproductive age women. Materials and methods A retrospective chart review was done for 502 patients who underwent surgery: 267 with endometriomas (endometrioma group) and 235 with other benign adnexal cysts (control group). Patients were placed into subgroups as younger (adolescents/young adults, aged <25 years) and older (aged ≥25 years) women. Total and differential white blood cell count, neutrophil-to-lymphocyte ratio, platelet indices and platelet-to-lymphocyte ratio (PLR) were evaluated with receiver operating characteristic curve analysis for differential diagnosis of endometriomas. Results The mean serum levels of PLR, plateletcrit (PCT), platelet count and CA-125 (reference range below 35 IU/mL) were significantly higher in the endometrioma group (p < 0.001). The area under the curve (AUC) for CA-125 was 0.85 [95% confidence interval (CI), 0.82–0.88] (p < 0.001) for the entire group. However, platelet count, PLR, and PCT showed poor discriminative ability for detecting endometriomas with AUC values of 0.59 (95% CI, 0.55–0.65, p < 0.001), 0.58 (95% CI, 0.53–0.63, p = 0.002) and 0.61 (95% CI, 0.56–0.66, p < 0.001), respectively. In age-stratified analysis, these platelet indices had also low diagnostic performance in both age groups. Conclusions Hematologic markers do not adequately differentiate ovarian endometriomas from other benign cysts in neither adolescents/young adults nor older women.

scholarly journals Predictive value of hematological parameters in testicular torsion: retrospective investigation of data from a high-volume tertiary care center

2018 ◽  
Vol 47 (2) ◽  
pp. 730-737 ◽  
Author(s):  
Cem Yucel ◽  
Yusuf Ozlem Ilbey
Keyword(s):  
Differential Diagnosis ◽  
Sensitivity And Specificity ◽  
Predictive Value ◽  
Hematological Parameters ◽  
Control Group ◽  
Monocyte Count ◽  
Scrotal Pain ◽  
Lymphocyte Ratio ◽  
Cell Counts ◽  
Testis Torsion

Objective To investigate the use of hematological parameters in the differential diagnosis of testis torsion and epididymo-orchitis, and to determine the predictive value of these parameters in the diagnosis of testis torsion. Methods This study retrospectively reviewed the medical data of patients who presented to our institute with the complaint of acute scrotal pain. Eighty-five patients who had undergone orchiectomy or surgical detorsion due to testis torsion and 72 patients with epididymo-orchitis were included in the study. The control group comprised 78 healthy males. The groups were compared with respect to age, hematological parameters, neutrophil to lymphocyte ratio (NLR), monocyte to eosinophil ratio (MER), and platelet to lymphocyte ratio (PLR). Results The monocyte count significantly differed between testis torsion and epididymo-orchitis, and was useful in the differential diagnosis. The mean neutrophil, platelet, and white blood cell counts, and the NLR, MER, and PLR values in the control group were significantly lower than those in the torsion and epididymo-orchitis groups. Conclusion The sensitivity and specificity of NLR in predicting testis torsion were as high as the sensitivity and specificity of doppler ultrasonography, suggesting the possible use of this parameter in the diagnosis of testis torsion.

scholarly journals An Investigation of the Relationship between Involvement Sites in Vitiligo Patients and Autoimmune Diseases and Hematological Parameters

2019 ◽  
Vol 4 (10) ◽  
Author(s):  
Ebru KARAGUN
Keyword(s):  
Hematological Parameters ◽  
Fasting Blood Glucose ◽  
Unknown Etiology ◽  
Control Group ◽  
Endocrine Disorders ◽  
Positive Correlation ◽  
Lymphocyte Ratio ◽  
History Of ◽  
The Mean ◽  
The Relationship

Aim-Objectives: Vitiligo is an acquired idiopathic disease which progresses with melanocyte destruction and is clinically characterized by depigmented lesions of unknown etiology. Vitiligo may be coexistence with a autoimmune and endocrine disorders. This study examined the sT3, fT4, TSH, Anti-TPO, Anti-Tg, Vitamin B12 and fasting blood glucose (FBG) values, and thrombocyte-to-lymphocyte ratio(TLR), neutrophil-to-lymphocyte ratio(NLR), the mean platelet volume(MPV) the correlation of depigmented lesions with the extent of body involvement sites(IS). Materials and Method: The study enrolled 67 patients aged 0‒65 who were diagnosed with non-segmental generalized vitiligo and in whom an increase in lesions had been observed in the last six months. The IS of the lesions in the patients were evaluated as IS ˂10%(1st group), 10%‒20% (2nd group), 20% - 30%(3rd group), 30% - 40%(4th group), 40% ‒50 %(5th group), and ˃50%(6th group). The control group consisted of patients who had presented to the outpatient clinic having had no history of vitiligo detected in themselves nor in their families. Results: No significant correlation was found between IS and sT3, fT4, TSH, Anti-TPO, Anti-Tg, Vit. B12, PBG or MPV. A moderately positive correlation was found between IS and duration (p <0.05) and a mildly positive correlation between IS and NLR and TLR (p <0.05). Conclusion: This study show that every patient diagnosed with vitiligo, independent of the IS, should undergo examination for autoimmune disease. A mild positive correlation between VTA and NLO-TLO was found to be an indicator of increased inflammation in vitiligo patients as the extent of lesions increased.

Evaluating the Risk of Developing Thrombocytopenia Within Five Days of Continuous Renal Replacement Therapy Initiation in Septic Patients

2020 ◽  
pp. 089719002095917
Author(s):  
Lauren Fay ◽  
Georgeanna Rechner-Neven ◽  
Drayton A. Hammond ◽  
Joshua M. DeMott ◽  
Mary Jane Sullivan
Keyword(s):  
Differential Diagnosis ◽  
Platelet Count ◽  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Primary Outcome ◽  
Control Group ◽  
Chi Square ◽  
Time Zero ◽  
Renal Replacement Therapy Initiation

Background: The differential diagnosis for thrombocytopenia in critical illness is often extensive. This study was performed to determine the incidence of thrombocytopenia in septic patients undergoing continuous renal replacement therapy (CRRT) versus those not undergoing CRRT. Objective: The primary outcome of this study was to compare the development of thrombocytopenia, defined as a platelet count ≤ 100 × 103/mm3, in septic patients within 5 days of time zero. Time zero was defined as the baseline platelet count upon hospital admission or CRRT initiation. Methods: An IRB approved, retrospective cohort study was conducted evaluating thrombocytopenia development in critically ill, septic patients who were initiated on CRRT versus those whom were not. Baseline and clinical characteristics were displayed using descriptive statistics. The primary outcome was evaluated overall and in subgroups of CRRT using Chi-square tests. Results: One hundred sixty patients, 80 per arm, were included in the study. Thrombocytopenia development within 5 days occurred more frequently in the renal replacement therapy (RRT) group compared to the control group (67.5% vs. 6.3%, p < 0.001). In the subgroup analysis of the RRT cohort, thrombocytopenia development within 5 days occurred more frequently in the continuous veno-venous hemofiltration (CVVH) group compared to the accelerated veno-venous hemofiltration (AVVH) group (76% vs. 53.3%, p = 0.049). Conclusion: There is a high likelihood that septic patients initiated on CRRT will develop thrombocytopenia during their hospital stay. Patients receiving CVVH may develop thrombocytopenia more frequently than those receiving AVVH. Overall, CRRT should remain a differential diagnosis for thrombocytopenia development in this patient population.

scholarly journals A STUDY ON CHANGES IN PLATELET COUNT AND PLATELET INDICES IN PATIENTS WITH PREECLMPSIAAND ECLAMPSIA: A CASE CONTROL STUDY

2020 ◽  
pp. 7-9
Author(s):  
Pulakesh Sinha ◽  
Sourav Barik ◽  
Apurba Bikash Pramanik ◽  
Victor Roy ◽  
Debarshi Jana
Keyword(s):  
Platelet Count ◽  
Tertiary Care ◽  
Total Sample ◽  
Screening Tests ◽  
Control Group ◽  
Medical Sciences ◽  
Multisystem Disorder ◽  
Platelet Indices ◽  
Group Iii ◽  
Group I

Preeclampsia is a hypertensive pregnancy specific multisystem disorder. It requires prompt intervention that may include observation in tertiary care setting and termination of pregnancy either by inducing labour or by caesarian section. To study the variation of platelet counts, platelet indices in preeclampsia and eclampsia Department of Pathology and Gynaecology & Obstetrics Ramakrishna Mission Seva Pratisthan, Vivekananda Institute of Medical Sciences from January 2017 to June 2018. Group I: Women affected with convulsion and having signs of preeclampsia during pregnancy or within seven days after delivery after ruling out epilepsy or any other convulsive disorder were treated as eclamptic women. Group II: Women having BP> 140/90 mmhg and significant proteinuria (>300mg/24hrs) and or edema are treated as preeclampsia. Group III: Normotensive women having pregnancy >20weeks were considered as control group. Total sample size was 66 pregnant women. 22 patients are taken from each group. The platelet indices e.g. MPV, PDW and also PLCR are in consistent relationship with PIH. The higher their values, the greater severity of PIH, from preeclampsia to eclampsia. The estimation of platelet count and indices offer early, simple, rapid assessments of the disease for its severity and the risk of complications. Therefore these tests may be considered as screening tests to be routinely performed in antenatal workup of women with PIH.

scholarly journals The role of monocyte to high-density lipoprotein cholesterol ratio in prediction of increased systemic inflammation and the risk of cardiovascular disease in endometriosis

2021 ◽  
Vol 38 (2) ◽  
pp. 106-110
Author(s):  
İsmail BIYIK ◽  
Fatih KESKİN ◽  
Nagihan SAZ
Keyword(s):  
Systemic Inflammation ◽  
Demographic Data ◽  
Hdl Cholesterol ◽  
Reproductive Age ◽  
Prognostic Indicators ◽  
Control Group ◽  
Distribution Width ◽  
Cholesterol Ratio ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

Endometriosis occurs in about 5-10 in 100 women of reproductive age. The pathophysiology of endometriosis is controversial. Some studies claimed an association between endometriosis and increased levels of inflammatory factors in peritoneal fluid and/or peripheral blood. Monocyte / HDL cholesterol ratio (MHR) and neutrophil/lymphocyte ratio (NLR) are inflammatory markers and are used as predictors and prognostic indicators of mortality and morbidity in many diseases. In this study, we aimed to investigate whether Monocyte / HDL cholesterol ratio (MHR) and neutrophil/lymphocyte ratio (NLR) are increased in endometriosis as in patients with chronic inflammation and cardiovascular diseases. This is a retrospective case-control study conducted with 87 women, 45 in the endometriosis group and 42 in the control group. The demographic data, biochemical, complete blood count parameters and lipid profile of the cases were recorded and compared between the groups. The mean age of the endometriosis group was 33.88 years and was older than the control group. In terms of other demographic data, there were no difference between the two groups. Although the platelet distribution width and triglyceride values of the endometriosis group were higher than controls, they were interpreted as clinically insignificant. There were no significant differences between the groups in terms of other laboratory parameters including MHR and NLR. In this study, MHR and NLR are found similar in endometriosis and control groups. Further studies are needed to investigate the relationship between increased systemic inflammation.

scholarly journals Platelet Indices in Neonates: A Comparative Study of Normal and Low Birth Weight Babies

2019 ◽  
Vol 39 (1) ◽  
pp. 35-41
Author(s):  
Tegsimran Duggal ◽  
Baljeet Maini ◽  
Gauri Chauhan ◽  
Bablu Kumar Gaur ◽  
Mukti Sharma ◽  
...  
Keyword(s):  
Platelet Count ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Blood Sample ◽  
Normal Weight ◽  
Control Group ◽  
Cord Blood Sample ◽  
Important Indicator ◽  
Distribution Width ◽  
Platelet Indices

Introduction: Birth weight is an important indicator of perinatal and neonatal outcome. Low birth weight (LBW) babies suffer from many problems in neonatal period and have more morbidity and mortality as compared to normal weight babies. Platelets play an important role in neonatal immunity. Platelet indices of LBW babies are not well understood and may have contributed to morbidities in these babies. This study was conducted to study the platelet indices in LBW babies.  Methods: All inborn LBW babies born in our centre and fulfilling the inclusion criteria were enrolled in the study. Study period was of one and half years (Oct 2015 – Apr 2017). Cord blood sample (2 ml) was collected and platelet indices namely Platelet Count (PC), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), were assessed. Blood sample was processed with a hospital laboratory based automated analyser. Neonatal morbidities were recorded. Platelet indices were analysed with respect to low birth weight. Results: The platelet count in LBW babies was lower than the control group. Other indices i.e. PDW and MPV however did not show significant variation between both the groups. Conclusions: LBW babies had lower platelet counts but other platelet indices were not significantly affected. The results need to be substantiated with further larger studies in the future.

scholarly journals Is there a correlation between inflammatory markers and coagulation parameters in women with advanced ovarian endometriosis?

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Shaojie Ding ◽  
Qiao Lin ◽  
Tianhong Zhu ◽  
Tiantian Li ◽  
Libo Zhu ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Area Under The Curve ◽  
Plasma Fibrinogen ◽  
Ca 125 ◽  
Ovarian Cysts ◽  
Control Group ◽  
Thrombin Time ◽  
Ovarian Endometriosis ◽  
Coagulation Parameters ◽  
Lymphocyte Ratio

Abstract Background Endometriosis is defined as a chronic inflammatory disease. Recent studies have shown that increased coagulation parameters including fibrinogen and platelets are associated with endometriosis. The objective of this study was to determine the levels of inflammatory markers and coagulation parameters and their correlations in women with endometriomas compared to those with benign ovarian cysts or normal pelvic anatomy. Methods Between June 2015 and June 2017, a total of 548 women who underwent laparoscopic/laparotomic surgery for ovarian endometriomas (OMA group, n = 226), non-endometriosis benign ovarian cysts (Cyst group, n = 210) and tubal reanastomosis (Control group, n = 112) were recruited in this study. Inflammatory markers including c-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and coagulation parameters including platelet count, thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time, and plasma fibrinogen as well as CA-125 were determined. Results Compared with Cyst group and Control group, TT and PT in OMA group were significantly shorter and plasma fibrinogen levels were significantly higher (P < 0.05). Moreover, the levels of plasma fibrinogen were positively correlated with CRP, NLR and PLR (P < 0.05). In addition, the confidence intervals for the area under the curve (AUC) for CA-125 × fibrinogen were significantly higher than those for CA-125 (0.904–0.952 vs. 0.899–0.949) in the diagnosis of endometrioma. Conclusions These results indicate that women with endometriomas demonstrate a hypercoagulable status due to the inflammatory nature of endometriosis. The combined determination for CA-125 and fibrinogen demonstrate a higher area under the curve than the single detection of CA-125 in those with endometriomas compared to these with benign ovarian cysts. Trial registration This study was approved by the Human Ethics Committee of the Women’s Hospital, School of Medicine, Zhejiang University (No.20170174) and all women provided written informed consent.

Can Inflammatory Hematological Parameters be a Guide to Late-onset Fetal Growth Restriction?

2020 ◽  
Author(s):  
Demet Aydogan kırmızı ◽  
Emre Baser ◽  
Taylan Onat ◽  
Melike Demir Caltekin ◽  
Mustafa Kara ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Late Onset ◽  
Hematological Parameters ◽  
Growth Restriction ◽  
Control Group ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Significant Difference

Abstract Purpose To compare the rates obtained from hematological parameters in cases of late-onset idiopathic fetal growth restriction (FGR) with healthy pregnancies and to evaluate the effect on neonatal outcomes. Methods The study group consisted of 63 pregnant women with late-onset idiopathic FGR and the control group consisted of 91 healthy pregnant women. The determined rates were calculated from the control hemograms of patients at 28 weeks. Both groups were compared for neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and other parameters. Results NLR, leukocyte and neutrophil levels were significantly higher in the FGR group (p<0.05). There was no significant difference in PLR, platelet and lymphocyte levels between the groups (p>0.05). To predict FGR, the best cut-off value of NLR was determined to be 4.11 with 56% sensitivity and 88% specificity values. Conclusion Neutrophil, lymphocyte and platelet interactions have an important role in FGR development. Inflammation can be involved in the etiopathogenesis in late-onset FGR.

scholarly journals Relationship Between Platelet Indices and Aortic Valve Sclerosis

2009 ◽  
Vol 16 (5) ◽  
pp. 563-567 ◽  
Author(s):  
Murat Sucu ◽  
Vedat Davutoglu ◽  
Ibrahim Sari ◽  
Orhan Ozer ◽  
Mehmet Aksoy
Keyword(s):  
Platelet Count ◽  
Aortic Valve ◽  
Smoking Status ◽  
Control Group ◽  
Aortic Valve Sclerosis ◽  
Platelet Production ◽  
Platelet Indices ◽  
Significant Difference ◽  
Group A ◽  
Production Indices

Objective: Aortic valve sclerosis (AVS) is a progressive disease that is characterized by aortic valve thickening without causing significant narrowing and in which pathology resembles atherosclerotic coronary heart disease. We aimed to evaluate the relationship between AVS and platelet indices including mean platelet volume (MPV), platelet distribution weight (PDW), and platelet count. Method: Two hundred ten patients who were evaluated in the echocardiography unit due to various reasons between January and October 2008 were consecutively included in the study. The patients were divided into 2 groups according to presence or absence of AVS. The patient group consisted of 150 patients (76 females and 74 males; mean age, 64.5 ± 11.5 years). Patients without AVS (24 females and 36 males; mean age, 49.8 ± 15.7 years) were assigned as control group. The MPV, PDW, and platelet count were measured. Results: The MPV (9.56 ± 1.3 fL vs 9.15 ± 1.0 fL, P = .022) and PDW (16.9 ± 2.3% vs 14.9 ± 2.3, P = .001) were significantly higher in patients with AVS (+) compared to the AVS (—) group. No significant difference was demonstrated between the groups in terms of white blood cell and platelet counts (P > .05). When the AVS (+) group was compared to the AVS (—) group, a significant difference was found in respect of hypertension, diabetes mellitus, and smoking status. Conclusion: Platelet production indices including MPV and PDW were increased in patients with AVS. The complex interrelationship between increased platelet production indices and AVS and value of antithrombotic therapies in patients with AVS need to be evaluated in further studies.

scholarly journals Evaluation of platelet and its indices as a marker of neonatal sepsis: a prospective case control study

2018 ◽  
Vol 5 (5) ◽  
pp. 1898 ◽  
Author(s):  
Ratana Ram Choudhary ◽  
Mohan Makwana ◽  
Harish Kumar Mourya ◽  
Jagdish Dabi ◽  
Kartika Gulati
Keyword(s):  
Platelet Count ◽  
Blood Culture ◽  
Neonatal Sepsis ◽  
Neonatal Morbidity ◽  
Signs And Symptoms ◽  
Control Group ◽  
Case Group ◽  
Platelet Indices ◽  
Sepsis Screen ◽  
Sepsis Screening

Background: Neonatal sepsis is major cause of neonatal morbidity and mortality worldwide. Blood culture and sepsis screening are currently used method, but their utility is limited due to delayed reporting and increased cost. Platelet indices are one such set of parameters which can be helpful in the future diagnosis of neonatal sepsis. This study was aimed to evaluate the significance of platelet indices either alone or in combination with existing sepsis screen as a marker of neonatal sepsis.Methods: Neonates admitted in the neonatal unit of Hospital and showing signs and symptoms of sepsis, and/or born to mothers with risk factor for sepsis were included in this study. Investigations sent for all these neonates included blood culture, sepsis screen (CRP, micro ESR, TLC, ANC, IT ratio) and platelet indices (Platelet count, MPV, PDW).Results: In present study, 81.12% neonates in case group had platelet count less than 1.5lacs/mm3 while in control group 20.91% neonates only had the same. This difference was statistically significant, (p<0.0001). Similarly, 70.91% neonates in case group had MPV more than >10.8 fl whereas in control group only 26.53% neonates had the same, with difference was statistically significant, (p<0.0001) Similarly, 65.81% neonates in case group and 34.69% in control group had PDW more than 19.1fl and this difference was statistically significant, (p=0.0001).Conclusions: High PDW, high MPV and low platelet count are more associated with neonatal sepsis. So, platelet and its indices may be used as a sensitive marker to identify septic babies and it may be combined with existing sepsis screen to specifically exclude non-septic case.

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