The effects of combination of Zingiber officinale and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients: a randomized controlled trial

Abstract Objectives Herbal medicines, as a treatment method, have received a great deal of attention. The effects of two herbal medicines namely Zingiber officinale and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients were examined. Methods A clinical trial with 100 suspected COVID-19 outpatients as participants was conducted. The participants were allocated randomly to two groups of 50 members. The intervention group received concurrent Zingiber officinale (Tablet Vomigone 500 mg II tds) and Echinacea (Tablet Rucoldup I tds) for seven days in addition to the standard treatment. The control group only received the standard treatment (Hydroxychloroquine). After seven days, alleviation of clinical symptoms and hospitalization rate were examined. In addition, 14 days after treatment, the hospitalization was assessed again by telephone follow up. Results The two groups were identical in terms of basic characteristics. Improvement level as to coughing, dyspnea, and muscle pain was higher in the intervention group (p value <0.05). There was no significant difference between the two groups in terms of the other symptoms. In addition, the hospitalization rate in the intervention and control groups were 2 and 6% respectively, which are not significantly different (p value >0.05). Conclusions Taking into account the efficiency and trivial side-effects of Zingiber officinale and Echinacea, using them for alleviation and control of the clinical symptoms in COVID-19 outpatients is recommended.

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Pengaruh Pemberian Tablet Fe Terhadap Hemoglobin Pada Taruni Politeknik Ilmu Pelayaran Semarang

Journal of Holistics and Health Science ◽

10.35473/jhhs.v2i2.47 ◽

2020 ◽

Vol 2 (2) ◽

pp. 52-67

Author(s):

Anggi Vina Hariyati ◽

Cahyaningrum ◽

Adil Zulkarnain

Keyword(s):

Intervention Group ◽

Sampling Technique ◽

Bivariate Analysis ◽

Control Group ◽

P Value ◽

Merchant Marine ◽

Purposive Sampling ◽

The Public ◽

Significant Difference ◽

And Control

Anemia is one of the public health problems that need more attention of the female because they experience menstruation and they are in the growth phase. From the data of Semarang City Health Office in 2011, it is shown the incidence of anemia in adolescents aged 10-19 years old are 68.24%. The prevention effort of the case is by measuring hemoglobin and prescribing blood supplement. The objective of the study is to find out the effect of Fe tablets on Hemoglobin in Semarang Merchant Marine Polytechnique students. The objective of the study is to find out the effect of Fe tablets on Hemoglobin in Semarang Merchant Marine Polytechnique students. This research used pre-experimental design with the two group pretest posttest. The population in this Study were all Merchant Marine Polytechnique Semarang at the 4th semester of female students amounting to 50 with the total respondents 34 respondents taken with purposive sampling technique. The data were collected by performing Hemoglobin examination. The results of the study show that the average Hemoglobin before being prescribed Fe on the intervention and control group was 11.29 g/dl. After being prescribed Fe to the intervention group, it is found the average increased to 13.69 g/dl, while in the control group it is found averaged 11.72 g/dl. Bivariate Analysis uses an independent t test, the value of t is 6.136 with a p-value of 0.000. It shows that the p-value is 0,000 <((0.05), this indicates that there is a significant difference in the decrease in Hemoglobin levels in the population after being prescribed blood supplement between the intervention and control groups in The Semarang Merchant Marine Politechnique Students. It is suggested that the female adolescents to consume more iron-containing foods or consume Fe supplements such as Fe, during menstruation. ABSTRAK Anemia merupakan salah satu masalah kesehatan masyarakat yang perlu khusus nya pada remaja putri yang perlu mendapatkan perhatian khusus karena remaja putri mengalami mestruasi tiap bulan dan dalam masa pertumbuhan . Hasil Data Dinas Kesehatan Kota Semarang tahun 2011. Kejadian anemia pada remaja usia 10-19 sebanyak 68,24%. Untuk menangani masalah tersebut pencegahan yang dilakukan yaitu dengan cara mengukur hemoglobin dan pemberian suplemen tablet tambah darah . Penelitian ini bertujuan untuk melihat Pengaruh Pemberian Tablet Fe Terhadap Hemoglobin Pada Taruni Politeknik Ilmu Pelayaran Semarang. Penelitian ini bertujuan untuk melihat Pengaruh Pemberian Tablet Fe Terhadap Hemoglobin Pada Taruni Politeknik Ilmu Pelayaran Semarang. Jenis penelitian ini menggunakan pre-eksperimen design dengan rancangan Two group pretest posttest. Populasi dalam penelitian iniadalah seluruh taruni politeknik ilmu pelayaran semarang semester 4 berjumlah 50 taruni dengan jumlah sempel 34 responden dengan tehnik pengambilan sempel purposive sampling. Pengambilan data dengan melakukan pemeriksaan Hemoglobin. Penelitian menunjukan bahwa rata-rata Hemoglobin sebelum diberikan pada taruni kelompok intervensi dan kontrol sama yaitu 11,29 g/dl. Dan setelah diberikan pada kelompok intervensi rata-rata meningkat menjadi 13,69 g/dl, sedangkan kelompok kontrol rata-rata sebesar 11,72 g/dl. Analisis bivariate Menggunakan uji t independen, didapatkan nilai t hitung 6,136 dengan p-value sebesar 0,000. Terlihat bahwa p-value 0,000 <a (0,05), ini menunjukkan bahwa ada perbedaan secara signifikan penurunan (selisih) kadar Hemoglobin b pada taruni sesudah diberikan tablet penambah darah antara kelompok intervensi dan kontrol pada taruni Politeknik Ilmu Pelayaran Semarang. Hendaknya bagi remaja putri lebih banyak mengomsumsi makanan yang mengandung zat besi atau mengomsumsi suplemen yang mengandung besi seperti Fe terutama saat mestruasi

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A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement

Iranian Journal of Allergy Asthma and Immunology ◽

10.18502/ijaai.v20i4.6959 ◽

2021 ◽

Author(s):

Zahra Alizadeh ◽

Nastaran Keyhanian ◽

Sara Ghaderkhani ◽

Simin Dashti-Khavidaki ◽

Raheleh Shokouhi Shoormasti ◽

...

Keyword(s):

Clinical Symptoms ◽

Intervention Group ◽

Control Group ◽

Low Light ◽

Reactive Protein ◽

Significant Difference ◽

Before And After ◽

And Control ◽

To Receive ◽

Chest Ct Scan

No effective antiviral drugs and vaccines are available for the treatment of patients with severe coronavirus 2019 (COVID-19). Therefore, available, safe, and inexpensive drugs and supplements such as melatonin are among the proposed options for controlling inflammation. We did a randomized, single-blind study in Imam Khomeini Hospital between June 30, 2020, and August 5, 2020. Mild to moderate COVID-19 patients aged 25-65 years were eligible to enter the study based on chest CT scan, clinical symptoms, and physician diagnosis. The intervention group was prescribed 6 mg of oral melatonin for 2 weeks, which consumed half an hour before bedtime every night in low light conditions. Clinical symptoms and C-reactive protein (CRP) were measured before and after treatment in the melatonin received and control (regular medications) groups. Among screened patients with COVID-19, 14 patients were assigned to receive melatonin, and 17 patients were considered as controls. A significant difference (p=0.005) between CRP 1 and CRP 2 levels (before and after using melatonin) was found in the melatonin group while this difference (p=0.069) was not significant in the control group. Also, the percentage of recovery (based on symptoms) in patients who took melatonin was higher than that of patients in the control group (85.7% VS 47.1%). The result of this study confirmed the effectiveness of melatonin in mild to moderate outpatients with COVID-19. More clinical trials on elderly, diabetic, obese patients and severe cases are suggested in future studies.

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Atorvastatin in Helicobacter Pylori Treatment: A Randomized Controlled Trial and Review

10.21203/rs.3.rs-575317/v1 ◽

2021 ◽

Author(s):

Mohammad Reza Mohammad Hoseini Azar ◽

Parham Porteghali ◽

Amin Sedokani

Keyword(s):

Helicobacter Pylori ◽

Standard Treatment ◽

Controlled Trial ◽

Intervention Group ◽

Trial Registration ◽

Control Group ◽

P Value ◽

Bismuth Subcitrate ◽

Significant Difference ◽

H Pylori

Abstract Background: Considering the increase in drug resistance over time to Helicobacter pylori treatment relying on the anti-inflammatory and antibacterial effects of atorvastatin to increase the success rate of H. pylori eradication, we examined the effect of adding atorvastatin to standard treatment of H. pylori eradication.Results: A total of 186 symptomatic patients who had been diagnosed with Helicobacter pylori infection and tested for H. pylori eradication were examined by a pathological response or positive urea breath test. Patients who received atorvastatin in addition to standard treatment were also identified based on a table of random numbers. Standard treatment included a 240mg bismuth subcitrate tablet, a 40mg pantoprazole tablet, a 500mg metronidazole tablet, and 2 capsules of 500mg amoxicillin, all taken BID for 14 days. After 4 weeks of treatment, all patients underwent stool testing for H. pylori fecal antigen. If the test was positive, the request was considered a failure of treatment, and if the test was negative, it was considered a successful eradication of H. pylori. The clinical trial registration code for this study is IRCT20190823044589N1. The eradication rate of H. pylori was 80% in the control group and 80.9% in the intervention group, which did not show a statistically significant difference between the two groups (P-value=0.971).Conclusion: Adding atorvastatin to 4-drug regimen of PPI, bismuth subcitrate, amoxicillin, and metronidazole as the first line of treatment for H. pylori eradication is ineffective.Trial registration: IRCT, IRCT20190823044589N1. Registered 28 December 2019 - Retrospectively registered, https://en.irct.ir/trial/41734

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Prophylactic Effect of Memantine in Docetaxel Induced Neuropathy in Patients With Breast Cancer

10.21203/rs.3.rs-692391/v1 ◽

2021 ◽

Author(s):

Pegah Mohammadzadeh ◽

Elnaz Shaseb ◽

Zohreh Sanaat ◽

Parvin Sarbakhsh ◽

Nasrin Gholami ◽

...

Keyword(s):

Breast Cancer ◽

Peripheral Neuropathy ◽

Intervention Group ◽

Metastatic Breast ◽

Control Group ◽

P Value ◽

Control Groups ◽

Significant Difference ◽

And Control

Abstract Purpose Peripheral neuropathy is a complication of taxane that in severe cases can limit the optimal treatment. The aim of this study was to evaluate the efficacy of memantine in prevention of docetaxel induced peripheral neuropathy in patients with breast cancer. Methods In this randomized clinical trial, 40 women between the ages of 18 and 64 years with non-metastatic breast cancer (stages I to III) were included (registry number: IRCT20160310026998N9 and registry date: 26 March 2019). All patients were treated with the AC-T regimen (with docetaxel). Patients in intervention group received memantine at a dose of 20 mg for 8 weeks at the beginning of the first cycle of docetaxel. Patients in control group did not take any medication for neuropathy prevention. To assess the neuropathy, DN4 and CTCAE questionnaires were used at baseline, one months, three months and six months after the intervention. Results The DN4 questionnaire score was remarkably less in memantine group in follow up one (p-value: 0.033) and three (p < 00.1). The CTCAE follow up score did not change during study. The Neuropathy duration and Neuropathy onset, were shown significant difference between the intervention and control groups, p = 0.050 and p = 0.001, respectively. From 40 patients, 8 (40%) in memantine group and 2 (10%) in control group, did not experience any kind of neuropathy. Conclusion Data showed that prophylactic administration of memantine 20 mg/day has been effective in prevention of severity and incidence of docetaxel induced neuropathy in patients with breast cancer.

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SWEET POTATO (IPMOEA BATATAS L.) LEAF: ITS EFFECT ON PROLACTIN AND PRODUCTION OF BREAST MILK IN POSTPARTUM MOTHERS

Belitung Nursing Journal ◽

10.33546/bnj.72 ◽

2017 ◽

Vol 3 (2) ◽

pp. 95-101

Author(s):

Ima Candra Kusuma ◽

Onny Setiani ◽

Umaroh Umaroh ◽

Noor Pramono ◽

Melyana Nurul Widyawati ◽

...

Keyword(s):

Breast Milk ◽

Sweet Potato ◽

Milk Production ◽

Ipomoea Batatas ◽

Intervention Group ◽

Control Group ◽

P Value ◽

Breast Milk Production ◽

Significant Difference ◽

And Control

Background: Sweet potato leaf is assumed to be one of alternative herbs that can increase breast milk production. However, there was no studies found in the literature that examine the sweet potato leaves to increase the levels of prolactin and milk production.Objective: To examine the effect of sweet potato (Ipomoea batatas L.) leaf on the levels of prolactin and milk production in postpartum mothers.Methods: This was a Quasy experimental study with pretest-posttest design with control group, conducted on November 2016 to December 2016 in the Health Center (Puskesmas) of Boyolali I. Thirty respondents were selected using consecutive sampling, which were divided to be 15 respodents in intervention group and 15 respondents in control group. Enzyme-linked immunosobent assay (ELISA) was used to measure prolactin levels, while breast milk production was measured based on the volume of breast milk and baby’s weight. Data were analzed using Independent t-test and paired t-test.Results: Finding showed that there was a significant difference in prolactin levels between the intervention (270.43) and control group (156.28) after intervention with p-value 0.000, and a significant difference in breast milk production in terms of breast milk volume (intervention group 136.33; and control group 119) with p-value 0.028; and baby’s weight (intervention group 3030.3; and control group 2787.33) with p-value 0.000.Conclusion: There was a significant effect of sweet potato (Ipomoea batatas L.) leaf on the levels of prolactin and breast milk production. Thus, it could be suggested that sweet potato leaves should be considered to be one of alternative treatements for health care providers, especially for midwives to help breastfeeding mothers in increasing their breast milk production and prolactin levels. Further research is needed to examine all factors affecting breast milk production.

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The Effect of Black Tea (Camellia sinensis (L) Kuntze) on Pediatrics With Acute Nonbacterial Diarrhea

Journal of Evidence-Based Complementary & Alternative Medicine ◽

10.1177/2156587216654600 ◽

2016 ◽

Vol 22 (1) ◽

pp. 114-119 ◽

Cited By ~ 2

Author(s):

Sareh Doustfatemeh ◽

Mohammad Hadi Imanieh ◽

Abdolali Mohagheghzade ◽

Mohammad M. Zarshenas ◽

Zahra Torkamani ◽

...

Keyword(s):

Standard Treatment ◽

Intervention Group ◽

Black Tea ◽

Control Group ◽

Old Patients ◽

Significant Difference ◽

The Mean ◽

And Control ◽

Single Blind

We aimed to evaluate the antidiarrheal effect of black tea in pediatric patients with acute nonbacterial diarrhea. This single-blind randomized clinical trial study was performed on 2 to 12-year-old patients, with acceptable criteria for acute nonbacterial diarrhea in Shiraz, Iran. In total, 120 patients took part in this study. Blocked randomization method was used to allocate them into 2 groups of intervention (black tea tablet + standard treatment) and control group (standard treatment; 60 patients in each). Frequency of defecation, volume, and consistency of stool were registered on arrival and 24 hours later. We used χ2 test, t test, and Mann-Whitney U test. After a 24-hour follow-up, the proportion of patients with formed stool was higher in the intervention group when compared with the control group ( P < .001). There was a significant difference between the mean number of defecations per 24 hours in both groups, after treatment ( P < .001). We found a possible antidiarrheal effect of black tea.

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Effectiveness of Exercises in Glycaemic Control and Maternal Outcome among Women with Gestational Diabetes Mellitus- A Pilot study

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/46594.14924 ◽

2021 ◽

Author(s):

Reena Wilma Frank ◽

Kaipangala Raja Gopal ◽

Devina E Rodrigues

Keyword(s):

Diabetes Mellitus ◽

Pilot Study ◽

Intervention Group ◽

Maternal Outcome ◽

Control Group ◽

P Value ◽

Significant Difference ◽

Moderate Effect ◽

And Control ◽

Interventional Group

Introduction: Diabetes Mellitus is a common medical problem that is very often seen in pregnancy in the present era. Pregnant women should keep in mind their health and lifestyle considerations or else pregnancy will end up with many complications. Pre-existing factors and pregnancy factors will be contributing and make pregnancy more complicated. Exercises are recommended as a healthy practice which prevents many diseases and provides a healthy life. Aim: To evaluate the glycaemic level by focusing on exercises to improve the maternal outcome. Materials and Methods: A Pilot study with Quasi-experimental pre-post control group design with 30 Gestational Diabetes Mellitus (GDM) women (15 in each group) were selected who met the inclusion and exclusion criteria. The study was conducted in tertiary care Hospital between June 2019 and December 2019. Based on the convenience sampling technique, the setting was selected and a simple random technique was adopted to select the subjects. The 15 subjects were included in each groups, both intervention and control group. Exercises were taught for the interventional group of women for 12 weeks. Regular treatment was continued for both groups which include medication, diet and regular walking. Pre-test and post-test glycaemic scores were done for both the groups. Mann-whitney test, ANOVA, post-hoc test, paired Eta square were also used and IBM Statistical Package for the Social Sciences (SPSS) version 23.0 was used. Results: The study shows there was a significant difference in the pre-Fasting Blood Sugar (FBS) and post FBS values in the intervention group p-value <0.027. The paired Eta square value was 0.303 which showed a moderate effect of the exercise on the glycaemic value in the interventional group. There was a significant difference in the pre glycosylated haemoglobin (HbA1c) and post HbA1c values in both the intervention and control group was p-value <0.023 and p-value <0.025, respectively. The maternal outcome shows increased severity of the complications in the control group while comparing with the intervention group such as pre-eclampsia, operative interference, and preterm deliveries. But there was no significant difference in the maternal outcome observed between intervention and control group p-value >0.05. Conclusion: Regular moderate-intensity aerobic and resistance exercise training during pregnancy is associated with lower blood glucose level. Thus, study concluded that exercise has a moderate effect on glycaemic control.

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Effectiveness of Distraction Therapy on Pain Relief among Children Undergoing Vein-Puncture in a Selected Hospital, Bhubaneswar

Journal of Advanced Research in Medicine ◽

10.24321/2349.7181.202008 ◽

2020 ◽

Vol 07 (02) ◽

pp. 15-21

Author(s):

Soumika Debnath ◽

Keyword(s):

Intervention Group ◽

Sampling Technique ◽

Pain Scale ◽

Control Group ◽

P Value ◽

Double Blind ◽

Significant Difference ◽

Post Test ◽

And Control ◽

Experimental Group

Aim: The present study is aimed to assess the effect of distraction therapy during venipuncture in reducing pain among 6-12 years children in the selected hospital at Bhubaneswar. Methods: The study was a double blind; Randomized control trial design was used and the formal consent was obtained from Pradyumna Bal Memorial Hospital and the investigator selected 182 samples using consecutive sampling technique and then randomized into experimental and control groups. The intervention group and the control were having 91 samples each. Measurement of pain experienced by the school going children was assessed with the help of Wong-Baker Faces Pain Scale. Descriptive and inferential statistics were used to analyze the data. Result: The mean pain score of children in experimental group was 2.571 and the standard deviation was 2.006. The p value in comparing the pain level of children in control and experimental group was <0.01, which was statistically significant at p<0.05 (confidence interval 95%) level indicating that there was significant difference in the post test level of pain between the experimental and control group. Conclusion: Hence the distraction therapy was responsive in reducing the vein-puncture pain among school going children.

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Pediatric Functional Constipation and Whey Protein: A Randomized Clinical Trial

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i1531286 ◽

2021 ◽

pp. 45-55

Author(s):

Fateme Motavasselian ◽

Majid Emtiazy ◽

Mehrdad Shakiba ◽

Majid Aflatoonian

Keyword(s):

Whey Protein ◽

Gastrointestinal Disease ◽

Protein A ◽

Intervention Group ◽

Functional Constipation ◽

Control Group ◽

P Value ◽

Significant Difference ◽

Age Range ◽

And Control

Background: Functional constipation is a chronic gastrointestinal disease in children. Pharmacological treatment of constipation is mostly based on the prescription of laxatives. In addition to this treatment, complementary therapies were also proposed to treat constipation. In this study, the effect of whey protein in the treatment of constipation was investigated. Method and Materials: A total of 56 children with functional constipation within the age range of 1 to 16 years were included in the study. Patients were randomly divided into the intervention (n=28) and control (n=28) groups. The intervention group received 15 g whey protein and the control group received 15 g placebo. Both groups received 0.4 - 0.8 gr/kg PEG powder. The amount of PEG was adjusted every four days based on having soft stools. Demographic information were collected and recorded. Furthermore, fecal consistency, stool frequency, symptoms of stool retention, fecal incontinence, and abdominal pain were recorded prior to the intervention and at the second and fourth weeks of the intervention. Results: All patients had soft daily stools at the end of the intervention. At the end of the fourth week, the mean required amounts of PEG powder were respectively 0.62 and 0.28 g/kg in the control and intervention groups, which showed a significant difference (p value ≤0.001). Conclusion: Based on these findings, whey protein is safe and can improve constipation. However, more studies with larger sample size and longer follow-up period are needed to confirm the results of this study.

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Investigating the effect of Sesame Ointment on Wound healing of Episiotomy

International Journal of Ayurvedic Medicine ◽

10.47552/ijam.v9i3.1072 ◽

2018 ◽

Vol 9 (3) ◽

pp. 182-184

Author(s):

Najmeh Amani Babadi ◽

Masoomeh Kheirkhah ◽

Faraz Mojab ◽

Hamid Haghani

Keyword(s):

Wound Healing ◽

Intervention Group ◽

Control Group ◽

P Value ◽

Significant Difference ◽

The Mean ◽

Randomized Control ◽

Spss Software ◽

And Control

Episiotomy is one of the most common midwifery interventions method for preventing injuries to the pelvic floor during the delivery process. Traditional medicine has a special place in improving the quality of postpartum care. Sesame is one of the herbs with anti-inflammatory, anti-bacterial and antioxidant activity. This study was evaluate the effect of sesame ointment on episiotomy healing. Methods: This randomized control clinical trial was performed on 104 eligible women. The samples were block randomly assigned to one of the groups Intervention and control. Samples were used sesame and placebo ointment for epizootics from 4 hours after delivery for ten days every 8 hours. Clinical evaluation of episiotomy ulcer was performed 4 hours, 7 and 10 days after delivery with using REEDA tool. SPSS software version 16 was used for data analysis. P value less than 0.05 was considered significant. Results: The average of wound healing rate was 7 days after episiotomy in the intervention group 0.09 ± 0.29 and in the control group was 0.73 ± 0.44. Independent t-test showed that the two groups had a significant difference (p <0.001).Healing of the wound 10 days after episiotomy showed that the mean scores in the control group (0.4 ± 0.49) and in the intervention group (0.02 ± 0.13), healing in the intervention group significantly decreased from the control group (p <0.001). Conclusion: Sesame ointment can be used as a pain relief and accelerator for episiotomy healing.

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