Physical activity does not attenuate the relationship between daily cortisol and metabolic syndrome in obese youth

Author(s):  
Emily Hill Guseman ◽  
Karin A. Pfeiffer ◽  
Joseph J. Carlson ◽  
Kathy Stansbury ◽  
Joey C. Eisenmann

Abstract: We examined the associations among daily cortisol, physical activity (MVPA) and continuous metabolic syndrome score (cMetS) in obese youth.: Fifty adolescents (mean age 14.8±1.9 years) were recruited from medical clinics. Daily MVPA (min/day) was assessed by accelerometry. Saliva was sampled at prescribed times: immediately upon waking; 30 min after waking; and 3, 6 and 9 h after waking. Fasting lipids, glucose, waist circumference and blood pressure were used to calculate a continuous metabolic syndrome score (cMetS). Multiple linear regression analysis was used to examine associations among variables.: The mean cMetS score was 4.16±4.30 and did not differ by clinic or sex. No significant relationship was found between cortisol area under the curve (cAUC) and cMetS, nor did the interaction of MVPA with cAUC significantly predict cMetS.: Physical activity, cortisol, and metabolic risk were not associated in this sample of obese adolescents. Future research should examine the role of insulin sensitivity in these relationships.

2020 ◽  
Vol 64 (12) ◽  
Author(s):  
Takuto Takahashi ◽  
Angela R. Smith ◽  
Pamala A. Jacobson ◽  
James Fisher ◽  
Nathan T. Rubin ◽  
...  

ABSTRACT Voriconazole (VCZ) is an antifungal agent with wide inter- and intrapatient pharmacokinetic (PK) variability and narrow therapeutic index. Although obesity was associated with higher VCZ trough concentrations in adults, the impact of obesity had yet to be studied in children. We characterized the PK of VCZ in obese patients by accounting for age and CYP2C19 phenotype. We conducted intensive PK studies of VCZ and VCZ N-oxide metabolite in 44 hematopoietic stem cell transplantation (HSCT) recipients aged 2 to 21 years who received prophylactic intravenous VCZ every 12 hours (q12h). Blood samples were collected at 5 and 30 minutes; at 1, 3, 6, and 9 hours after infusion completion; and immediately before the next infusion start. We estimated PK parameters with noncompartmental analysis and evaluated for an association with obesity by multiple linear regression analysis. The 44 participants included 9 (20%) with obesity. CYP2C19 metabolism phenotypes were identified as normal in 22 (50%), poor/intermediate in 13 (30%), and rapid/ultrarapid in 9 patients (21%). Obesity status significantly affects the VCZ minimum concentration of drug in serum (Cmin) (higher by 1.4 mg/liter; 95% confidence interval [CI], 0.0 to 2.8; P = 0.047) and VCZ metabolism ratio (VCZRATIO) (higher by 0.4; 95% CI, 0.0 to 0.7; P = 0.03), while no association was observed with VCZ area under the curve (AUC) (P = 0.09) after adjusting for clinical factors. A younger age and a CYP2C19 phenotype were associated with lower VCZ AUC. Obesity was associated with decreased metabolism of VCZ to its inactive N-oxide metabolite and, concurrently, increased VCZ Cmin, which is deemed clinically meaningful. Future research should aim to further characterize its effects and determine a proper dosing regimen for the obese.


2020 ◽  
Vol 20 (3) ◽  
pp. 55-64
Author(s):  
Andrea Da Silva Freire ◽  
David Dos Santos ◽  
Ana Vaz ◽  
João Lucas Lima ◽  
Glaciane Axt ◽  
...  

El trastorno de compulsión alimentar periódico (TCAP) está vinculado a varios trastornos psiquiátricos, como los de ansiedad. Aproximadamente el 50-60% de los pacientes con TCAP son resistentes a los tratamientos tradicionales disponibles y, por lo tanto, se necesitan estrategias que apoyen el tratamiento de TCAP, como la actividad física (AF). La práctica de AF parece ser una estrategia interesante para reducir TCAP y síntomas de ansiedad. Por lo tanto, dado que la AF tiene un papel en la reducción de los episodios de TCAP y en la mejora de los síntomas de ansiedad, entonces se necesita más investigación para aclarar el rol moderador de la AF en la TCAP, ya que se establecen correlaciones entre ansiedad-TCAP y ansiedad-AF. Por lo tanto, el objetivo de este estudio fue examinar la asociación entre AF y ansiedad en pacientes con TCAP. Treinta y dos pacientes fueron sometidos a cuestionarios psicológicos y de AF. Se realizaron un coeficiente de correlación de Pearson y un análisis de regresión lineal múltiple para relacionar el comportamiento del TCAP, la ansiedad y la AF. Los coeficientes de correlación entre las dimensiones del TCAP y ansiedad fueron casi todos significativos (excepto restricción), positivos y moderados (p <0.001). Por lo tanto, cuanto más altos sean los valores del TCAP, mayores serán los niveles de ansiedad (p <0.01). En conclusión, nuestros hallazgos respaldan que la PA se correlaciona con la ansiedad en pacientes con BED, lo que sugiere que la PA puede disminuir los síntomas, como las preocupaciones sobre el apetito, el peso y la forma del cuerpo. Binge-eating disorder (BED) is linked to several psychiatric disorders, such as anxiety disorders. Approximately 50-60% of BED patients are resistant to the traditional treatments available, and thus, strategies supporting the treatment of BED are needed, such as physical activity (PA). It seems to be an interesting strategy to reduce BED and anxiety symptoms. Thus, since PA has a role in reducing BED episodes and improving anxiety symptoms, then more research is needed to clarify the role of PA on BED, as correlations between anxiety-BED and anxiety-PA are established. Therefore, our aim is to examine the relationship between PA and anxiety in patients with BED. Thirty two patients we submitted to psychological and PA questionnaires. A Pearson's correlation coefficient and a multiple linear regression analysis were performed to relate eating disorder behaviour, anxiety and PA. The correlation coefficients between the dimensions of BED and anxiety were almost all significant (except restriction), positive and moderate (p<0.001). Thus, the higher the eating disorder values, the higher the anxiety levels (p<0.01). In conclusion, our findings support that PA correlates with anxiety in patients with BED, suggesting that PA may decrease symptoms, such as the appetite, weight and body shape concerns. O transtorno da compulsão alimentar periódica (TCE) está ligado a vários transtornos psiquiátricos, como os transtornos de ansiedade. Aproximadamente 50-60% dos pacientes com TCAP são resistentes aos tratamentos tradicionais disponíveis e, portanto, são necessárias estratégias de apoio ao tratamento, como a atividade física (AF). Parece ser uma estratégia interessante para reduzir os sintomas da TCAP e da ansiedade. Assim, como a AF tem um papel na redução de episódios de TCAP e melhora dos sintomas de ansiedade, são necessárias mais pesquisas para esclarecer o papel da AF na TCAP, à medida que são estabelecidas correlações entre ansiedade-TCLE e ansiedade-PA. Portanto, nosso objetivo é examinar a relação entre AF e ansiedade em pacientes com TCAP. Trinta e dois pacientes foram submetidos a questionários psicológicos e de AF. Um coeficiente de correlação de Pearson e uma análise de regressão linear múltipla foram realizadas para relacionar comportamento de transtorno alimentar, ansiedade e AF. Os coeficientes de correlação entre as dimensões do TCAP e ansiedade foram quase todos significativos (exceto restrição), positivos e moderados (p <0,001). Assim, quanto maiores os valores do transtorno alimentar, maiores os níveis de ansiedade (p <0,01). Em conclusão, nossos achados sustentam que a AF se correlaciona com a ansiedade em pacientes com TCAP, sugerindo que a AF pode diminuir os sintomas, como preocupações com apetite, peso e forma corporal.


2017 ◽  
Vol 49 (5S) ◽  
pp. 969
Author(s):  
James A. Janssen ◽  
Nathaniel T. Berry ◽  
Lilly Shanahan ◽  
Zachary A. Kincaid ◽  
Jessica M. Dollar ◽  
...  

2017 ◽  
Vol 4 (1) ◽  
pp. 189-215
Author(s):  
Yoiz Shofwa Shafrani

Perkembangan dunia perbankan syariah tidak lepas dari peran para nasabah yang memberikan kepercayaan terhadap pihak perbankan untuk penyimpanan asset keuangannya. Faktanya banyak kelompok nasabah yang memutuskan untuk menjadi nasabah di perbankan syariah karena faktor religiusitasnya. Faktor lain yang dapat ikut mempengaruhi keputusan nasabah adalah kualitas produk. Di mana kualitas produk merupakan karakteristik yang melekat dari suatu produk. Kemungkinan yang terjadi bahwa kebanyakan nasabah pada perbankan syariah juga masih merupakan nasabah perbankan konvensional.Tujuan yang ingin dicapai dalam penelitian ini adalah untuk mengetahui pengaruh kualitas produk dan tingkat religiusitas nasabah terhadap keputusan nasabah untuk menyimpan dananya atau tidak di BSM Cabang Purwokerto. Alat analisis yang digunakan adalah analisis regresi linier berganda, dengan jumlah sampel 100 nasabah. Diperoleh hasil Y = 5,046 + 0,101X1 + 0,218X2. Berdasarkan uji F yang sudah dilakukan maka dapat diketahui bahwa variabel kualitas produk dan religiusitas secara bersama – sama berpengaruh terhadap keputusan nasabah untuk menyimpan dananya di BSM Cabang Purwokerto. Berdasarkan uji t yang sudah dilakukan dapat diketahui bahwa secara partial baik variabel kualitas produk maupun variabel religiusitas berpengaruh terhadap keputusan nasabah untuk menyimpan dananya di BSM Cabang Purwokerto. The progress of the Islamic bank cannot be separated from the role of its customers who give trust to the bank to deposit their financial assets. It is a fact many groups of customers decide to be the customers of the Islamic bank because of their religiosity. The other influences factor of a customer’s decision is the quality of the product. The aim of this research was to determine the effect of product quality and level of customers’ religiosity towards customers’ decision whether to keep their funds in Syariah Mandiri Bank, Branch of Purwokerto, or not. The analytical tool used was multiple linear regression analysis, with a sample of 100 customers. The results indicate Y = 5,046 + 0,101X1 + 0,218X2. Based on F, it can be seen that both variables of product quality and religiosity simultanously affect the customers’ decision to keep theirfunds in BSM Branch of Purwokerto. Based on t test, it can be seen that independently, either variable of product quality or variables of religiosityinfluences the customers’ decision to keep their funds in BSM Branch of Purwokerto.


2019 ◽  
Vol 14 (2) ◽  
pp. 95
Author(s):  
Melia Frastuti ◽  
Dimas Pratama Putra ◽  
Erfan Effendi

Abstract     Almsgiving is one of the pillars supporting the upholding of Islam as the obligation for the adherents to improve horizontal relations between fellow humans and strengthen vertical relations with Allah SWT. The implementation of Islamic Social Responsibility (ISR) of the Islamic Bank gives a positive assessment in sharia agreement, justice and equality, responsibility for work, welfare, guarantee of nature preservation and benevolent assistance that is not profit-oriented.Proper almsgiving management and ISR implementation make Islamic banks trusted by the public in terms of service quality, satisfaction and loyalty of Muzzaki. It reduces bad images, and provides relevant impacts on social welfare and the progress of the era. The data analysis used to test the hypotheses is Multiple Linear Regression analysis. The data is collected by distributing questionnaires to Commissioners and Directors at 14 (fourteen) Islamic Commercial Banks spread throughout Indonesia. The result of this study shows partially prove the role of Islamic bank commissioners in the amsgiving management only, while the importance of the role of directors in Islamic banks in almsgiving management and the implementation of ISR partially. Keywords: Islamic Bank, Commissioners, Directors, Almsgiving and ISR


Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 161
Author(s):  
Paolo Custurone ◽  
Laura Macca ◽  
Lucrezia Bertino ◽  
Debora Di Mauro ◽  
Fabio Trimarchi ◽  
...  

The link between psoriasis and sport is a controversial issue. The topic has been poorly investigated, and nowadays there are many unsolved questions, dealing with the role of psoriasis in influencing the sporting habits of patients and, vice versa, the impact of sport activity on course, severity and extent of the disease, with particular regard to the indirect benefits on cardiovascular risk and metabolic syndrome. Moreover, the role of physical activity on patients’ quality of life and the potential limitations on physical activity due to joint involvement have not been well elucidated until now. In this narrative review we will try to provide answers to these queries.


2021 ◽  
Vol 12 (1) ◽  
pp. 49-59
Author(s):  
Asep Sumaryo ◽  
Purnama Putra

Indonesia is a country with the largest Muslim population in the world of its 240 million people,88.2% are Muslims. Islamic banks exist because of the public's need for alternative transactions thatare interest-free. However, the growth of Islamic banks in Indonesia is still not optimal, one of thefactors is that people are still not enthusiastic about Islamic banks and the lack of intention of thepeople to become customers of Islamic banks. There are several factors that affect the intention interms of planned behavior theory, namely attitudes, subjective norms and perceptions of behaviorcontrol. So the research aims to determine the effect of attitudes, subjective norms and perceptionsof behavioral control on the intention of the people of Bekasi city to become customers in Islamicbanks. The research method uses multiple linear regression analysis. The data used are the results ofquestionnaires distributed to 12 districts in the city of Bekasi. The sample consisted of 132 people inBekasi city who were taken by using purposive sampling technique. Data were tested partially andsimultaneously. The data is processed using SPSS (Statistical Product and Service Solution) version22. The results of this study show partially that attitude variables have a positive and significant effect,subjective norm variables have a positive and significant effect, behavioral control perceptions have apositive but insignificant effect on intention to become a customer. Islamic Bank. Meanwhile, attitudes,subjective norms and perceived behavioral control simultaneously have a significant positive effect onthe intention to become a customer of Islamic banks. Future research is expected to expand the scopeof research, add variables and other factors and extend the research period.


CNS Spectrums ◽  
2020 ◽  
pp. 1-9
Author(s):  
Konstantinos N. Fountoulakis ◽  
Elena Dragioti ◽  
Antonis T. Theofilidis ◽  
Tobias Wiklund ◽  
Xenofon Atmatzidis ◽  
...  

Abstract Background. The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model. Methods. Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed. Results. The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage. Conclusions. The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct “cores” of schizophrenia, the “Positive” and the “Negative,” while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.


Sign in / Sign up

Export Citation Format

Share Document