Nanostructured boron compounds for cancer therapy

2018 ◽  
Vol 90 (4) ◽  
pp. 653-663 ◽  
Author(s):  
Yinghuai Zhu ◽  
Narayan S. Hosmane
Keyword(s):  
Cancer Therapy ◽  
Chemical Properties ◽  
Slow Neutron ◽  
Nuclear Fission ◽  
Boron Compounds ◽  
Drug Detection ◽  
Boron Neutron Capture ◽  
Detection Technology ◽  
Boron Chemistry ◽  
Physical And Chemical

Abstract Nanostructured boron compounds have emerged as one of the promising frontiers in boron chemistry. These species possess unique physical and chemical properties in comparison with classical small boron compounds. The nanostructured boron composites generally have large amounts of boron contents and thus have the potential to deliver significant amount of boron to the tumor cells, that is crucial for boron neutron capture therapy (BNCT). In theory, BNCT is based on a nuclear capture reaction with the 10B isotope absorbing a slow neutron to initiate a nuclear fission reaction with the release of energetic particles, such as lithium and helium (α particles), which travel the distance of around nine microns within the cell DNA or RNA to destroy it. The recent studies have demonstrated that the nanostructured boron composites can be combined with the advanced targeted drug delivery system and drug detection technology. The successful combination of these three areas should significantly improve the BNCT in cancer treatment. This mini review summarizes the latest developments in this unique area of cancer therapy.

scholarly journals Fracture analysis and countermeasures of the grid switch castings

2020 ◽  
Vol 165 ◽  
pp. 06015
Author(s):  
Chao Feng ◽  
Siyuan Yang ◽  
Qiao Li ◽  
Mengbao Zhou ◽  
Songqi Wu ◽  
...  
Keyword(s):  
Chemical Properties ◽  
Fracture Analysis ◽  
Casting Defects ◽  
Physical And Chemical Properties ◽  
Direct Reading ◽  
X Ray ◽  
Detection Technology ◽  
Two Stages ◽  
Physical And Chemical ◽  
And Chemical Properties

Based on the detection technology of direct reading spectrum, metallographic microscope and X-ray, the defects of the grid switch castings were analyzed. The four main forms of casting fracture were summarized as poor physical and chemical properties, material misuse, casting defects and designing defects. In order to strengthen the quality control of the source of the product, it was proposed to carry out targeted network inspection in the two stages of material arrival and infrastructure acceptance.

Modelling of Paclitaxel Conjugated with Carbon Nanotubes as an Antitumor Agent for Cancer Therapy

2020 ◽  
Vol 16 (2) ◽  
pp. 224-234
Author(s):  
Hakim AL Garalleh ◽  
Ali Algarni
Keyword(s):  
Carbon Nanotubes ◽  
Cancer Therapy ◽  
Drug Loading ◽  
Chemical Properties ◽  
Antitumor Agent ◽  
Great Promise ◽  
Cancer Cell Growth ◽  
Large Sphere ◽  
Minimum Interaction ◽  
Physical And Chemical

Functionalized carbon nanoparticles (CNPs) show great promise for various drug delivery applications. These CNPs have distinct physical and chemical properties, such as low solubility, very high conductivity, and drug loading capability, and are thus important nanodevices for cancer therapy. Cancer is a highly challenging disease, because its therapy involves distinguishing diseased cells from healthy ones. This study aimed to determine the ability of CNPs conjugated with a chemotherapeutic agent to inhibit cancer cell growth. We developed two models to determine the effectiveness of paclitaxel (PTX) as an antitumor agent bonded to single-walled carbon nanotubes (SWCNTs) varying in radius (r). The models were used to mathematically evaluate the energy arising from the PTX–SWCNT interaction. The first model divided the PTX molecule into 15 subcomponents: 4 imidazole rings, 1 group of atoms forming a cylindrical nanotube, 6 methyl groups (small spheres represented as individual CH3 molecules), 3 carboxyl groups (medium-sized spheres represented as individual CO2 molecules), and 1 large sphere. In the second model, PTX was modeled as a spherical cage with a spheroidal structure. Next, we determined the minimum interaction energy between each subcomponent and an SWCNT of radius r, and then summed the interactions to determine the total energy (E). The numerical results indicated that SWCNTs can be loaded with PTX. We also determined the critical nanotube r required for acceptance of the PTX molecule. We believe that the findings of this research will encourage the development of new nanodevices capable of delivering larger amounts of drugs, genes, and proteins.

Characterizations of Diagnostic Properties and Detection Techniques of Fentanyl and Related Synthetic Opioids

2018 ◽  
Author(s):  
M. Shafiqur Rahman ◽  
Uttam K. Chakravarty
Keyword(s):  
Chemical Properties ◽  
Detection Methods ◽  
Drug Detection ◽  
Detection Techniques ◽  
Chemical Reagents ◽  
Synthetic Opioids ◽  
Detection Technology ◽  
Test Kit ◽  
Microfluidic Analysis ◽  
And Performance

Fentanyl, a synthetic opioid, is an extremely fast-acting synthetic narcotic analgesic having a high potency of approximately 100 to 200 times that of Morphine. As the synthetic opioid crisis continues to sweep across the world, detection technologies are required to be enhanced to detect, categorize, and identify synthetic opioids effectively. To detect fentanyl and its analogues, immunoassay screens are commercially available for urine specimens. Simple colorimetric assays, i.e., spot tests with paper strips, offer speed, simplicity of operation, portability, and affordability. The microfluidic behavior of the paper strips along with the properties of chemical reagents play significant role in drug detection methods. Therefore, the objectives of this study are to characterize the chemical properties of fentanyl and its analogues and to conduct microfluidic analysis for design optimization and performance evaluation of the fentanyl test strips. A computational fluid dynamics model is developed to evaluate the microfluidic properties. Analytical study and Experiments with test-kit samples are also conducted to validate the results of the numerical simulation. Finally, the performance parameters based on microfluidic analysis were reported showing the room for improvements in the detection technology of fentanyl and related synthetic opioids.

scholarly journals Cancer Therapy Based on Nanomaterials and Nanocarrier Systems

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Weili Qiao ◽  
Bochu Wang ◽  
Yazhou Wang ◽  
Lichun Yang ◽  
Yiqiong Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Tumor Tissue ◽  
Chemical Properties ◽  
Current Status ◽  
Cancer Targeting ◽  
Future Prospects ◽  
Drug Molecules ◽  
Physical And Chemical ◽  
And Chemical Properties

Targeted delivery of drug molecules to tumor tissue is one of the most interesting and challenging endeavors faced in pharmaceutical field, due to the critical and pharmacokinetically specific environment that exists in tumor. Over these years, cancer targeting treatment has been greatly improved by new tools and approaches based on nanotechnology. The review firstly introduces the specific physical and chemical properties of a serial of nanomaterials, such as nanoparticles, micelles, dendrimers, carbon nanotubes, quantum dots, and nanofibers. It then places great emphasis on their application in the field of cancer therapy when they are used as nanocarrier systems. Based on the current status, the paper further discusses the unsolved problems and makes a perspective for the future prospects of the nanocarrier systems.

scholarly journals Phototherapy Combined with Carbon Nanomaterials (1D and 2D) and Their Applications in Cancer Therapy

Materials ◽  
2020 ◽  
Vol 13 (21) ◽  
pp. 4830 ◽  
Author(s):  
Prabhavathi Sundaram ◽  
Heidi Abrahamse
Keyword(s):  
Cancer Therapy ◽  
Surface Area ◽  
Cancer Diagnosis ◽  
Carbon Nanomaterials ◽  
Chemical Properties ◽  
Therapeutic Modality ◽  
Light Sources ◽  
Carbon Based Nanomaterials ◽  
Physical And Chemical ◽  
Carbon Based

Carbon-based materials have attracted research interest worldwide due to their physical and chemical properties and wide surface area, rendering them excellent carrier molecules. They are widely used in biological applications like antimicrobial activity, cancer diagnosis, bio-imaging, targeting, drug delivery, biosensors, tissue engineering, dental care, and skin care. Carbon-based nanomaterials like carbon nanotubes and graphene have drawn more attention in the field of phototherapy due to their unique properties such as thermal conductivity, large surface area, and electrical properties. Phototherapy is a promising next-generation therapeutic modality for many modern medical conditions that include cancer diagnosis, targeting, and treatment. Phototherapy involves the major administration of photosensitizers (PSs), which absorb light sources and emit reactive oxygen species under cellular environments. Several types of nontoxic PSs are functionalized on carbon-based nanomaterials and have numerous advantages in cancer therapy. In this review, we discuss the potential role and combined effect of phototherapy and carbon nanomaterials, the mechanism and functionalization of PSs on nanomaterials, and their promising advantages in cancer therapy.

Statistical criteria of stellar population types

1966 ◽  
Vol 24 ◽  
pp. 101-110
Author(s):  
W. Iwanowska
Keyword(s):  
Stellar Population ◽  
Chemical Properties ◽  
Spectrophotometric Study ◽  
Physical And Chemical Properties ◽  
Population Type ◽  
The Galaxy ◽  
Distribution Parameters ◽  
Physical And Chemical ◽  
Statistical Criteria ◽  
And Chemical Properties

In connection with the spectrophotometric study of population-type characteristics of various kinds of stars, a statistical analysis of kinematical and distribution parameters of the same stars is performed at the Toruń Observatory. This has a twofold purpose: first, to provide a practical guide in selecting stars for observing programmes, second, to contribute to the understanding of relations existing between the physical and chemical properties of stars and their kinematics and distribution in the Galaxy.

Biophysical Measurement of Molecular Weight of Foot-and-Mouth Disease RNA Fragments

1974 ◽  
Vol 32 ◽  
pp. 262-263
Author(s):  
Sydney S. Breese ◽  
Howard L. Bachrach
Keyword(s):  
Chemical Properties ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Distilled Water ◽  
Bovine Plasma ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Carbon Coated ◽  
Rna Fragments ◽  
Physical And Chemical

Continuing studies on the physical and chemical properties of foot-and-mouth disease virus (FMDV) have included electron microscopy of RNA strands released when highly purified virus (1) was dialyzed against demlneralized distilled water. The RNA strands were dried on formvar-carbon coated electron microscope screens pretreated with 0.1% bovine plasma albumin in distilled water. At this low salt concentration the RNA strands were extended and were stained with 1% phosphotungstic acid. Random dispersions of strands were recorded on electron micrographs, enlarged to 30,000 or 40,000 X and the lengths measured with a map-measuring wheel. Figure 1 is a typical micrograph and Fig. 2 shows the distributions of strand lengths for the three major types of FMDV (A119 of 6/9/72; C3-Rezende of 1/5/73; and O1-Brugge of 8/24/73.

Tailoring microstructures of materials through biomimetics

1993 ◽  
Vol 51 ◽  
pp. 500-501
Author(s):  
Mehmet Sarikaya ◽  
Ilhan A. Aksay
Keyword(s):  
Chemical Properties ◽  
Design And Synthesis ◽  
Structure Sensitive ◽  
Macro Scale ◽  
Methods Of Synthesis ◽  
Successive Level ◽  
Engineering Materials ◽  
Physical And Chemical ◽  
And Chemical Properties ◽  
Synthesis Of Materials

Biomimetics involves investigation of structure, function, and methods of synthesis of biological composite materials. The goal is to apply this information to the design and synthesis of materials for engineering applications.Properties of engineering materials are structure sensitive through the whole spectrum of dimensions from nanometer to macro scale. The goal in designing and processing of technological materials, therefore, is to control microstructural evolution at each of these dimensions so as to achieve predictable physical and chemical properties. Control at each successive level of dimension, however, is a major challenge as is the retention of integrity between successive levels. Engineering materials are rarely fabricated to achieve more than a few of the desired properties and the synthesis techniques usually involve high temperature or low pressure conditions that are energy inefficient and environmentally damaging.In contrast to human-made materials, organisms synthesize composites whose intricate structures are more controlled at each scale and hierarchical order.

Response of corn (Zea mays L.) to various organic-based fertilizers in marginal upland of Sta. Rita, Samar

2017 ◽  
pp. 31-43
Author(s):  
Berta Ratilla ◽  
Loreme Cagande ◽  
Othello Capuno
Keyword(s):  
Block Design ◽  
Management Strategies ◽  
Chemical Properties ◽  
Organic Fertilizers ◽  
Growth And Yield ◽  
Physical And Chemical Properties ◽  
Total N ◽  
Randomized Complete Block Design ◽  
Physical And Chemical ◽  
And Chemical Properties

Organic farming is one of the management strategies that improve productivity of marginal uplands. The study aimed to: (1) evaluate effects of various organic-based fertilizers on the growth and yield of corn; (2) determine the appropriate combination for optimum yield; and (3) assess changes on the soil physical and chemical properties. Experiment was laid out in Randomized Complete Block Design, with 3 replications and 7 treatments, namely; T0=(0-0-0); T1=1t ha-1 Evans + 45-30-30kg N, P2O5, K2O ha-1; T2=t ha-1 Wellgrow + 45-30-30kg N, P2O5, K2O ha-1; T3=15t ha-1 chicken dung; T4=10t ha-1 chicken dung + 45-30-30kg N, P2O5, K2O ha-1; T5=15t ha-1 Vermicast; and T6=10t ha-1 Vermicast + 45-30-30kg N, P2O5, K2O ha-1. Application of organic-based fertilizers with or without inorganic fertilizers promoted growth of corn than the control. But due to high infestation of corn silk beetle(Monolepta bifasciata Horns), its grain yield was greatly affected. In the second cropping, except for Evans, any of these fertilizers applied alone or combined with 45-30-30kg N, P2O5, K2O ha-1 appeared appropriate in increasing corn earyield. Soil physical and chemical properties changed with addition of organic fertilizers. While bulk density decreased irrespective of treatments, pH, total N, available P and exchangeable K generally increased more with chicken dung application.

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