L’élaboration d’un dictionnaire bilingue des valeurs mobilières

As of today, one cannot find, in Canada, a dictionary totally dedicated to securities. The concept of securities refers to a large sphere that includes preferred shares and partnerships, as well as fraud and broker dealers. This paper will analyze the making of a bilingual dictionary of securities through four different steps: 1-the literature on the subject; 2-the nomenclature; 3-the microstructure; 4-the bilingual lexicon and the medium. At each of these steps, the following objectives will be followed: first, to compile the Canadian terminology which applies to securities; second, to offer to researchers, translators and professionals a lexicographical tool that is complete and useful; and third, to take into account, if need be, the legal aspects of the terms defined.

Phases of five-dimensional supersymmetric gauge theories

Five-dimensional $$ \mathcal{N} $$ N = 1 theories with gauge group U(N), SU(N), USp(2N) and SO(N) are studied at large rank through localization on a large sphere. The phase diagram of theories with fundamental hypermultiplets is universal and characterized by third order phase transitions, with the exception of U(N), that shows both second and third order transitions. The phase diagram of theories with adjoint or (anti-)symmetric hypermultiplets is also determined and found to be universal. Moreover, Wilson loops in fundamental and antisymmetric representations of any rank are analyzed in this limit. Quiver theories are discussed as well. All the results substantiate the ℱ-theorem.

Cancer Stem-Like Phenotype of Mitochondria Dysfunctional Hep3B Hepatocellular Carcinoma Cell Line

Mitochondria are major organelles that play various roles in cells, and mitochondrial dysfunction is the main cause of numerous diseases. Mitochondrial dysfunction also occurs in many cancer cells, and these changes are known to affect malignancy. The mitochondria of normal embryonic stem cells (ESCs) exist in an undifferentiated state and do not function properly. We hypothesized that mitochondrial dysfunction in cancer cells caused by the depletion of mitochondrial DNA might be similar to the mitochondrial state of ESCs. We generated mitochondria dysfunctional (ρ0) cells from the Hep3B hepatocellular carcinoma cell line and tested whether these ρ0 cells show cancer stem-like properties, such as self-renewal, chemotherapy resistance, and angiogenesis. Compared with Hep3B cells, the characteristics of each cancer stem-like cell were increased in Hep3B/ρ0 cells. The Hep3B/ρ0 cells formed a continuous and large sphere from a single cell. Additionally, the Hep3B/ρ0 cells showed resistance to the anticancer drug doxorubicin because of the increased expression of ATP-binding cassette Subfamily B Member 1. The Hep3B/ρ0 conditioned medium induced more and thicker blood vessels and increased the mobility and invasiveness of the blood vessel cells. Therefore, our data suggest that mitochondrial dysfunction can transform cancer cells into cancer stem-like cells.

Simulation of flow past a sphere on a rough bed using smoothed particle hydrodynamics (SPH)

This paper presents an investigation of flow past a sphere on a rough surface by means of simulation using the meshless numerical method, smoothed particle hydrodynamics (SPH) in the presence of a free surface. A representative of natural and engineered objects is spherical wall-mounted bodies. These are ideal to study the flow conditions around hydraulic structures, boulders, fish habitat structures or even architectural structures. The aim is to understand their effect on the hydrodynamics around the larger object sphere resting on them and their interaction. The Lagrangian particle-based scheme SPH using the open-source code DualSPHysics is validated against datasets from a laboratory-based flume experiment. The validation case was selected from the family of the flow past a sphere test cases since it reproduces the flow features in a simplified manner that can be observed in the vicinity of natural sediment grains or larger bodies. The validation results include flow velocity profiles in the vicinity of the large sphere and comparison with experiment data. The results stand in overall agreement with the experimental velocity and force measurements that demonstrates the applicability of SPH in aquatic environments. An SPH investigation on a rough bed in combination with objects/body near the bed in the presence of a free-surface flow has not been shown before in the literature. This is a novel application with insight into the fluid mechanics made possible by using DualSPHysics solver.

The Casimir Interaction between Spheres Immersed in Electrolytes

We investigate the Casimir interaction between two dielectric spheres immersed in an electrolyte solution. Since ionized solutions typically correspond to a plasma frequency much smaller than kBT/ℏ at room temperature, only the contribution of the zeroth Matsubara frequency is affected by ionic screening. We follow the electrostatic fluctuational approach and derive the zero-frequency contribution from the linear Poisson-Boltzmann (Debye-Hückel) equation for the geometry of two spherical surfaces of arbitrary radii. We show that a contribution from monopole fluctuations, which is reminiscent of the Kirkwood-Shumaker interaction, arises from the exclusion of ionic charge in the volume occupied by the spheres. Alongside the contribution from dipole fluctuations, such monopolar term provides the leading-order Casimir energy for very small spheres. Finally, we also investigate the large sphere limit and the conditions for validity of the proximity force (Derjaguin) approximation. Altogether, our results represent the first step towards a full scattering approach to the screening of the Casimir interaction between spheres that takes into account the nonlocal response of the electrolyte solution.

A continuum membrane model predicts curvature sensing by helix insertion

Protein domains, such as ENTH (Epsin N-terminal homology) and BAR (bin/amphiphysin/rvs), contain amphipathic helices that drive preferential binding to curved membranes. However, predicting how the physical parameters of these domains control this ‘curvature sensing’ behavior is challenging due to the local membrane deformations generated by the nanoscopic helix on the surface of a large sphere. To overcome this challenge, we here use a deformable continuum model that accounts for the physical properties of the membrane and the helix insertion to predict curvature sensing behavior and is in good agreement with existing experimental data. Specifically, we show that the insertion can be modeled as a local change to the membrane’s spontaneous curvature,. Using physically reasonable ranges of the membrane bending modulus к, and a of ∼0.2-0.3 nm-1, this approach provides excellent agreement with the energetics extracted from experiment. For small vesicles with high curvature, the insertion lowers the membrane energy by relieving strain on a membrane that is far from its preferred curvature of zero. For larger vesicles with low curvature, however, the insertion has the inverse effect, de-stabilizing the membrane by introducing more strain. The membrane energy cannot be directly predicted analytically, due to shape changes from surface relaxation around the anisotropic insertion. We formulate here an empirical expression that captures numerically calculated membrane energies as a function of both basic membrane properties (bending modulus к and radius R) as well as stresses applied by the inserted helix ( and area Ains). We show that the shape relaxation energy has a similar magnitude to the insertion energy, with a strong nonlinear dependence on . We therefore predict how these physical parameters will alter the energetics of helix binding to curved vesicles, which is an essential step in understanding their localization dynamics during membrane remodeling processes.

Deep-sea shipwrecks represent island-like ecosystems for marine microbiomes

Biogeography of macro- and micro-organisms in the deep sea is, in part, shaped by naturally occurring heterogeneous habitat features of geological and biological origin such as seeps, vents, seamounts, whale and wood-falls. Artificial features including shipwrecks and energy infrastructure shape the biogeographic patterns of macro-organisms; how they influence microorganisms is unclear. Shipwrecks may function as islands of biodiversity for microbiomes, creating a patchwork of habitats with influence radiating out into the seabed. Here we show microbiome richness and diversity increase as a function of proximity to the historic deep-sea shipwreck Anona in the Gulf of Mexico. Diversity and richness extinction plots provide evidence of an island effect on microbiomes. A halo of core taxa on the seabed was observed up to 200 m away from the wreck indicative of the transition zone from shipwreck habitat to the surrounding environment. Transition zones around natural habitat features are often small in area compared to what was observed at Anona indicating shipwrecks may exert a large sphere of influence on seabed microbiomes. Historic shipwrecks are abundant, isolated habitats with global distribution, providing a means to explore contemporary processes shaping biogeography on the seafloor. This work is a case study for how built environments impact microbial biodiversity and provides new information on how arrival of material to the seafloor shapes benthic microbiomes.

EXPRESS: Short-term upper limb immobilization impairs grasp representation

The present experiment aimed to gain more information on the effect of limb nonuse on the cognitive level of actions and, more specifically, on the content of the motor program used for grasping an object. For that purpose, we used a hand-grasping laterality task that is known to contain concrete information on manipulation activity. Two groups participated in the experiment: an immobilized group, including participants whose right hand and arm were fixed with a rigid splint and an immobilization vest for 24 hours, and a control group, including participants who did not undergo the immobilization procedure. The main results confirmed a slowdown of sensorimotor processes, which is highlighted in the literature, with slower response times when the participants identified the laterality of hand images that corresponded to the immobilized hand. Importantly, the grip-precision effect, highlighted by slower response times for hands grasping a small sphere versus a large sphere, is impaired by 24 hours of limb nonuse. Overall, this study provided additional evidence of the disengagement of sensorimotor processes due to a short period of limb immobilization.

ETHICAL ASPECT OF SPEECH CULTURE

The basis of word culture is the language norm. Speech culture is " the degree of reproduction, maturation of language techniques. In addition, he has not only kindness, literacy, but also the skills of accurate and correct application of language techniques, phonetic, spelling, orthoepic, morphological, syntactic, stylistic phenomena,-said M. Balakaev. Therefore, the scientist insists that it is necessary to correctly use words (lexical), correctly compose. Improving the speech culture of the Kazakh language is one of the requirements of national interest. A large sphere of culture of the Kazakh language is the culture of speech, the main regularity of its rise to a higher level is the norm of correct pronunciation. The role of writing and speech culture in the formation of the Kazakh literary language and its relationship to the problems of systematization of spelling rules is studied comprehensively in Kazakh linguistics. Language culture is developed on the basis of recognition of speech culture as national interests, formation of social attitude to speech culture, evaluation of speech culture as the main support of social Sciences and national culture, promotion of speech culture along with the culture of the nation.

Nonperturbative and Thermal Dynamics of Confined Fields in Dual QCD

In order to study the detailed dynamics and associated nonperturbative features of QCD, a dual version of the color gauge theory based on a topologically viable homogeneous fibre bundle approach has been analysed taking into account its magnetic symmetry structure. In the dynamically broken phase of magnetic symmetry, the associated flux tube structure on a S2 sphere in the magnetically condensed state of the dual QCD vacuum has been analyzed for the profiles of the color electric field using flux quantization and stability conditions. The color electric field has its intimate association with the vector mode of the magnetically condensed QCD vacuum, and such field configurations have been analyzed to show that the color electric flux gets localized towards the poles for a large sphere case while it gets uniformly distributed for the small sphere case in the infrared sector of QCD. The critical flux tube densities have been computed for various couplings and are shown to be in agreement with that for lead-ion central collisions in the near infrared sector of QCD. The possible annihilation/unification of flux tubes under some typical flux tube density and temperature conditions in the magnetic symmetry broken phase of QCD has also been analyzed and shown to play an important role in the process of QGP formation. The thermal variation of the profiles of the color electic field is further investigated which indicates the survival of flux tubes even in the thermal domain that leads the possibility of the formation of some exotic states like QGP in the intermediate regime during the quark-hadron phase transition.