scholarly journals The Effect of Omega-3 Supplement on Serum Lipid Profile in Patients Undergoing Hemodialysis: A Randomized Clinical Trial

2016 ◽  
Vol 54 (4) ◽  
pp. 222-227 ◽  
Author(s):  
Mosadegh Jabbari ◽  
Termeh Khoshnevis ◽  
Aria Jenabi ◽  
Fatemeh Yousefi
Keyword(s):  
Clinical Trial ◽  
Serum Creatinine ◽  
Lipid Profile ◽  
Randomized Clinical Trial ◽  
Linear Regression Analysis ◽  
Serum Triglyceride ◽  
Control Group ◽  
Case Group ◽  
Omega 3 ◽  
Beneficial Effects

Abstract Background. Some recent suggestions could show omega-3 condition deficiency following prolonged hemodialysis; however, these claims and speculations have not been well demonstrated with sufficient evidences. Hence, we attempted to assess the beneficial effects of omega-3 on lipid profile in patients with end-stage renal disease (ESRD) undergoing hemodialysis. Methods. One hundred and seventeen ESRD patients who were on maintenance dialysis in Rasoul-e-Akram and Madaen Hospitals were enrolled in this randomized clinical trial. These patients were divided into two groups randomly using block randomization method (57 patients as the case group receiving omega-3 for 12 weeks and 60 as the control group). Blood sample was taken from all patients for measurement of lipid profile, serum hemoglobin, and C-reactive protein at baseline as well as after the completion of interventions (after 12 weeks). Results. The average change in the value of HDL-C was significantly more in the patients who received omega-3 than in the control group (MD, -7 mg/dL; 95% CI, -11 to 0 p = 0.000). Also, the reduction in serum creatinine level was more in the omega-3 group than in the control group (MD, 0.7 mg/dL; 95% CI, -0.4 to 2.1 p = 0.023). The change in other indices including serum triglyceride, total cholesterol, and serum hemoglobin levels was not different between the two groups. The multivariable linear regression analysis showed no difference in serum HDL level between the two groups adjusted for sex, age, and time of dialysis, while the level of serum HDL-C could be adversely predicted by duration time. Similar regression model showed a between-group difference in serum creatinine in the presence of potential confounders. Conclusion. The change in serum HDL level following use of omega-3 supplement is influenced by time of dialysis, not by drug effect. However, consumption of omega-3 can significantly reduce serum creatinine.

scholarly journals The effect of topical endometrial scratching on pregnancy outcome in women with previous failure of intrauterine insemination: A non-randomized clinical trial

2021 ◽  
Author(s):  
Farahnaz Farzaneh ◽  
Farzaneh Khastehfekr
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Intrauterine Insemination ◽  
Control Group ◽  
Case Group ◽  
Male Factor ◽  
Chi Square ◽  
Endometrial Scratching ◽  
Chi Square Test ◽  
Endometrial Scratch

Background: The prevalence of infertility is increasing worldwide and the treatment is one of the important issues. Objective: This study aimed to evaluate the effect of local endometrial scratching on pregnancy outcomes in women with previous failure of intrauterine insemination. Materials and Methods: This non-randomized clinical trial study was performed on 336 women referred to the infertility clinic of Ali ebn-e Abitaleb Hospital of Zahedan (between May and November 2019). Women were divided into two groups: endometrial scratch as case and a control group. In the case group (n = 173), endometrial scratching was performed on days 8–9 of the menstrual cycle in addition to routine infertility treatments, while in the control group (n = 163), only routine treatment was performed. Chi-square test was used to compare the frequency of male factor severity and the percentage of successful pregnancies between both groups and was used to investigate the effect of male factor on the fertility rate in each group (moderate male factor and mild male factor). Results: The mean age of the women was 28.4 ± 5.2 yr. The success rate of pregnancy in the case group was 12.3% and in the control group 11%, which were not statistically significant (p = 0.697). Conclusion: Overall, the results of this study showed that endometrial scratching had no effect on the pregnancy rate. Key words: Infertility, Endometrial, Scratch, Insemination.

scholarly journals Effect of Long Term Use of Carbamazepine on Lipid Profile in Adult Epileptic Patients

2014 ◽  
Vol 30 (1) ◽  
pp. 27-34
Author(s):  
Md Khairul Kabir Patwary ◽  
Shakila Sultana ◽  
- Md Salahuddin ◽  
Abu Jafor Md Salahuddin ◽  
Mohammed Sayeed Hassan ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Focal Epilepsy ◽  
Serum Triglyceride ◽  
Control Group ◽  
Case Group ◽  
Healthy Population ◽  
Female Patients ◽  
Epileptic Patients ◽  
The Mean

Objective: To evaluate the effect of long term use of carbamazepine on lipid profile in adult epileptic patients Methodology: The study was conducted in the Department of Neurology at BSMMU, Dhaka over a period of 2 years from January 2010 to December 2011. Adult epileptic patients taking carbamazepine as anticonvulsant and attending the Epilepsy Clinic and Neurology OPD of BSMMU, Dhaka were the study population. A total of 107 cases and 107 controls were included in the study. Data were collected by interview of the patients, clinical examination and laboratory investigations using the research instrument Result: The mean age of case and control groups were almost identical (23.3 ± 6.8 vs. 23.8 ± 6.4 years, p = 0.972). The proportion of male and female patients was similar in both the study groups. Of the 107 cases, more than 70% had generalized epilepsy and the rest (29%) focal epilepsy. Of the 107 cases, 8% had family history of epilepsy. The prevalence of raised triglycerides and raised LDL were observed to be significantly higher in the case group than those in the control group (35.5% vs. 23.4%, p = 0.049 and 15% vs. 0.9%, p < 0.001 respectively). The prevalence of low HDL was also significantly higher in the former group than that in the latter group (43.9% vs. 18.7%, p < 0.001). The mean serum triglyceride and LDL were higher and mean HDL was lower in the case group than those in the control group. Over half (51.4%) of the case group exhibited dyslipidemia compared to the control group (27.1%). The risk of developing dyslipidemia in epileptic patients receiving carbamazepine for longer duration was nearly three-fold (95% of CI = 1.6 – 5.0) higher than that in the control group (p < 0.001). There is positive correlation between duration of carbamazepine treatment and lipid profile. Serum total cholesterol and triglycerides bear linear relationship with duration of treatment with carbamazepine (r = 0.201, p = 0.038 and r = 0.223, p = 0.021 respectively). The association of dyslipidemia with sex in epileptic patients receiving carbamazepine for more than 2 years. The proportion of dyslipdemia was considerably higher in the female patients than their male counterparts, although the difference was not statistically significant (55.3% vs. 41.9%, p < 0.211). Conclusion: A conclusion can be made from the above mentioned result that long-term use of carbamazepine in epileptic patients may cause dyslipidemia and the risk of having dyslipidemia in such patients is 3 times greater than the normal healthy population. Bangladesh Journal of Neuroscience 2014; Vol. 30 (1): 27-34

Oral Metronidazole and Cefixime as Prophylaxis on Wound Complications of Uncomplicated Appendicitis Following Appendectomy: A Randomized Clinical Trial

2021 ◽  
Author(s):  
Khosro Ayazi ◽  
Arash Mohammadi Tofigh ◽  
Shohra Qaderi ◽  
Farzad Esmaeili Tarki ◽  
Majid Samsami ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Single Dose ◽  
Randomized Clinical Trial ◽  
Open Appendectomy ◽  
Perforated Appendicitis ◽  
Prophylactic Antibiotics ◽  
Wound Complications ◽  
Control Group ◽  
Case Group ◽  
And Control

Abstract Backgrounds Without proper use of prophylactic antibiotics, the chance of infection at the site of surgery after appendectomy is around 10 to 30%. Although, in the case of nonperforated appendicitis, the therapeutic use of antibiotic prophylaxis is still contentious. Cephalosporins and Metronidazole has been shown to be effective against anaerobe micro-organisms, and its bioavailability after oral and parenteral administration is comparable. The aim of this research is to compare the incidence of infection-related complications following open appendectomy for nonperforated appendicitis in patients who were given prophylactic antibiotics (Metronidazole and Cephalosporins) either intravenously or orally. Materials & Methods In this randomized clinical trial, the open appendectomy was performed on 200 non-perforated appendicitis cases; 87 females and 113 males, with a mean age of 26 years. Of all the enrolled, 100 cases were given single-dose metronidazole and Cefixime orally (study group), and 100 cases were given single-dose intravenous metronidazole and Ceftriaxone (control group). Results The wound infection incidence did not vary substantially between the two groups. (5% and 7% in the control and case group, respectively, P = 0.552). In addition, the length of hospitalization was also similar between both groups (2.4 and 2.6 days in the in the case and control group, respectively, P = 168). Conclusion All in all, it has been concluded that a single-dose metronidazole and Cefixime taken orally before surgery could bestow impactful prophylactic effects for nonperforated appendicitis cases. Therefore, it could be used instead of the parenteral antibiotics (Intravenous Metronidazole and Ceftriaxone).

scholarly journals Using Dry Human Amniotic Membrane in Secondary Intention Wound Healing After Urological Cancer Surgery: The First Randomized Clinical Trial in Iran

2021 ◽  
Vol 14 (5) ◽  
Author(s):  
Ramin Hamidi ◽  
Ebrahim Hazrati ◽  
Davood Abbasi Azar ◽  
Farzad Allameh ◽  
Babak Javanmard ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Randomized Clinical Trial ◽  
Amniotic Membrane ◽  
Cancer Surgery ◽  
Control Group ◽  
Case Group ◽  
Human Amniotic Membrane ◽  
Urological Cancer ◽  
Secondary Intention

Background: Wound healing is a complex process and in some patients, it is a long process. Due to the presence of various underlying diseases in patients with cancer, this process is delayed, and as a result, the rate of complications increases. Therefore, some materials are needed to accelerate wound healing. Nowadays efficacy of dry human amniotic membrane in burn wounds and chronic wounds is proven; however, no studies have been performed on the effect of this tissue in the treatment of surgical wounds. Objectives: This study aimed at evaluating the efficacy of dry human amniotic membrane in the secondary repair of urological cancer surgery wounds. Methods: In this randomized clinical trial from January 2018 to June 2020, 40 patients who underwent urological cancer surgery and secondary intention wound healing were selected and randomly divided into 2 groups of 20 patients. In the case group, the dry human amniotic membrane was used for dressing wounds, and in the control group, normal dressing without an amniotic membrane was performed. Complications such as infection, sepsis, and reoperation, as well as the duration of wound healing and hospitalization of patients at intervals of 1 week, 1, and 3 months, were compared between the 2 groups. Results: The 2 groups matched in terms of gender, age, and wound location. The mean duration of hospitalization and wound healing was significantly lower in the case group (P < 0.05). The rate of complications was higher in the control group but was not significant. Conclusions: Dry human amniotic membranes due to the accelerated wound healing process and fewer complications could be a good choice for secondary healing of wounds after urological cancer surgery.

scholarly journals The effect of Myo-inositol on sperm parameters and pregnancy rate in oligoasthenospermic men treated with IUI: A randomized clinical trial

2019 ◽  
Author(s):  
Afsane Ghasemi ◽  
Fatemehsadat Amjadi ◽  
Seyedeh Masoumeh Ghazi Mirsaeed ◽  
Robabeh Mohammad Beigi ◽  
Samaneh Ghasemi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Sperm Motility ◽  
Potential Role ◽  
Intrauterine Insemination ◽  
Sperm Parameters ◽  
Control Group ◽  
Case Group ◽  
Significant Difference ◽  
Motility Of Sperm

Background: In about 40% of the couples, the cause of infertility problems is attributed to men because of low sperm production and disturbed motility of sperm. Pieces of evidence show that Myo-inositol has a potential role for the treatment of sperm morphology and male fertility. Objectives: This study aimed to determine the effect of Myo-inositol on the sperm parameters and fertility rate in patients with oligoasthenospermia treated by intrauterine insemination (IUI). Materials and Methods: This study was a randomized clinical trial conducted on 37 patients with oligoasthenospermia treated by IUI during 2016-2017. In this study, the patients were randomly divided into two groups of oligoasthenospermia treated with (Case group) and without Myo-inositol (Control group). The case group received 0.5 ml of Myo-inositol with a concentration of 2 mg/ml and incubated at 37°C incubator for 2 hr, but the control group had no interventions. Results: The results of this study showed that although there was no significant difference in sperm parameters including sperm motility and concentration before processing with Myo-inositol in the case group, but there was a significant increase in sperm motility during the treatment with Myo-inositol. The therapeutic effect of this method was confirmed on induction of pregnancy in 18% of the treated patients, in such a way that was about twice greater than those who did not receive the drug. Conclusion: According to the results of this study, the use of Myo-inositol is efficient enough to change sperm parameters to increase the chance of fertility. Key words: Myo-inositol, Pregnancy, Sperm, Motility, Oligoasthenospermic.

Calcitriol Effect on Outcomes of in Vitro Fertilization in Infertile Women with Vitamin D Deficiency: A Double-Blind Randomized Clinical Trial

2020 ◽  
Author(s):  
Leila Doryanizadeh ◽  
Bahar Morshed-Behbahani ◽  
Mohammad Ebrahim Parsanezhad ◽  
Mohammad Hossein Dabbaghmanesh ◽  
Azam Jokar
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Randomized Clinical Trial ◽  
Active Form ◽  
Clinical Pregnancy ◽  
Control Group ◽  
Case Group ◽  
Infertile Women ◽  
Experimental Group

Abstract Introduction Recent studies have addressed the role of micronutrients in fertilization, such as vitamin D. The present study aims to explore the effects of using calcitriol, an active form of vitamin D, on IVF results in women with vitamin D deficiency. Method This double-blinded randomized clinical trial was done on 180 infertile women, undergone IVF treatment. Out of them, 95 were found to have vitamin D deficiency (blood serum 25-dihydroxy vitamin D <30 ng/ml). Fifty one women in experimental group were treated with two 0.25 µg calcitriol pills daily during 4 weeks (discontinued 8 hours prior to the embryo transfer) and 44 subjects to the placebo group (mean vitamin D deficiency 27.5 ±1.8 in case group vs. 27.6±1.8 in control group, P>0.05). Final analysis includes outcomes of chemical and clinical pregnancy was done on 74 women (including 36 in case and 38 in control group). Results Our study showed that in the experimental group, chemical pregnancy success was significantly higher than that in the control group, 31.4 vs. 18.2% (P<0.05). However, there were no significant differences between the 2 groups in reaching the clinical pregnancy stage (25.5% in case group vs. 13.6% in control group) and continuation of pregnancy into week 20 (9.8% in case group vs. 11.6% in control group) (P>0.05). Conclusion Calcitriol administration by improving the implantation process can significantly increase the chances of successful IVF cycle results in infertile women with vitamin D deficiency.

scholarly journals Impact of Intermittent Fasting on Lipid Profile–A Quasi-Randomized Clinical Trial

2021 ◽  
Vol 7 ◽  
Author(s):  
Naseer Ahmed ◽  
Javeria Farooq ◽  
Hasan Salman Siddiqi ◽  
Sultan Ayoub Meo ◽  
Bibi Kulsoom ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Body Weight ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Randomized Clinical Trial ◽  
Significant Interaction ◽  
Intervention Group ◽  
Interaction Effects ◽  
Control Group ◽  
Intermittent Fasting

Background: Sub-optimal HDL is a prognostic marker of cardiovascular disease. South Asia has a high prevalence of sub-optimal HDL compared to other parts of the world. Intermittent fasting (IF) is a type of energy restriction which may improve serum HDL and other lipids thereby reducing the risk of cardiovascular diseases.Objective: The aim of the study was to evaluate the effect of IF on lipid profile and HDL-cholesterol in a sample of South Asian adults.Methods: A 6-week quasi-experimental (non-randomized) clinical trial was conducted on participants with low HDL (&lt; 40 mg/dl for men and &lt; 50 mg/dl for women). Participants of the control group were recommended not to change their diet. The intervention group was recommended to fast for ~12 h during day time, three times per week for 6 weeks. Pulse rate, blood pressure, body weight, waist circumference, serum lipid profile, and blood glucose levels were measured at baseline and after 6 weeks.Result: A total of 40 participants were enrolled in the study (N = 20 in each group), while 35 (20 control and 15 intervention) completed the trial and were included in data analysis of the study. Body measurements, including body weight, BMI and waist circumference, showed significant interaction effects (p's &lt; 0.001), indicating that there were larger reductions in the IF group than in the control group. Significant interaction effects were also observed for total (p = 0.033), HDL (p = 0.0001), and LDL cholesterol (p = 0.010) with larger improvements in the IF group.Conclusion: This study suggests that intermittent fasting may protect cardiovascular health by improving the lipid profile and raising the sub-optimal HDL. Intermittent fasting may be adopted as a lifestyle intervention for the prevention, management and treatment of cardiovascular disorders.Clinical Trial Registration: NCT03805776, registered on January 16, 2019, https://clinicaltrials.gov/ct2/show/NCT03805776

scholarly journals Correlation between Thyrotropin and Fasting Lipid Profile in Patients of Sub Clinical Hypothyroidism

2017 ◽  
Vol 23 (2) ◽  
Author(s):  
Syed Mohammad Zubair ◽  
Farhat Ijaz ◽  
Rana Khurram Aftab
Keyword(s):  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Tertiary Care ◽  
Serum Triglyceride ◽  
The Body ◽  
Whole Body ◽  
Control Group ◽  
Blood Collection ◽  
Case Group ◽  
Cross Sectional

AbstractA controversy exists regarding the association between subclinical hypothyroidism (SCH) and dyslipidemia. Moreover, studies on lipid ratios in SCH are rare, particularly in Asian Countries. The study also aims to find out whether any correlation exists between serum TSH levels and fasting lipid levels, which would indirectly affect morbidity and mortality.Methods:  The study was conducted at Physiology department, KEMU and Centre for Nuclear Studies KEMU & Mayo Hospital, Lahore which is a tertiary-care center. It was a cross-sectional study carried out over a period of 6 months. Control group consisted of 50 euthyroid persons taken from a population coming for whole-body health checkup. Case group consisted of 50 patients with SCH. Confounding variables were removed. Fasting blood samples were taken in a plain gel vaccutainer tube with an aseptic blood collection technique. The samples were centrifuged within 1 h at 3000 rpm for 5 min. These wereprocessed to obtain serum for the estimation of serum lipid profile and Thyrotropin (TSH) hormone level.Results:  The study examined the link between Thyrotropin levels and fasting lipid profile in patients of SCH versus euthyroid normal controls in a cross sectional adult population over a period of six months. Patients with SCH had significantly lower HDL-C, as compared to Controls. The Lipid profiles were each categorized and mean Thyrotropin levels were higher in subjects in the dyslipidemic sub-class than subjects in normal sub-class. Thyrotropin was positively asso-ciated with serum Triglyceride and negatively associated with HDL-C in cases of SCH. Thyrotropin is also positively associated with Total Cholesterol (TC) along with VLDL-C and LDL-C. In the Euthyroid (Control Group) population, Thyrotropin was positively associated with TC.Conclusion:  To conclude, Serum Thyrotropin was correlated with dyslipidemia in SCH and euthyroid subjects. In simple words, when Thyrotropin (TSH) increases upto 10 mIU/L the signs and symptoms of Hypothyroidism are not manifested, but chemical changes start to take place in the body, and the lipid metabolism is starting to take its toll. In SCH patients, TC, Triglyceride, LDL-C, HDL-C, start to rise as compared to normal euthyroid control groups. Thus there is a positive correlation between lipids and Thyrotropin, less HDL, which exhibited negative correlation in SCH subjects.AbstractA controversy exists regarding the association between subclinical hypothyroidism (SCH) and dyslipidemia. Moreover, studies on lipid ratios in SCH are rare, particularly in Asian Countries. The study also aims to find out whether any correlation exists between serum TSH levels and fasting lipid levels, which would indirectly affect morbidity and mortality.Methods:  The study was conducted at Physiology department, KEMU and Centre for Nuclear Studies KEMU & Mayo Hospital, Lahore which is a tertiary-care center. It was a cross-sectional study carried out over a period of 6 months. Control group consisted of 50 euthyroid persons taken from a population coming for whole-body health checkup. Case group consisted of 50 patients with SCH. Confounding variables were removed. Fasting blood samples were taken in a plain gel vaccutainer tube with an aseptic blood collection technique. The samples were centrifuged within 1 h at 3000 rpm for 5 min. These wereprocessed to obtain serum for the estimation of serum lipid profile and Thyrotropin (TSH) hormone level.Results:  The study examined the link between Thyrotropin levels and fasting lipid profile in patients of SCH versus euthyroid normal controls in a cross sectional adult population over a period of six months. Patients with SCH had significantly lower HDL-C, as compared to Controls. The Lipid profiles were each categorized and mean Thyrotropin levels were higher in subjects in the dyslipidemic sub-class than subjects in normal sub-class. Thyrotropin was positively asso-ciated with serum Triglyceride and negatively associated with HDL-C in cases of SCH. Thyrotropin is also positively associated with Total Cholesterol (TC) along with VLDL-C and LDL-C. In the Euthyroid (Control Group) population, Thyrotropin was positively associated with TC.Conclusion:  To conclude, Serum Thyrotropin was correlated with dyslipidemia in SCH and euthyroid subjects. In simple words, when Thyrotropin (TSH) increases upto 10 mIU/L the signs and symptoms of Hypothyroidism are not manifested, but chemical changes start to take place in the body, and the lipid metabolism is starting to take its toll. In SCH patients, TC, Triglyceride, LDL-C, HDL-C, start to rise as compared to normal euthyroid control groups. Thus there is a positive correlation between lipids and Thyrotropin, less HDL, which exhibited negative correlation in SCH subjects.Keywords:  Dyslipidemia, lipid profile, subclinical hypothyroidism.

Sign in / Sign up

Export Citation Format

Share Document