scholarly journals Correlation between Thyrotropin and Fasting Lipid Profile in Patients of Sub Clinical Hypothyroidism

2017 ◽  
Vol 23 (2) ◽  
Author(s):  
Syed Mohammad Zubair ◽  
Farhat Ijaz ◽  
Rana Khurram Aftab
Keyword(s):  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Tertiary Care ◽  
Serum Triglyceride ◽  
The Body ◽  
Whole Body ◽  
Control Group ◽  
Blood Collection ◽  
Case Group ◽  
Cross Sectional

AbstractA controversy exists regarding the association between subclinical hypothyroidism (SCH) and dyslipidemia. Moreover, studies on lipid ratios in SCH are rare, particularly in Asian Countries. The study also aims to find out whether any correlation exists between serum TSH levels and fasting lipid levels, which would indirectly affect morbidity and mortality.Methods:  The study was conducted at Physiology department, KEMU and Centre for Nuclear Studies KEMU & Mayo Hospital, Lahore which is a tertiary-care center. It was a cross-sectional study carried out over a period of 6 months. Control group consisted of 50 euthyroid persons taken from a population coming for whole-body health checkup. Case group consisted of 50 patients with SCH. Confounding variables were removed. Fasting blood samples were taken in a plain gel vaccutainer tube with an aseptic blood collection technique. The samples were centrifuged within 1 h at 3000 rpm for 5 min. These wereprocessed to obtain serum for the estimation of serum lipid profile and Thyrotropin (TSH) hormone level.Results:  The study examined the link between Thyrotropin levels and fasting lipid profile in patients of SCH versus euthyroid normal controls in a cross sectional adult population over a period of six months. Patients with SCH had significantly lower HDL-C, as compared to Controls. The Lipid profiles were each categorized and mean Thyrotropin levels were higher in subjects in the dyslipidemic sub-class than subjects in normal sub-class. Thyrotropin was positively asso-ciated with serum Triglyceride and negatively associated with HDL-C in cases of SCH. Thyrotropin is also positively associated with Total Cholesterol (TC) along with VLDL-C and LDL-C. In the Euthyroid (Control Group) population, Thyrotropin was positively associated with TC.Conclusion:  To conclude, Serum Thyrotropin was correlated with dyslipidemia in SCH and euthyroid subjects. In simple words, when Thyrotropin (TSH) increases upto 10 mIU/L the signs and symptoms of Hypothyroidism are not manifested, but chemical changes start to take place in the body, and the lipid metabolism is starting to take its toll. In SCH patients, TC, Triglyceride, LDL-C, HDL-C, start to rise as compared to normal euthyroid control groups. Thus there is a positive correlation between lipids and Thyrotropin, less HDL, which exhibited negative correlation in SCH subjects.AbstractA controversy exists regarding the association between subclinical hypothyroidism (SCH) and dyslipidemia. Moreover, studies on lipid ratios in SCH are rare, particularly in Asian Countries. The study also aims to find out whether any correlation exists between serum TSH levels and fasting lipid levels, which would indirectly affect morbidity and mortality.Methods:  The study was conducted at Physiology department, KEMU and Centre for Nuclear Studies KEMU & Mayo Hospital, Lahore which is a tertiary-care center. It was a cross-sectional study carried out over a period of 6 months. Control group consisted of 50 euthyroid persons taken from a population coming for whole-body health checkup. Case group consisted of 50 patients with SCH. Confounding variables were removed. Fasting blood samples were taken in a plain gel vaccutainer tube with an aseptic blood collection technique. The samples were centrifuged within 1 h at 3000 rpm for 5 min. These wereprocessed to obtain serum for the estimation of serum lipid profile and Thyrotropin (TSH) hormone level.Results:  The study examined the link between Thyrotropin levels and fasting lipid profile in patients of SCH versus euthyroid normal controls in a cross sectional adult population over a period of six months. Patients with SCH had significantly lower HDL-C, as compared to Controls. The Lipid profiles were each categorized and mean Thyrotropin levels were higher in subjects in the dyslipidemic sub-class than subjects in normal sub-class. Thyrotropin was positively asso-ciated with serum Triglyceride and negatively associated with HDL-C in cases of SCH. Thyrotropin is also positively associated with Total Cholesterol (TC) along with VLDL-C and LDL-C. In the Euthyroid (Control Group) population, Thyrotropin was positively associated with TC.Conclusion:  To conclude, Serum Thyrotropin was correlated with dyslipidemia in SCH and euthyroid subjects. In simple words, when Thyrotropin (TSH) increases upto 10 mIU/L the signs and symptoms of Hypothyroidism are not manifested, but chemical changes start to take place in the body, and the lipid metabolism is starting to take its toll. In SCH patients, TC, Triglyceride, LDL-C, HDL-C, start to rise as compared to normal euthyroid control groups. Thus there is a positive correlation between lipids and Thyrotropin, less HDL, which exhibited negative correlation in SCH subjects.Keywords:  Dyslipidemia, lipid profile, subclinical hypothyroidism.

scholarly journals Status of serum anti-mullerian hormone and lipid profile in polycystic ovarian syndrome: a cross-sectional study at tertiary care centre of central India

2018 ◽  
Vol 6 (4) ◽  
pp. 1327
Author(s):  
Sangita Paneri ◽  
Shakti Suslade ◽  
Angurbala Bafna ◽  
Jayshee Shreedhar ◽  
P. Dey Sarkar ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Follicle ◽  
Tertiary Care ◽  
Control Group ◽  
Case Group ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Female Population ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is the most common cause of chronic anovulation in young women and affects 5 to 10 % of the female population. Anti-Mullerian Hormone (AMH) level indicate the quantity of the ovarian follicle pool and may be a useful marker of ovarian reserves. In order to establish the pattern of change in serum AMH level and its contribution in alteration of lipid metabolism and PCOS related complications the present study was planned.Methods: Study was carried out in M.G.M. medical college, Govt Holker College and K. R. G’s Blessed mom centre from June -2016 to December -2017. The study population consisted total 50 women subjects among them 25 women suffering from PCOS aged between 18 to 35-year taken as case group and 25 age matched healthy women taken as control group. Fasting blood sample was collected from each subject and analyzed for AMH level and Lipid profile level.Results: Results revealed that significantly increased serum AMH, cholesterol, triglycerides, LDL, VLDL levels and significantly decreased HDL levels were observed in PCOS cases when compare to control subjects.Conclusions: Study concluded elevated AMH level leads to increase risk of polycystic ovarian syndrome and PCOS associated hyperlipidemia and other complications.

scholarly journals Study of Fasting Lipid Profile in Patients with Subclinical Hypothyroidism in a Tertiary Care Hospital in Bangladesh

2021 ◽  
Vol 16 (1) ◽  
pp. 17-20
Author(s):  
Mohammad Afjal Hossain ◽  
- Atiquzzaman ◽  
Mirza Sharifuzzaman ◽  
Farzana Amin ◽  
Lutful Kabir ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Tertiary Care ◽  
Thyroid Function Test ◽  
Significant Negative Correlation ◽  
Thyroid Stimulating Hormone ◽  
Care Hospital ◽  
Cross Sectional ◽  
Metabolic Complications ◽  
Normal Thyroid Function

Subclinical hypothyroidism (SCH) is a metabolic disorder with prevalence about 4-10% in general population. This study was conducted to observe the pattern of fasting lipid profile in SCH and to correlate the components of it with thyroid stimulating hormone and free thyroxin level. This cross sectional observational study included 31 newly diagnosed cases of SCH and 17 age and BMI matched healthy control subjects with normal thyroid function test. Fasting lipid profile was recorded and compared. TSH was significantly higher in SCH compared to controls (9.09±2.79 vs 2.31±0.92 μIU/ml; p=0.001). FT4 was comparable between the groups (1.17±0.18 vs 1.28±0.20 ng/dl; p=0.938). Significantly higher level of Total cholesterol and LDL-C were observed in SCH compared to controls (TC 194.77±29.70 vs 156.59±20.45 mg/dl; p=0.042 and LDL-C 124.81±27.85 mg/dl vs 88.59±18.41mg/dl; p=0.045 respectively). Triglycerides and HDL-C were comparable between the groups (TG 134.90±80.97 vs 118.12±49.14 mg/dl; p=0.171 and HDL-C 42.87±4.83 vs 44.47±5.66; p=0.633 respectively). TSH showed significant positive correlation with TC and LDL-C (r=0.591, p<0.001 and r=0.644, p<0.001 respectively), but not with TG or HDL-C (r=0.011, p=0.943 and r=0.115, p=0.435 respectively). FT4 only showed significant negative correlation with LDL-C (r=0.302; P=0.037) but not with TC, TG or HDL-C (TC: r=0.245, P=0.093; TG: r=0.121, p=0.411 and HDL-C: r=0.108, p=0.466 respectively). SCH is associated with raised TC and LDL-C. So patients with SCH are more vulnerable to develop future adverse cardio-metabolic complications. Faridpur Med. Coll. J. 2021;16(1):17-20

scholarly journals Effect of Long Term Use of Carbamazepine on Lipid Profile in Adult Epileptic Patients

2014 ◽  
Vol 30 (1) ◽  
pp. 27-34
Author(s):  
Md Khairul Kabir Patwary ◽  
Shakila Sultana ◽  
- Md Salahuddin ◽  
Abu Jafor Md Salahuddin ◽  
Mohammed Sayeed Hassan ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Focal Epilepsy ◽  
Serum Triglyceride ◽  
Control Group ◽  
Case Group ◽  
Healthy Population ◽  
Female Patients ◽  
Epileptic Patients ◽  
The Mean

Objective: To evaluate the effect of long term use of carbamazepine on lipid profile in adult epileptic patients Methodology: The study was conducted in the Department of Neurology at BSMMU, Dhaka over a period of 2 years from January 2010 to December 2011. Adult epileptic patients taking carbamazepine as anticonvulsant and attending the Epilepsy Clinic and Neurology OPD of BSMMU, Dhaka were the study population. A total of 107 cases and 107 controls were included in the study. Data were collected by interview of the patients, clinical examination and laboratory investigations using the research instrument Result: The mean age of case and control groups were almost identical (23.3 ± 6.8 vs. 23.8 ± 6.4 years, p = 0.972). The proportion of male and female patients was similar in both the study groups. Of the 107 cases, more than 70% had generalized epilepsy and the rest (29%) focal epilepsy. Of the 107 cases, 8% had family history of epilepsy. The prevalence of raised triglycerides and raised LDL were observed to be significantly higher in the case group than those in the control group (35.5% vs. 23.4%, p = 0.049 and 15% vs. 0.9%, p < 0.001 respectively). The prevalence of low HDL was also significantly higher in the former group than that in the latter group (43.9% vs. 18.7%, p < 0.001). The mean serum triglyceride and LDL were higher and mean HDL was lower in the case group than those in the control group. Over half (51.4%) of the case group exhibited dyslipidemia compared to the control group (27.1%). The risk of developing dyslipidemia in epileptic patients receiving carbamazepine for longer duration was nearly three-fold (95% of CI = 1.6 – 5.0) higher than that in the control group (p < 0.001). There is positive correlation between duration of carbamazepine treatment and lipid profile. Serum total cholesterol and triglycerides bear linear relationship with duration of treatment with carbamazepine (r = 0.201, p = 0.038 and r = 0.223, p = 0.021 respectively). The association of dyslipidemia with sex in epileptic patients receiving carbamazepine for more than 2 years. The proportion of dyslipdemia was considerably higher in the female patients than their male counterparts, although the difference was not statistically significant (55.3% vs. 41.9%, p < 0.211). Conclusion: A conclusion can be made from the above mentioned result that long-term use of carbamazepine in epileptic patients may cause dyslipidemia and the risk of having dyslipidemia in such patients is 3 times greater than the normal healthy population. Bangladesh Journal of Neuroscience 2014; Vol. 30 (1): 27-34

scholarly journals Association of subclinical hypothyroidism and HbA1c levels in non-diabetic subjects attending rural tertiary care centre in central India

2017 ◽  
Vol 5 (8) ◽  
pp. 3345 ◽  
Author(s):  
Vidya Sagar Ram ◽  
Granth Kumar ◽  
Manoj Kumar ◽  
Vivek Kumar Verma ◽  
Dheeraj Kela ◽  
...  
Keyword(s):  
Subclinical Hypothyroidism ◽  
Tertiary Care ◽  
Elevated Serum ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Tertiary Care Centre ◽  
Hypothyroid Patients ◽  
Serum Tsh ◽  
Hba1c Levels

Background: Subclinical hypothyroidism is defined as an elevated serum TSH level and normal concentrations of free T3 (FT3), free T4 (FT4), T3 and T4. A positive association between thyroid and diabetes mellitus is well recognized but to study the effect of thyroid disorders on glucose metabolism in non-diabetic patients is an area for extensive research. Present study was planned to assess correlation between subclinical hypothyroidism and glycosylated haemoglobin levels in non-diabetic patients.Methods: A case-control study was conducted on total 209 subjects. 109 patients were allotted in case group and 100 in control group. Controls were relatives and friends of patients who were matched for age and sex. Comparison between the case and the control groups were made using Student’s t-test (unpaired) and Box and Whisker Plot and regression graph were presented for correlation between serum TSH and HbA1c.Results: It was found that there was a positive correlation between the levels of serum TSH (µU/L) and HbA1c (%) in all the participants of the study by Pearson’s correlation coefficient (r=0.35, p < 0.0001).Conclusions: HbA1c levels are increased in subclinical hypothyroid patients. The effects of the elevated levels of Serum TSH on the HbA1c must be considered when interpreting the HbA1c for the diagnosis of diabetes or pre-diabetes in the subclinical hypothyroid patients.

scholarly journals Correlation between levels of serum ferritin and lipid profile status.

2020 ◽  
Vol 27 (12) ◽  
Author(s):  
Safia Rahman ◽  
Muhammad Ihtesham Khan ◽  
Samiyah Rahman ◽  
Saman Waqar
Keyword(s):  
Lipid Profile ◽  
Serum Ferritin ◽  
Serum Cholesterol ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Tertiary Care ◽  
Serum Triglyceride ◽  
The Body ◽  
High Density Lipoproteins ◽  
Tertiary Care Centre

Objectives: To analyse the correlation between ferritin level in serum and lipid profile in patients presenting to a Tertiary Care Centre. Study Design: Cross Sectional Descriptive study. Setting: Khyber Teaching Hospital Peshawar. Period: 1st January 2019 to 31st July 2019. Material & Methods: About 60 patients presenting to the laboratory referred for serum lipid profile or serum ferritin were included in the study. Sampling was done by purposive non probability technique. Blood was taken from patients in gel tube. Serum ferritin levels and lipid profile were done in all cases. Lipid profile included serum cholesterol, triglyceride level, low density lipoprotein and high density lipoproteins. The levels were recorded in a proforma. The serum ferritin level was correlated with the lipid profile status in all patient and the results were drawn accordingly. Results: About 60 patients were analysed. The mean age was 20.8± 5.2 years (range: 2 years to 60 years). There were 39 (65%) males and 21(35%) females. Out of 60 cases, serum ferritin level was normal, increased and lower in 15(25%), 40(66.6%) and 5 (8.3%) cases respectively. The cases where serum ferritin was abnormally raised, the significant changes in lipid profile were raised cholesterol and raised triglyceride (in 62.5% and 82.5% cases respectively). Conclusion: There is an association between raised serum ferritin and raised serum cholesterol level and serum triglyceride levels. This supports the link between serum ferritin regulation and lipid metabolism in the body. As dyslipidemia is a major cardiovascular risk factor. Therefore, a raised ferritin level must alert the physician about lipid profile of the patient and should prompt the physician to think about preventive measures against cardiovascular events in order to decrease the morbidity and mortality in patients at risk. 

scholarly journals Serum Lipid Profile in Hypothyroid Patients in Nepal

2015 ◽  
Vol 2 (4) ◽  
pp. 33-36
Author(s):  
Sudip Aryal ◽  
A Joshi
Keyword(s):  
Thyroid Hormone ◽  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Whole Body ◽  
Control Group ◽  
Overt Hypothyroidism ◽  
Significant Difference ◽  
Record Card ◽  
And Control ◽  
Hypothyroid Patients

INTRODUCTION: Hypothyroidism is non-curable common endocrine disorder in which the thyroid gland is unable to produce enough thyroid hormone. Present with a number of symptoms, Having a low level of thyroid hormone affects our whole body. Untreated hypothyroidism can be the cause of raised cholesterol levels. Many study have shown association between hypothyroidism and lipid profile. In this study, we evaluate the mean lipid profile status in subclinical hypothyroidism and hypothyroid patients.  MATERIAL AND METHODS: A hospital based retrospective study done from the record card maintained in Alka Hospital, Jawalakhel. Total number of participants were 215. Out of which 73 had overt hypothyroidism, 92 had subclinical hypothyroidism and 50 were taken as control. SPSS version 20 was used for data analysis.  RESULTS: The level of LDL, TG and TC was significantly higher in case of overt hypothyroidism as compared to control group, but no significant difference was found in subclinical hypothyroidism and control group. TG level was significantly lower in subclinical hypothyroidism cases.  CONCLUSION: Elevated HDL, LDL & TC is seen in overt hypothyroid patients. It is important to screen for lipid profile in hypothyroid patients.DOI: http://dx.doi.org/10.3126/jucms.v2i4.12065Journal of Universal College of Medical Sciences (2014) Vol.02 No.04 Issue 08Page: 33-36

scholarly journals The Effect of Omega-3 Supplement on Serum Lipid Profile in Patients Undergoing Hemodialysis: A Randomized Clinical Trial

2016 ◽  
Vol 54 (4) ◽  
pp. 222-227 ◽  
Author(s):  
Mosadegh Jabbari ◽  
Termeh Khoshnevis ◽  
Aria Jenabi ◽  
Fatemeh Yousefi
Keyword(s):  
Clinical Trial ◽  
Serum Creatinine ◽  
Lipid Profile ◽  
Randomized Clinical Trial ◽  
Linear Regression Analysis ◽  
Serum Triglyceride ◽  
Control Group ◽  
Case Group ◽  
Omega 3 ◽  
Beneficial Effects

Abstract Background. Some recent suggestions could show omega-3 condition deficiency following prolonged hemodialysis; however, these claims and speculations have not been well demonstrated with sufficient evidences. Hence, we attempted to assess the beneficial effects of omega-3 on lipid profile in patients with end-stage renal disease (ESRD) undergoing hemodialysis. Methods. One hundred and seventeen ESRD patients who were on maintenance dialysis in Rasoul-e-Akram and Madaen Hospitals were enrolled in this randomized clinical trial. These patients were divided into two groups randomly using block randomization method (57 patients as the case group receiving omega-3 for 12 weeks and 60 as the control group). Blood sample was taken from all patients for measurement of lipid profile, serum hemoglobin, and C-reactive protein at baseline as well as after the completion of interventions (after 12 weeks). Results. The average change in the value of HDL-C was significantly more in the patients who received omega-3 than in the control group (MD, -7 mg/dL; 95% CI, -11 to 0 p = 0.000). Also, the reduction in serum creatinine level was more in the omega-3 group than in the control group (MD, 0.7 mg/dL; 95% CI, -0.4 to 2.1 p = 0.023). The change in other indices including serum triglyceride, total cholesterol, and serum hemoglobin levels was not different between the two groups. The multivariable linear regression analysis showed no difference in serum HDL level between the two groups adjusted for sex, age, and time of dialysis, while the level of serum HDL-C could be adversely predicted by duration time. Similar regression model showed a between-group difference in serum creatinine in the presence of potential confounders. Conclusion. The change in serum HDL level following use of omega-3 supplement is influenced by time of dialysis, not by drug effect. However, consumption of omega-3 can significantly reduce serum creatinine.

scholarly journals A study of levothyroxine substitution therapy on subclinical hypothyroid patients and its effects on lipid profile in the department of medicine at tertiary care hospital

2020 ◽  
Vol 4 (2) ◽  
pp. 4-11
Author(s):  
Binod Raut ◽  
N Paudel ◽  
N Bhosekar
Keyword(s):  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Tertiary Care ◽  
Serum Triglyceride ◽  
Thyroid Stimulating Hormone ◽  
High Serum ◽  
Slight Reduction ◽  
Care Hospital ◽  
Free T4

Background: Subclinical hypothyroidism is represented by high serum thyroid stimulating hormone (TSH) and normal serum free T4 and T3, Recent studies on subclinical hypothyroidism and lipid profile indicates that the serum total cholesterol, LDL-C, and total triglycerides were significantly increased. Clinical evidence suggests that thyroid replacement therapy with levothyroxine has beneficial effect. Methods: It is a hospital based prospective observational study involving 122 patients based on non probability sampling conducted in the Department of Internal Medicine. The study involved patients who have been diagnosed with subclinical hypothyroidism with normal level of free T4, T3 and elevated levels of TSH with positive Thyroperoxidase (TPO) antibodies. Patients were advised to investigate lipid profile before and after prescribing levothyroxine. Follow up was done after 6-9 wks. Results: In this study 122 patients diagnosed with Subclinical hypothyroidism were prescribed with levothyroxine in which 112 came for follow up. The mean age of the patient was 46.81. There was significant reduction in mean TSH from 12.09 (±1.89)mIU/L to 7.97(±1.59)mIU/L,TC from 217.12( ±20.87)mg/dl to 198.47( ±17.34)mg/dl and LDL from 137.16(±14.57)mg/dl to 124.62( ±12.89)mg/dl was found along with significant reduction in VLDL was found after levothyroxine therapy, There was slight reduction in serum triglyceride was found with no significant alteration in HDL and BMI levels. Conclusion: The study showed significant reduction in the lipid profile including TC, LDL and VLDL after levothyroxine therapy. There was significant reduction in the level of TSH was also found whereas the level of free T4 and T3 were not much altered. There was no significant change found in the level of HDL and BMI.  

scholarly journals Effect of Simvastatin on induced apical periodontitis in rats: a tomographic and biochemical analysis

2016 ◽  
Vol 45 (4) ◽  
pp. 189-194
Author(s):  
Jussara Machado PEREIRA ◽  
Alex SEMENOFF-SEGUNDO ◽  
Natalino Francisco da SILVA ◽  
Álvaro Henrique BORGES ◽  
Tereza Aparecida Delle Vedove SEMENOFF
Keyword(s):  
Lipid Profile ◽  
Body Mass ◽  
Bone Repair ◽  
Negative Control Group ◽  
Negative Control ◽  
Apical Periodontitis ◽  
The Body ◽  
Control Group ◽  
Blood Collection ◽  
Male Wistar Rats

Abstract Introduction Simvastatin is one of several statins that are used to treat hypercholesterolemia, and in dentistry, few studies have attempted to associate the administration of this compound with bone repair. Objective To evaluate the effect of simvastatin on the progression of induced apical periodontitis in rats. Material and method To this end, 36 male Wistar rats were divided into 3 groups (N=12): Induced Apical Periodontitis Associated with Simvastatin Group (APSG N=12), Induced Periodontitis Apical Induced Group (APG N=12) and Negative Control Group (CG). On the first day, APG and APSG were anesthetized, and the coronal opening of the mandibular first molar was performed. For thirty days, the APSG received 6 mg of simvastatin daily via gavage. On the thirty-first day, all groups underwent blood collection and euthanasia. The jaws were removed and fixed in formalin. CT scans were performed to measure the periapical regions. In addition, the body mass and lipid profile were analyzed. The data were subjected to statistical analysis (ANOVA and Tukey’s test). Result The APG (3.42±0.65) showed the highest perimeters for the space periapical ligament, followed by APSG (1.54±0.78) and CG (0.64±0.24) (p<0.05). The lipid profile revealed the effect of simvastatin on the amount of glucose, triglycerides, HDL, and VLDL (p<0.05). Body mass APG showed the most weight gain (264.75±44.11), followed by CG (252.00±44.36) and APSG (245.41±42.56). The three groups showed significant differences in decreasing order (p<0.05). Conclusion The use of simvastatin decreased the progression of the increasing periapical ligament space in rats.

scholarly journals A prospective case control study of the effects of oligohydramnios on fetomaternal outcome in mothers with term pregnancy in a rural medical college

2018 ◽  
Vol 7 (11) ◽  
pp. 4706
Author(s):  
Dipak Mandi ◽  
Sayantan Sen ◽  
Vasundhara Goswami
Keyword(s):  
Demographic Data ◽  
Tertiary Care ◽  
Birth Asphyxia ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Perinatal Complications ◽  
Medical College ◽  
Increased Risk ◽  
Nicu Admission

Background: The aim of the current study was to assess the fetomaternal effects of oligohydramnios on term pregnancies in a rural tertiary care setup.Methods: A perspective case control hospital-based trial was conducted at Burdwan Medical College and Hospital for a period of one year. Pregnancies at term (37-42 weeks) were included in the study. 103 patients with sonographically diagnosed oligohydramnios were included in the case group. The control group comprised of 103 mothers at term with normal liquor volume. Demographic data and fetomaternal outcome parameters were assessed and compared.Results: There was increased incidence of fetal and perinatal complications including low birth weight, birth asphyxia and NICU admission. There were more perinatal deaths in the case group compared to the control group. Induction of labour, operative delivery, meconium stained liquor and incidence of preeclampsia were also increased in mothers with low AFI.Conclusions: Oligohydramnios is associated with an increased risk of labour and perinatal complications. Adequate antenatal surveillance and intranatal monitoring coupled with correction of underly-ing factors is the mainstay of management.

Sign in / Sign up

Export Citation Format

Share Document