Evaluation of the effects of different treatment modalities on angiogenesis in heart failure patients with preserved ejection fraction via VEGF and sVEGFR-1

Abstract Objective In this study, our aim was to investigate the clinical significance of VEGF, sVEGFR-1 in HFpEF patients. Materials and methods Seventy-two participants enrolled in this cross-sectional case-control study including HFpEF patients (n=41) and healthy (n=31) subjects. Blood samples were collected and serum VEGF, sVEGFR-1 analysis, and transthoracic echocardiography were performed. Results and discussion The average sVEGFR-1 level of HFpEF patient group was significantly higher than the control group (respectively 0.136 ng/L (0.04–0.34), 0.06 ng/L (0.01–0.25); p<0.001). The average VEGF level of HFpEF patients using beta blocker was significantly higher than the HFpEF patients not using it (respectively 0.585±0.194 ng/L; 0.349±0.269 ng/L; p=0.025). The average VEGF level of HFpEF patients using statins was significantly higher than the HFpEF patients without a medication (respectively 0.607±0.099 ng/L; 0.359±0.273 ng/L; p=0.038). Conclusion Our study is the first study demonstrating the relations among HFpEF, accompanying morbidities, VEGF and sVEGFR-1 levels. Statins and beta blockers may have positive effects on angiogenesis in HFrEF patients via increasing VEGF levels.

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Adrenal insufficiency in kidney transplant patients during low-dose prednisolone therapy: a cross-sectional case–control study

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfz180 ◽

2019 ◽

Vol 35 (12) ◽

pp. 2191-2197 ◽

Cited By ~ 2

Author(s):

Amalie Valentin ◽

Stina Willemoes Borresen ◽

Marianne Rix ◽

Thomas Elung-Jensen ◽

Søren Schwartz Sørensen ◽

...

Keyword(s):

Adrenal Insufficiency ◽

Low Dose ◽

Case Control Study ◽

Case Control ◽

Adrenal Crisis ◽

Control Group ◽

Cross Sectional ◽

Prednisolone Treatment ◽

Synacthen Test ◽

Control Study

Abstract Background Maintenance immunosuppressive regimens after renal transplantation (RTx) most often include prednisolone, which may induce secondary adrenal insufficiency, a potentially life-threatening side effect to glucocorticoid (GC) treatment due to the risk of acute adrenal crisis. We investigated the prevalence of prednisolone-induced adrenal insufficiency in RTx patients receiving long-term low-dose prednisolone treatment. Methods We performed a case–control study of patients on renal replacement therapy differing in terms of GC exposure. The study included 30 RTx patients transplanted >11 months before enrolment in the study and treated with prednisolone (5 or 7.5 mg prednisolone/day for ≥6 months) and 30 dialysis patients not treated with prednisolone. Patients underwent testing for adrenal insufficiency by a 250-µg Synacthen test performed fasting in the morning after a 48-h prednisolone pause. Normal adrenal function was defined as P-cortisol ≥420 nmol/L 30 min after Synacthen injection. This cut-off is used routinely for the new Roche Elecsys Cortisol II assay and is validated locally based on the Synacthen test responses in 100 healthy individuals. Results Thirteen RTx patients {43% [95% confidence interval (CI) 27–61]} had an insufficient response to the Synacthen test compared with one patient in the control group [3% (95% CI 0.6–17)] (P = 0.0004). Insufficient responses were seen in 9/25 and 4/5 RTx patients treated with 5 and 7.5 mg prednisolone/day, respectively. Conclusions We found a high prevalence of adrenal insufficiency among RTx patients receiving low-dose prednisolone treatment. We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.

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Subarticular Osteophytes in Patients with Osteoarthritis of the Hip. A Histomorphometric Cross-sectional Case-control Study.

10.21203/rs.3.rs-23875/v2 ◽

2020 ◽

Author(s):

Rasmus Klose-Jensen ◽

Andreas Wiggers Nielsen ◽

Louise Brøndt Hartlev ◽

Jesper Skovhus Thomasen ◽

Lene Warner Thorup Boel ◽

...

Keyword(s):

Femoral Head ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Control Group Design ◽

Cross Sectional ◽

Replacement Surgery ◽

Boundary Length ◽

Femoral Heads ◽

Control Study

Abstract Objective The objective of this cross-sectional case-control study was to determine the prevalence and size of marginal and subarticular osteophytes in patients with osteoarthritis (OA), and to compare these to that of a control group. Design We investigated femoral heads from 25 patients with OA following hip replacement surgery, and 25 femoral heads from a control group obtained post-mortem . The area and boundary length of the femoral head, marginal osteophytes, and subarticular osteophytes were determined with histomorphometry. Marginal osteophytes were defined histologically as bony projections at the peripheral margin of the femoral head, while subarticular osteophytes were defined as areas of bone that expanded from the normal curvature of the femoral head into the articular cartilage. Results The prevalence of OA patients with marginal- and subarticular osteophytes were 100% and 84%, respectively. Whereas the prevalence of the participants in the control group with marginal- and subarticular osteophytes were 56% and 28%, respectively. The area and boundary length of marginal osteophytes was (median (Interquartile range)) 165.3mm 2 (121.4 – 254.0) mm 2 and 75.1 mm (50.8 – 99.3) mm for patients with OA compared to 0 mm 2 (0 – 0.5) mm 2 and 0 mm (0 – 0.5) mm for the control group (P < 0.001). For the subarticular osteophytes, the area and boundary length was 1.0 mm 2 (0 – 4.4) mm 2 and 1.4 mm (0 – 6.5) mm for patients with OA compared to 0 mm 2 (0 – 0.5) mm 2 and 0 mm (0 – 0.5) mm for the control group (P < 0.001). Conclusion As expected, both marginal- and subarticular osteophytes at the femoral head, were more frequent and larger in patients with OA than in the control group. However, in the control group, subarticular osteophytes were more prevalent than expected from the minor osteophytic changes at the femoral head margin, which may suggest that subarticular osteophytes are an early degenerative phenomenon that ultimately might develop into clinical osteoarthritis.

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Diabetes and hypertension in patients with psoriasis: a cross sectional and case control study in a tertiary care hospital of Bangladesh

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20213063 ◽

2021 ◽

Vol 9 (8) ◽

pp. 2217

Author(s):

Samira Jamal ◽

Sheikh Anwarul Karim ◽

Sheikh Mahee Ridwan Raihan ◽

Rajat Biswas ◽

Mansurul Alam

Keyword(s):

Case Control Study ◽

Skin Diseases ◽

Tertiary Care ◽

Case Control ◽

Control Group ◽

Care Hospital ◽

College Hospital ◽

Cross Sectional ◽

Increased Risk ◽

Control Study

Background: In this study our main goal was to evaluate the association of psoriasis as a risk predictor for the occurrence of diabetes mellitus (DM) and hypertension (HTN).Methods: This case control study was carried out in the department of dermatology and venereology, Chittagong medical college hospital (CMCH), Chittagong, Bangladesh from 15 June 2011 to 14 May 2012. Where 60 patients with psoriasis and 60 patients with skin diseases other than psoriasis were included according to availability within the study period.Results: During study, among the psoriatic patients, most of the patients with DM and HTN had body mass index (BMI) within normal limit. During analysis of different clinical findings in psoriatic patients scaling was present in all the cases followed by Auspitz sign, koebnerization, itching, scalp involvement and nail changes. Patients with psoriasis were found to have higher incidence of DM and HTN in comparison to their non-psoriatic control group. It was also observed that psoriatic patients having DM and HTN had longer duration of diseases (p<0.05).Conclusions: In conclusion, our study indicates that patients with psoriasis have an increased risk of DM and HTN, confirming the findings from previous several case control and cross sectional studies. These data illustrate the importance of considering psoriasis as a systemic disorder rather than simply a skin disease. Awareness of concurrent diseases will provide the clinician an opportunity of screening .for others systemic diseases.

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NATURAL HISTORY OF LUMBAR CANAL STENOSIS: CLINICAL ASPECTS AND SAGITTAL BALANCE

Coluna/Columna ◽

10.1590/s1808-185120191803179255 ◽

2019 ◽

Vol 18 (3) ◽

pp. 209-213

Author(s):

VAGNER CLAYTON DE PAIVA ◽

MARCELO ITALO RISSO NETO ◽

GUILHERME REBECHI ZUIANI ◽

IVAN GUIDOLIN VEIGA ◽

WAGNER PASQUALINI ◽

...

Keyword(s):

Case Control Study ◽

Vertical Axis ◽

Case Control ◽

Surgical Indication ◽

Clinical Aspects ◽

Control Group ◽

Level Of Evidence ◽

Sagittal Vertical Axis ◽

Cross Sectional ◽

Control Study

ABSTRACT Objective To compare the sagittal alignment (SA) parameters in individuals with LCS and surgical indication with a control group and to study the correlations between SA parameters and ODI, VAS and EQ-5D in individuals with LCS and surgical indication. Methods In this multicenter cross-sectional case-control study, the individuals were allocated as follows. A stenosis group (SG) composed by patients with LCS confirmed by magnetic resonance imaging with surgical indication, treated between July 2010 and August 2016 and a control group (CG), without LCS. All subjects underwent anamnesis, completed the Health-related Quality of Life (HRQoL) and total spine radiographs were taken. Clinical data, HRQoL and radiographic parameters were correlated. Results Sixty-four individuals formed the SG and 14 the CG. The SG had higher values of mean age, coronal imbalance, sagittal vertical axis (SVA), pelvic tilt (PT), sacrofemoral distance (SFD), overhang (OH), PI-LL mismatch, Oswestry Disability Index (ODI) and Visual Analog Scale (VAS) for pain and smaller thoracic kyphosis (TK), total (TLPL) and regional lumbopelvic lordosis (RLPL) in all vertebrae, sagittal offset (SO) in all evaluated vertebrae and EuroQol-5D (EQ-5D) with p <0.05. In the SG, the only significant correlations (p <0.05) were between TK and ODI and EQ-5D; all the other sagittal parameters did not correlated with VAS, ODI or EQ-5D. Conclusion SG had SA parameters altered in relation to CG. There was a direct correlation between decrease in TK and worsening of ODI and EQ-5D in SG. Level of evidence: III; Case Control Study.

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High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study

Journal of Immunology Research ◽

10.1155/2017/3972706 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Sevgi Akarsu ◽

Ozlem Ozbagcivan ◽

Fatma Semiz ◽

Sebnem Aktan

Keyword(s):

Metabolic Syndrome ◽

Lupus Erythematosus ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Discoid Lupus Erythematosus ◽

Cross Sectional ◽

Significant Difference ◽

The Impact ◽

Control Study

Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control group. Additionally, we intended to determine the differences of sociodemographic and clinical data of the DLE patients with MetS compared to the patients without MetS. This was a cross-sectional, case-control study, including 60 patients with DLE and 82 age- and gender-matched control subjects. In DLE group, the presence of MetS was observed as more frequent (48.3% versus 24.4%, p=0.003), and hypertriglyceridemia (43.3% versus 22.0%, p=0.006) and reduced HDL-cholesterol (61.7% versus 23.2%, p<0.001) among the MetS components were found significantly higher when compared to the control group. DLE patients with MetS were at older age (50.45±11.49 versus 43.06±12.09, p=0.02), and hypertension, hyperlipidemia/dyslipidemia, and cardiovascular disease histories were observed at a higher ratio when compared to the patients without MetS. Between the DLE patients with and without MetS, no significant difference was observed in terms of clinical characteristics of DLE. Moreover, further large case-control studies with follow-up periods would be required to clearly assess the impact of MetS on the clinical outcomes of DLE.

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Study of blood levels of Lactate, Vitamin D and Nucleated Red Blood Cells for early prediction of Hypoxic–Ischemic Encephalopathy: A cross-sectional case-control study

10.21203/rs.3.rs-268008/v1 ◽

2021 ◽

Author(s):

Ahmed Saad ◽

Ahmed thabet ◽

Mohamed Soliman ◽

Alyaa Abdel-Aziz

Keyword(s):

Vitamin D ◽

Blood Cells ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Blood Levels ◽

P Value ◽

Cross Sectional ◽

Nucleated Red Blood Cells ◽

Control Study

Abstract Background Perinatal asphyxia is a serious medical condition in which there is a lack of oxygen or blood flow during, or even after the labor process. Methods A cross-sectional case-control study was conducted on 20 neonates with HIE comprising the cases (APGAR ≤ 5) and another 20 neonates representing the control group with their age, sex, and weight matched, admitted to NICU. Sarnat score was used to assess the severity of HIE. Results Venous blood levels of lactate and nucleated red blood cells per 100 white blood cells (NRBC/100 WBC) counts were significantly higher in HIE neonates than in the control group with a highly significant difference (p-value < 0.001). While serum Vitamin D was significantly lower in the HIE group than in the control (p-value < 0.001). Conclusion Serum lactate level, vitamin D level and NRBCs/100 WBCs might be used as biomarkers in the early prediction of HIE.

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Possible association between -954G/C iNOS polymorphism in nasal polyposis. A case-control study in a population group of Northern Romania

Romanian Journal of Rhinology ◽

10.1515/rjr-2016-0023 ◽

2016 ◽

Vol 6 (24) ◽

pp. 197-201

Author(s):

Andreea Catana ◽

Alma Maniu ◽

Doinel Radeanu ◽

Radu A. Popp ◽

Roxana F. Ilies ◽

...

Keyword(s):

Nasal Polyposis ◽

Case Control Study ◽

Pcr Amplification ◽

Case Control ◽

Control Group ◽

Restriction Enzyme Digestion ◽

Significant Finding ◽

Cross Sectional ◽

Increased Risk ◽

Control Study

Abstract BACKGROUND. Polymorphisms for genes encoding chemosensitive signalling proteins like NOS2 might contribute to the variability in individual susceptibility to nasal polyposis. NO produced by the inducible NO synthase enzyme NOS2A is generated at high levels in certain types of inflammation, so that the role of NOS2 might also be important in nasal polyposis etiopathogeny. MATERIAL AND METHODS. This is a cross-sectional, randomized, case-control study for the evaluation of the frequency of -954G/C NOS2A2 alleles among patients with nasal polyposis. The study included 91 cases of nasal polyposis diagnosed patients (nasal endoscopy and CT scan examination), and 117 healthy unrelated controls. NOS2 genotyping was carried out using PCR amplification of relevant gene fragment and it was followed by restriction enzyme digestion. Detection of the variant alleles was determined through analysis of resulting restriction fragment length polymorphism (RFLP) followed by gel electrophoresis. RESULTS. Molecular analysis revealed an increased frequency of NOS2 variant allele in the study group compared to the control group (p=0.019, OR=1.991, CI=1.08-3.67). A statistically significant finding was highlighted among allergic and nonallergic patients with nasal polyposis (p=0.046, OR=0.449. CI=0.208-0.969) and a relationship between nasal polyposis patients with asthma and non-asthmatic patients (p=0.119, OR=1.825, CI=0.875-3.80). CONCLUSION. The main finding of our study is that -954G/C polymorphism of NOS gene seems to be associated with an increased risk for nasal polyposis.

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Histomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hip

BMC Musculoskeletal Disorders ◽

10.1186/s12891-020-03648-w ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Rasmus Klose-Jensen ◽

Andreas Wiggers Nielsen ◽

Louise Brøndt Hartlev ◽

Jesper Skovhus Thomsen ◽

Lene Warner Thorup Boel ◽

...

Keyword(s):

Femoral Head ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Cross Sectional ◽

Replacement Surgery ◽

Hip Replacement Surgery ◽

Boundary Length ◽

Femoral Heads ◽

Control Study

Abstract Objective The objective of this cross-sectional case-control study was to determine the prevalence and size of marginal and subarticular osteophytes in patients with osteoarthritis (OA), and to compare these to that of a control group. Design We investigated femoral heads from 25 patients with OA following hip replacement surgery, and 25 femoral heads from a control group obtained post-mortem. The area and boundary length of the femoral head, marginal osteophytes, and subarticular osteophytes were determined with histomorphometry. Marginal osteophytes were defined histologically as bony projections at the peripheral margin of the femoral head, while subarticular osteophytes were defined as areas of bone that expanded from the normal curvature of the femoral head into the articular cartilage. Results The prevalence of OA patients with marginal- and subarticular osteophytes were 100 and 84%, respectively. Whereas the prevalence of the participants in the control group with marginal- and subarticular osteophytes were 56 and 28%, respectively. The area and boundary length of marginal osteophytes was (median (Interquartile range)) 165.3mm2 (121.4–254.0) mm2 and 75.1 mm (50.8–99.3) mm for patients with OA compared to 0 mm2 (0–0.5) mm2 and 0 mm (0–0.5) mm for the control group (P < 0.001). For the subarticular osteophytes, the area and boundary length was 1.0 mm2 (0–4.4) mm2 and 1.4 mm (0–6.5) mm for patients with OA compared to 0 mm2 (0–0.5) mm2 and 0 mm (0–0.5) mm for the control group (P < 0.001). Conclusion As expected, both marginal- and subarticular osteophytes at the femoral head, were more frequent and larger in patients with OA than in the control group. However, in the control group, subarticular osteophytes were more prevalent than expected from the minor osteophytic changes at the femoral head margin, which may suggest that subarticular osteophytes are an early degenerative phenomenon that ultimately might develop into clinical osteoarthritis.

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The association between rheumatoid arthritis and periodontal disease in a population-based cross-sectional case-control study

10.21203/rs.2.22043/v3 ◽

2020 ◽

Author(s):

Stefan Renvert ◽

Johan Sanmartin Berglund ◽

Rutger Gösta Persson ◽

Maria K. Söderlin

Keyword(s):

Rheumatoid Arthritis ◽

Medical Records ◽

Case Control Study ◽

Female Gender ◽

Population Based ◽

Case Control ◽

Control Group ◽

Binary Logistic Regression Analysis ◽

Cross Sectional ◽

Control Study

Abstract Background. The association between rheumatoid arthritis (RA) and periodontitis remains unclear. Methods. We studied oral health and periodontitis in a population-based case-control study of individuals with ≥ 10 remaining teeth ≥61 years of age and either with, or without a diagnosis of RA. 126 dentate individuals with RA were recruited together with age-matched control individuals without RA. The control individuals were recruited from the general population from the same city (n=249). A dental examination including a panoramic radiograph was performed on all participants. All individuals with RA were examined and medical records were reviewed by a rheumatologist. In the control group, none of the participants presented with symptoms of RA and their medical records were also negative. Results. The RA group included more women (66.7 % vs. 55.8 %) (p<0.01). Individuals in the RA group had a higher body mass index (BMI) (p<0.001). A diagnosis of periodontitis was more common in the RA group (61.1%) than in the control group (33.7 %) (p=0.001). Binary logistic regression analysis identified that a BMI > 25 (OR 6.2, 95% CI 3.6, 10.5, p= 0.000), periodontitis (OR 2.5 95% CI 1.5, 4.2 p=0.000), and female gender (OR 2.3, 95% CI 1.3-4.0, p=0.003) were associated with RA. Conclusion. RA was associated a diagnosis of periodontitis.

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