Evaluation of thiol disulphide levels in patients with pulmonary embolism

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Kamile Yücel ◽  
Said Sami Erdem ◽  
Ercan Kurtipek ◽  
Taha Tahir Bekci ◽  
Salim Neşelioğlu ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Serum Albumin ◽  
Antioxidant Defense ◽  
Prognostic Markers ◽  
Control Group ◽  
Healthy Controls ◽  
Strongly Correlated ◽  
The Novel ◽  
Healthy Individuals ◽  
Lower Serum

AbstractObjectivesMaintaining the thiol-disulphide balance is essential for antioxidant defense and apoptosis. The study aimed to evaluate of thiol-disulphide levels in patients with pulmonary embolism (PE).MethodsThe study included a total of 97 participants: 48 patients and 49 healthy individuals. Serum native thiol (NT), total thiol (TT) and disulphide (DS) levels (µmol/L) were measured using the novel spectrophotometric method.ResultsWe found significantly lower levels of NT (195.44±83.3 μmol/L), DS (20.42±9.20 μmol/L) and TT (236.26±90.66 μmol/L) in patients with PE compared with the healthy controls (304.42±62.13, 24.33±8.09 and 353.07±63.58 μmol/L respectively). Patients with PE had lower serum albumin levels (3.11±1.03 g/dL) and higher ischaemia modified albumin (IMA) levels (0.82±0.16 g/dL) compared with the controls (3.89±0.52 and 0.67±0.15 g/dL, respectively). Serum albumin levels in patients were strongly correlated with plasma IMA (r=−0.737; p<0.001), NT (r=0.786; p<0.001) and TT levels (r=0.841; p<0.001). Serum NT levels were strongly correlated with serum TT levels (r=0.981; p<0.001) in patients.ConclusionsThis study found lower TT, NT and DS levels in patients with PE than in the control group. Our study revealed that thiol-disulphide homeostasis could be altered during PE and further studies are needed to be used as prognostic markers for hospital mortality.

THUR 037 Identification of biofluid markers of TDP-43 pathology

2018 ◽  
Vol 89 (10) ◽  
pp. A5.4-A6
Author(s):  
Shafei Rachelle ◽  
Foiani Martha ◽  
Heller Carolin ◽  
Heslegrave Amanda ◽  
Woollacott Ione ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Frontotemporal Dementia ◽  
Observational Studies ◽  
Healthy Controls ◽  
The Novel ◽  
Healthy Individuals ◽  
University College ◽  
University College London ◽  
The Mean ◽  
The University

IntroductionFrontotemporal dementia (FTD) is usually caused pathologically by either tau or TDP-43. Previous biofluid assays of TDP-43 have not so far proved to be sensitive or specific for identifying those cases with TDP-43 pathology.Material and methodsWe set out to investigate the novel TDP-43 Simoa assay (Quanterix) assay in both plasma and CSF in a cohort of patients recruited from the University College London FTD observational studies with known or likely TDP-43 pathology (17), non-TDP-43 pathology (13), and healthy controls (10).ResultsThe mean [standard deviation] plasma TDP-43 concentration was higher in those with likely TDP-43 pathology (155.1 [223.4] pg/ml) than those with non-TDP pathology (112.39 [252.9] pg/ml), and healthy controls (50.0 [23.1] pg/ml), but the differences between groups was non-significant, with substantial overlap in concentrations between all three groups. The mean CSF TDP-43 concentration was 2.9 [0.3] pg/ml in those with likely TDP-43 pathology, 2.8 [0.4] pg/ml in those with non-TDP pathology, and 3.1 [0.5] pg/ml in healthy controls. DiscussionThe assay tested in this study does not accurately distinguish between those with likely TDP-43 pathology and either disease controls or healthy individuals. There remains an urgent need to develop a better biofluid assay for pathological TDP-43.

scholarly journals Study of the Relationship between Microbiome and Colorectal Cancer Susceptibility Using 16SrRNA Sequencing

2020 ◽  
Vol 2020 ◽  
pp. 1-17 ◽  
Author(s):  
Wanxin Liu ◽  
Ren Zhang ◽  
Rong Shu ◽  
Jinjing Yu ◽  
Huan Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gut Microbiota ◽  
Cancer Susceptibility ◽  
Precancerous Lesions ◽  
Bacterial Community Composition ◽  
Intestinal Flora ◽  
Control Group ◽  
Healthy Controls ◽  
Healthy Individuals

A lot of previous studies have recently reported that the gut microbiota influences the development of colorectal cancer (CRC) in Western countries, but the role of the gut microbiota in Chinese population must be investigated fully. The goal of this study was to determine the role of the gut microbiome in the initiation and development of CRC. We collected fecal samples of 206 Chinese individuals: 59 with polyp (group P), 54 with adenoma (group A), 51 with colorectal cancer (group CC), and 42 healthy controls (group HC).16S ribosomal RNA (rRNA) was used to compare the microbiota community structures among healthy controls, patients with polyp, and those with adenoma or colorectal cancer. Our study proved that intestinal flora, as a specific indicator, showed significant differences in its diversity and composition. Sobs, Chao, and Ace indexes of group CC were significantly lower than those of the healthy control group (CC group: Sobs, Chao, and Ace indexes were 217.3 ± 69, 4265.1 ± 80.7, and 268.6 ± 78.1, respectively; HC group: Sobs, Chao, and Ace indexes were 228.8 ± 44.4, 272.9 ± 58.6, and 271.9 ± 57.2, respectively). When compared with the healthy individuals, the species richness and diversity of intestinal flora in patients with colorectal cancer were significantly reduced: PCA and PCoA both revealed that a significant separation in bacterial community composition between the CC group and HC group (with PCA using the first two principal component scores of PC1 14.73% and PC2 10.34% of the explained variance, respectively; PCoA : PC1 = 14%, PC2 = 9%, PC3 = 6%). Wilcox tests was used to analyze differences between the two groups, it reveals that Firmicutes (P=0.000356), Fusobacteria (P=0.000001), Proteobacteria (P=0.000796), Spirochaetes (P=0.013421), Synergistetes (P=0.005642) were phyla with significantly different distributions between cases and controls. The proportion of microorganism composition is varying at different stages of colon cancer development: Bacteroidetes (52.14%) and Firmicutes (35.88%) were enriched in the healthy individuals; on the phylum level, the abundance of Bacteroidetes (52.14%-53.92%-52.46%–47.06%) and Firmicutes (35.88%-29.73%-24.27%–25.36%) is decreasing with the development of health-polyp-adenomas-CRC, and the abundance of Proteobacteria (9.33%-12.31%-16.51%–22.37%) is increasing. PCA and PCOA analysis showed there was no significant (P<0.05) difference in species similarity between precancerous and carcinogenic states. However, the composition of the microflora in patients with precancerous lesions (including patients with adenoma and polyp) was proved to have no significant disparity (P<0.05). Our study provides insights into new angles to dig out potential biomarkers in diagnosis and treatment of colorectal cancer and to provide scientific advice for a healthy lifestyle for the sake of gut microbiota.

scholarly journals Distinct effects of over-general autobiographical memory on suicidal ideation among depressed and healthy people

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wen Jiang ◽  
Guangtao Hu ◽  
Jingxuan Zhang ◽  
Ken Chen ◽  
Dongni Fan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Suicidal Ideation ◽  
Autobiographical Memory ◽  
Childhood Trauma ◽  
Study Data ◽  
Path Model ◽  
Control Group ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Healthy Control

Abstract Background Childhood trauma and over-general autobiographical memory (OGM) are crucial risk factors of suicide. This study aimed to investigate whether suicidal ideation was predicted by one’s childhood trauma and OGM and the mechanism of OGM underlying suicidal ideation in depression patients and healthy controls. Methods A total of 180 depression patients and 176 matched healthy individuals were recruited in this study. Data were analyzed using descriptive statistics, and Pearson’s correlation coefficient was obtained. Path analysis was conducted to test a meditational model. The multigroup comparison was applied to find differences between groups. Results Significant differences were detected between depression patients and healthy controls with respect to childhood trauma, OGM, suicidal ideation, and suicidal behavior. OGM was positively correlated with both current and worst-point suicidal ideation in the depression group and significantly correlated with worst-point suicidal ideation in the healthy control group. The path model showed that childhood trauma had a direct impact on the current suicidal ideation directly, and an indirect influence through OGM and worst-point suicidal ideation. Multigroup analysis further demonstrated that OGM affected and mediated the current suicidal ideation due to childhood trauma in depression patients, whereas only worst-point suicidal ideation was affected in healthy controls. Conclusions The OGM mediates suicidal ideation in depression patients, but only affects the worst-point suicidal ideation in the healthy controls. As it is one of the major risk factors of suicidal ideation in depression, amelioration of OGM might be an useful method to reduce or prevent suicidal ideation in depression patients.

scholarly journals FREQUENCY ANALYSIS OF SINGULAR FIRST-PERSON PRONOUNS AND VERBS IN THE UTTERANCES OF SCHIZOPHRENIA PATIENTS AND HEALTHY CONTROLS. A RESEARCH REPORT

2013 ◽  
Vol 55 (1) ◽  
pp. 87-98
Author(s):  
Monika Obrębska
Keyword(s):  
Frequency Analysis ◽  
Negative Symptoms ◽  
Paranoid Schizophrenia ◽  
Research Report ◽  
Control Group ◽  
First Person ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Personal Pronouns ◽  
Positive Type

Abstract The purpose of this article is to present the results of a frequency analysis of first-person pronouns and verbs in utterance texts of schizophrenia patients and healthy controls. Method: The study involved 130 hospitalized psychiatric patients diagnosed with paranoid schizophrenia and 130 healthy individuals. As a result of the study, the largest corpus to date of marked utterance texts of schizophrenic patients in the Polish language was obtained. The ratio of the number of singular first-person personal pronouns and verbs to the total number of personal pronouns and verbs used in any particular text was calculated and was then averaged for each of the four studied groups: a group of patients with positive schizophrenia symptoms, a group of patients with negative schizophrenia symptoms, a control group for the patients with positive symptoms, and a control group for the patients with negative symptoms. Results: The highest mean was found for the group of patients with positive schizophrenia symptoms, and the lowest for the group of healthy individuals. This difference was found to be statistically significant. Conclusion: The “egocentric orientation” and difficulty in defining one’s own identity experienced by psychotic patients, especially those with the positive type of schizophrenia, are reflected in their lexical choices.

scholarly journals Dissociative experiences in patients with epilepsy

2016 ◽  
Vol 74 (3) ◽  
pp. 189-194 ◽  
Author(s):  
Osman Özdemir ◽  
Vedat Cilingir ◽  
Pınar Güzel Özdemir ◽  
Aysel Milanlioglu ◽  
Mehmet Hamamci ◽  
...  
Keyword(s):  
Age At Onset ◽  
High Rate ◽  
Control Group ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Related Factors ◽  
Dissociative Experiences Scale ◽  
Dissociative Experiences ◽  
Patients With Epilepsy ◽  
Number Of Individuals

ABSTRACT A few studies have explored dissociative experiences in epilepsy patients. We investigated dissociative experiences in patients with epilepsy using the dissociative experiences scale (DES). Ninety-eight patients with epilepsy and sixty healthy controls were enrolled in this study. A sociodemographic questionnaire and the Dissociative Experiences Scale (DES), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were administered to the participants. The DES scores were significantly higher for the patients with epilepsy than the healthy individuals. The number of individuals with pathological dissociation (DES ≥ 30) was higher in the epilepsy group (n = 28) than in the control group (n = 8). Also, higher levels of dissociation were significantly associated with frequency of seizures, but were not associated with duration of epilepsy and age at onset of the disorder. These findings demonstrate that patients with epilepsy are more prone to dissociation than controls. The high rate of dissociative experiences among patients with epilepsy suggest that some epilepsy-related factors are present.

scholarly journals Application of the Audio Recorded Cognitive Screen and its relation to functioning in schizophrenia

2015 ◽  
Vol 27 (5) ◽  
pp. 279-290
Author(s):  
Brooke M. Gelder ◽  
Carmel M. Loughland ◽  
Vaughan J. Carr ◽  
Peter W. Schofield
Keyword(s):  
Functional Outcomes ◽  
Community Dwelling ◽  
Self Report ◽  
Control Group ◽  
Healthy Controls ◽  
Strongly Correlated ◽  
Neuropsychological Status ◽  
Vocational Functioning ◽  
Cognitive Screen ◽  
State Examination

ObjectiveThis study investigated the ability of the Audio Recorded Cognitive Screen (ARCS) to detect cognitive deficit in individuals with schizophrenia, relative to the Mini Mental State Examination (MMSE) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and explored the associations between the ARCS and functional outcomes. We hypothesised that the ARCS would be able to better discriminate between individuals with schizophrenia and healthy controls than the MMSE, and that ARCS performance would be correlated with measures of social and vocational functioning.MethodsThe participants were 19 community-dwelling individuals with schizophrenia or schizoaffective disorder and 19 healthy controls recruited from the Australian Schizophrenia Research Bank (ASRB). Participants completed the ARCS, MMSE, and self-report measures of social and vocational functioning. Clinical and diagnostic data stored by the ASRB were also utilised.ResultsThe schizophrenia group performed worse than the control group on the ARCS, with memory, t(36)=2.49, p=0.02, 95% CI [−1.84, −18.79] and fluency, t(36)=2.40, p=0.02, 95% CI [−1.87, −22.24] domains being the main discriminating measures. The RBANS also discriminated between the two groups, and ARCS and RBANS total scores were moderately to strongly correlated. There was no difference between the two groups on the MMSE after controlling for demographic variables. ARCS performance was associated with employment status [χ2(1)=7.16, p=0.007].ConclusionThe ARCS may be sensitive to the cognitive deficits in outpatients with schizophrenia and an indicator of functional outcomes in this population.

scholarly journals Relationship between Vitamin D Status and Striae Distensae: A Case-Referent Study

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Rafaela Koehler Zanella ◽  
Denis Souto Valente ◽  
Leo Francisco Doncatto ◽  
Daniele Dos Santos Rossi ◽  
Aline Grimaldi Lerias ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Levels ◽  
Silicone Implants ◽  
Control Group ◽  
Healthy Controls ◽  
Striae Distensae ◽  
Lower Serum ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Epidermal Atrophy

Vitamin D (VD) plays a role in the skin regulation. Striae Distensae (SD) are manifestations of epidermal atrophy that occurs after tissue tearing due to overstretching or rapid growth. The objective of this study was to investigate the relation between serum VD and occurrence of SD in women who had undergone mammaplasty with silicone implants. A case-referent study was conducted. The blood values of 25-hydroxyvitamin D (25OHD) were measured before the surgery. For each patient postoperatively diagnosed with SD, four other participants submitted to the same surgery, without the development of SD, were enrolled as the healthy controls. 67 women with SD after the surgery entered the study. 268 formed the control group. In the serum of healthy controls 25OHD mean was 27 ng/mL, and SD cases presented 20 ng/mL (P=0.01). Scarce values of VD have been observed in 56.71% of the cases presenting SD and in 39.91% without SD (P=0.002). Chance of having VD values lower than 20 ng/mL amongst cases with SD is 2.38 (P=0.0001). Lower serum levels of VD are linked to a higher occurrence of SD.

scholarly journals Serum Total Protein, Albumin, Globulin, and Prealbumin in Acne Patients

2020 ◽  
Author(s):  
Hao Jiang ◽  
Changyi Li ◽  
bin wei ◽  
Qiang Wang ◽  
Qinggao Wang ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Total Protein ◽  
Serum Levels ◽  
Control Group ◽  
Healthy Controls ◽  
Serum Globulin ◽  
Serum Total Protein ◽  
Protein Levels ◽  
Healthy Control ◽  
Age And Sex

Abstract Background/Objectives: This study was designed to investigate serum protein levels in acne patients.Method: Acne patients (n=362) and healthy volunteers (n=272) were matched in terms of both age and sex. Serum levels were measured.Results: Among the 362 acne patients and 272 age- and sex-matched healthy controls, serum albumin levels in female acne patients were lower than in the healthy controls (P < 0.05), serum albumin levels in male acne patients were lower than in the healthy controls (P < 0.01). Additionally, serum globulin and total protein levels were significantly lower in acne patients than in the healthy control group (P < 0.01). Serum levels of prealbumin were significantly lower in female acne patients than in the control group (P < 0.05). Finally, the severity of female and male acne patients was negatively correlated with serum total protein, albumin, globulin, and prealbumin levels. Conclusions: The results of this study suggested that acne patients are potentially accompanied with protein malnutrition.

Comparison of Vitamin D Levels in AMI patients and Healthy Individuals

2021 ◽  
Vol 15 (8) ◽  
pp. 1896-1898
Author(s):  
Aisha Bashir ◽  
Asima Karim ◽  
Asia Kanwal ◽  
Asma Salam
Keyword(s):  
Vitamin D ◽  
Cell Biology ◽  
Serum Vitamin ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Lower Serum ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Mean

Background: Research reports that serum Vitamin D levels are deficient in AMI patients. Aim: To compare serum Vitamin D levels between AMI patients and healthy controls. Methods: Study design was Cross Sectional Comparative. The study was conducted at Department of Physiology & Cell Biology, University of Health Sciences, Lahore 2018 to 2019. Serum vitamin D levels were measured in 80 study subjects. Among 80 study subjects, 40 had AMI and 40 were healthy controls. Results: The serum Vitamin D levels less than 20ng/ml were considered deficient. Mann Whitney U test was used to compare the groups. The mean serum Vitamin D levels of the AMI patients were significantly lower (7±2.47ng/ml) as compared to healthy controls (17.17±4.8ng/ml) at (p=0.000). Conclusion: AMI patients have significantly lower serum Vit. D levels as compared to healthy individuals. Keywords: Acute myocardial infarction, Serum Vitamin D

Evaluation Of Antioxidant Defense In Patients With Colorectal Carcinoma

2015 ◽  
Vol 87 (7) ◽  
Author(s):  
Katarzyna Malinowska ◽  
Michał Mik ◽  
Łukasz Dziki ◽  
Adam Dziki ◽  
Ireneusz Majsterek
Keyword(s):  
Colorectal Cancer ◽  
Superoxide Dismutase ◽  
Colorectal Carcinoma ◽  
Glutathione Peroxidase ◽  
Healthy Subjects ◽  
Antioxidant Defense ◽  
Antioxidant Response ◽  
Antioxidant Enzyme Activity ◽  
Control Group ◽  
Healthy Controls

AbstractCancers are among the most feared diseases of modern civilization. In Poland, colorectal cancer is one of the tumors with the worst prognosis. The ability to cure is primarily dependent on the stage of the disease at the time of diagnosis.was evaluate antioxidant response in patients with colorectal carcinoma.Twenty patients (14 men and 6 women) aged 61.9± 11.1 years with colorectal cancer were included in the study. Twenty healthy subjects (4 men and 16 women) aged 64 ± 15.3 years formed the control group. The erythrocyte activities of antioxidant enzymes, superoxide dismutase (SOD), and glutathione peroxidase (GPx),A significant increase of GPx, and SOD (p < 0.05) were seen in patients compared to healthy controls.The results indicate that the tested antioxidant enzyme activity of glutathione peroxidase and superoxide dismutase is increased in patients diagnosed with colorectal cancer compared to the control group.

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