The impact of advancing age on P-glycoprotein expression and activity: current knowledge and future directions

2007 ◽  
Vol 3 (3) ◽  
pp. 315-320 ◽  
Author(s):  
Arduino A Mangoni
Keyword(s):  
Current Knowledge ◽  
Future Directions ◽  
P Glycoprotein ◽  
The Impact ◽  
Expression And Activity

The Oxford Handbook of Hope

2017 ◽  
Keyword(s):  
Current Knowledge ◽  
Physical And Mental Health ◽  
Comprehensive Overview ◽  
Future Directions ◽  
Theoretical Perspectives ◽  
The Many ◽  
The Impact ◽  
Made In

The Oxford Handbook of Hope provides a comprehensive overview of current knowledge regarding the science and practice of hope. Hope has long been a topic of interest to philosophers and the general public, but it was only in recent decades that hope became a focus of psychological science. Rick Snyder defined hope as a cognitive trait that helps individuals to identify and pursue goals and consists of two components: pathways, the perceived capacity to identify strategies necessary to achieve goals, and agency, the willpower or motivation to pursue those pathways to achieve goals. Hope has become one of most robust and promising topics in the burgeoning field of positive psychology. This book reviews the progress that has been made in the past 25 years regarding the origins and influence of hope. Topics covered include current theoretical perspectives on how best to define hope and how it is distinct from related constructs, current best practices for measuring and quantifying hope, interventions and strategies for promoting hope across different settings and the lifespan, the impact that hope has on many dimensions and domains of physical and mental health, and the many ways and contexts in which hope promotes resilience and positive functioning. Experts in the field both review what is currently known about the role of hope in different domains and identify topics and questions that can help to guide the next decade of research. The handbook concludes with a collaborative vision on the future directions of the science of hope.

scholarly journals Nanoplastic Impact on the Gut-Brain Axis: Current Knowledge and Future Directions

2021 ◽  
Vol 22 (23) ◽  
pp. 12795
Author(s):  
Wojciech Grodzicki ◽  
Katarzyna Dziendzikowska ◽  
Joanna Gromadzka-Ostrowska ◽  
Marcin Kruszewski
Keyword(s):  
Current Knowledge ◽  
Intestinal Barrier ◽  
Plastic Pollution ◽  
Behavioral Disturbances ◽  
Future Directions ◽  
Human Environment ◽  
Synthetic Materials ◽  
Significant Burden ◽  
The Impact ◽  
The Brain

The widespread usage of plastic places a significant burden on the environment and impacts numerous aquatic and terrestrial species. Humans in particular can be affected by plastic pollution, predominantly via inhalation and ingestion, as well as trophic transfer along the food chain. Under natural conditions synthetic materials undergo degradation into micro- and nanoparticles, especially prone to interact with biological systems. Organisms exposed to nanoplastic accumulate it in multiple tissues, including the gut and the brain. This phenomenon raises a question about the impact of nanoparticulate plastics on the communication pathways between these organs. The aim of this review is to explore an unsettling possibility of the influence of nanoplastic on the gut-brain axis and provide a comprehensive summary of available data regarding this subject. The scarce but consistent evidence shows that exposure to plastic nanoparticles can indeed affect both the digestive and the nervous system. Reported outcomes include microbiota alterations, intestinal barrier permeability, oxidative stress, inflammation, neurotoxicity and behavioral disturbances. Taking into consideration these alarming observations and the ubiquitous presence of plastics in human environment, more research is urgently needed in order to identify any potential threats that nanoplastic exposure can pose to the functioning of the gut-brain axis.

scholarly journals Impact of Unsteady Flow Events on Bedload Transport: A Review of Laboratory Experiments

Water ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 907 ◽  
Author(s):  
Magdalena M. Mrokowska ◽  
Paweł M. Rowiński
Keyword(s):  
Unsteady Flow ◽  
Laboratory Experiments ◽  
Current Knowledge ◽  
Bedload Transport ◽  
Ephemeral Streams ◽  
Flow Conditions ◽  
Future Directions ◽  
Alluvial Rivers ◽  
Gravel Bed Streams ◽  
The Impact

Recent advances in understanding bedload transport under unsteady flow conditions are presented, with a particular emphasis on laboratory experiments. The contribution of laboratory studies to the explanation of key processes of sediment transport observed in alluvial rivers, ephemeral streams, and river reaches below a dam is demonstrated, primarily focusing on bedload transport in gravel-bed streams. The state of current knowledge on the impact of flow properties (unsteady flow hydrograph shape and duration, flood cycles) and sediment attributes (bed structure, sediment availability, bed composition) on bedload are discussed, along with unsteady flow dynamics of the water-sediment system. Experiments published in recent years are summarized, the main findings are presented, and future directions of research are suggested.

Translating Principles of Speech Science to Clinical Practice: Current and Future Trends in Craniofacial Disorders

2008 ◽  
Vol 18 (1) ◽  
pp. 31-40 ◽  
Author(s):  
David J. Zajac
Keyword(s):  
Clinical Practice ◽  
Speech Intelligibility ◽  
Current Practice ◽  
Computer Assisted ◽  
Behavioral Management ◽  
Single Word ◽  
Future Directions ◽  
Speech Science ◽  
The Impact ◽  
Opinion Article

Abstract The purpose of this opinion article is to review the impact of the principles and technology of speech science on clinical practice in the area of craniofacial disorders. Current practice relative to (a) speech aerodynamic assessment, (b) computer-assisted single-word speech intelligibility testing, and (c) behavioral management of hypernasal resonance are reviewed. Future directions and/or refinement of each area are also identified. It is suggested that both challenging and rewarding times are in store for clinical researchers in craniofacial disorders.

Free Fatty Acid Receptors as New Potential Targets in Colorectal Cancer

2020 ◽  
Vol 21 (14) ◽  
pp. 1397-1404
Author(s):  
Adrian Bartoszek ◽  
Jakub Fichna ◽  
Aleksandra Tarasiuk ◽  
Agata Binienda ◽  
Adam Fabisiak ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Current Knowledge ◽  
Developed Countries ◽  
Future Directions ◽  
Screening Programs ◽  
Pharmacological Targets ◽  
The Family ◽  
Free Fatty Acid Receptors

Colorectal cancer (CRC) is one of the most common cancers worldwide. In developed countries, its mortality remains high, yet the prevalence has established owing to effective screening programs; however due to the westernization of lifestyle, the incidences in many other countries have increased. Although the treatment of CRC has improved in the last few years, the side effects of these approaches cannot be neglected. Recently, members of the family of free fatty acid receptors (FFARs) have become attractive pharmacological targets in many diseases, including asthma; studies also point to their role in carcinogenesis. Here, we discuss current knowledge and future directions in FFAR research related to CRC. Contradictory results of FFARs modulation may derive from the pleiotropic effects of FFAR ligands, receptor distribution and different signal transduction. Hence, we indicate directions of further studies to fully use the potential of FFARs in CRC.

Alcohol Consumption and Risk of Uterine Fibroids

2020 ◽  
Vol 20 (4) ◽  
pp. 247-258 ◽  
Author(s):  
Hajra Takala ◽  
Qiwei Yang ◽  
Ahmed M. Abd El Razek ◽  
Mohamed Ali ◽  
Ayman Al-Hendy
Keyword(s):  
Alcohol Consumption ◽  
Animal Studies ◽  
Molecular Mechanisms ◽  
Legal Status ◽  
Current Knowledge ◽  
Uterine Fibroids ◽  
Future Directions ◽  
Working Adults ◽  
The Us ◽  
Alcohol Related Problems

Lifestyle factors, such as alcohol intake, have placed a substantial burden on public health. Alcohol consumption is increasing globally due to several factors including easy accessibility of this addictive substance besides its legal status and social acceptability. In the US, alcohol is the third leading preventable cause of death (after tobacco, poor diet and physical inactivity) with an estimated 88,000 people dying from alcohol-related causes annually, representing 1 in 10 deaths among working adults. Furthermore, the economic burden of excess drinking costs the US around $249 billion ($191.1 billion related to binge drinking). Although men likely drink more than women do, women are at much higher risk for alcohol-related problems. Alcohol use is also considered to be one of the most common non-communicable diseases, which affects reproductive health. This review article summarizes the current knowledge about alcohol-related pathogenesis of uterine fibroids (UFs) and highlights the molecular mechanisms that contribute to the development of UFs in response to alcohol consumption. Additionally, the effect of alcohol on the levels of various factors that are involved in UFs pathogenesis, such as steroid hormones, growth factors and cytokines, are summarized in this review. Animal studies of deleterious alcohol effect and future directions are discussed as well.

P-glycoprotein efflux pump expression and activity in Calu-3 cells

2001 ◽  
Vol 90 (5) ◽  
pp. 645
Author(s):  
Karen O. Hamilton ◽  
Gunilla Backstrom ◽  
Mehran A. Yazdanian ◽  
Kenneth L. Audus
Keyword(s):  
Efflux Pump ◽  
P Glycoprotein ◽  
Expression And Activity

scholarly journals Current Knowledge and Future Directions for Improving Subsoiling Quality and Reducing Energy Consumption in Conservation Fields

Agriculture ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 575
Author(s):  
Shangyi Lou ◽  
Jin He ◽  
Hongwen Li ◽  
Qingjie Wang ◽  
Caiyun Lu ◽  
...  
Keyword(s):  
Energy Consumption ◽  
Cover Crops ◽  
Current Knowledge ◽  
High Energy ◽  
Field Application ◽  
Research Progress ◽  
Monitoring And Control ◽  
Future Directions ◽  
Tillage Depth ◽  
And Control

Subsoiling has been acknowledged worldwide to break compacted hardpan, improve soil permeability and water storage capacity, and promote topsoil deepening and root growth. However, there exist certain factors which limit the wide in-field application of subsoiling machines. Of these factors, the main two are poor subsoiling quality and high energy consumption, especially the undesired tillage depth obtained in the field with cover crops. Based on the analysis of global adoption and benefits of subsoiling technology, and application status of subsoiling machines, this article reviewed the research methods, technical characteristics, and developing trends in five key aspects, including subsoiling shovel design, anti-drag technologies, technologies of tillage depth detection and control, and research on soil mechanical interaction. Combined with the research progress and application requirements of subsoiling machines across the globe, current problems and technical difficulties were analyzed and summarized. Aiming to solve these problems, improve subsoiling quality, and reduce energy consumption, this article proposed future directions for the development of subsoiling machines, including optimizing the soil model in computer simulation, strengthening research on the subsoiling mechanism and comprehensive effect, developing new tillage depth monitoring and control systems, and improving wear-resisting properties of subsoiling shovels.

scholarly journals Factors Moderating the Impact of After Death Communications on Beliefs and Spirituality

2021 ◽  
pp. 003022282110291
Author(s):  
Jennifer K. Penberthy ◽  
Marieta Pehlivanova ◽  
Tevfik Kalelioglu ◽  
Chris A. Roe ◽  
Callum E. Cooper ◽  
...  
Keyword(s):  
Life Experience ◽  
Death And Dying ◽  
Emotional Reaction ◽  
Physical Contact ◽  
Fear Of Death ◽  
Future Directions ◽  
Life After Death ◽  
Moderating Factors ◽  
The Impact ◽  
Beliefs And Attitudes

After death communications(ADCs) are defined as perceived spontaneous contacts with living individuals by the deceased. This research presents on a subset of data from a recent large international survey of individuals who experienced ADCs and provided systematic information regarding these experiences. In our research we explore the impact of having an ADC on reported spirituality, religiosity, beliefs and attitudes about death and dying and also explore the moderating factors of this impact. We found that having an ADC was perceived as a positive life experience and that it was associated with a reduction in fear of death, belief in life after death and that the deceased could communicate with the living, and increased reported spirituality. Moderating factors include aspects of having or desiring physical contact with the deceased as well as perceiving some emotional reaction to the ADCs. Future directions for research exploration are also provided based on our findings.

scholarly journals Urban Fire Severity and Vegetation Dynamics in Southern California

2020 ◽  
Vol 13 (1) ◽  
pp. 19
Author(s):  
Lauren E. H. Mathews ◽  
Alicia M. Kinoshita
Keyword(s):  
Vegetation Cover ◽  
Vegetation Index ◽  
Normalized Difference Vegetation Index ◽  
Current Knowledge ◽  
Fire Severity ◽  
Satellite Image ◽  
Burn Severity ◽  
Native Vegetation ◽  
Riparian Areas ◽  
The Impact

A combination of satellite image indices and in-field observations was used to investigate the impact of fuel conditions, fire behavior, and vegetation regrowth patterns, altered by invasive riparian vegetation. Satellite image metrics, differenced normalized burn severity (dNBR) and differenced normalized difference vegetation index (dNDVI), were approximated for non-native, riparian, or upland vegetation for traditional timeframes (0-, 1-, and 3-years) after eleven urban fires across a spectrum of invasive vegetation cover. Larger burn severity and loss of green canopy (NDVI) was detected for riparian areas compared to the uplands. The presence of invasive vegetation affected the distribution of burn severity and canopy loss detected within each fire. Fires with native vegetation cover had a higher severity and resulted in larger immediate loss of canopy than fires with substantial amounts of non-native vegetation. The lower burn severity observed 1–3 years after the fires with non-native vegetation suggests a rapid regrowth of non-native grasses, resulting in a smaller measured canopy loss relative to native vegetation immediately after fire. This observed fire pattern favors the life cycle and perpetuation of many opportunistic grasses within urban riparian areas. This research builds upon our current knowledge of wildfire recovery processes and highlights the unique challenges of remotely assessing vegetation biophysical status within urban Mediterranean riverine systems.

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