scholarly journals Prevalence of Polycystic Ovary Syndrome Awareness Among Female Medical Students

2020 ◽  
Vol 3 ◽  
pp. e10
Author(s):  
Hamyel Tahir ◽  
◽  
Amna Hassan ◽  
Qudsia Umaira Khan ◽  
Farida Hafeez ◽  
...  
Keyword(s):  
Medical Students ◽  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Follicular Development ◽  
World Health ◽  
Ethical Review ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Health Organization

Background: Polycystic ovary syndrome is one of the most common causes of infertility in woman, affecting 4-18% of reproductive aged women worldwide. It is characterized by hormonal imbalance leading to reproductive, metabolic and psychological dysfunction. It is a multi-organ syndrome affecting both female gonads and the pituitary gland. Polycystic ovary syndrome is idiopathic in occurrence. However, recent studies suggest that it can be caused by inherent abnormalities of ovarian steroidogenesis, follicular development, excessive gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH), and reduced follicle stimulating hormone (FSH) secretion. Objectives: To evaluate the knowledge and level of awareness of female students about polycystic ovary syndrome. To determine the prevalence of the symptoms of polycystic ovary syndrome. Methods: A cross sectional type of quantitative study was conducted following the approval from the Ethical Review Committee. The study was carried out on a sample of medical students, with a calculated sample size of 278 individuals according to the World Health Organization (WHO) formula. A questionnaire-based survey was implemented. Results: The most important question was regarding the awareness of polycystic ovary syndrome and to our interest 74.5% of the participants were aware of the disease. 42.2% of the participants gained knowledge of the disease from social media and the internet. The diagnosed cases of polycystic ovary syndrome in the sample was 11.2%, among which 41.9 % are receiving the treatment. Conclusion: The majority of the female medical students (74.5%) were aware of polycystic ovary syndrome in female medical students. 33.8% of the participants had a normal menstrual cycle of 28 days. A noticeable percentage of students had polycystic ovary syndrome and were under treatment. Our study can be further used to determine relations between polycystic ovary syndrome and a variety of factors, such as the duration of menstrual cycle, body mass index (BMI) or symptoms of this syndrome, such as the weight gain and acne.

Clinical and Hormonal Profile of Polycystic Ovary Syndrome

2009 ◽  
Vol 1 (2) ◽  
pp. 22-25
Author(s):  
Ferdousi Begum
Keyword(s):  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Insulin ◽  
Pcos Patient ◽  
Serum Prolactin ◽  
Transvaginal Sonography ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Hormonal Profile

ABSTRACT Objectives The objectives of the study were to find out the clinical features, biochemical and hormonal profile of patients with polycystic ovary syndrome (PCOS) in Bangladesh. Material and Methods A case control and cross-sectional study was undertaken among 78 PCOS patients attending infertility clinic and 33 controls at BIRDEM Hospital, Dhaka. Inclusion criteria for cases were oligo/amenorrhea, transvaginal sonography suggesting PCO and/ or features of hyperandrogenemia with exclusion of other causes. Controls were women with regular menstrual cycle. Results Age and height of cases and controls were similar. BMI >25 was 67% among cases and 19% among controls (P<0.001); waist hip ratio >0.8 was 64% among cases and 29% among controls (P<0.001). Mean BMI of cases was 28.2 + 4.5 and that of cases was 21.05 + 4.1; mean fasting glucose among cases was 5.93 + 1.08 and among controls was 4.4 + 1.11 mmol/L (P<0.01); mean fasting serum insulin level was 32.15+ 12.13 among cases was 11.32 +10.02 ìU/ml among controls(P<.001); insulin resistance (fasting HOMA-IR>6.8) was 42.32% in cases and 12% in control (P<.001). Patients with PCOS had following clinical and biochemical parameters: oligomenorrhea- 74%, amenorrhea- 26%, mean Ferriman-Galaway score -19.89 + 5.06. At day 3 of menstrual cycle meanserum LH was 12.79+7.1 mmol/L, serum FSH was 5.23 + 2.5 miu/ml and serum prolactin was 415.15+180.5 mmol/L; 30% had biochemical hyperandrogenemia. Conclusions PCOS patient in Bangladesh are usually overweight, hirsute (grade I and II), hyperandrogenemic, insulin resitant and have altered LH to FSH ratio.

scholarly journals POTENSI PENGGUNAAN METFORMIN SEBAGAI SUPLEMENTASI DIET PADA OBESITAS

2020 ◽  
Vol 8 (1) ◽  
pp. 38-43
Author(s):  
Harry Salomo
Keyword(s):  
Side Effects ◽  
Protein Kinase ◽  
Polycystic Ovary Syndrome ◽  
World Health Organization ◽  
Polycystic Ovary ◽  
Activity Patterns ◽  
World Health ◽  
Ovary Syndrome ◽  
Health Organization ◽  
Amp Activated Protein Kinase

ABSTRAK  Pendahuluan: Obesitas merupakan kondisi yang disebabkan oleh ketidakseimbaangan energi baik asupan maupun pola aktivitas fisik, dimana menurut World Health Organization (WHO) diartikan sebagai Indeks Massa Tubuh (IMT) ≥30 dan ≥25,00 pada kategori Asia. Obesitas merupakan permasalahan global, lebih lagi di Indonesia sedang terjadi peningkatan drastis, yaitu peningkatan 50% pada laki–laki dan 100% pada perempuan. Obesitas merupakan faktor risiko berbagai macam penyakit. Teori mengenai obesitas dan hiperinsulinemia ini masih menjadi kontroversi di kalangan peneliti tentang mana yang terjadi lebih dahulu, tetapi berdasarkan penelitian diet tinggi lemak mengakibatkan hiperinsulinemia yang lebih lanjut mengakibatkan obesitas. Manapun yang terlebih dahulu, yang jelas terdapat keadaan hiperinsulinemia pada obesitas. Pembahasan: Kondisi hiperinsulinemia ini bisa diinterupsi lebih lanjut dengan obat yang meningkatkan sensitivitas yaitu metformin. Mekanisme kerja metformin sebenarnya belum dipahami penuh, namun terdapat aktivasi AMP-activated Protein Kinase (AMPK) yang lebih lanjut mempengaruhi keseimbangan energi melalui berbagai jalur. Sebagai suplementasi metformin tergolong aman dan telah terbukti pada penggunaan jangka panjang, efek samping yang ditimbulkan biasanya ringan pada saluran pencernaan, efek samping berat asidosis laktat sangat jarang terjadi. Kesimpulan: Penggunaan metformin untuk menangani obesitas sebenarnya sudah sangat luas terutama pada pasien Polycystic Ovary Syndrome (PCOS), dan berbagai penelitian telah menunjukkan penurunan yang tidak besar namun signifikan .  Kata Kunci: AMPK, IMT, obesitas, metformin  ABSTRACT  Introduction: Obesity is a condition caused by energy disruption of both intake and physical activity patterns, which World Health Organization (WHO) defined as Body Mass Index (BMI) ≥30 dan ≥25.00 in Asian category. Obesity is a global problem, moreover in Indonesia there is a drastic increase, about 50% increase in men and 100% in women. Obesity is a risk factor for various diseases. The theory of obesity and hyperinsulinemia is still controversy among researchers about which one is happening first, but based on  studies  high-fat diet leads to hyperinsulinemia which further leads to obesity. Whichever comes first, clearly there is a state of hyperinsulinemia in obesity. Discussion:  This hyperinsulemia condition can be interrupted by drugs that capable to increase the sensitivity of metformin. The mechanism of action of metformin is not yet fully understood, but there is activation of AMP-activated protein kinase (AMPK) which further affects the energy balance through multiple pathways. As metformin supplementation is safe and has been known to be of long-term use, side effects are usually mild on the gastrointestinal tract, and severe side effects of lactic acidosis are very rare. Conclusion: The use of metformin for dealing with obesity has actually been very wide especially in patients with Polycystic Ovary Syndrome (PCOS), and various studies have shown a not great but significant decrease of body weight.  Keywords: AMPK, BMI, obesity, metformin

scholarly journals Manifestations of Polycystic Ovary Syndrome are Similar Regardless of the Degree of Menstrual Cycle Variation

2022 ◽  
Vol 6 (1) ◽  
pp. 96
Author(s):  
Begum Moriom Zamila ◽  
Hurjahan Banu ◽  
Md Shahed Morshed ◽  
Sukanti Shah ◽  
Afroza Begum ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Control Group ◽  
Menstrual Irregularity ◽  
Glycerol Phosphate ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Regular Cycle

Background: Menstrual irregularities may predict over adverse consequences in polycystic ovary syndrome (PCOS).Objective: To observe the relation of variants of menstrual cycles with clinical and biochemical features of PCOS.Methods: This cross-sectional study encompassed 200 PCOS women diagnosed by Rotterdam criteria and 120 age-matched healthy controls. Subgroups were classified according to menstrual cycle length as: polymenorrheic (<21 days), eumenorrheic (21-35 days), oligomenorrheic (36 days-3 months) and amenorrheic (>3 months). Glucose was measured by glucose oxidase, lipid by glycerol phosphate dehydrogenenase-peroxidase and all hormones by chemiluminescent immuno-assay method.Results: Around 86% of PCOS patients had menstrual irregularity, among which 75% had oligomenorrhea followed by amenorrhea (9%) and polymenorrhea (2%). All the subgroups of PCOS patients (polymenorrhea excluded from further analyses) had significantly poor metabolic manifestations than the control namely insulin resistance (IR), impaired glycaemic status, general and central obesity, metabolic syndrome and dyslipidaemia. Acanthosis nigricans (AN), hyperandrogenemia (HA) and IR had significant predictive association with PCOS patients with both irregular [OR (95% CI)- AN: 21.994 (6.427, 75.267), p<0.001; HA: 27.735 (8.672, 88.704), p<0.001; IR: 7.268 (2.647, 19.954), p<0.001] and regular cycle [AN: 16.449 (3.830, 70.643), p<0.001; HA: 24.635 (6.349, 95.590), p<0.001; IR: 6.071 (1.658, 22.234), p=0.006] in reference to control group. None of the variables had significant predictive associations with irregular cycle in reference to regular cycle in patients with PCOS.Conclusion: Oligomenorrhea was the most common variant of menstrual irregularity in PCOS patients. All menstrual variants including eumenorrhea had similar manifestations in PCOS women, but poorer than controls.International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 96-103

scholarly journals Sexuality in women with polycystic ovary syndrome: a pilot study

2010 ◽  
Vol 8 (4) ◽  
pp. 397-403 ◽  
Author(s):  
Jucilene Sales da Paixão Silva ◽  
Angela Maggio da Fonseca ◽  
Vicente Renato Bagnoli ◽  
Ana Lucia Cavalcanti ◽  
José Maria Soares Jr ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Sexual Satisfaction ◽  
Sexual Partner ◽  
Polycystic Ovary ◽  
Clinical Aspects ◽  
Clinical Parameters ◽  
Ovary Syndrome ◽  
Cross Sectional

ABSTRACT Objective: The objective of this study was to evaluate the sexual behavior of women with polycystic ovary syndrome and the relationship between sexual behavior and the clinical parameters related to this syndrome (obesity, hirsutism and menstrual irregularities). Methods: A cross-sectional study was carried out involving 48 women with polycystic ovary syndrome. The evaluation was based on the complaints reported by the women with particular emphasis on sexual satisfaction, the presence of a sexual partner, phases of the sexual response cycle (desire, arousal, orgasm and resolution phases), sexual frequency, practice of masturbation, evaluation of less usual sexual habits, degree of intimacy and the quality of communication in the women's involvement with their sexual partner. The variables of sexual behavior (sexual satisfaction, masturbation, sexual fantasies, frequency of desire, arousal and orgasm) were compared with three clinical parameters: menstrual cycle, hirsutism and body mass index (BMI). Results: The sexual initiation, ways of expressing sexuality, communication and intimacy with partner and sexual satisfaction were not influenced by the clinical aspects of the syndrome. With respect to association of polycystic ovary syndrome clinical parameters with sexual behavior, a statistically significant correlation was found with the menstrual cycle. Conclusion: The absence of menstruation affected sexual interest in activities not involving the partner, thus increasing the frequency of masturbation.

scholarly journals Is polycystic ovary syndrome appropriately diagnosed by obstetricians and gynaecologists across China: a nationwide survey

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Deng Yan ◽  
Wang Yan-Fang ◽  
Zhu Shi-Yang ◽  
Ma Rui-Lin ◽  
Ding Xue-Song ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Diagnostic Criteria ◽  
Polycystic Ovary ◽  
Final Analysis ◽  
Nationwide Survey ◽  
Care Quality ◽  
Cross Sectional Survey ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Rotterdam Criteria

Abstract Background To describe the diagnostic criteria used and their application accuracy in the practice of polycystic ovary syndrome (PCOS) caring among obstetricians and gynaecologists across China. Methods This was an Online cross-sectional survey of Obstetricians and gynecologists involved in PCOS caring conducted via the largest continuing education platform of obstetrics and gynecology across China from September 2019 to November 2019. Results A total of 2,328 respondents were eligible for the final analysis. Of these, 94.5 % were general obstetricians and gynaecologists (Ge-ObGyn), and 5.5 % were reproductive endocrinologists (Re-ObGyn). Overall, the most frequently used criteria were the Androgen Excess and Polycystic Ovary Syndrome Society (AE-PCOS) criteria (48.2 %), followed by the Rotterdam criteria (35.7 %) and NIH criteria (12.1 %). Of the respondents, 31.3 % used their diagnostic criteria in their clinical practice. More respondents who chose the Rotterdam criteria could accurately apply the diagnostic criteria than those who chose the AE-PCOS criteria (41.2 % vs. 32.1 %, P < 0.001). Compared with Ge-ObGyn, Re-ObGyn were less likely to use the AE-PCOS criteria (adjusted odds ratio, 0.513; 95 % CI, 0.328–0.802; P < 0.05) and 1.492 times more likely to accurately use their criteria (95 % CI, 1.014–2.196; P < 0.05). Conclusions Less than one-third of obstetricians and gynaecologists across China could accurately use the diagnostic criteria they choose to diagnose PCOS. There is an urgent need to train obstetricians and gynaecologists on PCOS diagnosis in an effort to improve the medical care quality of patients with PCOS.

scholarly journals Efficacy of Bushen Huatan Decoction combined with Baduanjin in the treatment of polycystic ovary syndrome with insulin resistance (IR-PCOS), kidney deficiency and phlegm dampness: study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Haiqing Qian ◽  
Wenting Xu ◽  
Lijuan Cui ◽  
Rong Wang ◽  
Jiahui Wang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Randomized Controlled Trial ◽  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Controlled Trial ◽  
Close Monitoring ◽  
Ovary Syndrome ◽  
Kidney Deficiency ◽  
Randomized Controlled

Abstract Background Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women. Insulin resistance (IR) has emerged as a central contributor to the pathogenesis of this disease. According to traditional Chinese medicine (TCM), kidney deficiency is the main syndrome of PCOS. The deficiency of the kidney cannot vaporize water-dampness, and the retention of water-dampness accumulates into phlegm dampness stagnation, resulting in visceral dysfunction and metabolic disorder. TCM involving syndrome differentiation and treatment is widely used to adjust women’s menstrual cycles. Our patented formula Bushen Huatan Decoction (BSHTD) has been proven to be effective in the clinical treatment of IR-PCOS. Baduanjin also plays an important role in improving metabolic syndrome through lifestyle intervention. This study investigates the clinical efficacy of Bushen Huatan Decoction combined with Baduanjin in IR-PCOS, to form a specific TCM-behaviour intervention plan in the treatment of IR-PCOS. Methods/design This is a randomized controlled trial involving 190 participants diagnosed with IR-PCOS. All participants will be randomly allocated into 5 groups: group A will receive metformin; group B, BSHTD; group C, Baduanjin; group D, BSHTD combined with metformin; and group E, BSHTD combined with Baduanjin. One course of treatment lasts 3 months, a total of two courses. The primary outcomes are changes in the homeostatic model assessment of insulin resistance (HOMA-IR) and improvements in the oral glucose tolerance test (OGTT) and insulin-releasing test (INS). The secondary outcomes are improvements in the menstrual cycle, ovulation rate, clinical pregnancy rate, basic serum sex hormone levels, free androgen index (FAI), Ferriman-Gallwey scores, body mass index (BMI) and TCM syndrome scores. The related observation indexes will be collected at baseline, during the process of treatment and at the 6-month follow-up. Simultaneously, close monitoring of possible adverse events will be performed throughout the trial process. Discussion This trial will investigate the efficacy of the comprehensive intervention program of Bushen Huatan Decoction combined with Baduanjin on the adjustment of the menstrual cycle, improvement of insulin resistance and correction of glucose metabolism disorder in IR-PCOS patients. It is expected to form an alternative treatment of TCM-behaviour intervention therapy for IR-PCOS and promote the Chinese fitness Qigong Baduanjin in the application of lifestyle diseases. Trial registration Chinese Clinical Trial Registry ChiCTR2100043415. Registered on 15 February 2021.

scholarly journals Link between autoimmune hypothyroidism and polycystic ovary syndrome.

2020 ◽  
Vol 27 (09) ◽  
pp. 1804-1808
Author(s):  
Anam Rehman ◽  
Shireen Jawed ◽  
Amna Rashid Tariq
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Thyroid Function ◽  
Polycystic Ovary ◽  
Thyroid Autoimmunity ◽  
Study Groups ◽  
Thyroid Peroxidase ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Autoimmune Hypothyroidism ◽  
Thyroid Peroxidase Antibody

Objectives: Polycystic ovary syndrome (PCOS) is a rampant endocrine disorder distressing women of child bearing age worldwide. Many current researches have detected the presence of some organ specific and non-specific autoantibodies in females with PCOS. Study Design: Cross Sectional study. Setting:  Aziz Fatimah Hospital, Faisalabad, Pakistan. Period: April to September 2017. Material & Methods: This study comprised of 88 female subjects of 17-35 years old. Participants were divided into four group’s i.e PCOS obese females, PCOS non-obese, obese females without PCOS and age matched controls. Thyroid function was evaluated by the measurement of serum TSH, FT3 and FT4 levels. Thyroid peroxidase antibody was detected as an indicator of thyroid autoimmunity. All parameters were measured by chemiluminescence immunoassay technique (CLIA). SPSS version 22 was used for the statistical analysis of the data. Results: Out of total 88 female participants, 38.6% were hypothyroid and 61.4% were euthyroid females. While on comparing the percentages of hypothyroidism among the study groups PCOS, non-PCOS patients and obese we found higher percentages of hypothyroidism among non-obese PCOS. Thyroid peroxidase antibody levels were higher in PCOS obese subjects. PCOS patients have 15 times more risk for hypothyroidism as compared to non-PCOS patients. Conclusion: Hypothyroidism was commonly found in PCOS patients with high levels of TPO-Antibody indicating that PCOS is an independent risk factor for hypothyroidism which suggests that evaluation of thyroid function and autoimmunity must be deliberated in PCOS patients.

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