Los Angeles’s 1863–1876 Boom

2017 ◽  
Vol 99 (2) ◽  
pp. 140-183
Author(s):  
Alexander Finkelstein
Keyword(s):  
Los Angeles ◽  
Urban Infrastructure ◽  
Health Claims ◽  
Cultural Institutions ◽  
Legal Cases ◽  
New Era ◽  
Political Scene ◽  
The Way

This article identifies the 1863–1876 period in Los Angeles as a boom, preceding the better-known boom of the 1880s. The author attributes the early boom to the 1860s drought and the costly legal cases stemming from the Land Act of 1851 that, together, decimated the Mexican-era ranchos and the cattle economy. Los Angeles entered a new era based on farming, health claims, growth, and boosterism fostered by a Euro-American network of opportunists who shaped the new political scene and economy, built a new urban infrastructure, and formed new social and cultural institutions. Along the way they created a racialized geography dominated by Euro-Americans.

News Briefing - Comms: 5G paving the way for a new era of connectivity

2018 ◽  
Vol 13 (3) ◽  
pp. 11-11
Author(s):  
J. Loughran
Keyword(s):  
New Era ◽  
The Way

scholarly journals Recent Advances in Single-Cell Profiling and Multispecific Therapeutics: Paving the Way for a New Era of Precision Medicine Targeting Cardiac Fibroblasts

2021 ◽  
Vol 23 (7) ◽  
Author(s):  
Sally Yu Shi ◽  
Xin Luo ◽  
Tracy M. Yamawaki ◽  
Chi-Ming Li ◽  
Brandon Ason ◽  
...  
Keyword(s):  
Heart Failure ◽  
Precision Medicine ◽  
Single Cell ◽  
Cardiac Fibroblasts ◽  
Rapid Development ◽  
Cardiac Fibroblast ◽  
New Era ◽  
Fibroblast Activation ◽  
Cell Gene Expression ◽  
The Way

Abstract Purpose of Review Cardiac fibroblast activation contributes to fibrosis, maladaptive remodeling and heart failure progression. This review summarizes the latest findings on cardiac fibroblast activation dynamics derived from single-cell transcriptomic analyses and discusses how this information may aid the development of new multispecific medicines. Recent Findings Advances in single-cell gene expression technologies have led to the discovery of distinct fibroblast subsets, some of which are more prevalent in diseased tissue and exhibit temporal changes in response to injury. In parallel to the rapid development of single-cell platforms, the advent of multispecific therapeutics is beginning to transform the biopharmaceutical landscape, paving the way for the selective targeting of diseased fibroblast subpopulations. Summary Insights gained from single-cell technologies reveal critical cardiac fibroblast subsets that play a pathogenic role in the progression of heart failure. Combined with the development of multispecific therapeutic agents that have enabled access to previously “undruggable” targets, we are entering a new era of precision medicine.

Cicero and Milo

1974 ◽  
Vol 64 ◽  
pp. 62-78 ◽  
Author(s):  
A. W. Lintott
Keyword(s):  
Civil War ◽  
Rule Of Law ◽  
The State ◽  
The Political ◽  
New Era ◽  
The Rule Of Law ◽  
Political Position ◽  
The Republic ◽  
Political Realignment ◽  
Political Scene

The battle of Bovillae on 18th January, 52 B.C., which led to Clodius' death, was literally treated by Cicero in a letter to Atticus as the beginning of a new era—he dated the letter by it, although over a year had elapsed. It is difficult to exaggerate the relief it afforded him from fear and humiliation for a few precious years before civil war put him once more in jeopardy. At one stroke Cicero lost his chief inimicus and the Republic lost a hostis and pestis. Moreover, the turmoil led to a political realignment for which Cicero had been striving for the last ten years—a reconciliation between the boni and Pompey, as a result of which Pompey was commissioned to put the state to rights. Cicero's behaviour in this context, especially his return to the centre of the political scene, is, one would have thought, of capital importance to the biographer of Cicero. Yet two recent English biographies have but briefly touched on the topic. It is true that, in the background of Cicero's personal drama, Caesar and Pompey were taking up positions which, as events turned out, would lead to the collapse of the Republic. However, Cicero and Milo were not to know this, nor were their opponents; friendly cooperation between the two super-politicians apparently was continuing. Politicians on all sides were still aiming to secure power and honour through the traditional Republican magistracies, and in this pursuit were prepared to use the odd mixture of violence, bribery and insistence on the strict letter of the constitution, which was becoming a popular recipe. In retrospect their obsession with the customary organs of power has a certain irony. Yet it is a testimony to the political atmosphere then. Their manoeuvres are also important because both the instability caused by the violence of Clodius and Milo, and the eventual confidence in the rule of law established under Pompey's protection, helped to determine the political position of the boni associated with Pompey in 49 B.C. Cicero's relationship with Milo is at first sight one of the more puzzling aspects of his career. What had they in common, except that Milo, like most late Republican politicians, was at one time associated with Pompey? Properly interpreted, however, this relationship may not only illuminate Cicero's own attitudes but illustrate the character of the last years of Republican politics.

scholarly journals Exploration of the Way out for Education Reform Based on the Status Quo of Chinese and Foreign Education Systems

2018 ◽  
Vol 2 (2) ◽  
pp. 37
Author(s):  
Yifan Wang
Keyword(s):  
Education Reform ◽  
Education System ◽  
Status Quo ◽  
New Era ◽  
The Status ◽  
Practical Reality ◽  
The Government ◽  
Foreign Education ◽  
Education In China ◽  
The Way

 Against the backdrop of growing national strength and rapid economic development, the government has placed more emphasis on education. In recent years, remarkable achievements have been registered in terms of education in China, which lays a solid foundation for cultivating comprehensive professionally-trained personnel in the new era. However, the current education system is ridden with many setbacks and problems. This paper conducts an analysis of the specific conditions of education both at home and abroad, status quo of education in China, makes some reflections on the direction and measures of China's education reform based on the practical reality of education in China. Measures should be taken to inject personalities into the traditional, exam-oriented education system, which keeps pace with the new era. As is known to all, it's important to strike a balance between public education and non-government funded education in a scientific and reasonable manner. The overhauling of traditional education policies will pave the way for China's educational renaissance and realize the great blueprint of the Chinese dream. 

scholarly journals Cashless Economy in India: Challenges Ahead

2020 ◽  
Vol 8 (1) ◽  
pp. 21-30
Author(s):  
Aslam Hasan ◽  
Mohammed Atif Aman ◽  
Mohd Ashraf Ali
Keyword(s):  
Money Laundering ◽  
Central Government ◽  
Online Banking ◽  
Electronic Payment ◽  
Payment Systems ◽  
New Era ◽  
Digital Money ◽  
The Way

In an attempt to curb-out black money, money laundering, and to have a sound economy, the central government of India has embarked on the cashless economy. It is the birth of a new era in the nation with life with digital money. This paper is going to conceptualize the meaning of a cashless system, explains online banking techniques in India, schemes by government to spread the cashless system in India and highlights the challenges of the cashless economy and electronic payment systems. The objective of this study is to examine the significant challenges that are faced by Indians on the way towards cashless. To achieve the objectives of this exploratory type of personal study, interviews will be conducted.

scholarly journals Are peptide conjugates the golden therapy against obesity?

2018 ◽  
Vol 238 (2) ◽  
pp. R109-R119 ◽  
Author(s):  
S J Brandt ◽  
M Kleinert ◽  
M H Tschöp ◽  
T D Müller
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Small Subset ◽  
New Era ◽  
Beneficial Effects ◽  
New Class ◽  
Sustained Weight Loss ◽  
Obesity Therapy ◽  
Glucagon Like Peptide 1 ◽  
The Way

Obesity is a worldwide pandemic, which can be fatal for the most extremely affected individuals. Lifestyle interventions such as diet and exercise are largely ineffective and current anti-obesity medications offer little in the way of significant or sustained weight loss. Bariatric surgery is effective, but largely restricted to only a small subset of extremely obese patients. While the hormonal factors mediating sustained weight loss and remission of diabetes by bariatric surgery remain elusive, a new class of polypharmacological drugs shows potential to shrink the gap in efficacy between a surgery and pharmacology. In essence, this new class of drugs combines the beneficial effects of several independent hormones into a single entity, thereby combining their metabolic efficacy to improve systems metabolism. Such unimolecular drugs include single molecules with agonism at the receptors for glucagon, glucagon-like peptide 1 and the glucose-dependent insulinotropic polypeptide. In preclinical studies, these specially tailored multiagonists outperform both their mono-agonist components and current best in class anti-obesity medications. While clinical trials and vigorous safety analyses are ongoing, these drugs are poised to have a transformative effect in anti-obesity therapy and might hopefully lead the way to a new era in weight-loss pharmacology.

Introduction

2005 ◽  
Author(s):  
T. C. Smout
Keyword(s):  
Nineteenth Century ◽  
Eighteenth Century ◽  
The Political ◽  
The People ◽  
Short Run ◽  
Political Scene ◽  
The Way

This book presents an overview of the first six decades of the Union of the Crowns. It also provides a picture of the uses to which judicial torture was put after 1660 and a summary of the straits in which Scotland found itself in the opening years of the eighteenth century. It then explores the problems which union posed to maritime lawyers of both nations, the dark reception that the Scots received in eighteenth-century England, and the way Enlightenment Scotland viewed the British unions. It examines the ambitions of Scottish élites in India, the frame for radical cooperation in the age of the Friends of the People and later, and the background for the sojourn of Thomas and Jane Carlyle in London. It finally outlined the Anglo-Scottish relations on the political scene in the nineteenth century. The parliamentary union did little in the short run for Anglo-Scottish relations. It is shown that Scots are indeed worried and worry a lot about Anglo-Scottish relations, but the English worried and worry about them hardly at all, except in times of exceptional crisis, as in 1638–54, 1703–7, 1745–7 and perhaps much later in the 1970s after oil had been discovered.

The Ford Sewing machinists’ strike, Dagenham, 1984–85

2019 ◽  
pp. 139-163
Author(s):  
Jonathan Moss
Keyword(s):  
Gender Equality ◽  
Turning Point ◽  
Women's Work ◽  
New Era ◽  
Female Workers ◽  
Women’S Work ◽  
Trade Unionism ◽  
Women's Experiences ◽  
The Way

This final chapter returns to Ford, Dagenham to analyse the second strike that was organised by female sewing-machinists for skill recognition in the winter of 1984-1985. Whilst the 1968 strike analysed in chapter 2 was optimistically hailed as a turning point symbolising a new era of gender equality, the sewing-machinists were dissatisfied because the skilled nature of their work was not recognised. For the women at Ford, the underlying grading grievance and the sense of injustice that led to the 1968 dispute continued to shape their experiences of work and trade unionism for the next 17 years. This dispute marks an appropriate place to begin to draw some broader conclusions about women’s experiences of workplace activism between 1968 and 1985. The Ford sewing-machinists’ eventual success in winning their grading intimates a transition had occurred in the way women’s work was valued in the intervening 17 years between the strikes – at least within the Ford factory. Drawing upon contemporary representations of the dispute and interviews with women involved, this final chapter considers whether the women themselves believed the strike represented a change in attitudes towards female workers.

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