scholarly journals Evaluation of Plasma D-Dimer Concentration Among Normal and Complicated Pregnancies, Saudi Arabia

2018 ◽  
Vol 7 (1) ◽  
pp. 17-23
Author(s):  
Rana Zaini ◽  
Amani Al-Rehaili ◽  
Rahma Kufia
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Latex Agglutination ◽  
Multiple Pregnancies ◽  
Third Trimester ◽  
Pregnant Females ◽  
The Relationship ◽  
Effect Of Age ◽  
D Dimer ◽  
Latex Agglutination Assay

Objectives: The purpose of the current work is to evaluate D-dimer plasma level among both normal and complicated pregnancies such as gestational diabetes (GD) and hypertension (GH) among Saudi females. It is also focused on exhibiting any possible factors that could also play a role in rising D-dimer levels besides the age of the pregnant woman and the period of gestation. Materials and Methods: A semi-quantitative latex agglutination assay was performed in the blood sample of healthy non-pregnant, pregnant and pregnant females with GD and GH. Results: The results exhibited that 92% of pregnancies with GH and 90% of multiple pregnancies had high D-dimer levels. The analysis of the effect of age of pregnant women on D-dimer concentrations presented that 100% of pregnant women with GD, GH or multiple pregnancies aged above 40, had high levels of D-dimer. The results of the relationship between gestational age of pregnancies and D-dimer showed that by reaching the third trimester, about 66.6% of women who had multiple pregnancies had D-dimer concentration above 2000 ng/mL. Interestingly, all the pregnant females with GH had D-dimer concentrations above 2000 ng/mL. Conclusions: This study postulated that the concentrations of D-dimer significantly increase during pregnancy associated with common complications such as GD and GH. It is the first study to demonstrate the possible risk factors during pregnancy, which include age, number of pregnancies, gestational age and pregnancies with GD and GH, especially among Saudi Arabian women.

scholarly journals Relationship Between Gestational Age and Severity of Gingivitis

2019 ◽  
Vol 6 (2) ◽  
pp. 126-129
Author(s):  
Dhandi Wijaya ◽  
Nur Adiba Hanum ◽  
Asih Handayani
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Cross Sectional Study ◽  
Hormonal Changes ◽  
Test Results ◽  
Third Trimester ◽  
Cross Sectional ◽  
Exact Test ◽  
The Relationship ◽  
Excessive Inflammatory Response

Increased levels of the hormones estrogen and progesterone in the blood during pregnancy can cause gingivitis due to vascular changes that cause the gingiva to become more sensitive especially to toxins and other irritants, such as plaques and calculus, which causes the gingiva to become easily inflamed. Pregnancy can also aggravate gingivitis due to the excessive inflammatory response of the gingiva to dental plaque and hormonal changes that occur during pregnancy. This study aims to determine the differences in the degree of gingivitis in pregnant women in each trimester of gestational age. This study was a cross-sectional study conducted in April 2019 on 80 pregnant women with gingivitis who examined their pregnancies at the Puskesmas Merdeka Palembang during the fourth week of March 2019. The relationship between the degree of gingivitis in each trimester of pregnancy was analyzed using Fisher's exact test with 95% confidence interval. The results showed that gingivitis was found most frequently in third trimester pregnancy (47.5%) and mild gingivitis, mostly experienced by pregnant women in trimester II pregnancy (52.6%), while moderate and severe gingivitis was more experienced by trimester pregnant women III (50% and 81.8%). The statistical test results showed a significant relationship between the gestational age and severity of gingivitis (p 0.05). It can be concluded that increasing gestational age is related to the increasing severity of gingivitis.

Thrombin generation, D-dimer and protein S in uncomplicated pregnancy

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
Mirjana K. Kovac ◽  
Sanja Z. Lalic-Cosic ◽  
Jelena M. Dmitrovic ◽  
Valentina J. Djordjevic ◽  
Dragica P. Radojkovic
Keyword(s):  
Pregnant Women ◽  
Reference Values ◽  
Gestational Age ◽  
Protein S ◽  
First Trimester ◽  
Second Trimester ◽  
Third Trimester ◽  
The Third ◽  
D Dimer ◽  
Protein S Activity

AbstractGestational age-specific reference values are essential for the accurate interpretation of haemostatic tests during pregnancy.Our 1-year prospective study included 40 healthy pregnant women with a median age of 30 (range 22–40) years; the subjects were followed in order to establish the gestational age dependent values for endogenous thrombin potential (ETP), D-dimer and protein S (activity and free).During the first trimester 50% of studied women had ETP >100% (reference values out of pregnancy); in the second trimester an ETP over 100% was observed in all women; ETP values remained unchanged during the third trimester. In the first trimester, the median D-dimer concentration of 0.30 mg/L, in the second 0.91 mg/L and in the third of 1.45 mg/L were observed. During the first trimester 14/40 subjects had protein S activity below reference range (<59%, out of pregnancy); the median value of 61.35; interquartile range (IQR) 20.38; in the second 21/37; the median value of 53.1 (IQR 15.65); in the third trimester 28/37 had low level of protein S activity with the median value of 49.0 (IQR 18.8). Free protein S showed a slight decrease from the first trimester; it remained almost stable during the rest of pregnancy, with the equal number of pregnant women with reduced free protein S.Related to the gestational age, a significant increase of ETP and D-dimer, from the second trimester was observed; the decrease of protein S was observed already from the early pregnancy, with more pronounced variability of protein S activity.

The sFlt-1 to PlGF Ratio in Pregnant Women with Rheumatoid Arthritis: Impact of Disease Activity and Sulfasalazine Use

Rheumatology ◽  
2021 ◽  
Author(s):  
Rugina I Neuman ◽  
Hieronymus T W Smeele ◽  
A H Jan Danser ◽  
Radboud J E M Dolhain ◽  
Willy Visser
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
Disease Activity ◽  
Pregnant Women ◽  
Gestational Age ◽  
Third Trimester ◽  
Low Disease Activity ◽  
The Third ◽  
Observational Prospective Cohort Study ◽  
Plgf Ratio

Abstract Objectives An elevated sFlt-1/PlGF-ratio has been validated as a significant predictor of preeclampsia, but has not been established in women with rheumatoid arthritis (RA). We explored whether the sFlt-1/PlGF-ratio could be altered due to disease activity in RA, and could be applied in this population to predict preeclampsia. Since sulfasalazine has been suggested to improve the angiogenic imbalance in preeclampsia, we also aimed to examine whether sulfasalazine could affect sFlt-1 or PlGF levels. Methods Making use of a nationwide, observational, prospective cohort study on pregnant women with RA, sFlt-1 and PlGF were measured in the third trimester. A total of 221 women, aged 21–42 years, were included, with a median gestational age of 30 + 3 weeks. Results No differences in sFlt-1 or PlGF were observed between women with high, intermediate or low disease activity (p= 0.07 and p= 0.41), whereas sFlt-1 and PlGF did not correlate with DAS28-CRP score (r=-0.01 and r=-0.05, respectively). Four (2%) women with a sFlt-1/PlGF-ratio ≤38 developed preeclampsia in comparison to three (43%) women with a ratio &gt; 38, corresponding to a negative predictive value of 98.1%. Sulfasalazine users (n = 57) did not show altered levels of sFlt-1 or PlGF in comparison to non-sulfasalazine users (n = 164, p= 0.91 and p= 0.11). Conclusion Our study shows that in pregnant women with RA, the sFlt-1/PlGF-ratio is not altered due to disease activity and a cut-off ≤38 can be used to exclude preeclampsia. Additionally, sulfasalazine use did not affect sFlt-1 or PlGF levels in this population.

scholarly journals A Sonographic Study on Estimating of Gestational Age by Placental Thickness

2020 ◽  
Vol 8 (1) ◽  
pp. 110-113
Author(s):  
Prashanth G Patil ◽  
KM Nataraj ◽  
Shaik Hussain Saheb
Keyword(s):  
Correlation Coefficient ◽  
Gestational Age ◽  
Ultrasound Examination ◽  
Prediction Interval ◽  
Good Alternative ◽  
Third Trimester ◽  
Biometric Parameters ◽  
Relationship Of ◽  
The Relationship ◽  
Placental Thickness

Background: Knowledge of gestational age (GA) is important because it affects clinical management in many ways. Ultrasonography has provided a safe and noninvasive means of dating a pregnancy. The purpose of the present study is to assess the relationship of placental thickness with gestational age and to compare it with other sonographic parameters used to estimate gestational age. Subjects and Methods: The study included 242 normal pregnant women who knew their last menstrual period (LMP). After taking consent, all the women underwent an ultrasound examination. During the scan, besides measuring routine biometric parameters, Placental thickness at the cord insertion was also measured. A retrospective study was designated to test the hypothesis that placental thickness in an age dependant variable and hence can predict gestational age. In the end, the predicted gestational age by placental thickness was compared with gestational age as determined by other sonographic parameters. Results: Placental thickness showed a linear progression in relation to the menstrual age. The correlation coefficient was found to be 0.86(p<0.001). The regression equation was formulated by regressing gestational age on the measured placental thickness. The correlation coefficient between GA-LMP and GA-USG was 0.92 as compared to 0.86 between GA-LMP and GA-PT. The standard error for other USG parameters was +2.32 compared to +2.96 for placental thickness. Conclusion: Placental thickness being a fusion of menstrual age, can be used to predict the gestational age by using the regression formula. Gestational age calculated by other USG parameters is closer to menstrual age as compared to that by placental thickness. The prediction interval was slightly more when the placental thickness was used instead of other USG parameters. Placental thickness is a good alternative parameter for predicting gestational age in the second and third trimester.

scholarly journals The Relationship between Restless Legs Syndrom and Sleep Quality in the Third Trimester Pregnant Women

2019 ◽  
Vol 6 (1) ◽  
pp. 22-27
Author(s):  
Semiha Aydın Özkan ◽  
Gülay Rathfisch ◽  
Özlem Karabulut ◽  
Türkan Karaca
Keyword(s):  
Sleep Quality ◽  
Pregnant Women ◽  
Third Trimester ◽  
Restless Legs ◽  
The Third ◽  
The Relationship ◽  
Restless Legs Syndrom

Predictive Value of Combination of D-dimer and Fibrinogen in Diagnosing Acute CVST

2021 ◽  
pp. 097275312110631
Author(s):  
Abhishek Pathak ◽  
Varun Kumar Singh ◽  
Anand Kumar ◽  
Vijaya Nath Mishra ◽  
Deepika Joshi ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Predictive Value ◽  
Sinus Thrombosis ◽  
Care Center ◽  
Tertiary Care ◽  
Cerebral Venous Sinus Thrombosis ◽  
Latex Agglutination ◽  
D Dimer ◽  
Latex Agglutination Assay

Background: Cerebral venous sinus thrombosis (CVST) is an uncommon subtype of stroke, and the role of D-dimer and fibrinogen in early diagnosis of CVST has been studied with varying results. The present study aims to study the role of the combination of D-dimer and fibrinogen in early diagnosis of acute CVST. Methods: Forty consecutive confirmed acute CVST cases admitted at a tertiary care center were recruited for the study. D-dimer and fibrinogen were assessed by a rapid semiquantitative latex agglutination assay. Results: Out of the 40 CVST patients, 21 (52.50%) were females. The mean age of the patients was 37.58 years ± 19.17 years. Common clinical features were headache ( N = 38 [95%]), papilloedema ( N = 15 [37.5%]), and seizures ( N = 12 [30%]). Although the sensitivity (75%) of the combination of D-dimer and fibrinogen assay was lower than that of D-dimer or fibrinogen alone, the specificity and positive predictive value (75% each) was higher. Conclusions: The combination of D-dimer and fibrinogen testing may aid in an early diagnosis of acute CVST and in better management.

THE RELATIONSHIP OF PLACENTAL THICKNESS WITHGESTATIONALAGE IN THIRD TRIMESTER AND PROBABLE FETAL OUTCOME

2021 ◽  
pp. 64-66
Author(s):  
Sambhunath Bandyopadhyay ◽  
Ritayan Sasmal ◽  
Debarshi Jana
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Age Determination ◽  
Fetal Outcome ◽  
Inclusion Criteria ◽  
Third Trimester ◽  
Relationship Of ◽  
The Relationship ◽  
Placental Thickness

Accurate gestational age determination is very important for management of continuation and termination planning of the pregnancy. rd To establish placental thickness as a parameter for determination of gestational age and fetal growth pattern at 3 trimester. 100 primigravida women who are fullling the inclusion criteria and attend gynae &obs OPD or admitted in their third trimester at IPGME&R from January 2017 to june 2018. Placental thickness at 3rd trimester USG scan is moderately correlated with gestational age, if placental thickness expressed in millimeter then it correlated with gestational age at weeks. rd st Placental thickness with >3.2 cm (32 mm) at 3 trimester almost associated with good fetal outcome, with APGAR score >8 at 1 min and birth weight >2500 gm.

scholarly journals Kisspeptin: new biomarker of pregnancy

2019 ◽  
Vol 8 (8) ◽  
pp. 3021
Author(s):  
Priyanka Meena ◽  
Rati Mathur ◽  
Mohan L. Meena
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Positive Relationship ◽  
Elisa Method ◽  
Medical College ◽  
Obstetrics And Gynaecology ◽  
Study Participants ◽  
Relationship Of ◽  
The Relationship ◽  
Single Blood Sample

Background: The recently identified hormone kisspeptin has been suggested to play an important regulatory role in placentation. The aim and objective of the study is the measurement of serum kisspeptin level in asymptomatic pregnant women and to find out the association of serum kisspeptin with gestational age in women with early pregnancy.Methods: This was a longitudinal study to the evaluation of 178 asymptomatic pregnant women with a gestation of 6 to 16 weeks attending routine antenatal booking visit recruited as study participants from the Antenatal Clinical of Obstetrics and Gynaecology Department, S.M.S. Medical College and Attached Hospitals, Jaipur, Rajasthan, India.Results: After initial clinical examination of every participant, a single blood sample was taken for the measurement of serum kisspeptin. Serum kisspeptin measurement test was performed by ELISA method and results were expressed as ng/ml. Pregnancy outcome was recorded prospectively. Mean serum kisspeptin level of study participants was 2.80±1.87ng/ml and median were 2.41 (Range 0.244-14.06ng/ml). Our result showed the relationship of serum kisspeptin with gestational age (GA) (p<0.000).Conclusions: serum kisspeptin level increases in pregnancy and showed positive relationship with gestational age significantly (p<0.000).

Sign in / Sign up

Export Citation Format

Share Document