scholarly journals Angiopoietin-like protein 3, 4 and 8 are linked to cardiovascular function in naïve sub-clinical and overt hypothyroid patients receiving levothyroxine therapy

2021 ◽  
Author(s):  
Sahar Hossam El Hini ◽  
Yehia Zakaria Mahmoud ◽  
Ahmed Abdelfadel Saedii ◽  
Sayed Shehata Mahmoud ◽  
Mohamed Ahmed Amin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Healthy Subjects ◽  
Experimental Studies ◽  
Cardiovascular Function ◽  
Stiffness Index ◽  
Overt Hypothyroidism ◽  
Thyroid Peroxidase ◽  
Cardiovascular Functions

Objective: Angiopoietin-like protein (ANGPTL) 3,4,8 are upcoming cardiovascular biomarkers. Experimental studies showed thyroid hormones altered their levels. We assessed: ANGPTL3,4,8 as predictor of cardiovascular functions among naïve-subclinical and naïve-overt hypothyroidism [SCH and OH]; and altered ANGPTL levels with levothyroxine replacement (LT4) and their association with improved cardiovascular risk factors and cardiovascular function. Design and Methods: Prospective follow-up study assessed ANGPTL3,4,8 levels, vascular status (flow mediated dilation% of brachial artery (FMD%), carotid intima media thickness (CIMT), aortic stiffness index (ASI)), left ventricle (LV) parameters (ejection fraction (EF), myocardial performance index (MPI), LV mass), well-known cardiovascular risk factors and HOMA-IR, at two time points: among naïve -SCH, naïve-OH and healthy subjects groups; and at six months after achieved euthyroid state with LT4 with calculating their increased or decreased delta changes (∆↑ or ∆↓) in longitudinal arm among LT4- hypothyroid groups. Results: Significantly elevated ANGPTL3,4 and 8 among hypothyroid groups than healthy subjects were reduced with LT4. Multivariate analysis revealed ANGPTLs as independent predictors of cardiovascular functions and the contributors for ANGPTL levels: ANGPTL3,4 for impaired FMD% and ANGPTL8 for LVmass among naïve-SCH; ANGPTL3 for EF% and ANGPTL8 for CIMT in naïve-OH; ∆↓ ANGPTL3 for ∆↓ ASI meanwhile ∆↑ freeT4 for ∆↓ ANGPTL3, ∆↓ fasting glucose, ∆↓ triglyceride and ∆↓ thyroid peroxidase antibody for ∆↓ ANGPTL4 among LT4-SCH. ∆↓ ANGPTL4 for ∆↓ MPI and ∆↓ LVmass meanwhile ∆↓ TSH and ∆↓ triglyceride for ∆↓ ntributors for ANGPTL level: ANGPTL3,4 for impaired FMD% and ANGPTL8 for LVmass among naïve-SCH; ANGPTL3 for EF% and g LT4-OH. Conclusion: Elevated ANGPTL3,4,8 levels are differentially independent predictors of endothelial and cardiac function and reduced with LT4 in SCH and OH.

Aortic elastic properties in patients with venous thromboembolism

2010 ◽  
Vol 25 (5) ◽  
pp. 246-251 ◽  
Author(s):  
N E Duran ◽  
E Oğuz ◽  
I Duran ◽  
A Ç Aykan ◽  
E Ertürk ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Elastic Properties ◽  
Healthy Subjects ◽  
Aortic Distensibility ◽  
Stiffness Index ◽  
History Of ◽  
The Relationship ◽  
Aortic Elastic Properties

Objectives The relationship between venous thrombosis (VT) and atherosclerosis is controversial in recent studies. Aortic elastic properties have a predictive value in detecting early stages of atherosclerosis. The aim of this study is to evaluate the relationship between aortic elastic properties and VT. Methods Elastic properties of aorta in patients with spontaneous VT, without history of known cardiovascular disease and cardiovascular risk factors ( n: 31), and in healthy subjects without cardiovascular risk factors ( n: 30) were compared. Elastic properties of the aorta were assessed with transthoracic echocardiography. Results A significant increase in aortic stiffness index (6.5 ± 1.0 versus 6 ± 0.7, P = 0.03) and a significant decrease in aortic strain and aortic distensibility were found in patients with VT compared with healthy subjects (8.4 ± 7 versus 13 ± 8, P = 0.01, 4.9 ± 4.8 versus 6.5 ± 4.4, P = 0.03, respectively). Conclusions Elastic properties of aorta in patients with spontaneous VT were impaired. These results may support the role of endothelial dysfunction in the pathogenesis of VT.

scholarly journals Subclinical Hypothyroidism and Cardiovascular Risk – An Overview of Current Understanding

2010 ◽  
Vol 7 (1) ◽  
pp. 53 ◽  
Author(s):  
Ulla Feldt Rasmussen ◽  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Subclinical Hypothyroidism ◽  
Large Scale ◽  
Thyroid Stimulating Hormone ◽  
Individual Variability ◽  
Overt Hypothyroidism ◽  
Therapeutic Trial ◽  
Treatment Benefit

Subclinical or mild hypothyroidism is often associated with adverse cardiovascular risk factors, such as high cholesterol, together with hypertension, endothelial dysfunction and other atherosclerotic cardiovascular risk factors. The ischaemic abnormalities are probably related to long-term consequences of a slowly progressing development of hypothyroidism. In recent years, it has become evident that a consensus on the exact limits for cut-off between normal and subclinically hypothyroid individuals is not currently possible. The main reasons for this are differences for measurement of serum thyroid-stimulating hormone (TSH), that reference populations are very different and that a person’s intra-individual variability is much narrower than any population-based interval. Finally, the prevalence of subclinical hypothyroidism varies from 4 to 17% in different normal populations. Available evidence indicates that patients with subclinical hypothyroidism have developed or are at risk of developing an adverse cardiovascular profile and subclinical hypothyroidism is most likely a mild variant of overt hypothyroidism. There is currently no evidence for a treatment benefit, but studies to demonstrate the expected minor improvements have not been performed on a sufficiently large scale. Patients should be informed about the disease and based on a combined clinical and laboratory judgement, should be offered a therapeutic trial in case of even vague symptoms.

scholarly journals COVID-19 in Chronic Kidney Disease: The Impact of Old and Novel Cardiovascular Risk Factors

2021 ◽  
pp. 1-10
Author(s):  
Manuel Alfredo Podestà ◽  
Federica Valli ◽  
Andrea Galassi ◽  
Matthias A. Cassia ◽  
Paola Ciceri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Cardiovascular Events ◽  
Experimental Studies ◽  
Cardiovascular Complications ◽  
High Risk Population ◽  
High Prevalence ◽  
The Impact

Cardiovascular disease is a frequent complication and the most common cause of death in patients with CKD. Despite landmark medical advancements, mortality due to cardiovascular disease is still 20 times higher in CKD patients than in the general population, which is mainly due to the high prevalence of risk factors in this group. Indeed, in addition to traditional cardiovascular risk factors, CKD patients are exposed to nontraditional ones, which include metabolic, hormonal, and inflammatory alterations. The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has brought novel challenges for both cardiologists and nephrologists alike. Emerging evidence indicates that coronavirus disease 2019 (COVID-19) increases the risk of cardiovascular events and that several aspects of the disease may synergize with pre-existing cardiovascular risk factors in CKD patients. A better understanding of these mechanisms is pivotal for the prevention and treatment of cardiovascular events in this context, and we believe that additional clinical and experimental studies are needed to improve cardiovascular outcomes in CKD patients with COVID-19. In this review, we provide a summary of traditional and nontraditional cardiovascular risk factors in CKD patients, discussing their interaction with SARS-CoV-2 infection and focusing on CO­VID-19-related cardiovascular complications that may severely affect short- and long-term outcomes in this high-risk population.

scholarly journals The Analysis of Arterial Stiffness in Heart Failure Patients in Comparison with Healthy Subjects and Patients with Cardiovascular Risk Factors

2019 ◽  
Vol 8 (10) ◽  
pp. 1721 ◽  
Author(s):  
Mauro Feola ◽  
Marzia Testa ◽  
Cinzia Ferreri ◽  
GianLuca Rosso ◽  
Arianna Rossi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Cardiovascular Risk ◽  
Arterial Stiffness ◽  
Cardiovascular Risk Factors ◽  
Healthy Subjects ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Control Group ◽  
Ventricular Ejection Fraction

The arterial stiffness in the pathogenesis and clinical outcome in heart failure (HF) patients still needs to be clarified. An increased pulse wave velocity (PWV) in HF patients in comparison with healthy subjects and cardiovascular risk factors (CVRF) patients has been demonstrated. The aim of this study was to evaluate the arterial stiffness in HF patients in comparison to control populations. Methods: Consecutive patients admitted for decompensated heart failure underwent echocardiogram and evaluation of arterial stiffness by measuring the PWV and the augmentation index (AIx75). The arterial stiffness was also calculated in a control group formed by healthy volunteers and in CVRF subjects. Results: Fifty-nine HF patients (62% males; age 75 years) with mean left ventricular ejection fraction (LVEF) 38% and N-terminal pro B-type natriuretic peptide (NT-proBNP) (8111 pg/mL) entered the study. The HF population were compared with 22 healthy controls (age 58 years) and 20 CVRF patients (age 72 years). The analysis of PWV demonstrated a velocity of 10.6 m/s (9–12.1 m/s), 11.7 m/second (10.4–12.8 m/s), and 10.1 m/second (8.6–10.8m/s) in controls, CVRF, and HF patients (p = 0.01). AIx75 was seen to be higher in the CVRF group vs. HF patients (34% vs. 22%, p = 0.001). In HF patients PWV was inversely correlated with the glomerular filtration rate (r = –0.40; p = 0.002) and directly with central systolic pressure (SP) (r = 0.29; p = 0.02), brachial SP (r = 0.33; p = 0.01) as well as AIx75 correlated with GFR (r = −033; p = 0.01). Conclusion: PWV proved to be different in HF patients in comparison with CVRF/healthy population. The strongest correlation was revealed between the values of PWV/AIx75 and renal function.

Comparison of cardiovascular risk factors and mood disorders in Shahid Hasheminejad Gas Processing Company (S.G.P.C) with healthy subjects

2011 ◽  
Vol 44 (13) ◽  
pp. S235-S236
Author(s):  
Mohammad Sobhan Sheikh-Andalibi ◽  
Amir Akhavan-Rezayat ◽  
Hosein Mohaddes-Ardabili ◽  
Mohammad Reza Baghshini ◽  
Majid Gayour-Mobarhan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Mood Disorders ◽  
Healthy Subjects ◽  
Gas Processing
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