scholarly journals Hypothyroid symptoms and the likelihood of overt thyroid failure: a population-based case–control study

2014 ◽  
Vol 171 (5) ◽  
pp. 593-602 ◽  
Author(s):  
Allan Carlé ◽  
Inge Bülow Pedersen ◽  
Nils Knudsen ◽  
Hans Perrild ◽  
Lars Ovesen ◽  
...  
Keyword(s):  
Population Based ◽  
Case Control ◽  
Overt Hypothyroidism ◽  
Likelihood Ratios ◽  
Dry Skin ◽  
Population Based Study ◽  
Autoimmune Hypothyroidism ◽  
Component Score ◽  
Post Test ◽  
The Individual

BackgroundIt is generally accepted that patients suffering from hypothyroidism may express few symptoms, but this has not been studied in a population-based study design.ObjectivesTo study the array of symptoms as they are reported in newly diagnosed overt autoimmune hypothyroidism using a population-based case–control design.MethodsPatients with new overt autoimmune hypothyroidism (n=140) and their individually matched thyroid disease-free controls (n=560) recruited from the same population underwent a comprehensive program and self-reported a number of symptoms. We identified the symptoms associated with overt hypothyroidism and calculated positive (LR+) and negative (LR−) likelihood ratios as well as diagnostic odds ratios (DORs) as measures for the association between disease state and symptoms.ResultsAmong 34 symptoms investigated, 13 symptoms were statistically overrepresented in hypothyroidism. Hypothyroid patients suffered mostly from tiredness (81%), dry skin (63%), and shortness of breath (51%). Highest DORs (95% CI) were reported for tiredness (5.94 (3.70–9.60)), hair loss (4.58 (2.80–7.51)), and dry skin (4.09 (2.73–6.16)). A hypothyroidism-component-score was defined as the number of hypothyroidism-associated symptoms (range: 0–13). LR+ for participants with a hypothyroidism-component-score of 0 was 0.21 (0.09–0.39), meaning that the post-test probability was lowered to 21% of what it was before asking for symptoms. LR+ for scores of 1–2/3/4–6/7–9/10–13 were: 0.47 (0.30–0.72)/1.16 (0.70–1.87)/1.90 (1.29–2.45)/3.52 (2.30–5.36)/6.29 (2.30–17.7).ConclusionsNone of the individual symptoms of hypothyroidism had high LRs or DORs. Thus, neither the presence nor absence of any individual hypothyroidism symptom was reliable in the decision making of who should have their thyroid function tested. Therefore, even minor suspicion should lead to a blood test.

scholarly journals Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case–control study

2012 ◽  
Vol 167 (4) ◽  
pp. 483-490 ◽  
Author(s):  
Allan Carlé ◽  
Inge Bülow Pedersen ◽  
Nils Knudsen ◽  
Hans Perrild ◽  
Lars Ovesen ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Intake ◽  
Case Control Study ◽  
Reference Group ◽  
Population Based ◽  
Case Control ◽  
Overt Hypothyroidism ◽  
Autoimmune Hypothyroidism ◽  
Normal Thyroid Function ◽  
Control Study

ObjectiveAlcohol consumption is an important protective risk factor for many autoimmune diseases. We wished to study the association between alcohol consumption and autoimmune hypothyroidism.DesignPopulation-based, case–control study, 1997–2001, Denmark.MethodsPatients with newly diagnosed autoimmune overt hypothyroidism (n=140) were prospectively identified in a population (2 027 208 person-years of observation), and their matched controls with normal thyroid function (n=560) were recruited simultaneously from the same population. Participants gave information on alcohol intake, smoking, previous diseases, education, and family history of hypothyroidism. The association between alcohol intake and development of hypothyroidism was analyzed in conditional regression models.ResultsHypothyroid cases had reported a lower alcohol consumption than controls (median units of alcohol (12 g) per week: 3 vs 5,P=0.002). In a multivariate regression model, alcohol consumption was associated with a reduction in risk for development of overt autoimmune hypothyroidism. Odds ratios (95% confidence interval) compared with the reference group with a recent (last year) consumption of 1–10 units of alcohol per week were as follows: 0 units/week, 1.98 (1.21–3.33); 11–20 units/week, 0.41 (0.20–0.83); and ≥21 units/week, 0.90 (0.41–2.00). Similar results were found for maximum previous alcohol consumption during a calendar year. No interaction was found with type of alcohol consumed (wine vs beer), sex, or region of inhabitancy.ConclusionsAlcohol consumption seems to confer considerable protection against development of overt autoimmune hypothyroidism irrespective of sex and type of alcohol consumed.

scholarly journals The HABP2 G534E Variant Is an Unlikely Cause of Familial Nonmedullary Thyroid Cancer

2016 ◽  
Vol 101 (3) ◽  
pp. 1098-1103 ◽  
Author(s):  
Ruta Sahasrabudhe ◽  
Jacob Stultz ◽  
John Williamson ◽  
Paul Lott ◽  
Ana Estrada ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Population Based ◽  
Case Control ◽  
Control Analysis ◽  
British Isles ◽  
Single Nucleotide ◽  
Population Based Study ◽  
Hürthle Cell ◽  
Genome Wide ◽  
Case Control Analysis

Abstract Context: A recent study reported the nonsynonymous G534E (rs7080536, allele A) variant in the HABP2 gene as causal in familial nonmedullary thyroid cancer (NMTC). Objective: The objective of this study was to evaluate the causality of HABP2 G534E in the TCUKIN study, a multicenter population-based study of NMTC cases from the British Isles. Design and Setting: A case-control analysis of rs7080536 genotypes was performed using 2105 TCUKIN cases and 5172 UK controls. Participants: Cases comprised 2105 NMTC cases. Patient subgroups with papillary (n = 1056), follicular (n = 691), and Hürthle cell (n = 86) thyroid cancer cases were studied separately. Controls comprised 5172 individuals from the 1958 Birth Cohort and the National Blood Donor Service study. The controls had previously been genotyped using genome-wide single nucleotide polymorphism arrays by the Wellcome Trust Case Control Consortium study. Outcome Measures: Association between HABP2 G534E (rs7080536A) and NMTC risk was evaluated using logistic regression. Results: The frequency of the HABP2 G534E was 4.2% in cases and 4.6% in controls. We did not detect an association between this variant and NMTC risk (odds ratio [OR] = 0.896; 95% confidence interval, 0.746–1.071; P = .233). We also failed to detect an association between the HABP2 G534E and cases with papillary (1056 cases; G534E frequency = 3.5%; OR = 0.74; P = .017), follicular (691 cases; G534E frequency = 4.7%; OR = 1.00; P = 1.000), or Hürthle cell (86 cases; G534E frequency = 6.3%; OR = 1.40; P = .279) histology. Conclusions: We found that HABP2 G534E is a low-to-moderate frequency variant in the British Isles and failed to detect an association with NMTC risk, independent of histological type. Hence, our study does not implicate HABP2 G534E or a correlated polymorphism in familial NMTC, and additional data are required before using this variant in NMTC risk assessment.

scholarly journals Risk of Immune Thrombocytopenia Induced By Influenza Vaccine. a Nationwide Population-Based Study in France

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 1086-1086
Author(s):  
Margaux Lafaurie ◽  
Bérangère Baricault ◽  
Maryse Lapeyre-Mestre ◽  
Laurent Sailler ◽  
Agnès Sommet ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Research Funding ◽  
Case Series ◽  
Population Based ◽  
Case Control ◽  
Population Based Study ◽  
Case Series Study ◽  
Increased Risk ◽  
Series Study

Introduction: Epidemiological studies suggest a risk of immune thrombocytopenia (ITP) following viral infections, particularly influenza. Conversely, an increased risk of ITP following vaccination has been proven for some vaccines like Measles-Mumps-Rubella vaccine. However, the risk of ITP induced by influenza vaccine is debated. Two case-controls studies has been conducted, with contradictory results: in the Berlin Case-Control Surveillance Study, an increased risk has been found (odds ratio - OR: 3.8 [95% confidence interval - CI: 1.5- 9.1]. Conversely, the French PGRx study suggested the absence of risk of ITP after influenza vaccination [OR: 0.9; 95% CI: 0.4-2.1]. These studies were limited by the number of ITP patients included (169 and 198, respectively) and other limitations. Therefore, we aimed to assess the risk of ITP induced by influenza vaccine in a nationwide cohort in France. Methods: We conducted a population-based study in France within the FAITH cohort (NCT03429660). This cohort is built within the National Health Database that links sociodemographic, hospital and out-hospital data. The FAITH cohort includes all adult patients with incident ITP in France since 2009. Patients are identified using a validated algorithm combining diagnosis codes and drug exposures (with very high positive predictive values). We included in the present study all patients with incident primary ITP aged ≥65 years at ITP diagnosis (indication of influenza vaccination in the general population in France) between July 2009 and June 2015. We assessed the link between influenza vaccine and ITP onset using two designs: a case-control and a self-controlled case series designs. In the case-control design, ITP cases were matched with four controls from the general population for age, sex and place of residency. Index dates for controls were similar to index dates of their matched cases. Cases and controls were compared for exposure to influenza vaccine in the 6 weeks before the index date using conditional logistic regression models adjusted for exposure to other drugs known as inducers of ITP. In the self-controlled case series study, only vaccinated ITP cases were included. The analysis compared the incidence of ITP within periods of risk (6 weeks following vaccination) to the incidence of ITP within other periods of time. We further excluded the 2 weeks prior to vaccine dispensing from the analysis to address selective survival bias (healthy vaccinee effect). Incidence rate ratios (IRRs) adjusted for seasonality were calculated. Results: We included 3,142 incident primary ITP patients aged ≥65 years matched with 12,528 controls in the case-control study. Overall, 147 cases (4.7%) and 579 controls (4.6%) were vaccinated with influenza vaccine during the 6 weeks prior to the index date (adjusted OR: 0.99; 95% CI: 0.80-1.23]). In the self-controlled case series study, 1,875 vaccinated ITP cases were included. Among them, 146 (7.8%) patients were diagnosed for ITP during one of the risk periods following vaccination. The adjusted IRR was 0.96 [95 CI%: 0.80-1.17]. Conclusion: This nationwide population-based study using two different designs showed no increased risk of ITP after influenza vaccination. Disclosures Moulis: Novartis pharma: Research Funding, Speakers Bureau; Amgen pharma: Research Funding, Speakers Bureau; CSL Behring: Research Funding.

Identification of MYH Mutation Carriers in Colorectal Cancer: A Multicenter, Case-Control, Population-Based Study

2007 ◽  
Vol 5 (3) ◽  
pp. 379-387 ◽  
Author(s):  
Francesc Balaguer ◽  
Sergi Castellví–Bel ◽  
Antoni Castells ◽  
Montserrat Andreu ◽  
Jenifer Muñoz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Population Based ◽  
Case Control ◽  
Control Population ◽  
Population Based Study ◽  
Mutation Carriers

scholarly journals Health-related quality of life varies in different respiratory disorders: a multi-case control population based study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Veronica Cappa ◽  
Alessandro Marcon ◽  
Gianfranco Di Gennaro ◽  
Liliya Chamitava ◽  
Lucia Cazzoletti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Population Based ◽  
Case Control ◽  
Control Population ◽  
Health Related Quality ◽  
Population Based Study ◽  
Respiratory Disorders ◽  
Related Quality ◽  
Health Related

scholarly journals Protein S levels and the risk of venous thrombosis: results from the MEGA case-control study

Blood ◽  
2013 ◽  
Vol 122 (18) ◽  
pp. 3210-3219 ◽  
Author(s):  
Maria Carolina Pintao ◽  
Daniel D. Ribeiro ◽  
Irene D. Bezemer ◽  
Andrea A. Garcia ◽  
Marieke C. H. de Visser ◽  
...  
Keyword(s):  
At Risk ◽  
Venous Thrombosis ◽  
Total Protein ◽  
Case Control Study ◽  
Protein S ◽  
Population Based ◽  
Case Control ◽  
Population Based Study ◽  
Key Points ◽  
Control Study

Key PointsLow free protein S and low total protein S levels could not identify subjects at risk for venous thrombosis in a population-based study. Protein S testing and subsequent testing on PROS1 mutations should not be considered in unselected patients with venous thrombosis.

scholarly journals Pre-Eclampsia, Soluble Fms-Like Tyrosine Kinase 1, and the Risk of Reduced Thyroid Function: Nested Case-Control and Population Based Study

2010 ◽  
Vol 65 (4) ◽  
pp. 213-214
Author(s):  
Richard J. Levine ◽  
Lars J. Vatten ◽  
Gary L. Horowitz ◽  
Cong Qian ◽  
Pal R. Romundstad ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Thyroid Function ◽  
Population Based ◽  
Case Control ◽  
Population Based Study ◽  
Nested Case Control
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