Effect of vitamin D treatment in hypoparathyroid patients: a study on calcium, phosphate and magnesium homeostasis

1997 ◽  
Vol 136 (1) ◽  
pp. 52-60 ◽  
Author(s):  
Lene Mortensen ◽  
Lars Hyldstrup ◽  
Peder Charles
Keyword(s):  
Vitamin D ◽  
Calcium Phosphate ◽  
Control Group ◽  
Type I ◽  
Calcium Balance ◽  
Phosphate Homeostasis ◽  
Balance Study ◽  
Magnesium Homeostasis ◽  
Study Results

Abstract Aim: This study was undertaken to examine the effects of long-term vitamin D treatment on calcium, phosphate and magnesium homeostasis at organ level in hypoparathyroid patients. Methods: Fifteen vitamin D-treated hypoparathyroid patients were studied, eight of the patients in a combined 47Ca kinetic and calcium, phosphate and magnesium balance study. Results were compared with a matched control group of 12 normal individuals. Results: All the patients had normal serum levels of calcium, phosphate and magnesium. Absolute intestinal calcium absorption was increased (P <00001). Urinary calcium excretion was normal, but active tubular calcium reabsorption (TmCa/glomerular filtration rate) was low (P<0·001). Bone resorption rates and bone mineralization rates were very low (P <0001 and P <0·05). Twenty-four-hour urinary hydroxyproline excretion and serum cross-linked carboxyterminal telopeptide of type I were in the upper normal range. Serum alkaline phosphatase was normal, but serum carboxyterminal propeptide of human type I procollagen and serum osteocalcin were significantly reduced (P <0·05). Calcium balance was positive and significantly different from controls (P <0·001). All parameters from phosphate homeostasis were normal. Intestinal magnesium absorption was low though not significantly different from normal (P = 0·06). Urinary excretion of magnesium was not significantly higher than normal, but renal magnesium reabsorption was reduced (P <0·001). Magnesium balance was low, though the difference was not significant (P <0·06). Conclusion: Long-term vitamin D treatment in hypoparathyroid patients resulted in a positive calcium balance. Bone turnover was very low. Results of bone markers and resorption rate were conflicting. Vitamin D treatment apparently normalized the abnormalities previously found in phosphate homeostasis of hypoparathyroid patients. Magnesium homeostasis was disturbed, with a more negative balance compared with normal subjects, implying a state of magnesium deficiency in these patients. European Journal of Endocrinology 136 52–60

scholarly journals BCI-Based Rehabilitation on the Stroke in Sequela Stage

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Yangyang Miao ◽  
Shugeng Chen ◽  
Xinru Zhang ◽  
Jing Jin ◽  
Ren Xu ◽  
...  
Keyword(s):  
Motor Function ◽  
The Body ◽  
Control Group ◽  
Stroke Patients ◽  
Time Period ◽  
Average Improvement ◽  
Study Results ◽  
Electroencephalogram Eeg ◽  
Positive Effect

Background. Stroke is the leading cause of serious and long-term disability worldwide. Survivors may recover some motor functions after rehabilitation therapy. However, many stroke patients missed the best time period for recovery and entered into the sequela stage of chronic stroke. Method. Studies have shown that motor imagery- (MI-) based brain-computer interface (BCI) has a positive effect on poststroke rehabilitation. This study used both virtual limbs and functional electrical stimulation (FES) as feedback to provide patients with a closed-loop sensorimotor integration for motor rehabilitation. An MI-based BCI system acquired, analyzed, and classified motor attempts from electroencephalogram (EEG) signals. The FES system would be activated if the BCI detected that the user was imagining wrist dorsiflexion on the instructed side of the body. Sixteen stroke patients in the sequela stage were randomly assigned to a BCI group and a control group. All of them participated in rehabilitation training for four weeks and were assessed by the Fugl-Meyer Assessment (FMA) of motor function. Results. The average improvement score of the BCI group was 3.5, which was higher than that of the control group (0.9). The active EEG patterns of the four patients in the BCI group whose FMA scores increased gradually became centralized and shifted to sensorimotor areas and premotor areas throughout the study. Conclusions. Study results showed evidence that patients in the BCI group achieved larger functional improvements than those in the control group and that the BCI-FES system is effective in restoring motor function to upper extremities in stroke patients. This study provides a more autonomous approach than traditional treatments used in stroke rehabilitation.

Bone loss and vitamin D deficiency post gastrectomy for gastro-esophageal malignancy.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 165-165 ◽  
Author(s):  
Kiran Virik ◽  
Robert Wilson
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Disease ◽  
Bone Health ◽  
Nutritional Supplementation ◽  
Type I ◽  
Mineral Density ◽  
Post Surgery

165 Background: Metabolic bone disease is a known but incompletely understood consequence of gastrectomy. Post gastrectomy osteoporosis (OP) is multifactorial. Evidence suggests that patients who undergo this surgery require long term bone health assessment and nutritional support. Methods: 30 post gastrectomy patients (2000-2008) from a single centre in Australia were evaluated re bone health post surgery and post nutritional supplementation. Exploratory analysis included: age, gender, pathology, type of surgery, 25 OH-vitamin D, calcium, parathyroid hormone (PTH), bone mineral density (BMD), vertebral XRs, urinary calcium and N telopeptides of type I collagen. Other risk factors evaluated were: smoking, corticosteroid use, alcohol intake, hyperthyroidism, menopausal status, hyperparathyroidism (hPTH), pre-existing bone disease. Results: The median age of the cohort was 67.5 (range 53-83) of whom 22 (73%) were male. Histology showed 16 (53%) gastric adenocarcinoma, 6 (20%) esophageal adenocarcinoma, 2 (7%) GISTs, 5 (17%) gastric/duodenal lymphoma and 1 other category. Similar numbers of patients underwent total (12) and partial/distal gastrectomy (12), with 6 having a subtotal gastrectomy. 22 (73%) had a Roux-en-Y or BR II reconstruction and 8 had a BRI/other. Median time from surgery to first BMD was 54.5 months (range 12-360) with median correlative calcium level 2.24 (range 1.97-2.49), median vitamin D level 43 (range 11-82) and median PTH 6.4 (range 1.8-13.8). Osteoporosis was diagnosed in 14 (47%) of patients, osteopenia in 14 and 2 (7%) patients had a normal BMD. Low vitamin D was seen in 23 (77%) patients, low calcium levels in 5 (17%) and secondary hPTH in 12 (41%). Post nutritional supplementation preliminary results showed 2/23 (9%) had a low vitamin D level, 3/11 (27%) had secondary hPTH, 5/19 (26%) had osteoporosis, 12/19 (63%) had osteopenia and 2/19 had a normal BMD. Analysis of other risk factors is to follow. Conclusions: Poor bone health and vitamin D deficiency is a clinically significant problem post gastrectomy. Patients should undergo long term nutritional and bone health surveillance in addition to their oncological follow up post resection.

scholarly journals Peritoneal Resting with Heparinized Lavage Reverses Peritoneal Type I Membrane Failure. A Comparative Study of the Resting Effects on Normal Membranes

2014 ◽  
Vol 34 (7) ◽  
pp. 698-705 ◽  
Author(s):  
Erika De Sousa ◽  
Gloria Del Peso ◽  
Laura Alvarez ◽  
Silvia Ros ◽  
Ana Mateus ◽  
...  
Keyword(s):  
Median Time ◽  
Previous History ◽  
Control Group ◽  
Type I ◽  
Transfer Coefficients ◽  
Functional Changes ◽  
Ultrafiltration Failure ◽  
History Of ◽  
Peritoneal Function

BackgroundUltrafiltration failure (UFF) is a serious complication of long-term peritoneal dialysis (PD). Peritoneal rest (PR) has been demonstrated as a valid treatment to reverse the functional changes that occur in UFF. The effects of PR on a normally functioning human peritoneum are unknown but are expected to be neutral. Our hypothesis was that PR positively modifies peritoneal function in patients with UFF, in contrast to the absence of effects when PR is applied under normal conditions.Patients and MethodsWe studied 84 PR periods, comparing 35 patients with UFF and 49 controls (resting for abdominal surgery with temporary discontinuation of PD). We analyzed peritoneal transport pre-PR and post-PR by calculating the mass transfer coefficients of creatinine (Cr-MTAC), the dialysate/plasma creatinine ratio (D/P Cr) and the ultrafiltration (UF).ResultsBaseline data was similar for the 2 groups, although the UFF group had a longer median time in PD (39 [18 – 60] vs 10 [5 – 23] months; p = 0.00001). Peritoneal rest induced a decrease in D/P Cr, Cr-MTAC and an increase in UF capacity in the UFF group ( p = 0.0001, p = 0.004 and p = 0.001, respectively), without causing changes in the control group. Peritoneal rest in patients with more than 6 months of UFF was not able to reduce peritoneal solute transport or improve UF capacity. Response to PR did not differ among UFF patients with or without a previous history of peritonitis. Peritoneal rest enabled patients with UFF to continue on PD for a median time of 23 months (range, 13 – 46 months).ConclusionsPeritoneal rest induces functional changes in patients with UFF but not in those with no functional abnormalities. This demonstrates that PR works only when abnormal but reversible functional conditions are present. However, the effect is highly dependent on how early PR is applied.

scholarly journals Influence of long term stress exposure on somatisation symptoms outcome

2004 ◽  
Vol 4 (4) ◽  
pp. 28-31
Author(s):  
Sabaheta Hasić ◽  
Emina Kiseljaković ◽  
Radivoj Jadrić ◽  
Belma Zečević ◽  
Nešina Avdagić ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Control Group ◽  
Stress Exposure ◽  
War Stress ◽  
Control Subjects ◽  
Study Results ◽  
Significant Difference ◽  
Student’S T ◽  
And Control

Long term stress exposure results in somatisation symptoms appearance. Cardiovascular, respiratory, gastrointestinal and muscle-bone symptoms arise because of intensified activity of autonomic nervous system caused by chronic stress. The aim of the study was to examine the relationship between long term war stress exposure and appearance of somatisation. 40 students of health-care faculties in Sarajevo, of both sexes, were included in investigation and divided in two groups-somatisation and control. Somatisation group subjects (N=20) lived in B&H under war conditions, from 1992-1995. Control subjects (N=20) spent the same period outside B&H. For evaluation of somatisation symptoms we used SCL-90-R test. The obtained data were statistically evaluated using Student’s t-test and χ2 test. Confidence level was set at ρ < 0,05. Our results showed statistically significant difference in somatisation level between somatisation and control subjects group. Different intensity of appearance of certain symptoms in male and female was established. The score of somatisation dimension between somatisation and control group showed statistically significant level (p < 0,0001). Study results confirmed correlation of chronic stress exposure (living in war environment) and somatisation symptom appearance. Individual organic systems had various level of symptom expression. The influence of sex on intensity of individual symptoms of somatisation is possible.

scholarly journals MORPHOLOGICAL COMPOSITION OF BLOOD AND BIOCHEMICAL PROCESSES IN THE ORGANISM OF FEMALE RATS F1 UNDER LONG-TERM EXPOSURE OF CITRIC ACID

2020 ◽  
Vol 21 (2) ◽  
pp. 183-188
Author(s):  
U. І. Теsarinska ◽  
R. S. Fedoruk ◽  
S. Ya. Маrtynyk ◽  
Т. V. Yurynec ◽  
V. А. Smuk ◽  
...  
Keyword(s):  
Citric Acid ◽  
Biochemical Parameters ◽  
Group Analysis ◽  
Relative Content ◽  
The Body ◽  
Female Rats ◽  
Control Group ◽  
Study Results ◽  
Morphological Composition

The paper considers the effect on rats of long-term feeding of an aqueous solution of citric acid (C6H12O6 x H2O, "chemically pure.") in the amount of 8 mg/l. The study was performed on 10 laboratory female rats F1 of the Wistar line, obtained from F0 females. Two groups were set up: control and experimental, 5 animals in each. Animals were under standard conditions with natural light regime day/night, aqueous solutions of citrate, water, and feed received ad libitum. Were determined the morphological composition and biochemical parameters of the blood of female F1 rats. The results of the study indicate the absence of an unfavorable effect of citric acid on red blood cells. Concerning white blood, there is a decrease in the number of leukocytes, which may be due to the development of an adaptive response of the body to citric acid or the inhibition of citric acid's immune response to long-term adaptive action. There is a significant increase in the relative content of eosinophils in females F1, which probably may be due to the action of citric acid. The analysis of the obtained results of blood biochemical parameters indicates a certain tendency to decrease, in terms of control, the content of serum iron, as well as its total and unsaturated Fe-binding capacity. Ferrum saturation of serum transferrin was present at the level of animals in the control group. Analysis of the study results indicates no changes in control in the activity of enzymes: Alkaline phosphatase ALT and AST, also have no statistically significant confirmation of differences in the control group. The level of urea was statistically not significantly higher in terms of control. Thus, long-term watering of citric acid to female rats in the generation F0 and F1 during their physiological and sexual gestation and pregnancy reveal un-favorable effects in female rats F1. However, there was distinguished the adaptive immune-biological response of the animals organism. The immunological response was supported by a decrease in the number of leukocytes and a significant increase in the relative content of eosinophils. The results of biochemical studies of serum indicate the absence of statistically significant differences in animals of the control group.

scholarly journals 25-Hydroxyvitamin D and matrix metalloproteinases-2, -9 level in patients with primary open angle glaucoma and pseudoexfoliative glaucoma/syndrome

2017 ◽  
Vol 10 (1) ◽  
pp. 10-16
Author(s):  
Inessa S Beletskaya ◽  
Tatiana L Karonova ◽  
Sergey Yu Astakhov
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Study Groups ◽  
Control Group ◽  
Open Angle ◽  
Hydroxyvitamin D ◽  
Study Results ◽  
Clinically Significant

Aim. To determine serum 25(OH)D and plasma MMP-2 and MMP-9 levels in patients with primary open-angle glaucoma (POAG), pseudoexfoliation glaucoma (PEG), and pseudoexfoliation syndrome (PES) - to assess potential associations between vitamin D status and these diseases. Methods. We included 238 patients (105 males and 133 females) aged from 55 to 75 years. One hundred twenty two patients had PEG, 46 patients had POAG, 32 had PES. 38 subjects were healthy, and were considered as the control group. Cases with clinically significant systemic diseases and concomiatant eye diseases were excluded, if there was a confirmed pathogenic impact of vitamin D and MMP. The serum 25(OH)D level was investigated by immunochemiluminescence method, plasma MMP-2 and MMP-9 levels - by ELISA. Results. Serum 25(OH)D level was between 4.6 and 82.25 nM/l (mean 41.7 nM/l), so most participants showed vitamin D deficiency. It was shown that mean serum 25(OH)D level in patients with PEG, POAG and PES was similar (39.3 ± 1.2, 38.8 ± 2.1 and 40.51 ± 2.4 nM/l, p > 0.05), but it was lower than that in the control group (52.7 ± 2.1 nM/l, p < 0.01). Plasma MMP-2 concentration was the same in all study groups. Plasma MMP-9 level was higher in POAG and PES patients (48.23 ± 3.26 and 54.01 ± 3.57 ng/ml) than in the control group (32.60 ± 2.34 ng/ml, p < 0.001) and PEG patients (40.86 ± 3.60 ng/ml, p < 0.05). We found positive correlations between MMP-2 and MMP-9 levels in patients with PEG (r = 0.48, p = 0.001) and patients with POAG (r = 0.43, p = 0.003). The correlation analysis showed also a negative relation between 25(OH)D and MMP-9 (r = -0.32, p = 0.02), MMP-2 (r = -0.33, p = 0.02) in patients with POAG. Summary. Study results confirmed a potential role of vitamin D in apoptosis regulation and tissue remodeling in patients with POAG and PES. Hence, vitamin D deficiency can be considered as a risk factor for glaucoma development.

scholarly journals Effect of fertility health awareness strategies on fertility knowledge and childbearing in young married couples (FertStart): study protocol for an effectiveness-implementation hybrid type I multicentre three-arm parallel group open-label randomised clinical trial

BMJ Open ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. e051710
Author(s):  
Sze Ling Chan ◽  
Julian Thumboo ◽  
Jacky Boivin ◽  
Seyed Ehsan Saffari ◽  
Shanqing Yin ◽  
...  
Keyword(s):  
Semen Analysis ◽  
Randomised Trial ◽  
Married Couples ◽  
Control Group ◽  
Type I ◽  
Age At First Birth ◽  
Fertility Awareness ◽  
Hybrid Type ◽  
Study Results ◽  
Post Randomisation

IntroductionBirth rates have been declining in many advanced societies including Singapore. We designed two interventions with vastly different resource requirements, which include fertility education, personalised fertility information and a behavioural change component targeting modifiable psychological constructs to modify fertility awareness and childbearing intentions. We aim to evaluate the effect of these two interventions on knowledge, attitudes and practice around childbearing compared with a control group among young married couples in Singapore and understand the implementation factors in the setting of an effectiveness-implementation hybrid type 1 three-arm randomised trial.Methods and analysisWe will randomise 1200 young married couples to no intervention (control), Fertility Health Screening group (FHS) or Fertility Awareness Tools (FAT) in a 7:5:5 ratio. Couples in FHS will undergo an anti-Mullerian hormone test and semen analysis, a doctor’s consultation to explain the results and standardised reproductive counselling by a trained nurse. Couples in FAT will watch a standardised video, complete an adapted fertility status awareness (FertiSTAT) tool and receive an educational brochure. The attitudes, fertility knowledge and efforts to achieve pregnancy of all couples will be assessed at baseline and 6 months post-randomisation. Birth statistics will be tracked using administrative records at 2 and 3 years. The primary outcome is the change in the woman’s self-reported intended age at first birth between baseline and 6 months post-randomisation. In addition, implementation outcomes and cost-effectiveness of the two interventions will be assessed.Ethics and disseminationThis study has been reviewed and approved by the Centralized Institutional Review Board of SingHealth (2019/2095). Study results will be reported to the study funder and there are plans to disseminate them in scientific conferences and publications, where authorship will be determined by the International Committee of Medical Journal Editors guidelines.Trial registration numberNCT04647136; ClinicalTrails.gov Identifier.

scholarly journals Total, Free and Bioavailble 25 OH D and Bone Disease in Primary Hyperparathyroidism

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A270-A270
Author(s):  
Lívia Marcela Santos ◽  
Monique Nakayama Ohe ◽  
Sthefanie Giovanna Pallone ◽  
Isabela Ohki Nacaguma ◽  
Renata Elen Costa Silva ◽  
...  
Keyword(s):  
Vitamin D ◽  
Primary Hyperparathyroidism ◽  
Statistical Difference ◽  
Control Group ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Bone Parameters ◽  
Study Results ◽  
Low Levels ◽  
Vitamin D Supplements

Abstract Background: Low levels of vitamin D 25OHD are frequently described in PHP patients. The aim of this study was to evaluate bone parameters and vitamin D status in PHP patients and controls. Methods: Prior to surgery, 64 PHP patients and 63 healthy matched control subjects regarding age, gender and body mass index were enrolled in this study along 18 months. 25OHD and PTH were measured using Roche® Immunoassays. Bone mineral density (BMD) by dual X-ray absorptiometry (DXA) (Hologic QDR 4500) and TBS (InSight™) were determined in all patients and controls. Distribution of total, bioavailable and free (calculated) 25OH and its correlation with TBS and DXA in both groups was evaluated. DBP (vitamin D binding protein) SNPs genetic analysis was performed by ABI 7500 real time PCR System. None of the patients and controls were taking vitamin D supplements before the study. Results: PHP patients had lower BMD values than controls in all sites (p&lt;0.01). TBS measurements were also reduced in PHP patients compared to controls, as expected (1233 vs 1280, p=0.04). There was no statistical difference in free, total and bioavailable 25OHD measurements between the PHP and the control group, mean±SD: 3.4±1.7 vs 3.1±1.7 pg/mL (p=0.44), 22.6± 6.1 vs 20.6± ng/dL (p=0.13) 1.53±0.66 vs 1.41±0.61 ng/mL (p=0.28), respectively. Likewise, there was no statistical difference in DBP haplotypes 1s/1s, 1f/1f, 1s/1f, 2/2, 1s/2, 1f/2 analysis between groups. There was no correlation with 25OHD and DXA measurements in both groups. However, total 25OHD presented statistical significant correlation with TBS measurements in the PHP group (r=0.28; p=0.02) and total, free and bioavailable 25OHD measurements with TBS in the control group (r=0.42; r=0.42; r=0.43; p&lt;0.01). Conclusion: Vitamin D status correlates with TBS, but not with DXA, highlighting the relation of the vitamin D with the microarchitecture bone parameters in both PHP patients and controls. However, this correlation was more evident among controls than in PHP patients, spotlighting the primary hyperparathyroidism effects in bone.

scholarly journals Long-term dental intervention and laboratory examination in a patient with Vitamin D-dependent rickets type I

Medicine ◽  
2020 ◽  
Vol 99 (41) ◽  
pp. e22508
Author(s):  
An-Qi Liu ◽  
Li-Shu Zhang ◽  
Hao Guo ◽  
Mei-Ling Wu ◽  
Tian-Yi Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type I ◽  
Laboratory Examination ◽  
Dental Intervention

Alterations in calcium metabolism in patients on long-term bisphosphonate therapy for metastatic breast cancer (MBC): A potential therapeutic target?

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 1044-1044
Author(s):  
C. Simmons ◽  
G. Dranitsaris ◽  
M. Clemons ◽  
B. Y. Wong ◽  
R. Veith ◽  
...  
Keyword(s):  
Vitamin D ◽  
Logistic Regression ◽  
Metastatic Breast ◽  
Vitamin D Supplementation ◽  
Bisphosphonate Therapy ◽  
Control Group ◽  
Potential Therapeutic Target ◽  
Explanatory Variables ◽  
Normal Women

1044 Background: The effect of long-term potent BP use on calcium homeostasis in MBC pts is poorly understood. These effects and the need for calcium and Vitamin D supplementation may have significant implications for pt management in both the metastatic and adjuvant settings. Methods: We evaluated serum calcium (sCa), PTH, and 25(OH)D levels and their inter-relationships in 30 MBC pts after prolonged BP use for bone metastases (BM), compared with a control group (CG) of 1484 normal women without bone or mineral disease (JCEM 2003;88:185). The MBC pts were prescribed oral calcium (1g/d) and vitamin D (400IU/d) for 1 month prior to analysis. To determine whether MBC pts differed from CG with respect to the sCa-PTH correlation, logistic regression was performed with sCa, log-transformed PTH and an interaction term (Ca × lnPTH). Results: Mean age of the two groups did not differ [MBC group (58.5 ± 2.0 yr) vs. CG (55.2 ± 0.4 yr, p >.05)]. VitD-deficiency (25vitD < 40 nM) was equally prevalent in the two groups [MBC (23%) vs. CG (25%)]. sCa was significantly higher in MBC pts (2.473 ± 0.019 mM) compared to CG (2.377 ± 0.003, p <0.001). However, PTH was not decreased in MBC pts (4.60 ± 0.36 pM), compared to CG (4.56 ± 0.06, t-test, p=0.91). Logistic regression was highly significant (p<0.0001), as were coefficients for both explanatory variables (sCa, p <0.0001 and lnPTH, p = 0.009) and their interaction (p=0.011). Conclusion: In pts with BM and prolonged BP use there appears to be a shift in the calcium set-point such that PTH release is activated by higher levels of sCa than in controls. We are currently studying whether prophylaxis for relative vit D deficiency in this population can not only correct this shift but also improve pt symptoms No significant financial relationships to disclose.

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