Interethnic Analysis Of Bdnf Level Quantitative Indicator In Youths

2018 ◽  
Author(s):  
N.P. Belousova
Keyword(s):  
Bdnf Level ◽  
Quantitative Indicator

scholarly journals The long-term bio-behavioural effects of juvenile sildenafil treatment in Sprague-Dawley versus Flinders Sensitive Line rats

2021 ◽  
pp. 1-20
Author(s):  
Juandré Lambertus Bernardus Saayman ◽  
Stephanus Frederik Steyn ◽  
Christiaan Beyers Brink
Keyword(s):  
Sprague Dawley ◽  
Long Term Effects ◽  
Bdnf Level ◽  
Treatment Groups ◽  
Sd Rats ◽  
Behavioural Effects ◽  
Sensitive Line ◽  
Level Analysis ◽  
Flinders Sensitive Line

Abstract Objective: To investigate the long-term effects of juvenile sub-chronic sildenafil (SIL) treatment on the depressive-like behaviour and hippocampal brain-derived neurotrophic factor (BDNF) levels of adult Sprague-Dawley (SD) versus Flinders Sensitive Line (FSL) rats. Methods: SD and FSL rats were divided into pre-pubertal and pubertal groups, whereafter 14-day saline or SIL treatment was initiated. Pre-pubertal and pubertal rats were treated from postnatal day 21 (PND21) and PND35, respectively. The open field and forced swim tests (FST) were performed on PND60, followed by hippocampal BDNF level analysis one day later. Results: FSL rats displayed greater immobility in the FST compared to SD rats (p < 0.0001), which was reduced by SIL (p < 0.0001), regardless of treatment period. Hippocampal BDNF levels were unaltered by SIL in all treatment groups (p > 0.05). Conclusion: Juvenile sub-chronic SIL treatment reduces the risk of depressive-like behaviour manifesting during young adulthood in genetically susceptible rats.

Spectral Analysis of Heart Rate Variability as a Quantitative Indicator of Driver Mental Fatigue

2002 ◽  
Author(s):  
Zengyong Li ◽  
Kun Jiao ◽  
Ming Chen ◽  
Yushu Yang ◽  
Chengtao Wang ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Spectral Analysis ◽  
Mental Fatigue ◽  
Quantitative Indicator

Feature extraction for rolling bearing fault diagnosis by electrostatic monitoring sensors

2014 ◽  
Vol 229 (10) ◽  
pp. 1887-1903 ◽  
Author(s):  
Ying Zhang ◽  
Hongfu Zuo ◽  
Fang Bai
Keyword(s):  
Feature Extraction ◽  
Fault Diagnosis ◽  
Hankel Matrix ◽  
Rolling Bearing ◽  
Difference Spectrum ◽  
Permutation Entropy ◽  
Feature Extraction Method ◽  
Bearing Fault ◽  
Quantitative Indicator ◽  
Bearing Fault Diagnosis

There are mainly two problems with the current feature extraction methods used in the electrostatic monitoring of rolling bearings, which affect their abilities to identify early faults: (1) since noises are mixed in the electrostatic signals, it is difficult to extract weak early fault features; (2) traditional time and frequency domain features have limited ability to provide a quantitative indicator of degradation state. With regard to these two problems, a new feature extraction method for rolling bearing fault diagnosis by electrostatic monitoring sensors is proposed in this paper. First, the spectrum interpolation is adopted to suppress the power-frequency interference in the electrostatic signal. Then the resultant signal is used to construct Hankel matrix, the number of useful components is automatically selected based on the difference spectrum of singular values, after that the signal is reconstructed to remove background noises and random pulses. Finally, the permutation entropy of the denoised signal is calculated and smoothed using the exponential weighted moving average method, which is used to be a quantitative indicator of bearing performance state. The simulation and experimental results show that the proposed method can effectively remove noises and significantly bring forward the time when early faults are detected.

scholarly journals The Utility of BDNF Detection in Assessing Severity of Huntington’s Disease

2021 ◽  
Vol 10 (21) ◽  
pp. 5181
Author(s):  
Klaudia Plinta ◽  
Andrzej Plewka ◽  
Krzysztof Pawlicki ◽  
Nikola Zmarzły ◽  
Magdalena Wójcik-Pędziwiatr ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Functional Evaluation ◽  
Early Disease ◽  
Bdnf Level ◽  
Clinical Profiles ◽  
Clinical Pictures ◽  
Disease Stages ◽  
The Relationship

Brain-derived neurotrophic factor (BDNF) is involved in the survival and maturation of neurons, and also promotes and controls neurogenesis. Its levels are lowered in many neurodegenerative diseases, including Huntington’s disease (HD). Clinical pictures of HD can be very diverse, which makes it difficult to assess its severity; however, molecular markers may be helpful. The aim of the study was to determine the relationship between HD severity and the plasma BDNF concentration in HD patients. The study recruited 42 patients with diagnosed and genetically confirmed HD and 40 healthy volunteers. BDNF levels were determined in plasma with the enzyme-linked immunosorbent assay (ELISA). Correlations between BDNF levels and clinical profiles and HD severity were also investigated. The BDNF level was significantly lower in HD patients compared to the control. There was no correlation between the BDNF level and motor symptoms and cognitive impairment. In the early disease stages, BDNF levels were associated with a better neurological examination, independence, and functional evaluation, in contrast to later HD stages, where the correlations were inverse. Multidirectional correlations between parameters of saccadic disorders and the BDNF level do not allow for drawing a conclusion, whether or not there is a relationship between the severity of saccadic disorders and the BDNF concentration.

scholarly journals The farther the better: Investigating how distance from human self affects the propensity of a peptide to be presented on cell surface by MHC class I molecules, the case of Trypanosoma cruzi

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243285
Author(s):  
Davide Vergni ◽  
Rosanna Gaudio ◽  
Daniele Santoni
Keyword(s):  
Immune Response ◽  
Cell Surface ◽  
Trypanosoma Cruzi ◽  
Mhc Class I ◽  
Experimental Testing ◽  
Genomic Information ◽  
Quantitative Indicator ◽  
A Cell ◽  
New Vaccines ◽  
Mhc Class I Molecules

More than twenty years ago the reverse vaccinology paradigm came to light trying to design new vaccines based on the analysis of genomic information in order to select those pathogen peptides able to trigger an immune response. In this context, focusing on the proteome of Trypanosoma cruzi, we investigated the link between the probabilities for pathogen peptides to be presented on a cell surface and their distance from human self. We found a reasonable but, as far as we know, undiscovered property: the farther the distance between a peptide and the human-self the higher the probability for that peptide to be presented on a cell surface. We also found that the most distant peptides from human self bind, on average, a broader collection of HLAs than expected, implying a potential immunological role in a large portion of individuals. Finally, introducing a novel quantitative indicator for a peptide to measure its potential immunological role, we proposed a pool of peptides that could be potential epitopes and that can be suitable for experimental testing. The software to compute peptide classes according to the distance from human self is free available at http://www.iasi.cnr.it/~dsantoni/nullomers.

CORRELATION BETWEEN ANTONYMS AND OTHER LEXICAL AND SEMANTIC CATEGORIES

2021 ◽  
pp. 108-118
Author(s):  
D. V. Movchan
Keyword(s):  
General Scheme ◽  
Practical Implementation ◽  
Figurative Meaning ◽  
Quantitative Indicator ◽  
Semantic Categories ◽  
Polynomial Structure ◽  
Common Concept ◽  
Polysemous Words

The article argues that antonymous words are not isolated in the language but are part of the general scheme of thematic classification of the vocabulary, entering into close ties with representatives of synonymous and polysemantic groups. Proof of this position is the availability of antonymous-synonymous blocks and paradigms of meanings of antonymous words-polysemants in the language. This fact serves to understand the antonymy of lexical as a relationship between members of opposing dichotomous series, as well as expands the boundaries of closed binary structures, which are traditionally used to make antonymous connections. Antonymous relations are established to connect two opposites in pairs, as well as to combine several units into one polynomial structure. Words are found to have more antonyms than the corresponding number of meanings. This proves that some semes of one word are opposed by two or more synonymous antonyms. From the above-mentioned, it follows that the antonyms of polysemous words can be stated only within one family. Such a framework can be defined by limiting the range of antonymous units to a third common concept, under which two antonyms are summed up; establishing the antonyms of polysemous words through the contextual indicative minimum; distinguishing between the direct and figurative meaning of the word. The antonymous connections within the framework of the synonymous-antonymous paradigm are established to demonstrate a qualitatively heterogeneous character, differ in the strength of the manifestation of the relations of opposites and the frequency of practical implementation. The analysis of the manifestations of antonyms between the members of the dichotomous synonymous series allows distinguishing the following types: radial, linear, and cross radial. It is proved that the quantitative indicator of the formation of certain antonymous pairs from among the members of synonymous series depends on the volume of the synonymous series being compared, from the nature of semantic differences of the words of each series, from the emotional, evaluative, and stylistic characteristics of the members of the series, and the distribution of the words with relatively opposite meanings.

scholarly journals Effect of 9 weeks continuous vs. interval aerobic training on plasma BDNF levels, aerobic fitness, cognitive capacity and quality of life among seniors with mild to moderate Alzheimer’s disease: a randomized controlled trial

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Lievyn Enette ◽  
Thomas Vogel ◽  
Sylvie Merle ◽  
Anna-Gaelle Valard-Guiguet ◽  
Nathalie Ozier-Lafontaine ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Performance ◽  
Aerobic Fitness ◽  
Aerobic Training ◽  
Bdnf Level ◽  
Fitness Parameters ◽  
Functional Capacities

Abstract Background Evidence suggests that aerobic-type training confers physical benefits and appears to contribute positively to brain health. This study aims to compare the effect of 9-weeks continuous (CAT) to interval aerobic training (IAT) on brain derived neurotrophic factor (BDNF) plasma level, aerobic fitness, cognitive performance, and quality of life among senior with Alzheimer’s disease (AD). Methods 52 participants were randomly allocated into three groups (CAT n = 14; IAT n = 17; and Controls n = 21). CAT and IAT consisted of 18 sessions of 30-min cycling, twice a week, over 9 weeks. During the same period, controls were engaged in interactive information sessions. Plasma BDNF level; aerobic fitness parameters (Metabolic equivalent task - METs; Maximal Tolerated Power – MTP); functional capacities (6-Minute Walk Test - 6MWT); cognitive performance (Mini Mental State Examination; Rey auditory verbal learning test; and digit span test) and quality of life (Quality Of Life of Alzheimer’s Disease scale - QoL-AD) were measured in all participants at baseline and 9 weeks later. A third plasma BDNF level was quantified following a 4 weeks detraining. Results No significant change was measured in terms of plasma BDNF level and cognitive performance after interventions, in all groups compared to baseline. After 9 weeks, CAT and IAT significantly improved aerobic fitness parameters compared to controls (METs: + 0.6 and + 1.0 vs. + 0.4; MTP: + 16 watts and + 20 watts vs. + 10 watts; and functional capacities (6MWT: + 22 m and + 31 m vs. -40 m). Compared to controls, QoL-AD after CAT was improved (+ 2 points; p = 0.02). Conclusions Neither aerobic exercise modalities significantly modified plasma BDNF levels and cognitive performances. CAT and IAT enhanced aerobic fitness and functional capacities in AD patients and CAT their QoL. Trial registration ClinicalTrials.gov website (NCT02968875); registration date: 7 September 2016. “Retrospectively registered”.

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