scholarly journals Features of the influence of oat extract on the antioxidant activity of goose liver

2021 ◽  
Vol 23 (2) ◽  
pp. 41-45
Author(s):  
Yu. V. Nikolaeva ◽  
◽  
O. O. Danchenko ◽  
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Enzymes ◽  
Antioxidant System ◽  
Unsaturated Fatty Acids ◽  
Physiological Stress ◽  
Bird Species ◽  
Natural Antioxidants ◽  
Control Group ◽  
Poultry Feeding ◽  
Fat Soluble Vitamins

The use of antioxidants in poultry feeding helps to relieve stress of various etiologies. Natural antioxidants have a number of advantages over synthetic ones. The aim of the study was to determine the effect of Avena sativa oat extract on the peculiarities of the functioning of the antioxidant system of goose liver during the physiological stress of contour and juvenile feather formation (from the 14th to the 56th day). The state of the antioxidant system in liver tissues was determined by the coefficient of antioxidant activity, the content of the final products of lipoperoxidation, the activity of antioxidant enzymes and the content of fat-soluble vitamins. The results of the experiment showed that the goslings of the control group during the formation of contour feathers have a decrease in antioxidant activity of the liver by 2.36 times, and juvenile — 1.90 times compared to the initial value of this indicator. Adding oat extract to the diet of geese during feather formation increases the antioxidant activity of their liver. Under the influence of the extract, the physiological stress associated with the formation of contour feathers (28 days) is significantly reduced by reducing the content of the main substrate of lipoperoxidation of unsaturated fatty acids, despite the decrease in the activity of all antioxidant enzymes. Increasing antioxidant activity in the liver during the formation of juvenile feathers is due to the inclusion of alternative mechanisms of antioxidant protection, implemented by increasing the activity of endogenous antioxidants: superoxide dismutase by 29.6 (P≤0.05), catalase by 34.6% (P≤0.05), glutathioperoxidase by 41.2% (P≤0.01), and the content of vitamin E by 32.7% (P≤0.05) and β-carotene by 30.9% (P≤0,05). Under the influence of the extract there is not only a significant increase in the weight of geese at the end of the experiment, but also an improvement in their pterylographic performance. Therefore, in the future, it would be advisable to conduct similar studies on wild bird species in kennels, as the process of feather formation is of fundamental importance for these birds.

scholarly journals Antioxidant profile for rats with the closed cranial cerebral trauma in the treatment of cerebrogermum

2016 ◽  
Author(s):  
V. D. Lukianchuk ◽  
M. V. Ohloblina ◽  
O. V. Koveshnikov
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Blood Serum ◽  
Antioxidant System ◽  
Mechanical Damage ◽  
Control Group ◽  
Experiment Data ◽  
Antioxidant Profile ◽  
Cerebral Trauma ◽  
Main Components

The work is devoted to the research of the condition of the main components of the antioxidant system at the terms of the closed cranial cerebral trauma and at its pharmaceutical correction of Cerebrogermum.  It is determined that in case of using of Cerebrogermum the activity of superoxiddismutasa is rised in the blood serum in average on 35 % concerning the significations of the control group (the closed cranial cerebral trauma without treatment), on 72 hour of experiment the activity of this are fixed in the groups of both intact and reviewer rats. It does not also yield to reviewer preparation the ability of Cerebrogermum to resist to oxidizing stress because of the activity of catalasa. In relation to the estimation of antioxidant activity it considerably outweighs sizes for rats under influence of Cerebrogermum ( in average on 65 %) which are registered in the control group. The received in the experiment data give the basis to assert that the potential cerebral protector owns the exactly ability to resist to oxidative stress that is formed on a background of the mechanical damage of cerebrum.

scholarly journals COMPARATIVE EFFECTIVENESS OF SYNTHETIC AND NATURAL ANTIOXIDANTS IN TOXIC LIVER DAMAGE BY CARBON TETRACHLORIDE

2018 ◽  
Vol 1 (67) ◽  
pp. 64-69 ◽  
Author(s):  
Наталья Симонова ◽  
Natalya Simonova ◽  
Владимир Доровских ◽  
Vladimir Dorovskikh ◽  
Михаил Штарберг ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Antioxidant System ◽  
Liver Damage ◽  
Malonic Dialdehyde ◽  
Natural Antioxidants ◽  
Control Group ◽  
Lipid Hydroperoxides ◽  
Diene Conjugates ◽  
Toxic Liver Damage ◽  
Experimental Group

Currently there is an active search for medicines increasing the stability of liver to pathological effects, reinforcing its neutralizing function, promoting its functional recovery after various injuries, including poisoning by industrial poisons. Therefore, the study of opportunities to reduce toxic liver damage by carbon tetrachloride introduction of synthetic and natural antioxidants is of interest. In experimental conditions the possibility to correct free radical lipid oxidation of rats’ organism membranes was studied with the introduction of the succinate containing drug called Reamberin (Polysan, St.Petersburg) and licorice syrup. The animals were divided into 4 groups and each of them had 10 rats: the group with intact animals which were held in standard conditions of vivarium; the control group in which rats were given carbon tetrachloride during 3 days daily; the experimental group in which before the introduction of carbon tetrachloride animals had a daily intra-abdominal intake of the Reamberin in a dose of 100 mg/kg (20 ml/kg); the experimental group in which before the introduction of carbon tetrachloride animals had a daily oral intake of the licorice syrup in a dose of 5 ml/kg. It was found out that in the blood and in the liver of experimental animals an introduction of carbon tetrachloride during 3 days contributes to the increase of lipid hydroperoxides level (by 24-43%), of diene conjugate (by 19-47%), and of malonic dialdehyde (by 61-81%) against the decrease of antioxidant system activity in the blood of intact animals. The introduction of the succinate containing drug to rats in the conditions of oxidative stress contributes to the decrease in the blood and in the liver of lipid hydroperoxides by 13-26%, of diene conjugates by 11-28%, and of malonic dialdehyde by 30-34% in comparison with the rats of the control group. Adding of the licorice syrup to rats contributes to the reliable decrease in the blood and in the liver of lipid hydroperoxides by 6-23%, of diene conjugates by 9-24%, and of malonic dialdehyde by 25-30% in comparison with the rats of the control group. While analyzing the effect of the antioxidants on the activity of the components of antioxidant system it was shown that the level of ceruloplasmin in the blood and in the liver of animals was reliably higher by 10-47%, of vitamin E by 13-42% in comparison with the same parameters of the rats of the control group. So, the application of the synthetic and natural antioxidants in the conditions of introduction of carbon tetrachloride of the organism of animals under experiment leads to the stabilization of the processes of peroxidation against the increase of antioxidant system activity.

scholarly journals THE STATE OF ANTIOXIDANT SYSTEM OF BLOOD IN PATIENTS SUFFERING FROM PSYCHOSTIMULANTS AND OPIOIDS ADDICTION SYNDROME

2018 ◽  
Vol 25 (5) ◽  
pp. 136-140
Author(s):  
D. A. Lubchenko ◽  
I. M. Bykov ◽  
M. A. Popova ◽  
M. G. Litvinova
Keyword(s):  
Antioxidant Activity ◽  
Blood Plasma ◽  
Drug Addiction ◽  
Antioxidant System ◽  
Control Group ◽  
Antioxidant Protection ◽  
Thiol Groups ◽  
Oxidative Modifications ◽  
Disease Pattern ◽  
Activity Of Enzymes

Aim. This study was designed to perform the comparative evaluation of functioning of antioxidant system of blood in patients 137 Kubanskij nauchnyj medicinskij vestnik 2018; 25 (5) suffering from psychostimulants and opioids addiction syndrome.Materials and methods. The study was performed using biological material of 52 patients divided into 3 groups. Patients who were considered to be conditionally healthy were included in the 1st (control) group. The 2nd group was presented by the patients suffering from opioids addiction syndrome, the 3rd group included patients suffering from psychostimulants addiction syndrome. Some parameters of the thiol metabolism and general antioxidant activity were identified in the blood plasma of patients as well as the level of products of oxidative modifications of biomolecules and the activity of enzymes of antioxidant protection in the erythrocytes.Results. In the course of the performed studies it was revealed that the decreased antioxidant activity of the blood plasma by 28-40% was characteristic for the examined patients as well as the imbalance of enzymes of the antiradical protection of erythrocytes and the high intensity of oxidative modifications of biomolecules characterized by the increase in the thiobarbituric value by 2,4-3 times. The activity of superoxide dismutase in erythrocytes of patients of both test groups decreased by 35-43%, while the catalase activity increased by 15-21% in comparison with the relevant indices of the control group. The presence of such changes in the functioning of enzymes of the antioxidant protection can indirectly prove the presence of hypoxia in the examined patients. Besides, the increase in the content of easily-accessible thiol groups by 2,6-2,8 times and the decrease in the content of SH-groups difficult for access by 2,5-3,2 times was noted in patients suffering from the drug addiction. The reconstruction of the balance of various types of thiol groups can be associated with the confirmatory reconstruction of protein molecules induced by the oxidative modifications and combining of toxins.Conclusion. The study in prooxidant-antioxidant status revealed the common traits in the disease pattern in patients suffering from various types of drug addiction. The received data allow us to discuss the perspectives of the criteria search for the laboratory biochemical monitoring of the patients with drug addiction and the possibilities of the antioxidant correction of metabolic disorders as a component of the complex therapy for such patients.

scholarly journals Antioxidant system state in patients with multiple sclerosis current in therapy

2011 ◽  
Vol 57 (6) ◽  
pp. 661-670 ◽  
Author(s):  
L.P. Smirnova ◽  
N.V. Krotenko ◽  
E.V. Grishko ◽  
N.M. Krotenko ◽  
V.M. Alifirova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Antioxidant Activity ◽  
Blood Serum ◽  
Antioxidant System ◽  
Malonic Dialdehyde ◽  
Control Group ◽  
Total Antioxidant Activity ◽  
Different Types ◽  
Total Antioxidant ◽  
High Level

Activity of erytrocyte glutationperoxidase (GP), glutationreductase (GR), glutationtransferase (GT), glucose-6-phosphatdehydrogenase (G6PDH), catalase and superoxiddysmutase (SOD), and also, the level of malonic dialdehyde (MDA) and total antioxidant activity of blood serum were studied in patients with different types of multiple sclerosis. Investigation of peripherical blood was carried out on first day of treatment and after standard therapy of copaxone. All MS patients had high level of MDA and activity of GP in erythrocytes in comparison with a control group. Other antioxidant enzymes of erythrocytes and total antioxidant activity of blood serum exhibited weak positive dynamics in patients with a relapsing remittance of multiple sclerosis (RRMS). Decrease of activity of antioxidant system in patients with secondary progression multiple sclerosis (SPMS) was more pronounced and remained unchanged after the treatment. This is consistent with the more severe clinical course of thise disease.

scholarly journals Dietary Postbiotic Lactobacillus plantarum Improves Serum and Ruminal Antioxidant Activity and Upregulates Hepatic Antioxidant Enzymes and Ruminal Barrier Function in Post-Weaning Lambs

Antioxidants ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 250 ◽  
Author(s):  
Wan Ibrahim Izuddin ◽  
Ali Merzza Humam ◽  
Teck Chwen Loh ◽  
Hooi Ling Foo ◽  
Anjas Asmara Samsudin
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Enzymes ◽  
Lactobacillus Plantarum ◽  
Barrier Function ◽  
Nutrient Utilization ◽  
Control Group ◽  
Gut Health ◽  
Ruminal Fluid ◽  
Animal Trials ◽  
Junction Protein

Postbiotics from Lactobacillus plantarum have been reported to improve growth performance, nutrient utilization, immune status and gut health in livestock. However, there is scarce information on the antioxidant activity of postbiotics and its modulation of antioxidant activity and rumen barrier function in animals. We investigated the antioxidant activity of postbiotics from L. plantarum RG14, RG11 and TL1 and dietary effects in post-weaning lambs on serum and ruminal antioxidant activity, hepatic antioxidant enzymes and ruminal barrier function. Postbiotic RG14 showed the highest antioxidant activity in both 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay and was chosen to be evaluated in animal trials. Twelve post-weaning Dorper lambs were allotted to the control group and postbiotic group (0.9% (v/w) postbiotic RG14). The improvement in antioxidant activity of the postbiotic group was observed by greater glutathione peroxidase (GPX) in serum and ruminal fluid and lower serum TBARS. The findings were strengthened by the upregulation of hepatic GPX1, GPX4 and copper, zinc superoxide dismutase (Cu/Zn SOD) in the postbiotic group. Lambs received postbiotics had higher regulation of rumen barrier function through upregulation of tight junction protein (TJP), occludin (OCLD), claudin-1 (CLDN1) and CLDN4. The current study demonstrated that dietary postbiotics enhanced the serum and ruminal fluid antioxidant activity, reduced the serum lipid peroxidation and upregulated hepatic antioxidant enzymes and ruminal barrier function.

scholarly journals EVALUATION OF ANTIDIABETIC, HYPOLIPIDEMIC AND ANTIOXIDANT ACTIVITY OF POLYHERBAL FORMULATION IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED DIABETES IN RATS

2017 ◽  
Vol 9 (10) ◽  
pp. 105
Author(s):  
Yuvraj Singh Surana ◽  
Purnima Ashok ◽  
Rajendran R.
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Enzymes ◽  
Blood Glucose ◽  
Oral Administration ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Favourable Effect ◽  
Control Group ◽  
Histopathological Changes

Objective: To evaluate antidiabetic, hypolipidemic and antioxidant activity of polyherbalformulation (PHF) aqueous extract in streptozotocin-nicotinamide induced diabetes in rats.Methods: Fasting blood glucose, lipid profiles, serum insulin and glycosylate haemoglobin (HbA1C) were determined in normal and streptozotocin-nicotinamide induced diabetic rats after oral administration of the PHF for 45 d. Antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and malondialdehyde (MDA) levels were evaluated in kidney and liver tissue. Histopathological changes in diabetic rat vital organs were also observed after PHF treatment.Results: Daily oral administration of PHF (200 and 400 mg/kg, b.w.) and metformin (5 mg/kg, b.w.) showed beneficial effects on blood glucose level (P<0.001) and hyperlipidaemia due to diabetes. The PHF treatment also enhances serum insulin level and body weight of diabetic rats as compared to diabetic control group. Furthermore, the PHF has favourable effects on histopathological studies, in streptozotocin-nicotinamide induced diabetes. Antioxidant enzymes and GSH levels were found to be significantly increased and levels of MDA were decreased in treated diabetic animals.Conclusion: PHF possesses antidiabetic, hypolipidemic and antioxidant properties. PHF has also showed favourable effect on histopathological changes in streptozotocin-nicotinamide induced diabetic animals.

scholarly journals Antioxidant system of rats with heavy metals and phospoorganic pesticides intoxication and peptides applying

2015 ◽  
Vol 17 (3) ◽  
Author(s):  
Ye. B. Dmukhalska ◽  
Ya. I. Honsky
Keyword(s):  
Heavy Metals ◽  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Antioxidant Enzymes ◽  
Free Radical ◽  
Antioxidant System ◽  
The State ◽  
Antioxidant Protection ◽  
Free Radical Processes ◽  
Radical Processes

<p>The effect of peptide tsysteil-histidil-tyrosil-histidil-isoleucine on the state of antioxidant protection (superoxide<br />dismutase, catalase) and lipid peroxidation has been reached. The peptide exhibits antioxidant activity, the correction<br />of the peptide reduces free radical processes and decreases the products of lipid peroxidation and increases<br />antioxidant enzymes activity.</p>

scholarly journals Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke

2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
Nasrin Sheikh ◽  
Heidar Tavilani ◽  
Aliakbar Rezaie ◽  
Asad Vaisi-raygani ◽  
Saeedeh Salimi
Keyword(s):  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Ischemic Stroke ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Control Group ◽  
Significant Difference ◽  
Total Antioxidant ◽  
And Control

Some evidence suggests the neuroprotection of estrogen provided by the antioxidant activity of this compound. The main objective of this study was to determine the level of estradiol and its correlation with the activity of antioxidant enzymes, total antioxidant status and ferritin from ischemic stroke subjects. The study population consisted of 30 patients with acute ischemic stroke and 30 controls. There was no significant difference between estradiol in stroke and control group. The activity of superoxide dismutase and level of ferritin was higher in stroke compared with control group (P<.05,P<.001, resp.). There was no significant correlation between estradiol and glutathione peroxidase, glutathione reductase, catalase, total antioxidant status, and ferritin in stroke and control groups. We observed inverse correlation between estradiol with superoxide dismutase in males of stroke patients (r=−0.54,P=.029). Our results supported that endogenous estradiol of elderly men and women of stroke or control group has no antioxidant activity.

scholarly journals CONDITION OF LIPID PEROXIDE OXIDATION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS

2018 ◽  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Glutathione Peroxidase ◽  
Blood Plasma ◽  
Glutathione Reductase ◽  
Antioxidant System ◽  
Infectious Mononucleosis ◽  
Malonic Dialdehyde

The indicators of the activity of lipid peroxidation and the antioxidant system were studied in dynamics in 158 patients with infectious mononucleosis depending on the severity of the clinical course of the disease. It is proved that lipid peroxidation is significantly activated in patients with infectious mononucleosis as the severity of the disease increases and therefore increases the oxidative activity of blood plasma, the concentration of dyne conjugates and malondialdehyde in the blood, decreases the activity of antioxidant enzymes of erythrocytes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase), glutathione peroxidase and glutathione reductase activity in plasma and lowering the concentration of total and reduced glutathione in the blood, as well as reduce the antioxidant activity of blood plasma and erythrocytes. Lipid peroxidation significantly increase and the activity of the antioxidant system decrease in patients with infectious mononucleosis in the acute period of the disease, as evidenced by the increased concentration of dyne conjugates, malonic dialdehyde and total oxidative plasma activity in the blood, reduced activity of the total antioxidant activity of plasma and erythrocytes, the decrease in the activity of antioxidant enzymes of erythrocytes catalase, superoxide dismutase, glutathione peroxidase, glutathione peroxidase and glutathione reductase of blood plasma, the decrease in the concentration of glutathione in the blood. The most pronounced disorders of lipid peroxidation and antioxidant system activity were found in patients with moderate-severe and severe infectious mononucleosis. The development of cytolytic syndrome in infectious mononucleosis is associated with the action of reactive oxygen forms species and lipid hydroperoxide.

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

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