DIGESTION OF PROTEIN BY PREMATURE INFANTS

PEDIATRICS ◽  
1951 ◽  
Vol 7 (1) ◽  
pp. 19-23
Author(s):  
MYRON S. FEINSTEIN ◽  
CLEMENT A. SMITH

Absorption of N from cow's milk mixtures supplemented with equal amounts of N as casein and casein hydrolysates was determined in 20 metabolic periods on five premature infants. The supplemental protein or hydrolysate furnished from 33.3 to 46.2% of the nitrogen intake and total N fed was equivalent to 4.22 to 8.49 G. protein/kg. body weight. With either supplement from 86 to 94% of the dietary N was absorbed and neither resulted in consistently superior nitrogen absorption. Weight gains were not consistently better during either type of supplemental feeding. The evidence of equally satisfactory nitrogen absorption and weight gain would substantiate the prevailing belief that protein digestion is not impaired after premature birth.

2020 ◽  
pp. 97-99
Author(s):  
T. Erler

Background. Medical care for premature babies in Germany is divided into two levels. Perinatal centers of the first level provide care for infants with body weight at birth <1500 g. Perinatal centers of the second level provide care for children whose body weight exceeds 1500 g. In order to be included in the list of first level institutions, the hospital must, among other, be able to pick up children from other institutions in the surrounding region. Mobile incubators are used for this purpose. Such an incubator is a kind of a mobile intensive care unit. In some cases, the incubator is delivered to the desired location by helicopter, but in most cases, specialized road transport is used. Objective. To describe neonatological medical care in Germany. Materials and methods. Analysis of own experience and available literature data on this issue. Results and discussion. In recent years, Germany experiences a decrease in the number of births, which causes the problem of professional training of doctors. Hospitals with the fewest births are closed due to lack of efficiency. Although there are some fluctuations from year to year, in general, the number of premature babies with extremely low birth weight remains approximately constant. Prematurity remains one of the most important problems of modern medicine, as it is accompanied by high mortality rates. The earlier the premature birth is and the lower the body weight is, the higher these rates are. Prematurity is caused by numerous risk factors. Multiple pregnancies are accompanied by the highest risk of premature birth. The presence of twins or triples increases this risk by 7.7 times. Other risk factors include vaginal bleeding in late pregnancy, preeclampsia, and a history of preterm birth. Over the past 20 years, the survival of children born before 32 weeks of pregnancy or weighing <1500 g has increased by almost 20 %. The smallest premature baby born in our clinic is a baby born at 24 weeks of gestation with a body weight of 350 g. Nowadays in Germany, the survival rate of infants born after 24 weeks of gestation is almost 80 %, and after 29 weeks – almost 100 %. It should be noted that maintaining the life of a premature baby from birth to discharge costs 250-300 thousand euros. Bronchopulmonary dysplasia is an important problem of premature infants, especially in case of mechanical lung ventilation (MLV) or joining infections. Up to 40 % of children who die from complications of bronchopulmonary dysplasia can be saved. If possible, MLV and infections should be avoided, premature births should be prevented, so-called neuroprotective ventilation and nasal or mask devices that do not require intubation should be used. Surfactants have made great progress in the management of premature infants. The modern LISA (less invasive surfactant administration) method allows to inject a surfactant into a child’s lungs without intubation. In the early 20th century, 100 % oxygen was used in the resuscitation of newborns, but now we use air (21 % oxygen) or a mixture containing up to 30 % oxygen. To prevent necrotizing enterocolitis, premature infants are prescribed probiotics based on lyophilized lactic acid bacteria and bifidobacteria. Breast milk is an another way to prevent this complication of prematurity. There is a breast milk bank in Potsdam. Conclusions. 1. Prematurity remains one of the most important problems of modern medicine, as it is accompanied by high mortality rates. 2. Multiple pregnancies are accompanied by the highest risk of premature birth. 3. Nowadays in Germany, the survival rate of children born after 24 weeks of gestation is almost 80 %, and after 29 weeks – almost 100 %. 4. Surfactants and the LISA method have made great progress in the management of premature infants. 5. Probiotics and breast milk are prescribed to premature babies to prevent necrotizing enterocolitis.


PEDIATRICS ◽  
1949 ◽  
Vol 4 (1) ◽  
pp. 148-148

National statistics show that the single greatest cause of infant deaths is premature birth which accounts for one half of all infant deaths in the first month of life. As pediatricians well know, the tragedy is that many of these infant lives could be saved—if given the specialized care needed. Despite the fact that at least 1 in 20 babies is born prematurely, a great many practitioners have little specialized training in the care of these infants and little knowledge of their particular problem.


2013 ◽  
Vol 3 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Gordana Grgić ◽  
Elvira Brkičević ◽  
Dženita Ljuca ◽  
Edin Ostrvica ◽  
Azur Tulumović

Introduction: Preterm delivery is the delivery before 37 weeks of gestation are completed. The incidence of preterm birth ranges from 5 to 15%. Aims of the study were to determine the average body weight, Apgar score after one and five minutes, and the frequency of the most common complications in preterminfants.Methods: The study involved a total of 631 newborns, of whom 331 were born prematurely Aims of this study were to (24th-37th gestational weeks-experimental group), while 300 infants were born in time (37-42 weeks of gestation-control group).Results: Average body weight of prematurely born infants was 2382 grams, while the average Apgar score in this group after the fi rst minute was 7.32 and 7.79 after the fifth minute. The incidence of respiratory distress syndrome was 50%, intracranial hemorrhage, 28.1% and 4.8% of sepsis. Respiratory distresssyndrome was more common in infants born before 32 weeks of gestation. Mortality of premature infants is present in 9.1% and is higher than that of infants born at term.Conclusions: Birth body weight and Apgar scores was lower in preterm infants. Respiratory distress syndrome is the most common fetal complication of prematurity. Intracranial hemorrhage is the second most common complication of prematurity. Mortality of premature infants is higher than the mortality of infants born at term birth.


1974 ◽  
Vol 83 (1) ◽  
pp. 151-160 ◽  
Author(s):  
A. C. Field ◽  
A. R. Sykes ◽  
R. G. Gunn

SUMMARYExcretion of D.M., N, Ca, P and Mg in faeces, and N, P and Mg in urine were measured at intervals over 12 months in breeding Scottish Blackface sheep grazing hill pastures. These values were used with data on reproductive performance and body compositional changes, to calculate the energy, nitrogen and mineral balances. The sheep were: 11 6½-year-old with sound mouths (SM), 16 6½-year-old with broken mouths (BM), 16 5½-year-old with all permanent incisors clipped to gum level (CM) and 16 2½-year-old (Y). An energy supplement was given at the end of gestation and during early lactation. All faeces were collected and creatinine was used as an internal marker to estimate urine volume.Faecal D.M. output ranged from 443 to 662 g/day, with highest values in November and lowest in May. Average values for the BM sheep were lower than those for the other groups but when output was expressed as a power function of body weight, the values for the Y sheep were 15% higher than those for the other groups. Faecal excretions of Ca and P in January and February were very low and the values for P were half the expected endogenous faecal loss.Urinary output ofN ranged from 6·0 g/day in February to 22·2 g/day in August and the corresponding urinary urea N: total N ratios were 0·24 and 0·69. Urinary Mg output was highest in late summer and early winter but urinary P showed no consistent trends.The estimated daily intakes of DOM (g) were 936 in November 1969, 599 in January, 414 in February, 1075 in May, 1150 in August and 946 in November 1970.The loss of energy from the body between mating (November) and mid-lactation (June) ranged from 9·5 to 16·8% of the total calculated ME requirements in the Y and BM sheep, respectively. Maintenance requirements averaged 204 kJ/kg body weight/day and the value for the Y sheep was 12% higher than the mean for the older sheep.Nitrogen and mineral balances were calculated for February, May, August and November. The sheep were protein-deficient in winter, not from a shortage of crude protein in the diet but because of its low digestibility (34%). Intakes of Ca and P in winter were low and a real possibility of a P deficiency exists. Estimates of the concentrations of N and of minerals in the herbage consumed by the sheep were made and compared with those obtained for cut herbage from the same pastures. It would appear that the sheep selected herbage of a higher protein content than that of the cut herbage. Herbage selection was greatest in November.


2012 ◽  
Vol 88 ◽  
pp. S106
Author(s):  
N. Kharitonova ◽  
I. Belyaeva ◽  
G. Yatsyk ◽  
E. Bombardirova

2001 ◽  
Vol 137 (1) ◽  
pp. 85-96 ◽  
Author(s):  
R. SANDERSON ◽  
M. S. DHANOA ◽  
C. THOMAS ◽  
A. B. McALLAN

Growth and efficiencies of nitrogen and energy utilization for growth by 72 young British Friesian steers (initial live weight (LW) 110 kg) offered a well preserved, formic acid-treated, perennial ryegrass silage with and without supplements of fish meal were examined. Silage was offered either alone or mixed with 50, 100 or 150 g fish meal/kg silage dry matter (DM) and each diet was offered either ad libitum or intakes were restricted to 16, 19 or 22 g dietary DM/kg LW/day. Treatments were imposed over a period of 132 days. Body component weight gains were determined by comparative slaughter.Increasing the level of either feeding or fish meal increased rates of empty body weight gain linearly (P<0·001) and curvilinearly (P<0·05) respectively. Fish-meal supplementation increased rates of ash and crude protein gain (P<0·001) but, in comparison with the curvilinear response to increasing level of feeding (P<0·001), had small linear effects on fat gain (P>0·01). Consequently, in terms of whole body composition, animals given fish meal were leaner than animals offered silage alone. Fish-meal supplementation had no significant effect on the composition of the carcass but increased the concentration of protein in the liver and gastrointestinal tract.The increase in nitrogen intake associated with feeding fish meal resulted in a reduction in the efficiency of nitrogen utilization as level of fish meal increased. Nitrogen intake required for maintenance was estimated to be 1·054 g/kg LW0·75. In spite of marked differences in the composition of the empty body-weight gain, there was no evidence to support an effect of fish meal on the efficiency of metabolizable energy (ME) utilization for growth (kf) which was estimated to be 0·346 on the basis of data scaled by LW0·75. ME intake required for maintenance (MEm) was estimated to be 0·536 and 0·502 MJ/kg LW0·75 for silage alone and the 150 g fish-meal level respectively.


1993 ◽  
Vol 57 (2) ◽  
pp. 237-245 ◽  
Author(s):  
J. C. MacRae ◽  
A. Walker ◽  
D. Brown ◽  
G. E. Lobley

AbstractTwelve Suffolk-Finn Dorset lambs were reared from 25 to 40 or 25 to 55 kg body weight on either pelleted dried grass or a ration of pelleted grass plus barley (ratio 1:1) in a comparative slaughter experiment designed to determine the amounts of total nitrogen and individual amino acids accreted in different body components during growth. Nitrogen (N) balance measurements were determined frequently during this growth phase and accumulated N retentions were compared with the total N accretion determined by comparative slaughter. Total N and individual amino acids accumulated in carcass, wool, skin, offal and blood, head and feet, gastro-intestinal tract and liver were linearly related to body weight in all cases other than for cysteine in carcass. At 25 kg live weight, proportionately 0·52 of total body N was in carcass components, 0·115 in wool, 0·08 in skin, 0·10 in offal and blood, 0·095 in head and feet, 0·06 in the gastro-intestinal tract and 0·02 in liver. However as the animals grew from 25 to 55 kg, 0·256 of the total N accretion was in wool, which was rich in cysteine (98 g/kg total amino acid). Carcass accretion represented only 0·449 of total body N accretion. The N balance technique overestimated net protein accretion by 0·24 (s.e. 0·036).


1972 ◽  
Vol 27 (2) ◽  
pp. 285-298 ◽  
Author(s):  
Robert Moss ◽  
J. A. Parkinson

1. In the wild, red grouse live largely on heather, a high-fibre (25%), low-protein (7%) food. Digestibility trials were carried out under semi-natural conditions, with magnesium as a digestibility marker. Two trials were done, one in autumn and one in spring.2. Digestibility of the dry matter varied from 21 to 30% and metabolizable energy from 1.1 to 1.6 kcal/g. These variations were inversely related to intake and could partly be accounted for by facultative variations in holocellulose and lignin digestion.3. Digestion of soluble carbohydrates, protein (measured as α-amino-nitrogen) and holocellulose varied between trials according to the initial concentration in the food. The digestibility of soluble carbohydrate was high (78–83%) in autumn (16% in food) and low (61–66%) in spring (11% in food) and that of protein was relatively low (24–31%) in autumn (6% in food) and high (42–48%) in spring (7% in food). Digestibility of crude fat was 30–33% for four birds and 20% for one bird.4. By comparison with poultry, voluntary intake of dry matter was very high relative to body-weight and intake of energy appeared to be adequate. None the less, all birds lost weight during the trials, presumably for reasons other than energy shortage.5. Urate excretion increased in parallel with body-weight losses, but formed only 2% of the total N output at low weight losses, in which event the main nitrogenous compounds in the droppings were α-amino N (presumably largely from undigested protein), ammonium salts and ornithuric acid.6. The ornithuric acid was presumably a detoxication product of prolignins and possibly tannins and other polyphenols. Its excretion by grouse corresponds to the excretion of hippuric acid by ruminants.


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