Excretion of Technetium in Human Milk

PEDIATRICS ◽  
1983 ◽  
Vol 71 (5) ◽  
pp. 841-842
Author(s):  
M. JEFFREY MAISELS ◽  
RONALD O. GILCHER
Keyword(s):  
Nuclear Medicine ◽  
Breast Milk ◽  
Human Milk ◽  
Breast Feeding ◽  
Half Life ◽  
Milk Protein ◽  
Radioactive Material ◽  
Nursing Mother ◽  
Technetium 99M

The radioisotope technetium-99m(99mTc) is widely used in nuclear medicine for a variety of scanning procedures. On occasion, it may be necessary to perform such studies on a nursing mother, and it is important to know what dose of radioactive material a nursing infant might receive and how soon after the isotope administration the mother may resume breast-feeding. Technetium is one of the halide elements and is handled, biologically, much like iodine.1 Like iodide,2,3 the pertechnetate ion (99mTcO4-) is concentrated in the thyroid gland1,4 and stomach5,6 and in the breast milk of nursing mothers4-6 and women with the amenorrhea-galactorrhea syndrome.7 In this report we present studies on 99mTcO4- in breast milk, including its binding to milk protein, biologic half-life, and calculations of radioactivity that might be ingested by a nursing infant.

Radioactive Excretion in Human Milk Following Administration of Technetium Tc 99m Macroaggregated Albumin

PEDIATRICS ◽  
1982 ◽  
Vol 70 (2) ◽  
pp. 231-234
Author(s):  
W. B. Pittard ◽  
R. Merkatz ◽  
B. D. Fletcher
Keyword(s):  
Nuclear Medicine ◽  
Breast Milk ◽  
Human Serum Albumin ◽  
Radiation Dose ◽  
Human Milk ◽  
Radiation Hazard ◽  
Base Line ◽  
Pulmonary Emboli ◽  
Lung Scan ◽  
Total Body

Albumin-tagged sodium pertechnetate (technetium) is routinely used in nuclear medicine for scanning procedures of the lung. The rate of excretion of this radionuclide into breast milk and the resultant potential radiation hazard to the nursing infant have received little attention. Therefore the milk from a nursing mother who required a lung scan because of suspected pulmonary emboli using an intravenous injection of 4 mCi of technetium Tc 99 macroaggregated human serum albumin was monitored. Albumin tagging severely limited the entrance of technetium into her milk and the radio-activity of the milk returned to base line by 24 hours. A total of 2.02 µCi of technetium was measured in the 24-hour milk collection after technetium injection and 94% of this amount was excreted by 15.5 hours. This amount of technetium administered orally to a newborn would deliver a total body radiation dose of .3 mrad. Therefore, an infant would receive trivial doses of radiation if breast-feeding were resumed 15.5 hours after administration of the radionuclide to the mother and nursing can clearly be resumed safely 24 hours after injection.

Drugs and Breast Milk

PEDIATRICS ◽  
1990 ◽  
Vol 86 (1) ◽  
pp. 147-148
Author(s):  
JOAN S. DORFMAN
Keyword(s):  
Breast Milk ◽  
American Academy ◽  
Human Milk ◽  
Breast Feeding ◽  
American Academy Of Pediatrics ◽  
Maternal Medication ◽  
Anti Inflammatory ◽  
Nonnarcotic Analgesics

To the Editor.— I have just reviewed the the article, "Transfer of Drugs and Other Chemicals Into Human Milk," from the American Academy of Pediatrics Committee on Drugs, which appeared in the November issue of Pediatrics.1 I would appreciate further information on a change that has appeared since the previous publication in the September, 1983 issue of Pediatrics.2 Naproxen has been deleted from the current table of maternal medication usually compatible with breast-feeding under the category "narcotics, nonnarcotic analgesics, anti-inflammatory agents."

Human Breast Milk Contains Bovine lgG. Relationship to Infant Colic?

PEDIATRICS ◽  
1991 ◽  
Vol 87 (4) ◽  
pp. 439-444
Author(s):  
Patrick S. Clyne ◽  
Anthony Kulczycki
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Milk Protein ◽  
Cow’S Milk ◽  
Human Breast Milk ◽  
Human Breast ◽  
Cow's Milk ◽  
Milk Samples ◽  
Infant Colic ◽  
Β Lactoglobulin

Previous studies have suggested that an unidentified cow's milk protein, other than β-lactoglobulin and casein, might play a pathogenetic role in infant colic. Therefore, a radioimmunoassay was used to analyze human breast milk and infant formula samples for the presence of bovine IgG. Milk samples from 88 of the 97 mothers tested contained greater than 0.1 µg/mL of bovine IgG. In a study group of 59 mothers with infants in the colic-prone 2- to 17-week age group, the 29 mothers of colicky infants had higher levels of bovine IgG in their breast milk (median 0.42 µg/mL) than the 30 mothers of noncolicky infants (median 0.32 µg/mL) (P < .02). The highest concentrations of bovine IgG observed in human milk were 8.5 and 8.2 µg/mL. Most cow's milk-based infant formulas contained 0.6 to 6.4 µg/mL of bovine IgG, a concentration comparable with levels found in many human milk samples. The results suggest that appreciable quantities of bovine IgG are commonly present in human milk, that significantly higher levels are present in milk from mothers of colicky infants, and that bovine IgG may possibly be involved in the pathogenesis of infant colic.

scholarly journals Variation in the Protein Composition of Human Milk during Extended Lactation: A Narrative Review

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1124 ◽  
Author(s):  
Sergio Verd ◽  
Gemma Ginovart ◽  
Javier Calvo ◽  
Jaume Ponce-Taylor ◽  
Antoni Gaya
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Protein Content ◽  
Milk Protein ◽  
Mammalian Species ◽  
Protein Composition ◽  
Developed Countries ◽  
First Year ◽  
Second Year ◽  
First Year Of Life

The aim of this review is to evaluate changes in protein parameters in the second year postpartum. There is considerable agreement among authors about the declining trend of human milk protein concentrations, but most research on protein content in breast milk focuses on the first year of life and comes from developed countries. Whereas this is the case for exclusive breastfeeding or for breastfeeding into the first year of life, the opposite applies to weaning or extended breastfeeding. This review is predominantly based on observational epidemiological evidence and on comparative research linking breast milk composition with cutting down on breastfeeding. Studies dating back several decades have shown an increase in the proportion of immunoglobulins, lactoferrin, and serum albumin during weaning. According to the limited data available, it seems likely that the regulation of milk protein composition during involution can be ascribed to alterations in tight junctions. In studies on humans and other mammalian species, offspring suckle more from mothers that produce more dilute milk and the increase in milk protein concentration is positively correlated to a decrease in suckling frequency during weaning. High milk protein contents were first reported in nonindustrial communities where breastfeeding is sustained the longest, but recent papers from urbanized communities have taken credit for rediscovering the increase in protein content of human milk that becomes evident with prolonged breastfeeding. This review presents an overview of the changes in breast milk protein parameters in the second year postpartum to enable milk banks’ practitioners to make informed nutritional decisions on preterm infants.

scholarly journals Consumption of breast milk, formula and other non-human milk by children aged under 2 years: analysis of eighty-six low- and middle-income countries

2020 ◽  
pp. 1-9
Author(s):  
Paulo AR Neves ◽  
Aluísio JD Barros ◽  
Phillip Baker ◽  
Ellen Piwoz ◽  
Thiago M Santos ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Breast Feeding ◽  
Milk Formula ◽  
Milk Consumption ◽  
Middle Income ◽  
Middle Income Countries ◽  
Country Level ◽  
Low And Middle Income ◽  
Economic Inequalities

Abstract Objective: To investigate the prevalence and socio-economic inequalities in breast milk, breast milk substitutes (BMS) and other non-human milk consumption, by children under 2 years in low- and middle-income countries (LMIC). Design: We analysed the prevalence of continued breast-feeding at 1 and 2 years and frequency of formula and other non-human milk consumption by age in months. Indicators were estimated through 24-h dietary recall. Absolute and relative wealth indicators were used to describe within- and between-country socio-economic inequalities. Setting: Nationally representative surveys from 2010 onwards from eighty-six LMIC. Participants: 394 977 children aged under 2 years. Results: Breast-feeding declined sharply as children became older in all LMIC, especially in upper-middle-income countries. BMS consumption peaked at 6 months of age in low/lower-middle-income countries and at around 12 months in upper-middle-income countries. Irrespective of country, BMS consumption was higher in children from wealthier families, and breast-feeding in children from poorer families. Multilevel linear regression analysis showed that BMS consumption was positively associated with absolute income, and breast-feeding negatively associated. Findings for other non-human milk consumption were less straightforward. Unmeasured factors at country level explained a substantial proportion of overall variability in BMS consumption and breast-feeding. Conclusions: Breast-feeding falls sharply as children become older, especially in wealthier families in upper-middle-income countries; this same group also consumes more BMS at any age. Country-level factors play an important role in explaining BMS consumption by all family wealth groups, suggesting that BMS marketing at national level might be partly responsible for the observed differences.

scholarly journals Study on knowledge and practice of nursing mother regarding exclusive breast feeding irrespective of socio-demographic characteristics

2019 ◽  
Vol 1 (Number 1) ◽  
pp. 14-17
Author(s):  
Nadia Begum ◽  
Monowar Ahmad Tarafdar ◽  
Saizuddin Kabir ◽  
Shila Rani Das ◽  
Sultana Begum ◽  
...  
Keyword(s):  
Breast Milk ◽  
Breast Feeding ◽  
Cross Sectional Study ◽  
Demographic Characteristics ◽  
Global Strategy ◽  
Cross Sectional ◽  
Major Barrier ◽  
Nursing Mother ◽  
Exclusive Breast Feeding ◽  
Knowledge And Practice

This descriptive type of cross- sectional study was conducted in Dhamrai, Dhaka among nursing mother with a sample size 120 using semi-structured questionnaire to determine the knowledge and practice regarding exclusive breast feeding irrespective of socio-demographic characteristics from January 2018 to February 2018 employing purposive sampling method. The percentage of mother-infant pair were highest within 20-30 years (65%) of age group. About 13.33% of mothers were illiterate, 33.33% had primary level and only 2.50% completed graduation; more than half (56.67%) of the mothers were housewives. It was revealed that 55.83% of the respondents had knowledge of exclusive breast feeding, however 42.50% of them gave only breast milk up to 6 months. The initiation of breast feeding within 1 hour was 47.50%, 32.50% within 1-2 hours. 8.83% after 2 hours, 9.16% of the respondents did not remember about the exact time and 2.50% did not breast fed their babies, the reason of not feeding breast milk was insufficient milk secretion. Premature complementary feeding was associated with an increased occurrence of vomiting (47.50%), diarrhea (59.16%), dyspnea (19.16%) but 55% of the respondents did not mentioned specific condition. One of the ten steps to successful breastfeeding is initiating breastfeeding within the first hour of delivery, the major barrier to achieving the recommendations of the Global Strategy for Infant and Young Child Feeding.

scholarly journals Vitamin A and Breast-Feeding: A Comparison of Data from Developed and Developing Countries

1994 ◽  
Vol 15 (2) ◽  
pp. 1-16 ◽  
Author(s):  
Vicky Newman
Keyword(s):  
Developing Countries ◽  
Breast Milk ◽  
Vitamin A ◽  
Human Milk ◽  
Breast Feeding ◽  
Developed Countries ◽  
Lactating Women ◽  
Vitamin A Status ◽  
Sufficient Vitamin ◽  
Liver Storage

The vitamin A status of lactating women, its effect on the vitamin A content of human milk, and the adequacy of human milk as a source of vitamin A for the infant were assessed, comparing data from developing countries with those from developed countries. The vitamin A concentration in breast milk during the first two weeks of lactation is nearly double that at one month. It is even higher in preterm milk than in term milk during the first several months. Human milk alone provides sufficient vitamin A to prevent clinical deficiency throughout the first 12 months of life, even in presumably more poorly nourished populations in developing countries. However, it is not sufficient to allow liver storage after about six months of lactation.

scholarly journals Energy intake from human milk covers the requirement of 6-month-old Senegalese exclusively breast-fed infants

2013 ◽  
Vol 110 (10) ◽  
pp. 1849-1855 ◽  
Author(s):  
Anta Agne-Djigo ◽  
Komlan M. Kwadjode ◽  
Nicole Idohou-Dossou ◽  
Adama Diouf ◽  
Amadou T. Guiro ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Energy Intake ◽  
Breast Feeding ◽  
Best Practice ◽  
Energy Content ◽  
Milk Intake ◽  
Exclusive Breast Feeding ◽  
Breast Fed ◽  
Comprehensive Study

Exclusive breast-feeding until 6 months is advised by the WHO as the best practice to feed infants. Yet, some studies have suggested a gap between energy requirements and the energy provided by human milk for many infants at 6 months. In order to assess the adequacy of WHO recommendations in 6-month-old Senegalese lactating infants, a comprehensive study was designed to measure human milk intake by the dose-to-the mother 2H2O turnover method. Infants' energy intakes were calculated using daily breast milk intake and the energy content of milk was estimated on the basis of creamatocrit. Of the fifty-nine mother–infant pairs enrolled, fifteen infants were exclusively breast-fed (Ex) while forty-four were partially breast-fed (Part). Infants' breast milk intake was significantly higher in the Ex group (993 (sd 135) g/d, n 15) compared with the Part group (828 (sd 222) g/d, n 44, P= 0·009). Breast milk energy content as well as infants' growth was comparable in both groups. However, infants' energy intake from human milk was significantly higher (364 (sd 50) kJ/kg per d (2586 (sd 448) kJ/d)) in the Ex group than in the Part group (289 (sd 66) kJ/kg per d (2150 (sd 552) kJ/d), P< 0·01). Compared with WHO recommendations, the results demonstrate that energy intake from breast milk was low in partially breast-fed infants while exclusively breast-fed 6-month-old Senegalese infants received adequate energy from human milk alone, the most complete food for infants. Therefore, advocacy of exclusive breast-feeding until 6 months should be strengthened.

scholarly journals Detection of SARS-CoV-2 in Human Breast Milk

2020 ◽  
Author(s):  
Rüdiger Groß ◽  
Carina Conzelmann ◽  
Janis A. Müller ◽  
Steffen Stenger ◽  
Karin Steinhart ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Breast Feeding ◽  
Human Population ◽  
Close Contact ◽  
Human Breast Milk ◽  
Human Breast ◽  
Milk Samples ◽  
Respiratory Droplets

SARS-CoV-2 (CoV-2) is mainly transmitted in the human population during close contact and respiratory droplets. It is currently unclear, however, whether CoV-2 is shed into milk and may also be transmitted from infected mothers to newborns trough breast feeding. Two recent reviews on the topic (1,2) did not find evidence for CoV-2 in human milk. However, the number of breast milk samples analyzed so far is small and samples were taken only once from each mother (2).

scholarly journals Deteksi Karakteristik Peluruhan Radionuklida Medis 99Mo Untuk Memperoleh 99mTc Menggunakan Spektrometer Gamma dengan Sumber Standar Cair Campuran 133Ba dan 152Eu

2020 ◽  
Vol 24 (2) ◽  
pp. 96
Author(s):  
Mawar - Mawar ◽  
Sri Dewi Astuti ◽  
Siska Febriana
Keyword(s):  
Nuclear Medicine ◽  
Half Life ◽  
Liquid Mixture ◽  
Product Formation ◽  
Optimal Time ◽  
Bone Scanning ◽  
Radioisotope Production ◽  
Technetium 99M ◽  
The Third ◽  
99Mtc Generator

Technetium-99m (99mTc) is a subsidiary of metastable 99Mo with a half-life of 6 hours. The relatively short half-life, causing 99mTc widely used for diagnostic purposes in nuclear medicine, especially in bone scanning for a faster decay. This research aims to determine the optimal time to product formation of 99mTc until elution profiles have detected 99Mo energy. The instrument used is the 99Mo/99mTc generator with standard sources 133Ba and 152Eu liquid mixture. The results obtained showed that 99mTc radioisotope production is still good until the third day elution 99Mo, whereas in the fourth to ninth day 99Mo energy detected on the decline, so that the activity of the 99mTc resulting product cannot be used for diagnosis.

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