Use of Multiple Visits to Increase Blood Pressure Tracking Correlations in Childhood

PEDIATRICS ◽  
1991 ◽  
Vol 87 (5) ◽  
pp. 708-711
Author(s):  
Matthew W. Gillman ◽  
Bernard Rosner ◽  
Denis A. Evans ◽  
Laurel A. Smith ◽  
James O. Taylor ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Correlation Coefficient ◽  
Diastolic Pressure ◽  
Pearson Correlation ◽  
Systolic Pressure ◽  
Pearson Correlation Coefficient ◽  
Increase Blood Pressure ◽  
Multiple Visit

Previous studies of childhood blood pressure have shown tracking correlations, which estimate the magnitude of association between initial and subsequent measurements, to be lower than corresponding adult values. Inasmuch as this disparity could arise from failing to account for a larger week-to-week variability in children, blood pressure was measured for 4 successive years, on four weekly visits in each year, and with three measurements at each visit, using a random-zero sphygmomanometer, in a cohort of 333 schoolchildren aged 8 through 15 at entry. Ninety percent of subjects had measurements in 1 or more years of follow-up. For all follow-up periods (1, 2, and 3 years from baseline), the Pearson correlation coefficient (r) for both systolic and diastolic blood pressure rose substantially with the number of weekly visits used to calculate each subject's yearly blood pressure (P < .0001). For systolic pressure, the 3-year r values for 1, 2, 3, and 4 visits were .45, .55, .64, and .69, respectively. For diastolic pressure (Korotkoff phase 4), the corresponding values were .28, .41, .47, and .54. These higher multiple-visit estimates of tracking approximate published adult values and raise the possibility that prediction of adult blood pressure from childhood measurements may be improved by averaging readings from multiple weekly visits.

Relationship between Invasive and Non-Invasive Hemodynamic Measures in Experimental Pulmonary Hypertension

2020 ◽  
Vol 16 (1) ◽  
pp. 47-53
Author(s):  
Vicente Benavides-Córdoba ◽  
Mauricio Palacios Gómez
Keyword(s):  
Heart Rate ◽  
Pulmonary Hypertension ◽  
Ejection Fraction ◽  
Right Ventricle ◽  
Correlation Coefficient ◽  
Pearson Correlation ◽  
Systolic Pressure ◽  
Control Group ◽  
Pearson Correlation Coefficient ◽  
Non Invasive

Introduction: Animal models have been used to understand the pathophysiology of pulmonary hypertension, to describe the mechanisms of action and to evaluate promising active ingredients. The monocrotaline-induced pulmonary hypertension model is the most used animal model. In this model, invasive and non-invasive hemodynamic variables that resemble human measurements have been used. Aim: To define if non-invasive variables can predict hemodynamic measures in the monocrotaline-induced pulmonary hypertension model. Materials and Methods: Twenty 6-week old male Wistar rats weighing between 250-300g from the bioterium of the Universidad del Valle (Cali - Colombia) were used in order to establish that the relationships between invasive and non-invasive variables are sustained in different conditions (healthy, hypertrophy and treated). The animals were organized into three groups, a control group who was given 0.9% saline solution subcutaneously (sc), a group with pulmonary hypertension induced with a single subcutaneous dose of Monocrotaline 30 mg/kg, and a group with pulmonary hypertension with 30 mg/kg of monocrotaline treated with Sildenafil. Right ventricle ejection fraction, heart rate, right ventricle systolic pressure and the extent of hypertrophy were measured. The functional relation between any two variables was evaluated by the Pearson correlation coefficient. Results: It was found that all correlations were statistically significant (p <0.01). The strongest correlation was the inverse one between the RVEF and the Fulton index (r = -0.82). The Fulton index also had a strong correlation with the RVSP (r = 0.79). The Pearson correlation coefficient between the RVEF and the RVSP was -0.81, meaning that the higher the systolic pressure in the right ventricle, the lower the ejection fraction value. Heart rate was significantly correlated to the other three variables studied, although with relatively low correlation. Conclusion: The correlations obtained in this study indicate that the parameters evaluated in the research related to experimental pulmonary hypertension correlate adequately and that the measurements that are currently made are adequate and consistent with each other, that is, they have good predictive capacity.

scholarly journals Bed-Based Ballistocardiography: Dataset and Ability to Track Cardiovascular Parameters

Sensors ◽  
2020 ◽  
Vol 21 (1) ◽  
pp. 156
Author(s):  
Charles Carlson ◽  
Vanessa-Rose Turpin ◽  
Ahmad Suliman ◽  
Carl Ade ◽  
Steve Warren ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Stroke Volume ◽  
Systolic Blood Pressure ◽  
Correlation Coefficient ◽  
Pearson Correlation ◽  
Health Assessment ◽  
Initial Study ◽  
Pearson Correlation Coefficient ◽  
Medical Systems ◽  
Cardiovascular Parameters

Background: The goal of this work was to create a sharable dataset of heart-driven signals, including ballistocardiograms (BCGs) and time-aligned electrocardiograms (ECGs), photoplethysmograms (PPGs), and blood pressure waveforms. Methods: A custom, bed-based ballistocardiographic system is described in detail. Affiliated cardiopulmonary signals are acquired using a GE Datex CardioCap 5 patient monitor (which collects ECG and PPG data) and a Finapres Medical Systems Finometer PRO (which provides continuous reconstructed brachial artery pressure waveforms and derived cardiovascular parameters). Results: Data were collected from 40 participants, 4 of whom had been or were currently diagnosed with a heart condition at the time they enrolled in the study. An investigation revealed that features extracted from a BCG could be used to track changes in systolic blood pressure (Pearson correlation coefficient of 0.54 +/− 0.15), dP/dtmax (Pearson correlation coefficient of 0.51 +/− 0.18), and stroke volume (Pearson correlation coefficient of 0.54 +/− 0.17). Conclusion: A collection of synchronized, heart-driven signals, including BCGs, ECGs, PPGs, and blood pressure waveforms, was acquired and made publicly available. An initial study indicated that bed-based ballistocardiography can be used to track beat-to-beat changes in systolic blood pressure and stroke volume. Significance: To the best of the authors’ knowledge, no other database that includes time-aligned ECG, PPG, BCG, and continuous blood pressure data is available to the public. This dataset could be used by other researchers for algorithm testing and development in this fast-growing field of health assessment, without requiring these individuals to invest considerable time and resources into hardware development and data collection.

scholarly journals Evaluation of blood pressure in school children aged 12-16 years

2017 ◽  
Vol 4 (4) ◽  
pp. 1218
Author(s):  
Balakrishnan Nadesan ◽  
Mani Madhavan Sachithananthamoorthi ◽  
Sivaraman Thirumalaikumarasamy ◽  
Ezhilarasu Ramalingam
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Diastolic Blood Pressure ◽  
School Children ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Cross Sectional ◽  
Significant Difference ◽  
History Of ◽  
Family History Of Hypertension

Background: Hypertension is considered as a major health issue in developed as well as developing countries and its possible origin during childhood prompts pediatricians to routinely include measurement of blood pressure (BP) as an integral part of pediatric physical examination. The objectives of the study were to evaluate the normal range of blood pressure in adolescent school going students of 12-16 years, prevalence of hypertension and relationship of BP with variables like age, body mass index (BMI), socioeconomic status and family history of hypertension.Methods: A cross sectional study was undertaken for a period of one year in adolescent school children in age groups between 12-16 years. Detailed clinical examination was done in 1060 adolescent school children and BP was recorded in right upper limb and correlation of BP with BMI, family history of hypertension and diabetes were studied.Results: Mean systolic and diastolic pressure showed linear relationship with age. There was a highly statistically significant difference between mean systolic and diastolic blood pressure between lower and middle socio-economic class. Prevalence of obesity in our study was 1.13%, overweight was 7.83%. Prevalence of hypertension in obese children was 33.33% and in overweight children 18.07%. Family history of hypertension and diabetes carry a significant correlation with elevated systolic and diastolic blood pressure in adolescents.Conclusions: This study revealed that socio economic factors play a significant role in determining the blood pressure of the individual. Children of middle class have significantly elevated mean systolic pressure and mean diastolic pressure than low socio-economic groups. 

Evaluating the Situational Specificity of Relaxation in Mild Essential Hypertension

1980 ◽  
Vol 51 (2) ◽  
pp. 667-674
Author(s):  
John E. Martin ◽  
Leonard H. Epstein
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Diastolic Blood Pressure ◽  
Systolic Pressure ◽  
Progressive Relaxation ◽  
Multiple Baseline ◽  
Self Monitoring ◽  
Situational Specificity ◽  
Blood Pressures

A multiple baseline across subject/settings design was employed to assess the specificity of the effects of progressive relaxation in two recently diagnosed, mild hypertensives. Relaxation was implemented successively across laboratory and home settings. In Subject 1, laboratory relaxation was associated with control over diastolic blood pressure, while in Subject 2, control over systolic pressure was observed. Improvements to normotensive levels were observed for both subjects, and the changes were maintained in both settings for Subject 2 at 6- and 12-mo. follow-up. Subject 1 discontinued her medications, relaxation, and self-monitoring of blood pressure, which was associated with an increase in blood pressure during treatment maintenance; however, at 6- and 12-mo. follow-up, both home and laboratory blood pressures were within normotensive range.

scholarly journals SAT-LB126 Metformin Attenuates Sodium Retention and Blood Pressure in Hypertensive Diabetic Mice by Reducing the Phosphorylation of Renal NCC and Its Association With the Actin Cytoskeleton

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Mohammed F Gholam ◽  
Alina Waleed ◽  
Kubra M Tuna ◽  
Morgan Carson-Marino ◽  
Kevin M Chacko ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Actin Cytoskeleton ◽  
Correlation Coefficient ◽  
Western Blotting ◽  
Pearson Correlation ◽  
Left Kidney ◽  
Control Group ◽  
Pearson Correlation Coefficient ◽  
Sodium Retention ◽  
Oral Gavage

Abstract Metformin is the first-line drug in the treatment of type 2 diabetes mellitus. The aim of this work was to evaluate the efficacy of metformin treatment in reducing blood pressure and investigate the molecular mechanism using a preclinical animal model. Adult male and female diabetic db/db mice with a blood glucose of greater than 300 mg/dl were salt-loaded (8% NaCl) for 10 days to induce hypertension. The mice were subject to metabolic cage studies for 24 hour urine collections in order to measure urinary electrolytes, albumin, and creatinine. Blood pressure was measured weekly by the tail-cuff method to assess the effect of metformin or vehicle given by oral gavage (dose of 60 mg/kg of body weight per day). At the end of the study the mice was euthanized and the left kidney was formalin-fixed and paraffin-embedded for immunohistochemistry while the right kidney was homogenized for Western blotting. Western blotting showed attenuation of total NCC and phospho-NCC in diabetic db/db mice given an oral gavage of metformin (Pearson correlation coefficient: 0.9470 +/- 2.52e-3) compared to vehicle (Pearson correlation coefficient: 0.9800 +/- 2.86e-3). Immunohistochemical analysis showed less co-localization of the actin cytoskeleton protein filamin and phosphorylated NCC in the metformin treated group compared to the control group. Taken together, we show metformin decreases sodium retention and blood pressure by reducing the density of renal NCC at the luminal membrane and the association between NCC and the actin cytoskeleton.

scholarly journals Renal evaluation in patients with type 2 diabetes mellitus and its association with diastolic blood pressure

2016 ◽  
Vol 25 (1) ◽  
pp. 25-32
Author(s):  
Fokine D. Anna ◽  
Mendieta Z. Hugo ◽  
Mendieta A.M. Ruth
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diastolic Blood Pressure ◽  
Pearson Correlation ◽  
Disease Epidemiology ◽  
The Difference

Background: HbA1c is correlated with the estimated glomerular filtration rate (eGFR) and diastolic blood pressure (DBP). Our main objective was to evaluate the trend of biochemical and clinical variables, in relation to the eGFR in patients with type 2 diabetes mellitus (T2DM). Methods: This was a retrospective, longitudinal, and descriptive study, including patients with T2DM, who were cared for from January 2014 until December 2014, at the Clínica de Diabetes, Hospital Regional “Gral. Ignacio Zaragoza", ISSSTE, Mexico City, Mexico. eGFR was calculated using three formulas: the chronic kidney disease – epidemiology collaboration (CKD-EPI), Cockcroft-Gault, and modification of diet in renal disease (MDRD), during two periods of observation, 3 and 6 months. The results were compared by Student t tests or Wilcoxon-Mann-Whitney test depending on the variable distribution. Pearson correlation was employed to determine the relation between the eGFR determined with each formula and the analyzed variables. Results: The mean age was 56.5±11.3 years in the group of 3 months’ follow-up (n=110) and 57.1±13.8 years in the group of 6 months’ follow-up (n=47). In both groups, the formula with the lowest percentages of cases of CKD was CKD-EPI and the difference of this formula had a basal and final significant positive correlation with the DBP. Conclusion: The CKD-EPI formula showed the lowest percentages of cases of CKD in a short follow-up period, and its difference is consistently associated with the DBP, confirming the importance of controlling the later to mitigate the evolution to CKD.

Noninvasive measurement of systolic and diastolic blood pressure in swine

1982 ◽  
Vol 242 (1) ◽  
pp. H127-H130 ◽  
Author(s):  
B. C. Hodgkin ◽  
D. E. Burkett ◽  
E. B. Smith
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Doppler Ultrasound ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Ulnar Artery ◽  
Arterial Blood ◽  
Significant Difference ◽  
Sample Correlation ◽  
The Difference

Arterial blood pressure was measured noninvasively using Doppler ultrasound and an occluding cuff. The subjects were 28 domestic pigs (10-49 kg) anesthetized with pentobarbital sodium (25 mg/kg). Indirect pressure measurements were made with the Doppler unit placed over the radial or the ulnar artery proximal to the carpal joint. Comparison was made with directly measured pressure to determine the reliability and reproducibility of the indirect method. Direct systolic pressures between 73 and 230 mmHg and diastolic pressures between 52 and 165 mmHg were measured. There was no significant difference between directly and indirectly measured systolic pressure (P greater than 0.20). Indirectly measured diastolic pressure tended to be lower than direct diastolic pressure, the difference by the paired t test being significant to P = 0.06. For systolic pressure the sample correlation coefficient was 0.94, and for diastolic pressure, 0.88. Both systolic and diastolic blood pressure can be accurately measured in the anesthetized pig using Doppler ultrasound and an occluding cuff.

scholarly journals Efektifitas Terapi Relaksasi Benson Terhadap Tekanan Darah Pada Penderita Hipertensi

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Joko Tri Atmojo ◽  
Made Mahaguna Putra ◽  
Ni Made Dewi Yunica Astriani ◽  
Putu Indah Sintya Dewi ◽  
Tjahja Bintoro
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Sampling Technique ◽  
T Test ◽  
Relaxation Therapy ◽  
The Mean ◽  
Paired T Test

Background: Hypertension is associated with an increase in systolic pressure or diastolic pressure or the pressure of both. Hypertension is defined as persistently high blood pressure where the systolic pressure above 140 mmHg and diastolic pressure above 90 mmHg. One of the non-pharmacological treatments for hypertension is with Benson relaxation therapy. The purpose of this research was to analyze the effect of Benson relaxation therapy on blood pressure in patients with hypertension in Unggahan Village. Method: The research design was a pra-experimental design with one group pre-post test design. The research sample consisted of 30 people. The sampling technique used non-probability sampling with techniques purposive sampling and data from respondents was collected by using a digital tensimeter measuring instrument. This study used a Paired t-test examination significant standard α=0.05. Result: The result of the study shows that before was given a Benson relaxation therapy that was Mean systolic blood pressure is 149.93, and the Mean diastolic blood pressure is 89.33. Then, after giving a Benson relaxation therapy that was Mean systolic blood pressure is 138.97 and the Mean diastolic blood pressure is 84.07. The results of the examination Paired t-test, obtained the score p pre and post (0,000) < α (0,05), which means that H0 is ferected and Ha accepted. Conclusion: Thus, it can be concluded that there is an effect of Benson relaxation therapy on blood pressure in patients with hypertension in Unggahan Village.

Tracking Correlations of Blood Pressure Levels in Infancy

PEDIATRICS ◽  
1978 ◽  
Vol 61 (1) ◽  
pp. 121-125
Author(s):  
Robert S. Levine ◽  
C. H. Hennekens ◽  
B. Klein ◽  
J. Gourley ◽  
F. W. Briese ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Prospective Studies ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Pressure Measurements ◽  
Elevated Blood ◽  
Increased Risk ◽  
Adults And Children ◽  
The Relationship

The association between elevated blood pressure levels in adults and increased risk of coronary and cerebrovascular disease has been well documented.1,2 Prospective studies of blood pressure in both adults and children have also shown strongly positive tracking correlations,3-5 tracking correlations being defined as the relationship between blood pressure measurements obtained at two points in time from the same individuals. In adults 35 to 70 years of age, tracking correlations of 0.6 for systolic pressure3,4 and 0.5 for diastolic pressure4 have been reported over four-year follow-up intervals. In children, Zinner et al.5 reported correlations of 0.25 for systolic pressure and 0.14 for diastolic pressure over a four-year follow-up interval.

scholarly journals Comparison of 3D T1-SPACE and DSA in evaluation of intracranial in-stent restenosis

2020 ◽  
pp. 20190950
Author(s):  
Qiuji Shao ◽  
Qiang Li ◽  
Qiaowei Wu ◽  
Tianxiao Li ◽  
Li Li ◽  
...  
Keyword(s):  
Correlation Coefficient ◽  
Stent Implantation ◽  
Pearson Correlation ◽  
Arterial Stenosis ◽  
Pearson Correlation Coefficient ◽  
Non Invasive ◽  
Stent Restenosis ◽  
Space Technique ◽  
In Stent Restenosis

Objective: In-stent restenosis (ISR) after stenting for intracranial stenosis is a significant issue. This study aimed to evaluate the usefulness of the 3D T1-SPACE technique in the follow-up of patients after stent implantation. Methods: Fifteen patients with intracranial arterial stenosis were prospectively enrolled 6–8 months after stenting. Digital subtraction angiography (DSA) and 3D T1-SPACE imaging were performed to evaluate the degree of stenosis and the enhancement of the vessel wall. Bland–Altman plots were used to assess the agreement between the two imaging methods, and the Pearson correlation coefficient was calculated as a measure of the linear correlation. Results: Eight Enterprise stents and seven Wingspan stents were used in 15 patients. The follow-up DSA after 6–8 months showed that the degree of stenosis was 40% (range, 30–72%), and ISR occurred in 4 of 15 (26.7%) lesions. The degree of stenosis assessed using the 3D T1-SPACE imaging technique was 35% (range, 30–75%). All four patients with ISR demonstrated significant enhancement. The Pearson correlation coefficient between the two methods was 0.959 (p < 0.05), and the Bland–Altman plot showed that all data points were within the consistency limits ([Formula: see text] ± 1.96 s). Conclusion: As a non-invasive imaging modality, 3D T1-SPACE showed great consistency with DSA in measuring the degree of stenosis after intracranial stenting. It may be used as an optional method for detecting ISR. Advances in knowledge: This study evaluated the usefulness of 3D T1-SPACE technique in the follow-up of patients after stent implantation, which could be used as an optional and non-invasive method in detection of in-stent restenosis.

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