scholarly journals Роль системи Hp в адаптації показників специфічного імунітету до впливу помірних фізичних навантажень

2014 ◽  
Vol 5 (1) ◽  
pp. 28-32
Author(s):  
V. L. Sokolenko ◽  
S. V. Sokolenko
Keyword(s):  
Physical Activity ◽  
Immune System ◽  
T Lymphocyte ◽  
Physical Training ◽  
Peripheral Blood ◽  
B Lymphocyte ◽  
General Level ◽  
Moderate Physical Activity ◽  
Haptoglobin Phenotype ◽  
The Impact

The aim of this study is to determine the role of haptoglobin phenotype in realization of adaptive responses of cellular and humoral immunity indices to moderate exercise caused by physical training. The study was implemented in the group of second-year students aged 18–20 who lived in the same climatic and geographical conditions for a long period of time. The students didn’t have any acute or chronic diseases and attended the main group of physical training. 60 persons were investigated. Immune system indices analysis was carried out in September before and after physical training lessons. Leukocyte level was calculated using hemocytometer, lymphocyte level was determined on the base of blood smear (dyeing for Romanowsky–Giemsa). Expression of surface antigene by peripheral blood lymphocyte was determined by immuno-fluorescence method with the use of monoclonal antibodies. The level of immunoglobulin in plasma was determined by radial immunodiffusion or Mancini method. To assess the phenotype of haptoglobin (Hp) we used the method of electrophoresis in starch gels. In the course of research we have detected the reduction of the relative and total number of lymphocytes regardless of haptoglobin phenotype in the group of students after physical training; this is a typical feature of the initial stages of stress response. We observed statistically reliable decrease in total number of analyzed subpopulations of T-lymphocyte in the group of students with phenotype Hp2-2 which was obviously the result of changes in the general level of lymphocytes in the peripheral blood. In the group of students with phenotype Hp1-1 absolute number of T-lymphocyte with phenotype CD3+ and CD4+ is reduced. In the group of students with phenotype Hp2-1 we have seen only the tendency to decrease in functional mature T-lymphocyte and their helper subpopulation. In the group of students with phenotype Hp2-2 the relative number of helper T-lymphocyte with the phenotype of CD4+ was reduced after moderate physical activity and it caused the decline in immune regulating index CD4+/CD8+. Changes of the level of B-lymphocyte with CD72+ phenotype were not found regardless of the haptoglobin phenotype. Analysis of the impact of moderate physical activity on major classes of serum immunoglobulin revealed the reduction of IgG level in the group of students with phenotype Hp2-2. Thus, we draw the conclusion that serum haptoglobin system shares the adaptive reactions of immune system to moderate physical activity. The most pressing phenotype is Hp2-2. Even in the group of students with immune pressing haptoglobin phenotypes, the analyzed parameters do not go beyond the homeostatic regulations after physical activity and it indicates satisfactory level of immune system adaptation to performed physical activity. 

scholarly journals Accelerometer-Measured Physical Activity and Its Impact on Sleep Quality in Persons Suffering From Restless Legs Syndrome

2020 ◽  
Author(s):  
Anne Reimers ◽  
Verena Heidenreich ◽  
Hans-Joachim Bittermann ◽  
Guido Knapp ◽  
Carl-Detlev Reimers
Keyword(s):  
Physical Activity ◽  
Sleep Quality ◽  
Negative Correlation ◽  
Restless Legs Syndrome ◽  
Quality Parameters ◽  
Moderate Physical Activity ◽  
Activity Levels ◽  
Restless Legs ◽  
Physical Activity Levels ◽  
The Impact

Abstract Background: Main symptoms of the restless legs syndrome (RLS) are sleep onset insomnia and difficulty to maintain sleep. Previous studies showed that regular physical activity can reduce the risk of developing RLS. However, the relationships of physical activity on sleep quality parameters in subjects suffering from RLS have not been investigated by applying accelerometry. Thus, the present study investigates the impact of physical activity during the day (7-12 h, 12-18 h, 18-23 h) on sleep quality in subject suffering from idiopathic RLS as well as their intensity and extent of physical activity by applying a real-time approach.Methods: In a sample of 47 participants suffering from idiopathic RLS, physical activity and sleep quality were captured over one week by using accelerometers. For data analysis physical activity levels and step counts during three periods of a day (morning, afternoon, evening) were correlated with sleep quality parameters of the following night.Results: In this observational study, significant correlations of physical activity with the sleep parameters were rarely confirmed (exception: negative correlation of steps in the morning with periodic leg movements in sleep and negative correlation of physical activity in the evening and total sleep period). However, the physical activity levels of the participants were unexpectedly high compared to population-level data and variance in physical activity was low. The average activity was 13,817 (SD=4,086) steps and 347 (SD=117) minutes of moderate physical activity per day in females and 10,636 (SD=3,748) steps and 269 (SD=69) minutes of moderate physical activity in males, respectively. However, the participants conducted no vigorous physical activity.Conclusions: To investigate the effects of daily physical activity and RLS symptoms interventional studies with different intensities of physical activities at different points of time during the day are needed.

scholarly journals Interaction of physical activity and diet: implications for haemostatic factors

1999 ◽  
Vol 2 (3a) ◽  
pp. 383-390 ◽  
Author(s):  
Rainer Rauramaa ◽  
SB Väisänen
Keyword(s):  
Physical Activity ◽  
Blood Coagulation ◽  
Lifestyle Changes ◽  
Regular Physical Activity ◽  
Moderate Intensity ◽  
Moderate Physical Activity ◽  
Platelet Aggregability ◽  
Moderate Intensity Physical Activity ◽  
Intensity Physical Activity ◽  
The Impact

AbstractRegular moderate intensity physical activity and habitual diet providing no more than one third of energy from fats have been recommended for the prevention of atherosclerotic diseases. The background for these guidelines is the key role of plasma lipids. However, the importance of thrombogenesis in acute myocardial infarction has become obvious during the last decade. Hyperlipidaemia and excess of adipose tissue increase platelet aggregability and blood coagulation, and decrease fibrinolysis. Both regular physical activity and dietary fat reduction decrease blood lipids and body fat thereby diminishing the risk of thrombosis. Currently, data on interactions between physical activity and diet on haemostasis are scarce, and the few studies available have not demonstrated additional effects when these two lifestyle modifications have been combined. This paper is restricted only to studies using controlled randomized design. Regular moderate intensity physical activity as well as diet rich in omega-3 fatty acids decrease platelet aggregability. The effects of regular physical activity on plasma fibrinogen remain contradictory, while the impact of diet is even less clear. Plasminogen activator inhibitor-1, a possible link between insulin resistance syndrome and coronary heart disease, may decrease due to physical training or low fat diet. It can be hypothesized that moderation in physical activity and diet carries a more powerful impact on blood coagulation and fibrinolysis than either lifestyle modification alone. Studies focusing on the interactions of regular moderate physical activity and fat-modified diet are needed in efforts to optimize the preventive actions by lifestyle changes.

Impact of Social Isolation on Physical Activity and Factors Associated With Sedentary Behavior in Older Adults During the COVID-19 Pandemic

2021 ◽  
pp. 1-5
Author(s):  
Giovana Z. Mazo ◽  
Felipe Fank ◽  
Pedro S. Franco ◽  
Bruna da Silva Vieira Capanema ◽  
Franciele da Silva Pereira
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Sedentary Behavior ◽  
Social Isolation ◽  
Low Income ◽  
Low Income Countries ◽  
Moderate Physical Activity ◽  
Cross Sectional ◽  
Factors Associated ◽  
The Impact

The objective was to analyze the impact of social isolation on moderate physical activity and factors associated with sedentary behavior of older adults during the COVID-19 pandemic. This was a cross-sectional study involving 111 older adults (aged 71.0 ± 6.87 years). The data were collected at two time points: in November 2019 and in June 2020. There was a decline in moderate physical activity when the minutes/week were compared before and during social isolation (p < .001). Sedentary behavior was associated with the condition of living alone. Older adults who lived alone were 3.29 times more likely to spend 4 hr or more in sedentary behavior than those who lived with a partner (95% confidence interval [1.01, 10.74]). Government agencies must establish PA-related health promotion strategies, especially in developing and low-income countries. Therefore, home exercises need to be encouraged to prevent the consequences of this pandemic period.

Keep Your Brain Tissue Healthy

2021 ◽  
pp. 27-66
Author(s):  
Charles Alessi ◽  
Larry W. Chambers ◽  
Muir Gray
Keyword(s):  
Physical Activity ◽  
Immune System ◽  
Inflammatory Response ◽  
Stress Reduction ◽  
Indirect Effects ◽  
Cognitive Abilities ◽  
Direct And Indirect Effects ◽  
The Impact ◽  
The Brain

This chapter starts by advising how to reduce the impact of stress. When stress becomes long term, the immune system becomes less sensitive to cortisol, and since inflammation is partly regulated by this hormone, this decreased sensitivity heightens the inflammatory response and allows inflammation to get out of control, increasing our risk of many diseases. You can reduce your stress yourself through a variety of methods, including physical activity and mindfulness-based stress reduction. Adequate sleep is also a major factor that can improve cognitive abilities and reduce the risk of dementia, and this chapter outlines what we need to know about sleep cycles, insomnia, and sleep disordered breathing, and how to sleep more and sleep better. The chapter then covers how to protect your brain from over medication (polypharmacy). It finishes by discussing how to maintain and indeed increase your levels of physical activity, and how increasing physical activity has both direct and indirect effects on the brain.

scholarly journals Impact of first and second eye cataract surgery on physical activity: a prospective study

BMJ Open ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. e024491 ◽  
Author(s):  
Lynn B Meuleners ◽  
Ying Ru Feng ◽  
Michelle Fraser ◽  
Kate Brameld ◽  
Kyle Chow
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Cataract Surgery ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Vigorous Physical Activity ◽  
Moderate Physical Activity ◽  
Bilateral Cataract ◽  
Eye Surgery ◽  
The Impact

ObjectivesTo investigate the impact of first eye and second eye cataract surgery on the level of physical activity undertaken by older adults with bilateral cataract.DesignProspective cohort study.SettingThree public ophthalmology clinics in Western Australia.ParticipantsFifty-five older adults with bilateral cataract aged 55+ years, awaiting first eye cataract surgery.Outcome measuresThe primary outcome measure was participation in moderate leisure-time physical activity. The secondary outcomes were participation in walking, gardening and vigorous leisure-time physical activity. Participants completed a researcher-administered questionnaire, containing the Active Australia Survey and visual tests before first eye cataract surgery, after first eye surgery and after second eye surgery. A Generalised Estimating Equation linear regression model was undertaken to analyse the change in moderate leisure-time physical activity participation before first eye surgery, after first eye surgery and after second eye surgery, after accounting for relevant confounders.ResultsParticipants spent significantly less time per week (20 min) on moderate leisure-time physical activity before first eye cataract surgery compared with after first eye surgery (p=0.04) after accounting for confounders. After second eye cataract surgery, participants spent significantly more time per week (32 min) on moderate physical activity compared with after first eye surgery (p=0.02). There were no significant changes in walking, gardening and vigorous physical activity throughout the cataract surgery process.ConclusionFirst and second eye cataract surgery each independently increased participation in moderate leisure-time physical activity. This provides a rationale for timely first and second eye cataract surgery for bilateral cataract patients, even when they have relatively good vision.

How Can Mass Participation Physical Activity Events Engage Low-Active People? A Qualitative Study

2013 ◽  
Vol 10 (6) ◽  
pp. 900-909 ◽  
Author(s):  
Frances Early ◽  
Paula Corcoran
Keyword(s):  
Physical Activity ◽  
Marketing Research ◽  
Moderate Physical Activity ◽  
Activity Levels ◽  
Mortality And Morbidity ◽  
Risk Of Mortality ◽  
Public Health Challenge ◽  
Positive Experiences ◽  
Mass Participation ◽  
The Impact

Background:Regular, moderate physical activity reduces the risk of mortality and morbidity; however increasing the physical activity levels of less active people is a public health challenge. This study explores the potential of mass participation physical activity events to engage less active people, through analyzing the accounts of participants in 2 events who identified themselves as low-active before entering.Methods:Seven participants in a sponsored run and 7 in a sponsored walk were interviewed and transcripts were analyzed using grounded theory techniques.Results:Participants had positive experiences encapsulated in 3 categories: Performing (physical completion of the event culminating in a sense of achievement); Relating (enjoying relationships); Soaking up the Atmosphere (enjoying the event ambience). The way in which these categories were manifested was affected by the event context.Conclusions:Mass participation events have potential to engage low-active people. The impact of participation resonated with factors that are positively associated with physical activity in other settings, and event characteristics matched key criteria for attracting low-active groups identified through social marketing research. Suggestions are given for how to capitalize on the findings for health promotion.

The Impact of Selected Aspects of Life on the Incidence of Back Pain in Relation to Age of Patients

2017 ◽  
Vol 1 (1) ◽  
pp. 9-17
Author(s):  
Jerzy Błyszczuk ◽  
Renata Błyszczuk
Keyword(s):  
Physical Activity ◽  
Back Pain ◽  
Modern Society ◽  
Basic Knowledge ◽  
Survey Study ◽  
Moderate Physical Activity ◽  
Lumbar Region ◽  
Therapeutic Massage ◽  
Males And Females ◽  
The Impact

<b>Intodruction:</b> The most common reasons for back pain in modern society include inadequate physical activity, obesity and lack of basic knowledge on the correct positions of the spine. There are also other reasons such as pathological changes including damage and degeneration of annular fibers in the spinal disk, posttraumatic back pain and incorrect posture. <br/><b>Materials and methods:</b> On the basis of a survey study on the population of 240 individuals (120 males and 120 females) we aimed to answer the following questions: how body index, physical activity, type of profession and education level correlate with the frequency of back pain in relation to age. Furthermore, responders reported the most commonly injured spine regions and types of treatments. <br/><b>Results and Conclusions:</b> Obese individuals more often suffer from back pain. Moderate physical activity is beneficial on spine prophylaxis. Aging correlates with higher risk of back pain. Back pain is the most commonly reported in the lumbar region. Common painkiller medications and restricted physical activity represent main treatments of back pain. Visiting a doctor, physiotherapy and therapeutic massage are less common. These conclusions hold true for both males and females.

scholarly journals Influence of moderate physical load on parameters of the immune system among residents of contaminated areas

2016 ◽  
Vol 7 (1) ◽  
pp. 48-52 ◽  
Author(s):  
V. L. Sokolenko ◽  
S. V. Sokolenko
Keyword(s):  
Physical Activity ◽  
Immune System ◽  
Blood Serum ◽  
Cellular Immunity ◽  
Physical Training ◽  
Recovery Period ◽  
Relative Number ◽  
Training Group ◽  
System Parameters ◽  
Therapeutic Exercises

The aim of this research was to evaluate the effects of physical stress caused by physical activity on parameters of immune system among the residents of areas contaminated with radionuclides. In the 2000–2015 we examined 125 students ofCherkasyStateUniversity, including the control group of people from uncontaminated areas, persons working in a basic physical training group and those with symptoms of vegetative-vascular dystonia, who worked in a therapeutic physical training group. Immune system parameters were analyzed: a day before physical training, immediately after the training and two days after the training to assess the recovery period. Indicators of cellular immunity were determined by immunophenotyping and dyeing on Romanowsky-Giemsa. The level of immunoglobulins in blood serum was determined by radial immunodiffusion on Mancini. The level of cortisol in blood serum was determined by the immunoenzyme method. Here we established that even in the absence of physical activity, some immunosuppression of T-cell immunity was observed in residents of contaminated areas. Working in the basic physical training group resulted in a significant decrease in the relative number of lymphocytes and increasing in the relative number of band neutrophils, which is a typical feature of the early stages of stress response. A statistically significant reduction in relative and absolute number of cells with phenotypes CD3+, CD5+, CD4+ and immunoregulatory index CD4+/CD8+ was observed. There were no significant changes of cytotoxic T lymphocytes with phenotype CD8+ and natural killer cells with phenotype CD16+. Increase of the relative number of B cells, that express CD72 antigen, and growth trend in serum IgM were registered. All parameters analyzed were within the physiological homeostatic norm, however, some reached extreme recommended levels. Recovery period lasted 2 days. Individuals working in therapeutic physical training group did not show statistically significant changes in immune system parameters. Thus, therapeutic exercises don't reach the stress level and can be potentially safe for the natural resistance of the body. So, among residents of areas contaminated with radionuclides due to the Chernobyl accident, moderate load during physical training lessons causes short-term compensatory changes of cellular immunity within the homeostatic norm with effective and rapid recovery. Taking into account the immunosuppression, caused by chronic exposure to low doses of ionizing radiation, it is important to choose exercises, their duration and intensity carefully , giving preference to therapeutic exercises. 

scholarly journals Moderate to intense physical activity is associated with improved clinical, CD4/CD8 ratio and immune activation status in HIV infected patients on ART

2021 ◽  
Author(s):  
Enrique Bernal ◽  
Monica Martinez ◽  
José Antonio Campillo ◽  
Gabriel Puche ◽  
Carlos Baguena ◽  
...  
Keyword(s):  
Physical Activity ◽  
T Lymphocytes ◽  
Immune Activation ◽  
Healthy Lifestyle ◽  
Moderate Physical Activity ◽  
Cross Sectional ◽  
Hla Dr ◽  
The Impact ◽  
Intense Physical Activity ◽  
Activation Status

Abstract Background Physical activity has anti-inflammatory effects and reduces morbidity and mortality in general population, but its role in the clinical, CD4/CD8 ratio and immune activation status in HIV-infected patients has been poorly studied. Methods A cross-sectional study was carried out in a cohort of 155 HIV-infected patients on stable ART to compare clinical, biochemical, CD4/CD8 ratio and immune-activation status according to their physical activity in the last two years (sedentary/low vs. moderate/intense) assessed by the iPAQ. A binary logistic regression and mixed ANOVA were performed to evaluate the impact of levels of physical activity on CD4/CD8 ratio. Results In our series 77 (49.7%) out of 155 patients were sedentary and 78 (50.3%) practiced moderate/intense physical activity. Moderate/intense physical activity was associated with lower CDC HIV-stage (p=0.046), better metabolic control (lower BMI, p=0.024; glucose, p=0.024; and triglyceride, p=0.002), higher CD3 +CD4 + T lymphocytes (p=0.016), lower CD8 + T lymphocytes (p=0.018), higher CD4/CD8 ratio (p=0.001), lower CD4 +CD8 + (p=0.026), CD4 +CD86 + (p=0.045), CD4 +HLA-DR + (p=0.011), CD8 +HLA-DR + (p=0.048) T lymphocytes and CD16 +HLA-DR + NK cells (p=0.026). Sedentary lifestyle (OR=2.12, p=0.042), CD4 nadir (OR=1.005, p&lt;0.001) and CD8 +CD38 + T cells (OR=1.27, p=0.006) were independently associated with low CD4/CD8 ratio (&lt;0.8). Earlier and more intense CD4/CD8 ratio recovery was observed in patients with higher physical activity in the two-year follow-up with a significant interaction between these variables: F(2, 124) = 3.31, p=0.049, partial η2=0.042). Conclusions Moderate to high physical activity is associated with beneficial health effects, improving metabolic profile and reducing chronic inflammation in patients living with HIV. Although more studies and clinical trials are needed to confirm these findings, healthy lifestyle, including at least moderate physical activity, should be recommended to HIV patients on stable ART.

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