scholarly journals A mikroorganizmusok patogenitása és virulenciája: definíciók, példázatok és molekuláris háttérismeretek

2021 ◽  
Vol 162 (50) ◽  
pp. 1991-1999
Keyword(s):  
Infectious Disease ◽  
Virulence Factors ◽  
Molecular Level ◽  
Holistic Approach ◽  
Causative Role ◽  
Genetic Knowledge ◽  
Phenotypic Characters ◽  
Psychological Attributes ◽  
Long Time ◽  
The Given

Összefoglaló. A fertőző betegségek kóroki hátterének felderítésére irányuló törekvések hosszú időre tekintenek vissza. Fogalmakkal és követelményekkel (posztulátumokkal) igyekeztek körülírni, hogy egy mikroorganizmus mikor tekinthető egy adott fertőző betegség okozójának. Egy patogén rendszertani kategóriába tartozó mikroorganizmus kimutatása a betegből önmagában még nem elegendő bizonyíték arra, hogy a betegségnek valóban az a kórokozója. Igazolni kell a továbbiakban, hogy rendelkezik azokkal a virulenciafaktoroknak nevezett tényezőkkel, amelyek valójában képessé teszik az adott betegség kiváltására. Robert Koch idejében csak fenotípusos ismeretek álltak rendelkezésre, azok figyelembevételével fogalmazta meg posztulátumait. Később, a megszerzett molekuláris ismeretek birtokában, a posztulátumokat molekuláris szinten is értelmezték. A beteg személyét biológiai, szociális és pszichés egységként kezelő holisztikus megközelítésnek is eleget téve, a posztulátumokat a kórokozó mellett az esetben érintett gazdaszervezet egyedi tulajdonságainak figyelembevételével tovább szélesítették. A dolgozat a fenti kérdéseket példákkal illusztrálva tárgyalja, majd kitér a gyakorlati hasznosítás lehetőségeire. Orv Hetil. 2021; 162(50): 1991–1999. Summary. Efforts to explore the casual background of infectious diseases have been ambitioned for a long time. Terms and requirements (postulates) have been created to describe in which case a microorganism can be regarded as a causative agent of a given infectious disease. Demonstration of a representative of a pathogenic taxonomic category in the patient, however, does not prove its causative role in itself. It should also be verified if the microbe possesses the so-called virulence factors enabling it to trigger the given disease. At the time when Robert Koch formulated his postulates, only phenotypic characters were at his disposal. Later, in possession of a substantial genetic knowledge, the postulates have been adapted to molecular level. For having a holistic approach, the postulates have been extended also to the host’s individual biological, social and psychological attributes. This paper discusses the above issues with examples for illustration, and outlines their practical applicabilities. Orv Hetil. 2021; 162(50): 1991–1999.

scholarly journals Assessment of Research and Development Financing Based on the Strategies in EU: Case of Sweden, Slovakia and Romania

2021 ◽  
Vol 13 (15) ◽  
pp. 8628
Author(s):  
Emília Duľová Spišáková ◽  
Barbora Gontkovičová ◽  
Emil Spišák
Keyword(s):  
European Union ◽  
Research And Development ◽  
Economic Reform ◽  
The European Union ◽  
2030 Agenda ◽  
Processing Data ◽  
Europe 2020 ◽  
Europe 2020 Strategy ◽  
Long Time ◽  
The Given

Research and development have been of interest to the European Union for a long time. This topic is also underlined in economic reform agendas and plans that have the form of strategies with clearly set targets. The article deals with the issue of financing R&D activities from the perspective of the share of expenditure to GDP, the total amount of funds spent on R&D, the share of expenditure per capita, and the structure of expenditure. The aim is to analyze and compare development in the field of R&D financing in selected countries of the European Union with emphasis on achieving the Europe 2020 target and to point out the expected development of the indicator for the first years of the validity of the 2030 Agenda for Sustainable Development. During the processing of the article, mathematical and statistical methods (regression and correlation analysis) were used in addition to standard logic methods intended for processing data and drawing conclusions (synthesis, induction). The final evaluates the achievement of the target in the field of R&D financing in accordance with the target of the Europe 2020 strategy and, using regression, predicts the development of the given indicator for coming years.

Structural Basis for the Understanding of Entry Inhibitors Against SARS Viruses

2021 ◽  
Vol 28 ◽  
Author(s):  
Prem Kumar Kushwaha ◽  
Neha Kumari ◽  
Sneha Nayak ◽  
Keshav Kishor ◽  
Ashoke Sharon
Keyword(s):  
Viral Entry ◽  
Molecular Level ◽  
Virus Entry ◽  
Holistic Approach ◽  
Symptomatic Treatment ◽  
Host Cells ◽  
Structural Basis ◽  
Viral Fusion ◽  
Structural Studies ◽  
Entry Inhibitors

: Outbreaks due to Severe Acute Respiratory Syndrome-Corona virus 2 (SARS-CoV-2) initiated in Wuhan city, China, in December 2019 which continued to spread internationally, posing a pandemic threat as declared by WHO and as of March 10, 2021, confirmed cases reached 118 million along with 2.6 million deaths worldwide. In the absence of specific antiviral medication, symptomatic treatment and physical isolation remain the options to control the contagion. The recent clinical trials on antiviral drugs highlighted some promising compounds such as umifenovir (haemagglutinin-mediated fusion inhibitor), remdesivir (RdRp nucleoside inhibitor), and favipiravir (RdRp Inhibitor). WHO launched a multinational clinical trial on several promising analogs as a potential treatment to combat SARS infection. This situation urges a holistic approach to invent safe and specific drugs as a prophylactic and therapeutic cure for SARS-related-viral diseases, including COVID-19. : It is significant to note that researchers worldwide have been doing their best to handle the crisis and have produced an extensive and promising literature body. It opens a scope and allows understanding the viral entry at the molecular level. A structure-based approach can reveal the molecular-level understanding of viral entry interaction. The ligand profiling and non-covalent interactions among participating amino-acid residues are critical information to delineate a structural interpretation. The structural investigation of SARS virus entry into host cells will reveal the possible strategy for designing drugs like entry inhibitors. : The structure-based approach demonstrates details at the 3D molecular level. It shows specificity about SARS-CoV-2 spike interaction, which uses human angiotensin-converting enzyme 2 (ACE2) as a receptor for entry, and the human protease completes the process of viral fusion and infection. : The 3D structural studies reveal the existence of two units, namely S1 and S2. S1 is called a receptor-binding domain (RBD) and responsible for interacting with the host (ACE2), and the S2 unit participates in the fusion of viral and cellular membranes. TMPRSS2 mediates the cleavage at S1/S2 subunit interface in S-protein of SARS CoV-2, leading to viral fusion. Conformational difference associated with S1 binding alters ACE2 interaction and inhibits viral fusion. Overall, the detailed 3D structural studies help understand the 3D structural basis of interaction between viruses with host factors and available scope for the new drug discovery process targeting SARS-related virus entry into the host cell.

scholarly journals INTEGRATED SYNOPTICAL METHOD FOR CALCULATING ASSIMILATION CAPACITY OF SEA WATERS

2017 ◽  
pp. 115-120
Author(s):  
Hikmat Hamid oglu Asadov ◽  
Sima Ajdar gizi Askerova
Keyword(s):  
Sea Water ◽  
Water Masses ◽  
Optimum Regime ◽  
Optimization Task ◽  
Maximum Value ◽  
Long Time ◽  
Negative Effect ◽  
Optimum Order ◽  
Assimilation Capacity ◽  
The Given

Pollution of sea waters is one of major attributes of coastal industrial centers and the norming of such emissions is one of major countermeasures. The assimilation capacity of sea waters is a major factor relevant at norming and planning of outflows into sea waters. At present time the synoptical method has been developed, which doesn’t require carrying out long time and repeated observing of the level of pollution of sea waters. This method has formed the basis for developing the integrated synoptical method for calculating sea water assimilation capacity. The suggested method provides for division of the sea waters into separated homogenous water masses. The aim of the study is to develop an inverse integrated synoptical method allowing synthesizing of such an optimum order for loading separate water masses with pollutants upon, at which the calculated total value of assimilation capacity would reach its maximum. The article shows the possibility of utilization of known synoptical method for determining assimilation capacity of sea waters in the inverse order, i.e. for calculating the maximum value of pollutant put into the fixed zone of sea waters, upon a condition of reaching the given amount of assimilation capacity and absence of essential negative effect on ecosystem. The task of calculating an optimum regime function of discrete type, upon which the integrated value of assimilation capacity would reach the maximum value, has been formulated. The solution of analogue equivalent of the formed optimization task is carried out using the Euler equation for a non-conditional variation optimization task, taking into account the accepted limitation condition. The recommendations on optimum loading of different sea water zones with determined type of pollutant have been given.

scholarly journals METODOLOGY OF DEEP PERCEPTION OF A PERSON’S MIND

2016 ◽  
Author(s):  
T. Yacenko ◽  
O. Polianychko ◽  
O. Pedchenko
Keyword(s):  
Personal Growth ◽  
Holistic Approach ◽  
Training Programme ◽  
Academic Training ◽  
Psychodynamic Theory ◽  
Adequate Understanding ◽  
Statics And Dynamics ◽  
General Training ◽  
Personal Changes ◽  
The Given

In the article an issue is raised on methodology of forming competency in a future psychologist on the basis of adequate understanding of wholeness of the psychic; comparison of academic and psychodynamic approaches to the problem of academic training of a psychologist is done as well as analysis of the leading sects in psychology relevant to psychodynamic approach. There were introduced main positions of psychodynamic theory, which are accordant with orthodox psychoanalysis in the same way as the principles of psyche in its integrity. Content of the given article stresses the importance of taking into account interconnections between the spheres of the conscious and the unconscious in their integrity and functional asymmetry in deep psychocorrection of the future psychologists. Researches are also directed to an issue of statics and dynamics of organization of the psychical in the integrity of its functioning. Researches convince of the need to ensure a holistic approach to improvement of the training of applied psychologists. The psychodynamic theory integrates seamlessly into the general training programme for psychologists, expands the horizons of personal growth, development of reflective intelligence and sensitivity of a future expert. All this greatly complements a format of academic training of psychologists in its orientation to mastering the standard knowledge. Moreover, the passage of deep correction catalyses personal changes towards the harmonization of the psyche structure, development of those characteristics of a person that are desirable for the formation of professional excellence and ensuring the effectiveness of psychological counselling.

scholarly journals Application of Latent Dirichlet Allocation (LDA) for clustering financial tweets

2021 ◽  
Vol 297 ◽  
pp. 01071
Author(s):  
Sifi Fatima-Zahrae ◽  
Sabbar Wafae ◽  
El Mzabi Amal
Keyword(s):  
Language Processing ◽  
Latent Dirichlet Allocation ◽  
Sentiment Classification ◽  
Research Areas ◽  
Preprocessing Method ◽  
Long Time ◽  
Standard Text ◽  
The Given ◽  
Dirichlet Allocation

Sentiment classification is one of the hottest research areas among the Natural Language Processing (NLP) topics. While it aims to detect sentiment polarity and classification of the given opinion, requires a large number of aspect extractions. However, extracting aspect takes human effort and long time. To reduce this, Latent Dirichlet Allocation (LDA) method have come out recently to deal with this issue.In this paper, an efficient preprocessing method for sentiment classification is presented and will be used for analyzing user’s comments on Twitter social network. For this purpose, different text preprocessing techniques have been used on the dataset to achieve an acceptable standard text. Latent Dirichlet Allocation has been applied on the obtained data after this fast and accurate preprocessing phase. The implementation of different sentiment analysis methods and the results of these implementations have been compared and evaluated. The experimental results show that the combined uses of the preprocessing method of this paper and Latent Dirichlet Allocation have an acceptable results compared to other basic methods.

Renewed thinking on groundwater age

2021 ◽  
Author(s):  
Grant Ferguson ◽  
Mark Cuthbert ◽  
Kevin Befus ◽  
Tom Gleeson ◽  
Chandler Noyes ◽  
...  
Keyword(s):  
Environmental Flows ◽  
Numerical Models ◽  
Groundwater Age ◽  
Holistic Approach ◽  
Water Levels ◽  
Residence Times ◽  
Groundwater Sustainability ◽  
Long Time ◽  
Mean Residence Times ◽  
Recharge Rates

<p>Groundwater age and mean residence times have been invoked as measures of groundwater sustainability, with the idea that old or "fossil" groundwater is non-renewable. This idea appears to come from the link between groundwater age and background recharge rates, which are also of questionable use in assessing the sustainability of groundwater withdrawals. The use of groundwater age to assess renewability is further complicated by its relationship with flow system geometry. Young groundwaters near recharge areas are not inherently more renewable than older groundwaters down gradient. Similarly, there is no reason to preferentially use groundwater from smaller aquifers, which will have smaller mean residence times than larger aquifers for the same recharge rate. In some cases, groundwater ages may provide some information where groundwater recharge rates were much higher in the past and systems are no longer being recharged. However, there are few examples where the relationship between depletion and changes in recharge over long time periods has been rigorously explored. Groundwater age measurements can provide insights into the functioning of groundwater flow systems and calibration targets for numerical models and we advocate for their continued use, but they are not a metric of sustainable development. Simple metrics to assess groundwater sustainability remain elusive and a more holistic approach is warranted to maintain water levels and environmental flows.</p>

scholarly journals INDICATORS AFFECTING VIDZEME REGION SMART DEVELOPMENT

2017 ◽  
Vol 1 ◽  
pp. 240
Author(s):  
Sarmite Rozentale ◽  
Aigars Andersons
Keyword(s):  
Rural Areas ◽  
Local Governments ◽  
Holistic Approach ◽  
Cultural Dimensions ◽  
Territorial Development ◽  
Economic Dimension ◽  
Long Time ◽  
Social Environmental ◽  
Smart Specialization ◽  
Development Analysis

The study aims to determine the main indicators of rural smart development concept for territorial development analysis and decision-making in Vidzeme region (Latvia). In the framework of the study the theoretical literature and planning documents were analysed, focusing on the indicators of rural areas and sustainable development. For a long time the development was associated primarily with the economic growth - GDP, employment and income growth. In recent years, the economic dimension is supplemented with social, environmental, cultural and political aspects. A holistic approach interprets close relations and balanced integration between the economic, social, political, ecological and cultural dimensions of local and regional development. Such approach requires the search for new indicators that describe the development of rural areas and are directly relevant to each individual area. The results present that in the development of Vidzeme smart specialization, the local governments and the state has the greatest impact. It is most affected by the local government's capacity to develop cooperation with residents and entrepreneurs, and a stable and sustainable economic situation in the country.

scholarly journals A case of chronic progressive chorea

2021 ◽  
Vol XVIII (1) ◽  
pp. 29-39
Author(s):  
V. D. Lapukhin
Keyword(s):  
Infectious Disease ◽  
Acute Infectious Disease ◽  
Long Time ◽  
Chorea Minor ◽  
Typical Picture

Patient T., whom I have the honor to present to the Society, suffers from the form of the disease that, according to a typical picture, can be defined as chorea chronica progressiva. The first to emerge from chronic progressive chorea as a separate nosological unit was the American neuropathologist Huntington, in honor of whom chronic chorea was called Huntingtons chorea for a long time, in contrast to chorea minor, first described by Sydenham; the latter is a more common form of Witta's dog and carries on itself all the signs of an acute infectious disease.

scholarly journals ON THE ESSENCE, THE PLACE, THE PART AND CHARACTER OF THE TASKS WITH PARAMETERS IN THE GEOMETRY COURSES OF THE INSTITUTIONS OF GENERAL SECONDARY EDUCATION

2020 ◽  
Vol 1 (191) ◽  
pp. 150-154
Author(s):  
Olena Synyukova ◽  
◽  
Oleh Chepok ◽  
Keyword(s):  
Secondary Education ◽  
Euclidean Plane ◽  
Euclidean Geometry ◽  
Axiomatic Theory ◽  
Geometrical Figure ◽  
Long Time ◽  
Mutual Displacement ◽  
The Given ◽  
Independent Assessment ◽  
Parameter Relation

The so-called tasks with parameters for a long time now have become an integral part as of the every to some extent profound course of algebra or of algebra and the beginnings of cultures at the institutions of general secondary education, as of the corresponding tasks of the State Final Attestation in Mathematics and the External independent assessment in mathematics. And it isn’t accidental because in the most often cases the solution of the task with a parameter turns for the student into a small investigation by his own. The realization of such investigation favors the formation of the creative practical-oriented personality. Simultaneously we must state that, despite of the existence of a lot of the high scientific and methodical level created corresponding training books, it is difficult just now to find in the methodical literature the clear answers to the natural questions of what is meant on the whole by the task with parameter (or with parameters) and its solution. At the same time, in the courses of geometry of the institutions of general secondary education to the tasks with parameters it is given next to nothing consideration. But in fact such tasks in the courses are present, their importance for the proper construction of the courses can be exaggerated. In the paper the problems of what must be understand by the task with the parameter or with the parameters and by its solution are analyzed. The essence, the part and the place of the tasks with parameters in the geometry courses of institutions of general secondary education are elucidated. Euclidean geometry as an axiomatic theory investigates the sets that in their overwhelming majority represent by themselves the mathematical abstructions of the spatial forms of the surrounding, some relations between such set and quantities that characterize such sets and relations. In the contrast to the courses of algebra, in the geometrical courses the part of parameters may be played by all of the three mentioned components. Geometrical figures can change by the size and by the form. Changing by the size bring us to the concept of the scalar quantity. Changing by the form are considered in the tasks of paving and, for example, in the tasks of finding the amount and the types of symmetries of geometrical figure in dependence of its form. The part of the parameter-relation can be played by different variants of mutual displacement of the given figures in Euclidean plane or in Euclidean space. According to their content, different geometrical tasks with parameters are considered in the work. The task of the existence of geometrical figures, the tasks, conserning the character of some geometrical places of points, the tasks of tracing with the help of a compass and a ruler are among them.

scholarly journals Solving the Large-Scale TSP Problem in 1 h: Santa Claus Challenge 2020

2021 ◽  
Vol 8 ◽  
Author(s):  
Radu Mariescu-Istodor ◽  
Pasi Fränti
Keyword(s):  
Large Scale ◽  
Computing Time ◽  
Real Life ◽  
Problem Instance ◽  
Santa Claus ◽  
Design Choice ◽  
Long Time ◽  
Problem Instances ◽  
The Given ◽  
Important Design

The scalability of traveling salesperson problem (TSP) algorithms for handling large-scale problem instances has been an open problem for a long time. We arranged a so-called Santa Claus challenge and invited people to submit their algorithms to solve a TSP problem instance that is larger than 1 M nodes given only 1 h of computing time. In this article, we analyze the results and show which design choices are decisive in providing the best solution to the problem with the given constraints. There were three valid submissions, all based on local search, including k-opt up to k = 5. The most important design choice turned out to be the localization of the operator using a neighborhood graph. The divide-and-merge strategy suffers a 2% loss of quality. However, via parallelization, the result can be obtained within less than 2 min, which can make a key difference in real-life applications.

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