scholarly journals Features of community5acquired pneumonia clinical recurrence in children

2020 ◽  
pp. 59-65
Author(s):  
V.Y. Pasik ◽  
Keyword(s):  
Respiratory Failure ◽  
Young Children ◽  
Clinical Manifestations ◽  
Clinical Analysis ◽  
Community Acquired Pneumonia ◽  
Main Group ◽  
Control Group ◽  
Pathological Changes ◽  
Clinical Recurrence ◽  
Hepatobiliary System

Pneumonia is an acute nonspecific inflammation of the lung tissue, which is based on infectious toxicosis, respiratory failure, water-electrolyte and other metabolic disorders with pathological changes in all organs and systems of the child's body. Pneumonia is the cause of death in more children than any other infectious disease, killing more than 800 000 children under 5 each every year, or about 2 200 daily, including more than 153 000 newborns. Mortality from pneumonia in different regions of Ukraine is variable from 1.5 to 6.0 per 10 000 children, which is reflected in the structure of mortality of children in the first year of life, because respiratory diseases in it are 3–5%. Purpose — to determine the features of the clinical course of pneumonia in young children. Materials and methods. During 3 years, 2 groups of children aged from 1 month to 36 months were surveyed at the base of Vinnytsia children's regional clinical hospital. The main group consisted of 338 children with community-acquired pneumonia, the control group — 40 almost healthy peers. All children included in our study underwent analysis of complaints, medical history and life, physical and instrumental examination. Clinical and biochemical blood tests were performed using conventional techniques. Radiography was performed on a Jumong SG Health Care device according to standard methods. Ultrasound examination of the hepatobiliary system was performed using a Mindray scanner. Statistical processing of the obtained results was performed using the program IBM SPSS Statistics (version 20), using parametric and non-parametric methods of estimating the obtained results. The reliability of the difference between the values between the independent quantitative values in the correct distribution was determined using the Student's t test, the values of P<0.05 were considered reliable. Results. 82.5% of the main group was diagnosed with bilateral community+acquired pneumonia, 14.5% — right-sided and 3.0% — left-sided. Focal pneumonia had 167 patients, segmental — 164 children and shared — 7 children. The majority (62.1%) of the surveyed children of the main group had grade III (severe) community-acquired pneumonia. Among the complaints in most patients documented fever (98.2±0.78%), dry cough (93.5±1.34%), runny nose (40.5±2.67%). In 54.1% the fever was febrile. The most frequent (63.9±2.61%) among the pathological changes in the clinical analysis of blood in the examined children were found to increase the level of ESR and leukocytosis (27.2±2.42%). In 95.9% of patients in the main group, X-ray examination revealed an increase in pulmonary pattern, homogeneous darkening had 53.2%, focal shadows were detected in 45.8%. Complications were found in 37.6% of the examined children. It was noted that during the objective examination of children with pneumonia, 23.1% (n=78) during palpation was found liver enlargement. 55.5% of our cohort was diagnosed with an increase in the size of the liver, 28.1% — deformity of the gallbladder, 12.0% — thickening of the gallbladder wall and 16.7% — dyskinesia of the biliary tract. We found that the level of ALT and AST in patients with community-acquired pneumonia was significantly (p<0.05) higher than in the control group. Conclusions. The importance of the problem of pneumonia in childhood is due to the high incidence in children. In our study, we identified not only the typical clinical manifestations of the disease in question, but also identified a number of specific lesions of the hepatobiliary system. The obtained results are important practical findings for pediatricians, pulmonologists, infectious diseases physicians and pediatric gastroenterologists. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the author. Keywords: community-acquired pneumonia, fever, leukocytosis, respiratory failure, lesions of the hepatobiliary system, young children.

scholarly journals PECULIARITIES OF CLINICAL PASSING OF ATOPIC DERMATITIS AND VITAMIN D EXCHANGE IN EARLY CHILDREN

2020 ◽  
pp. 27-35
Author(s):  
N. V. Kamut ◽  
M. M. Kiselova
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Young Children ◽  
Clinical Manifestations ◽  
Serum Vitamin ◽  
Scientific Data ◽  
Main Group ◽  
Severe Atopic Dermatitis ◽  
Serum Vitamin D ◽  
Vitamin D Levels

The article is devoted to the study of features of clinical course of atopic dermatitis and vitamin D exchange in young children conducted by us by estimation of severity of atopic dermatitis depending on the value of SCORAD index, determination of 25(OH)D concentration in serum of children by immunochemical method with chemocentric analysis according to the classification approved by experts of the international endocrinological society. In the examination of 188 young children, two groups were formed on the basis of the Lviv City Children's Clinical Hospital. Children from 1 month to 1 year of age with manifestations of atopic dermatitis (n = 120), who were born full-term and had no birth defects, metabolic disorders, severe perinatal CNS lesions formed the main group. The comparison group consisted of 68 healthy young children without chronic diseases. All children had atopic dermatitis in the main group and were classified by severity (depending on the SCORAD index): children with mild severity – 31 (26 %), moderate 47 (39 %), and severe 42 (35 %). As a result of the study, we found a association between the severity of clinical manifestations of atopic dermatitis and the level of vitamin D in the serum. Comparative analysis of the severity of atopic dermatitis, depending on the level of vitamin D in the serum, showed that with severe atopic dermatitis in children of the main group, the level of 25(OH)D was significantly lower compared to its indicators in children with moderate to severe (P < 0.05). Serum vitamin D levels are significantly lower in all forms of atopic dermatitis severity and correlate significantly with the overall SCORAD severity score, erythema intensity, excoriation, itching, and sleep disturbances. The scientific data on the presence of feedback correlation (r = –0,48; P < 0,05) between the development of atopic dermatitis in children and their level of 25(OH)D in serum were added. Our findings suggest that there is a need for a differentiated approach to treating early-stage atopic dermatitis of varying severity, a personalized therapeutic approach to choosing a vitamin D supplementation, given the level of 25(OH)D in the serum.

scholarly journals Clinical evaluation of the effectiveness of treatment of the hand-foot syndrome – skin toxicity of antitumor target therapy with multi-kinase inhibitors

2018 ◽  
Vol 12 (3) ◽  
pp. 140-149 ◽  
Author(s):  
Evgeniya A. Shatokhina ◽  
Larisa S. Kruglova ◽  
Oleg A. Shukhov
Keyword(s):  
Lipoic Acid ◽  
Kinase Inhibitors ◽  
Clinical Manifestations ◽  
Main Group ◽  
Betamethasone Dipropionate ◽  
Control Group ◽  
Positive Trend ◽  
Alpha Lipoic Acid ◽  
Significant Difference ◽  
Hand Foot Syndrome

Background. The effective treatment of the hand-foot syndrome is a necessary component of the complex treatment of patients receiving antitumor therapy with multikinase inhibitors. Aims. The assessment of a new effective method for the treatment of palm-plantar syndrome in patients receiving multi-kinase inhibitors. Materials and methods. There are 27 patients received antitumor treatment with multi-kinase inhibitors and had clinical manifestations of the hand-foot syndrome (HFS) for observation. The main group (14 patients) used a combination of an alpha-lipoic acid at a dose of 600 mg per day per os and an ointment containing 0.005% calcipotriol and 0.05% betamethasone dipropionate 2 times a day. The control group, included 13 patients, used a combination with a cream containing 10% urea and ointment containing 0.05% betamethasone dipropionate. Results. After a week of treatment, the regression of the skin process was observed in both groups, but it was more evident in the main group: significant differences in severity of erythema, paresthesia, pain and burning sensation, the Dermatological Life Quality Index (DLQI) were observed at this stage of therapy (p < 0.05). After 2 weeks of therapy: a more positive trend in the main group in terms of erythema, paresthesia and burning, but the most significant difference is DLQI – 17.4 in the main group and 22.8 in the control group (p < 0.0001). At the end of the 3rd week of therapy: differences with the main characteristics of erythema, desquamation, paresthesia (p < 0.0008), pain (p < 0.0001), DLQI (p < 0.0001). At the end point of the study (after 4 weeks of therapy), significant differences were found in reducing the symptoms and the main parameters for evaluating the effectiveness of DLQI in patients of the main group with a reliability of p < 0.0001. The high correlation of DLQI was found with erythema, pain, burning, paresthesia and desquamation. Conclusions. The treatment of the hand-foot plantar syndrome combined using alpha-lipoic acid inside and topical therapy in the form of an ointment containing calcipotriol and betamethasone dipropionate, can be recommended for patients receiving targeted therapy with multi-kinaseinhibitors.

scholarly journals FEATURES OF CLINICAL MANIFESTATIONS, CELLULAR AND HUMORAL IMMUNITY OF NEWBORNS WITH INTRAUTERINE MIXED INFECTIONS

2020 ◽  
pp. 427-433
Author(s):  
M.A. YUSUPOVA ◽  
◽  
K.I. ISMOILOV ◽  
Keyword(s):  
Humoral Immunity ◽  
Phagocytic Activity ◽  
Clinical Manifestations ◽  
Main Group ◽  
Phagocytic Index ◽  
Control Group ◽  
Mixed Infections ◽  
Secondary Immunodeficiency ◽  
Group I ◽  
Cellular And Humoral Immunity

Objective: To study the features of clinical manifestations, cellular and humoral immunity of newborns with intrauterine mixed infections (IUMI). Methods: A comprehensive survey of 45 infants with IUMI was carried out. Depending on the classification of IUMI they were divided into 3 main groups: group I – 24 patients (53%) with the viral-bacterial association, group II – 12 patients (27%) with the viral-viral association, and group III – 9 patients (20%) with the viral-parasitic association. The control group consisted of 10 newborns born from uninfected, somatically healthy mothers. Diagnosis of IUMI was based on the detection of specific antibodies of the IgA, IgG and IgM classes, as well as phagocytic activity and phagocytic index of leukocytes. In addition, general clinical, biochemical, bacteriological and instrumental research methods have been conducted. Results: The blood serum IgA and IgM indices in patients of the main group were significantly higher, and the mean IgG values were lower compared to the control group. Analysis of cellular immunity parameters in the main group showed a decrease in the number of mature T-lymphocytes (CD3), B-lymphocytes (CD20), the number of T-helpers and cells that produce IL-2 in the peripheral blood, compared with the control group. In the main group, there was also an increase in the number of apoptosis cells (CD95), cells with high cytotoxic activity (CD25, CD71) and the percentage of natural killer cells (CD16). A decrease in the phagocytic activity and phagocytic index of neutrophils was recorded, which indicates the insufficiency of the nonspecific component of immunity. Conclusions: In newborns, various changes were found both on the part of specific and nonspecific components of immunity. This indicates the development of secondary immunodeficiency in this category of patients and makes it necessary to add to the main treatment of immune corrective therapy. Keywords: Congenital infections, mixed intrauterine infections, TORCH syndrome, opportunistic infections, secondary immunodeficiency.

scholarly journals Prediction of community-acquired pneumonia complications in military men

2012 ◽  
Vol 93 (6) ◽  
pp. 864-870
Author(s):  
I M Borisov ◽  
T G Shapovalova
Keyword(s):  
Acute Kidney Injury ◽  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Toxic Shock Syndrome ◽  
Comparison Group ◽  
Kidney Injury ◽  
Community Acquired Pneumonia ◽  
Main Group ◽  
Prediction Algorithm ◽  
Toxic Shock

Aim. To develop diagnostic algorithm to predict the risk of community-acquired pneumonia development. Methods. 2000 patients with community-acquired pneumonia (male conscripts aged 18 to 22 years, mean age 19.2±0.19). A comparative analysis of two groups of patients to assess the algorithm for toxic shock syndrome, acute respiratory failure and acute kidney injury prediction was performed. In the comparison group (n=782, 1998 to 2003), prediction of complications was based on doctors’ personal knowledge and experience without using the prediction algorithms. In the main group (n=1218, 2003 to 2008), the established prediction algorithm was used. Results. The introduction of community-acquired pneumonia complications prediction algorithm allowed to decrease the incidence of such complications significantly. Toxic shock syndrome was diagnosed in 8.8% of patients in the comparison group and in 3.7% of patients of the main group (р 0.05), acute respiratory failure - in 43.1% of patients of the comparison group and in 19.5% of patients of the main group (р 0.05). The effectiveness of the algorithm for toxic shock syndrome prognosis was 90.8%, sensitivity - 91.8%, specificity - 89.7%, accuracy - 94.5%. The effectiveness of the algorithm for acute kidney injury prognosis was 90.7%, sensitivity - 90.7%, specificity - 90.8%, accuracy - 95.1%. Conclusion. Offered prediction algorithms can help a physician to suspect a possibility of potentially dangerous and lethal complications development in patients with community-acquired pneumonia at the early stages of the disease. It allows to adjust the treatment, to simplify the estimate for transportation need, to detect the indications for patients admission, including the admission to intensive care unit, and improve the results of treatment.

scholarly journals Analysis of the Effect of Emergency Ventilators on the Treatment of Critical Illness Based on Smart Medical Big Data

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Haiwang Sha ◽  
Fen He
Keyword(s):  
Respiratory Failure ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Pulmonary Ventilation ◽  
Clinical Manifestations ◽  
Effective Rate ◽  
Control Group ◽  
Oxygen Balance ◽  
Respiratory Muscle Fatigue

Respiratory failure refers to pulmonary ventilation and ventilatory dysfunction caused by various reasons, which makes the patient unable to maintain the gas exchange required for stillness and causes a series of pathophysiological changes and corresponding clinical manifestations. In order to solve the problem of respiratory failure in critically ill patients, it is of great significance to analyze the role of microprocessor-based emergency ventilator in the treatment of critically ill patients. This article aims to study the role of microprocessor-based emergency ventilator in the treatment of critically ill patients. This paper presents the key technology based on the ARM11 processor. A breathing motion model is detected and established through a ventilator. The research objects are mainly divided into group A and group B. By comparing the two groups of emergency ventilator ventilation, it can effectively prevent the increase in respiratory muscle fatigue, reduce oxygen consumption, improve the patient's ventilation function and oxygen balance, quickly correct hypoxia and carbon dioxide storage, cooperate with drug treatment, and quickly take out the ventilator after relief. Good treatment results were achieved. The results show that the emergency ventilator controlled by a microcomputer is effective. The total effective rate of the control group was 71.11%, which was significantly lower than that of the observation group (86.67%).

Results of the inclusion of osteopathic correction in the complex therapy of patients with chronic gastritis

2021 ◽  
pp. 80-89
Author(s):  
R. T. Fazlyakhmetov ◽  
R. R. Safiullin ◽  
A. V. Ustinov
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Eradication Therapy ◽  
Clinical Manifestations ◽  
Integrated Approach ◽  
Main Group ◽  
Control Group ◽  
Study Results ◽  
Complex Therapy

Introduction. Many key questions regarding the etiology, pathogenesis, clinical manifestations and treatment of chronic gastritis remain open. So, despite the success of chronic gastritis pharmacotherapy, much attention is paid to non-drug methods of therapy, in particular, osteopathy. However, evidences of the osteopathic methods effectiveness for the chronic gastritis treatment, obtained by objective instrumental methods, are insufficiently presented in the modern literature.The goal of research — to study the results of osteopathic correction inclusion in the complex therapy of patients with chronic gastritis.Materials and methods. The study involved 50 patients with chronic gastritis, divided by simple randomization into a control group (25 people) and a main group (25 people). The participants in the control group received standard eradication therapy according to a three-component scheme. The participants of the main group additionally received osteopathic correction. In both groups, at the beginning and at the end of the study, there were performed fibroesophagogastroduodenoscopy with targeted biopsy to assess the gastric mucosa state, Helicobacter pylori identification, and intragastric pH-metry to assess gastric juice acidity.Results. According to the study results, a statistically significant (p<0,05) decrease in edema and hyperemia of gastric mucosa was found in the control and main groups. There was a statistically significant (p<0,001) decrease in gastric aciditywith osteopathic accompaniment, compared with unaccompanied drug treatment. In both groups, there was a statistically significant (p<0,05) decrease in the incidence of Helicobacter pylori carriage. Conclusion. Based on the obtained results, it can be assumed that an integrated approach using osteopathic correction in the treatment of chronic gastritis may be more effective than the standard course of treatment.

Hepatoprotective therapy with low molecular weight sugar drug for pregnant women with liver dysfunction amid early toxicosis and hepatotoxicity

2021 ◽  
Vol 20 (2) ◽  
pp. 19-28
Author(s):  
E.V. Mozgovaya ◽  
◽  
M.A. Kryshnya ◽  
E.V. Shelaeva ◽  
S.V. Nagorneva ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Pregnant Women ◽  
Bile Acids ◽  
Alanine Aminotransferase ◽  
Clinical Manifestations ◽  
Main Group ◽  
Control Group ◽  
Low Molecular Weight ◽  
Sugar Solution ◽  
Drug Induced

Objective. To assess the efficacy and safety of low molecular weight sugar solution as a hepatoprotector in the first trimester of pregnancy in patients with liver functional disorders against the background of early toxicosis and / or hepatotoxicity. Patients and methods. The study included 70 patients: the main group (n = 30) – pregnant women with functional hepatopathies who received therapy with drug Heptrong; the control group (n = 30) – pregnant women who received standard treatment, of which 15 patients had hepatotoxicity (essential phospholipid therapy) and 15 patients with early toxicosis (intravenous saline fluid therapy, Cerucal), as well as 10 pregnant women with early toxicosis who were treated without drugs (the placebo group). Results. Pregnant women with early toxicosis noted a decrease in its clinical manifestations against the use of the drug Heptrong after 2.3 ± 0.8 days from the onset of therapy; by the end of therapy, all patients had no vomiting, and nausea stopped in 80%, which was not observed in comparison groups. The normalization of alanine aminotransferase (≤40 U/L) occurred in 80% of pregnant women in the main group (p < 0.01) and in 66% (p < 0.01) when treating with essential phospholipids. The normalization of alanine aminotransferase (≤40 U/L) occurred in 90% (p < 0.01) and 33.3% (p = 0.03), respectively. A significant decrease in the level of bile acids (from 8.49 ± 2.1 μmol/L to 2.74 ± 1.1 μmol/L; p < 0.05) and improvement in the indicators of the antioxidant system – an increase in total antiradical activity (from 804.0.0 ± 10.5 μmol/L to 839.0 ± 11.0 μmol/L; p < 0.05) and a decrease in the level of conjugated dienes (from 3.77 ± 0.2 μmol/L to 3.26 ± ± 0.1 μmol/L; p < 0.05) – were observed only in the main group. A number of other indicators of the “liver panel” tended to improve only in the main group. Conclusion. Heptrong is an effective hepatoprotective drug, which considerably improves the state of pregnant women during early toxicosis and helps to reduce liver transaminases and bile acids in pregnant women with hepatotoxicity. Due to the antiinflammatory and pronounced antioxidant effect, which is not observed in standard pharmacological treatment, Heptrong can be used to prevent late obstetric complications. Key words: Heptrong, drug-induced hepatopathies, “liver panel” indicators, early toxicosis

scholarly journals STUDY OF RIVAROXABAN FOR VENOUS THROMBOEMBOLISM PROPHYLAXIS AFTER LOWER EXTREMITY FRACTURES IN RUSSIAN CLINICAL PRACTICE

2018 ◽  
pp. 47-51
Author(s):  
M. V. Belov
Keyword(s):  
Lower Extremity ◽  
Dabigatran Etexilate ◽  
Clinical Manifestations ◽  
Bleeding Risk ◽  
Recurrent Dislocation ◽  
Main Group ◽  
Control Group ◽  
Thromboembolism Prophylaxis ◽  
Vein Thrombosis ◽  
Femur Fractures

Thepurposeof the study was to evaluate the efficacy and safety of rivaroxaban in patients after surgical treatment for the lower extremity fractures.Patients and methods. Retrospective multicenter study included 663 patients with femur fractures, 43 patients with complications after total hip arthroplasty (periprosthetic femur fractures, recurrent dislocation) and 10 patients with shinbone fractures. The majority (81.99%) of patients were elderly or senile. In postoperative period all patients received a standard prophylactic dose of anticoagulants. Out of them 75 (main group) – rivaroxaban (10 mg/day), 241 (control group) – other drugs (enoxaparin – 40 mg/day and dabigatran etexilate 150 or 220 mg/day). The efficacy of prophylaxis was assessed by clinical picture and Doppler ultrasound scans.Results.Average bed day made up 9.28. During hospitalization no cases of PE were recorded. In the main and control groups the rate of deep vein thrombosis with clinical manifestations made up 1.89 and 3.31%, respectively. No cases of fatal bleeding occurred. Signs of continuous bleeding in the area of surgical intervention (soaking dressings or recurring wound hematomas) in the main group was recorded rarely (3.15%) than in the control one (8.29%).Conclusion.Reduction of VTE rate with no increase in bleeding risk indicates the feasibility of rivaroxaban use for postoperative PE prophylaxis in patients with lower extremity fractures.

scholarly journals Influence of Nature of Infant Nutrition on Formation of Body Resistance

2021 ◽  
Vol 65 (6) ◽  
pp. 145-154
Author(s):  
T. G. Malanicheva ◽  
E. V. Agafonova ◽  
N. V. Ziatdinova ◽  
I. N. Skidan
Keyword(s):  
Incidence Rate ◽  
Respiratory Diseases ◽  
Comparison Group ◽  
Resistance Index ◽  
Community Acquired Pneumonia ◽  
Main Group ◽  
Control Group ◽  
Healthy Children ◽  
Acute Respiratory Diseases ◽  
Body Resistance

Purpose of the Study: Assessment of the influence of the type of the adapted infant milk formula in infants on the formation of the body resistance. Children Characteristics and Study Methods. 105 virtually healthy children were examined, as follows: 35 children were breastfed (control group), 70 children were formula fed including 35 children that received NENNY with prebiotics formula based on the goat milk (main group), 35 children – formulas based on the cow milk with probiotics and prebiotics (comparison group). The incidence rate of the acute respiratory diseases (ARD) as well as the number of the pneumonia histories in the infants were assessed, and the body resistance index was calculated. The laboratory assessment of the child body immunoresistance was carried out using the method of imprint smears from the nasal mucous membranes and the method of nasal washes. Results. It was determined that there were 2 times more children of the main group with no history of the acute respiratory diseases when infant than in the comparison group. In general, the good resistance (were sick 0-3 times a year) in the main group was registered in 82.9% of the children, while it was only 60% in the comparison group. The average number of the ARD cases per year was 2.3 ± 0.02 in the main group, which is 1.5 times less than in the comparison group – 3.6 ± 0.04 (p <0.05), and in 1, 3 times more than that in the control group – 1.8 + 0.03 (p<0.05). In average, the resistance index was 0.28 ± 0.02 in the main group, while it was 0.36 ± 0.03 in the comparison group, and 0.25 ± 0.02 in the control group. When studying the incidence rate of the community-acquired pneumonia in the infants, it was revealed that 2.8% of them were ill in the control group, 5.7% of them in the main group, and 8.5% in the comparison group. When feeding the child with formulas based on the goat’s milk, the level of mucosal immunity of the nasal mucosa and enzyme systems of the intraleukocyte microbicidal system is assured, which is virtually indistinguishable from the level of immunity achieved with breastfeeding. Conclusion. Adapted NENNY with prebiotics formulas can be recommended for children who are formula fed when infant in order to increase the body’s resistance and to reduce the incidence rate of the acute respiratory diseases and community-acquired pneumonia.

scholarly journals Study of the FUT2 gene association with infection and clinical manifestations of Helicobacter pylori infection

2021 ◽  
pp. 27-32
Author(s):  
A. S. Klimova ◽  
E. V. Shrayner ◽  
A. I. Khavkin ◽  
N. V. Kokh ◽  
G. I. Lifshits ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Polymorphic Locus ◽  
Clinical Manifestations ◽  
Main Group ◽  
Control Group ◽  
Significant Difference ◽  
Taqman Pcr ◽  
Pcr Method ◽  
H Pylori ◽  
Fut2 Gene

The aim of the pilot study of a group of adolescents with H. pylori infection was to study the preliminary data obtained on the rs602662 locus of the FUT2 gene and to establish its role in the realization of clinical manifestations of chronic gastritis, gastric ulcer and duodenal ulcer associated with H. pylori.Methods: The study included 91 patients. The study for the presence of the polymorphic locus rs602662 of the FUT2 gene was carried out by the standard TaqMan PCR method on a Real-Time CFX96 Touch amplifier. The duration of the study was 6 months.Results: The main group included 25 adolescents aged 16 to 17 years 11 months, the control group included 20 patients. Patients infected with H. pylori more often noticed symptoms of dyspepsia - in 36%, compared with the control group - 9.7%. The presence of a family history in the main group for associated diseases had a significant difference, χ2 = 4.97, p <0.05.To assess the contribution of the genotype of the rs602662 locus of the FUT2 gene to the risk of clinical manifestations in H. pylori infection, the main group was divided into subgroups. In the distribution of alleles in these groups, statistically significant differences were revealed.Allele “A” has a protective effect against the onset of clinical symptoms of dyspepsia. The odds ratio (OR) with the carriage of allele “A” (genotypes A / A and G / A versus G / G) to have clinical symptoms with a positive H. pylori status was 0.175 (CI = [0.049-0.625] chi2 = 7.79 p = 0.0053).Conclusion. As a result of the study, we were unable to identify a significant association of alleles and genotypes of the rs602662 locus of the FUT2 gene with clinical manifestations of H. pylori infection. At the same time, carriers of the A allele have a pronounced association with the absence of clinical symptoms in patients with a positive H. pylori infection status of 0.175 (C.I. = [0.049-0.625] chi2 = 7.79 p = 0.0053).

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