scholarly journals Features of Pap smears in women of reproductive life with papillomavirus 16, 18

Author(s):  
Shafag Eldar Aliyeva ◽  

Introduction. According to modern data, cervical diseases do not occur by chance. Precancerous lesions vary from person to person and become invasive over time. The need for specific diagnostic methods for early detection of cervical cancer in women of reproductive age always remains relevant. Over the years, numerous diagnostic, cytological and histological studies have been carried out to identify malignant lesions of the cervix. Human papillomavirus (HPV) is a widespread sexually transmitted infection that affects both women and men around the world and plays an important role in the development of cervical disease. It is the most common sexually transmitted virus in the United States of America. For the first time in 1942, Papanicolaou emphasized the possibility of using smears (PAP smears) from the cervix and from the vagina to diagnose cervical disease. PAP preparations of smears are mainly multilayered flat epithelial cells of the ectocervix and vagina, endocervical cylindrical cells, including mononuclear and polynuclear inflammatory cells that enter the vagina through diapedesis from the surface of the epithelial layer, mixing with the mucoid fluid produced by the endocervical epithelial fluid. Purpose — using objective criteria for cytological examination to identify neoplastic changes in the cervix. Materials and methods. The study included 100 women of reproductive age (18–45 years old) during 2015–2020. Of these, 20 were in the control group (group I — control) and 80 — in the high-risk group for cervical cancer (group II — the main group). Group II women were also divided into 2 subgroups: II A — with pathology of the cervix (n=41), II B — without pathology of the cervix (n=39). The study included patients with a positive result on HPV 16/18 including patients whose PAP smears revealed intracellular damage. Pap smears were included in the study according to the following criteria. The smears contained a sufficient number of squamous epithelial cells and their integrity was preserved. Endocervical cells were monitored in all PAP smears. The examination was carried out with at least 5 cells in each, not completely, and with 2 clusters of endocervical glandular or squamous metaplastic cells. Squamous epithelial cells covered at least 10% of the preparation. Bloody, technically artifactic preparations without clinical data have not been studied. The deficit rate did not exceed 3%, and high interest rates on artifacts were not included in the study. Despite the small number of cells in the presence of abnormal cells, this was unequivocally considered sufficient. Results. Interpretation of PAP smear results identified n=35 ASCUS patients, n=24 LSIL, n=21 HSIL patients in the PAP smear positive reproductive age group. HPV serotypes 16.18 were found in 24 of these patients. In women of the II B subgroup, no pathological changes in the cervix were observed. Conclusions. In women of reproductive age with positive HPV 16, 18, for the diagnosis of precancerous diseases of the cervix, taking pap smears is an integral part of the study. As a result of the study, it was revealed that, despite the absence of a clinical picture, pathological changes at the cell level are detected. Key words: HPV16, 18, ASCUS, LSIL, HSIL, PAP.

2017 ◽  
Vol 11 (2) ◽  
pp. 49-54
Author(s):  
Chusnul Khotimah ◽  
Dyah Noviawati Setya Arum ◽  
Munica Rita Hernayanti

Cervical cancer is the second most common cancer in the world. In developing countries still ranks first as a cause of cancer deathsin women of reproductive age. Pap smear has proved very useful for early detection of cervical cancer since pre-cancerous stage,but many women are reluctant to undergo a pap smear because of ignorance, shame, fear, and cost factors. While the Pap smearcoverage lowest in Imogiri health center II is 0%. The type of research is a descriptive study with cross-sectional approach. Todescribe the level of knowledge and overview of the implementation of Pap smears in women in fertile age couple in the KemasanHamlet Karang Tengah Village Imogiri Bantul. The entire population of mothers in fertile age couple who attended of the PKK andwilling to become respondents in the Kemasan Hamlet Karang Tengah Village Imogiri Bantul. The results of research that themajority of respondents aged> 35 years (51.1%), basic education (50%), does not work (53.44%), obtain resources through onesource (63.3%). The level of knowledge about Pap smears in women PUS (Pasangan Usia Subur) in the Kemasan Hamlet KarangTengah Village Imogiri Bantul 2015 is in the category enough that 72.7% and most did not carry out pap smear that is, 86.4%. Theconclusion that the level of knowledge about the EFA mother pap smear EFA in the Kemasan Hamlet Karang Tengah Village ImogiriBantul 2015 enough and did not carry out pap smear.


2019 ◽  
Vol 1 (1) ◽  
pp. 56
Author(s):  
Julaecha Julaecha ◽  
Nurfitriani Nurfitriani

Cervical cancer is a malignant disease that occurs in the cervik. Course of the disease is preceded by the condition of pre-concerous lesions of the cerviks is the existence of dysplasi/cervical intraepithelial neoplasia (NIS). On each day is expeced to 40-45 new cases and about 20-25 people  die from cervical cancer. Based on those considered very necessary to provide education  on cervical cancer in women of reproductive age in the prevention of cervical cancer prevention effort.Target outcomes expected are: there is an increased knowledge an increase in knowledge between before and after extension and capable of early detection of cancer  serviks increase. Implementation method to provide counseling.The results  showed that there was important of mother’s interest in doing pap smears examination before and after counseling.


Author(s):  
Ike Nurrochmawati ◽  
◽  
Ambar Dwi Retnoningrum ◽  
Remita Yuli Kusumaningrum ◽  
◽  
...  

Background: Cervical cancer is the fourth most prevalent cancer in women. Pap smear and visual inspection acetic acid (VIA) are essential screening tests to early detect cervical cancer. However, the use of screening tests remained low among women of reproductive age in Nganjuk district, East Java. This study aimed to determine the effectiveness of health education using flip chart and video on knowledge about early detection of cervical cancer among women of reproductive age in Nganjuk district, East Java. Subjects and Method: A randomized control trial conducted in Rejoso, Nganjuk, East Java, from October to November 2019. A sample of 120 women of reproductive age was randomized into two groups: (1) Experiment group that received health education using a flip chart and video, and (2) Control group that received no intervention. The dependent variable was knowledge of early detection of cervical cancer. The independent variable was health education using a flip chart and video. The data were collected using questionnaire. The data were analyzed by independent t-test. Results: After the intervention, knowledge about early detection of cervical cancer in the experimental group (Mean= 80.40; SD= 10.54) was higher than the control group (Mean= 70.53; SD= 9.68), and it was statistically significant (p <0.001). Conclusion: Health education using a flip chart and video is effective in improving knowledge about early detection of cervical cancer among women of reproductive age. Keywords: early detection, cervical cancer, health education, women of reproductive age Correspondence: Ike Nurrochmawati. School of Health Sciences Satria Bhakti, Nganjuk. Jl. Panglima Sudirman VI, Nganjuk, East Java. Email: [email protected]. Mobile: +6282141578108. DOI: https://doi.org/10.26911/the7thicph.02.36


2015 ◽  
Vol 143 (12) ◽  
pp. 2604-2612
Author(s):  
I. SALIMOVIĆ-BEŠIĆ ◽  
M. HUKIĆ

SUMMARYThe objectives of this study were to identify human papillomavirus (HPV) genotypes in a group of Bosnian-Herzegovinian women with abnormal cytology and to assess their potential coverage by vaccines. HPVs were identified by multiplex real-time PCR test (HPV High Risk Typing Real-TM; Sacace Biotechnologies, Italy) of 105 women with an abnormal cervical Pap smear and positive high-risk (HR) HPV DNA screening test. The most common genotypes in the study were HPV-16 (32·6%, 48/147), HPV-31 (14·3%, 21/147), HPV-51 (9·5%, 14/147) and HPV-18 (7·5%, 11/147). The overall frequency of HR HPV-16 and/or HPV-18, covered by currently available vaccines [Gardasil® (Merck & Co., USA) and Cervarix®; (GlaxoSmithKline, UK)] was lower than the overall frequency of other HPVs detected in the study (40·1%, 59/174,P= 0·017). Group prevalence of HR HPVs targeted by a nine-valent vaccine in development (code-named V503) was higher than total frequency of other HPVs detected (68·0%, 100/147,P< 0·001). Development of cervical cytological abnormalities was independent of the presence of multiple infections (χ2= 0·598,P= 0·741). Compared to other HPVs, dependence of cervical diagnosis and HPV-16, -18 (P= 0·008) and HPV-16, -18, -31 (P= 0·008) infections were observed. Vaccines targeting HR HPV-16, -18 and -31 might be an important tool in the prevention of cervical disease in Bosnia and Herzegovina.


Author(s):  
◽  
Eti Poncorini Pamungkasari ◽  
Rita Benya Adriani ◽  
◽  

ABSTRACT Background: Cervical cancer is the second most common type of cancer in women. Pap smear examination can detect early and prevent late diagnosis of cervical cancer. Perception of benefits is one of the constructs of the Health Belief Model that can predict women’s intention in having a Pap smear. This study aimed to examine the effect of perceived benefit on Pap smear uptake using a meta-analysis. Subjects and Method: A meta analysis was conducted by searching articles from PubMed, Springer Link, Google Scholar databases. Keywords used “Health Belief Model” OR “HBM” OR “Perceived Benefit” AND “Pap smear” OR “Pap Test”. The inclusion criteria were full text, articles published from 2014 to 2019, and using cross sectional study design. The articles were selected by PRISMA flow chart. The quantitative data were analyzed by RevMan 5.3. Results: There were 6 articles that met the criteria. This study reported that strong perceived benefit increased Pap smear uptake in women of reproductive age (aOR= 1.15; 95% CI= 1.06 to 1.24; p<0.001) with I2 = 88%. Conclusion: Strong perceived benefit increases Pap smear uptake in women of reproductive age. Keywords: perceived benefit, pap smear, cervical cancer, health belief model Correspondence: Maranata. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 085867548771. DOI: https://doi.org/10.26911/the7thicph.03.133


Author(s):  
Swati Mittal ◽  
Anagha J. Kamath

Background: Cervical cancer is a malignant neoplasm arising from cells of cervix uteri. It is the second most common cancer among women worldwide, affecting about 16 per 1,00,000 women each year.Methods: A cross sectional study of 400 women of reproductive age group (21-49 years) attending Lady Goschen Hospital and KMC Hospital, Attavar, Mangalore was conducted, and women were screened for the presence of cervical cancer by Pap smear. The results were analyzed with respect to age distribution, age at marriage, parity, symptoms and per-speculum findings. Pregnant women and women with active infection of the genital tract were excluded from the study population.Results: The age range was 21 to 49 years. Mean age was 38.14 years. Of the 400 women, 398 were married and majority of these, 237 (59.5%), got married between 21-25 years. Menstrual irregularity was the most common presenting symptom, 150/400 (37.5%). Abnormal per speculum findings were seen in 102/400 (25.5%). 17 of 400 Pap smears were abnormal, of which 1 (0.25%) was AG-FN, 2 ASCUS (0.5%), 3 (0.75%) ASC-H, 1 (0.25%) LSIL, 7 (1.75%) HSIL and 3 (0.75%) SCC. Mean age for cancer cervix patients was 42.33 years.Conclusions: Pap smear screening, which appears to be the most feasible and affordable mode for control of carcinoma cervix in developing countries like India, should be carried out in all women of reproductive age group.


Author(s):  
D. D. Naik ◽  
Balaiah Donta ◽  
Saritha Nair ◽  
B. N. Mali

Background: Cervical cancer is one of the most common cancers among women. Due to this disease 80 percent die at an advance stage. This may be due to lack of awareness and knowledge, lack of access to proper treatment including screening facility. This study is undertaken with an objective to investigate knowledge attitude, practice and health seeking behaviour about sexually transmitted infections (STIs) and cervical cancer among eligible women in a slum community in Mumbai.Methods: Baseline data of women was drawn from an intervention study entitled “Enhancing knowledge and promoting health seeking behaviour of couples on sexually transmitted infections and cervical cancer in urban slums of Mumbai” for this article. This data was collected from a random sample of 1958 women in reproductive age group through a semi-structured interview schedule from two urban slums of Mumbai. Information was collected on socio-economic and demographic characters, awareness and symptoms of STIs and cervical cancer, and health seeking behaviour.Results: The study revealed that majority of women had heard about the STIs, 37.7 percent were aware of cervical cancer whereas only 3.6 percent of women were aware of Pap smear test. About 11 percent of women experienced at least one symptom of STI, 0.3 percent of women reported of having sexual partner other than spouse. Most women were not aware of STIs symptoms specific to men.Conclusions: Study concludes that the need to disseminate knowledge regarding STI symptoms, cervical cancer and Pap smear test for early detection of cervical cancer as well as promoting better health seeking behaviour with respect to cervical cancer and STIs. Considering of sensitivity of the topic it is necessary to design separate programmes for women.


Author(s):  
Lisa Iversen ◽  
Shona Fielding ◽  
Øjvind Lidegaard ◽  
Philip C Hannaford

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