scholarly journals The estimate of the rubella elimination status in the Russian Federation in 2019

2021 ◽  
Author(s):  
T. Chekhlyaeva ◽  
O. Czvirkun ◽  
N. Turaeva ◽  
D. Erokhov ◽  
L. Barkinkhoeva ◽  
...  
Keyword(s):  
Russian Federation ◽  
Molecular Genetic ◽  
Genetic Research ◽  
Incidence Rates ◽  
Genetic Monitoring ◽  
Successful Implementation ◽  
Reference Laboratory ◽  
Regional Office ◽  
The Russian Federation ◽  
Endemic Transmission

In 2002, the WHO Regional Office for Europe developed a Strategic Program for the Prevention of Measles and Congenital Rubella Infections in the European Region, which was revised in 2004. As a result of the revision, an additional target was set to eliminate endemic rubella in the region by 2010. Rubella is a disease that is well controlled by vaccination, which will determine the theoretical possibility of interrupting its global transmission. Since 2013, the Russian Federation has been implementing the National Rubella Elimination Program. Elimination criteria have been revised as the Program progresses. Currently, the main criterion for rubella elimination is the absence of endemic (local) transmission of the virus for at least 36 months, which should be confirmed by molecular genetic research methods. In addition, in the Russian Federation, an incidence rate of less than 1 case per 1 million population is also used as one of the elimination criteria. The successful implementation of the Program is supported by the fact that since 2013, against the background of a high (over 95%) coverage of preventive vaccinations, there has been a decrease in incidence rates and their stabilization at a level of less than 1 per 1 million population since 2014. Genetic monitoring of rubella virus strains circulating among the population showed the termination of endemic transmission of the virus. During the implementation of the Elimination Program, the prevailing genotypes of the virus circulating in Russia were genotypes 1E and 2B, which have a global distribution. The data obtained from the results of molecular genetic monitoring made it possible to determine that the strains isolated during the period under consideration belong to different clusters, which speaks in favour of their imported character. Considering the above factors: high vaccination coverage, low incidence and lack of endemic transmission of the virus, the WHO Committee on verification of measles and rubella elimination in 2017 awarded the Russian Federation the status of a country that has achieved rubella elimination. The continuation of the phase of elimination of infection is confirmed annually. This article presents the results of a comprehensive assessment of the rubella elimination status in the Russian Federation by specialists from the National Scientific and Methodological Center for Measles and Rubella and WHO EURO Moscow regional reference laboratory for measles and rubella based on epidemiological data and data from molecular genetic studies in 2019.

scholarly journals Molecular-Genetic Monitoring of SARS-CoV-2 Genovariants in the Territory of the Volga Federal District of the Russian Federation. Communication 1

2021 ◽  
pp. 122-127
Author(s):  
N. A. Osina ◽  
Ya. M. Krasnov ◽  
N. P. Guseva ◽  
E. G. Boolgakova ◽  
I. V. Domanina ◽  
...  
Keyword(s):  
Russian Federation ◽  
Molecular Genetic ◽  
Clinical Manifestations ◽  
Federal District ◽  
Genetic Monitoring ◽  
Antigenic Structure ◽  
Three Samples ◽  
Sequencing Method ◽  
The Russian Federation

Emergence of various genovariants of the SARS-CoV-2 virus, which are characterized by a higher ability to spread and a more severe clinical manifestations compared to the initial variants, require molecular-genetic monitoring of strains circulating in the Russian Federation.The aim of the work was to identify the VOC SARS-CoV-2 genovariants in the territory of the Republics of Bashkortostan, Tatarstan, Udmurtia, and Samara, Penza, Saratov, Ulyanovsk, and Orenburg Regions.Materials and methods. The identification of genovariants and the determination of the type of mutations was carried out by the Sanger fragment sequencing method.Results and discussion. The study examined 298 samples of clinical material obtained from the Centers for Hygiene and Epidemiology in the Republics of Bashkortostan, Tatarstan, Udmurtia, Samara, Penza, Saratov, Ulyanovsk, and Orenburg Regions. In 17 % of cases, the variability of the SARS-CoV-2 virus was observed for one or more markers: in three samples, a new coronavirus of the B. 1.1.7 line (“British”) was detected; in a number of cases, only one mutation was detected in the virus found in samples – deletion Y144 or substitution D138Y, E484K, N501Y, and very rarely two mutations – deletion Y144 and substitution E484K. The presence of the L141-G142-V143 deletion localized in the recurrent deletion region RDR2 of the S-gene was shown in 10 % of the cases. The data obtained indicate the heterogeneity in macroorganism of the population of the new coronavirus with the deletion L141-G142-V143, which leads to a change in the antigenic structure of the virus, which probably allows the virus to evade the immune response.

scholarly journals Tapping the Potential of the Molecular Genetic Expert Research of Objects of Animal Origin in the Fight against Their Illegal Trafficking

2021 ◽  
Vol 16 (3) ◽  
pp. 62-72
Author(s):  
Sergei V. Aramilev ◽  
Viktoriya V. Gulevskaya ◽  
Georgii G. Omel’yanyuk ◽  
Anna A. Rybakova ◽  
Irina V. Storozhenko
Keyword(s):  
Russian Federation ◽  
Dna Analysis ◽  
Criminal Responsibility ◽  
Molecular Genetic ◽  
Genetic Research ◽  
Biological Tissues ◽  
Wild Animal ◽  
Animal Origin ◽  
Animal Populations ◽  
The Russian Federation

Currently, the legal framework for protecting natural resources from human assault is being developed at the international level. However, the statistical data on the sentencing of persons convicted on the territory of the Russian Federation under Articles 258 and 258.1 of the Criminal Code of the Russian Federation in 2020 given in the article indicates: the crimes causing the reduction in the number of animal populations, and as a result, the loss of biodiversity, are challenging to prove; a small number of perpetrators are brought to criminal responsibility; punishment in the form of imprisonment is imposed only in isolated cases. However, using molecular genetic research methods for the biological material of wild animals, it is possible to fill in a significant part of the missing information or obtain new evidentiary information about the circumstances of crimes, including illegal hunting. The application of the DNA barcoding method, developed in the early 2000s, makes it possible to establish the taxonomic affiliation of living organisms when it is impossible to do this by classical methods, for example, if the organism is represented by a micro-number of biological tissues, and is also at the stages of the life cycle (egg, larva, embryo) with an insufficient number of morphological features. Thus, advanced DNA technologies allow us to obtain a considerable amount of previously inaccessible information.The issue of the illegal wild animal trafficking sold as “raised in captivity” is relevant for the pet industry and zoos and has implications both for animal welfare and the preservation of the natural environment. Methods based on the DNA analysis can also be applied for solving problems related to establishing the source of origin of the animal, in some cases – its habitat. The article provides cases from expert practice of ANO “Amur Tiger” when using molecular genetic methods of wild animal analysis allowed solving investigative and judicial tasks.

A clinical case of transcleral fixation of an artificial iridochrustalic diaphragm during its decentration in a patient with aniridia and aphakia

2021 ◽  
pp. 206-208
Author(s):  
D.O. Shkvorchenko ◽  
◽  
I.M. Gorshkov ◽  
S.A. Kakunina ◽  
K.S. Norman ◽  
...  
Keyword(s):  
Key Words ◽  
Russian Federation ◽  
Clinical Case ◽  
Functional Results ◽  
Successful Implementation ◽  
Ministry Of Health ◽  
Visual Functions ◽  
The Russian Federation ◽  
The Right

Purpose. To evaluate the clinical and functional results of the technique of transcleral fixation of the artificial iridochrustalic diaphragm during its decentration in a patient with aniridia and aphakia. Material and methods. Under observation was a 32-year-old patient K. with a diagnosis on the right eye: iridochrustalic diaphragm decentralization, posttraumatic aniridia, posttraumatic aphakia, who underwent a method of transcleral fixation of a displaced artificial iridochrustalic diaphragm developed at the Academician S. N. Fedorov Eye Microsurgery of the Moscow Ministry of Health of the Russian Federation. Results. Patient K. is subjectively satisfied with the visual functions obtained in the right eye. Conclusion. Thus, this clinical case demonstrates a very successful implementation of the fixation of the iridochrustalic diaphragm with its displacement to obtain satisfactory visual functions in the patient. Key words: aniridia, iridochrustalic diaphragm, transcleral fixation.

Molecular Epidemiological Monitoring of Circulation of Coxsackievirus A10

2021 ◽  
pp. 43-49
Author(s):  
LN Golitsyna ◽  
VV Zverev ◽  
NV Ponomareva ◽  
NI Romanenkova ◽  
Thao Thanh Thi Nguyen ◽  
...  
Keyword(s):  
Russian Federation ◽  
Molecular Genetic ◽  
Clinical Manifestations ◽  
Foot And Mouth Disease ◽  
Sewage Water ◽  
Epidemiological Surveillance ◽  
Molecular Monitoring ◽  
South Vietnam ◽  
Epidemiological Monitoring ◽  
The Russian Federation

Background: Coxsackievirus A10 (CV-A10) is currently one of the most common etiological agents of enterovirus infection (EVI). Over the past decade, severe and fatal cases of CV-A10 infection have become more frequent while clinical manifestations of the disease are similar to those of Enterovirus A71 infection. The objective of our study was to characterize circulation of Coxsackievirus A10 in the Russian Federation in 2008–2019 and to study the phylogenetic relationships of strains isolated in Russia and Vietnam. Materials and methods: In 2008–2019, 220 CV-A10 strains were isolated from patients with various clinical manifestations of EVI and from sewage water samples taken in the Russian Federation and then studied using molecular genetic methods. In addition to that, we analyzed 26 CV-A10 strains isolated from patients with hand, foot, and mouth disease (HFMD) and acute flaccid paralysis in South Vietnam in 2018–2019. Results: We established a two-year periodicity of CV-A10 active circulation in Russia. In the structure of clinical forms of CV-A10 infection, herpetic angina prevailed (30.8 %), followed by minor illness (25.25 %), respiratory diseases (15.66 %), exanthema (14.65 %), gastrointestinal disorders (8.08 %), and asymptomatic infections (2.02 %). Symptoms of CNS damage (meningitis, meningoencephalitis) were observed in 3.53 % of cases. Most CV-A10 strains from Vietnam were isolated from patients with CNS affection of varying degrees of severity. During the study period, CV-A10 strains of genotypes C, E, and F3 circulated in the territory of the Russian Federation whereas the strains from South Vietnam were represented by genotypes F3 and F1. The studied strains showed a genetic relationship with those of CV-A10 circulating in different countries. Vietnamese and some Russian strains of the F3 genotype were genetically close to the strains isolated from severe cases. Conclusions: Molecular monitoring of CV-A10 circulation is an important component of the global epidemiological surveillance of EVI.

Some Issues of Morbidity with Temporary Incapacity for Work in the Ural Federal District

2021 ◽  
pp. 37-44
Author(s):  
AS Shastin ◽  
VG Gazimova ◽  
OL Malykh ◽  
TS Ustyugova ◽  
TM Tsepilova
Keyword(s):  
Public Health ◽  
Russian Federation ◽  
Disease Incidence ◽  
Federal District ◽  
Incidence Rates ◽  
Statistical Information ◽  
Working Age ◽  
The Russian Federation ◽  
The Common ◽  
Working Age Population

Introduction: In the context of a decreasing size of the working-age population, monitoring of the health status and disease incidence in this cohort shall be one of the most important tasks of public and occupational health professionals. Health risk management for the working population in the Russian Federation requires complete and reliable data on its morbidity, especially in view of the fact that its average age demonstrates a stable growth. It is, therefore, crucial to have precise and consistent information about the morbidity of the working-age population. Objective: The study aimed to assess incidence rates of diseases with temporary incapacity for work in the constituent entities of the Ural Federal District of the Russian Federation. Materials and methods: We reviewed data on disease incidence rates published by the Federal State Statistics Service in the Common Interdepartmental System of Statistical Information, Section 15.12, Causes of Temporary Disability, and Section 2.9.I.4, Federal Project for Public Health Promotion. The constituent entities under study were ranked according to the number of cases and days of temporary incapacity per 100 workers and E.L. Notkin scale was used to determine grade the incidence. The statistical analysis was performed using STATISTICA 10 software. Long-term average values of certain indicators, median values, standard deviation (σ) and coefficients of variation were estimated. The difference in the indices was assessed using the Mann-Whitney test. Results: Compared to 2010, incidence rates of diseases with temporary incapacity for work in the constituent entities of the Ural Federal District in 2019 demonstrated a significant decline. The sharp drop was observed in 2015. We also established that the Common Interdepartmental System of Statistical Information contains contradictory information on disease incidence. Conclusion: It is expedient to consider the issue of revising guidelines for organization of federal statistical monitoring of morbidity with temporary incapacity for work and to include this indicator in the system of public health monitoring.

scholarly journals Revisiting the Issue of the Molecular-genetic Structure of the Causative Agent of the Bovine Leukemia Virus in the Russian Federation

2016 ◽  
Vol 9 (42) ◽  
Author(s):  
Irina Mikhailovna Donnik ◽  
Maksim Valeryevich Petropavlovsky ◽  
Anna Sergeevna Krivonogova ◽  
Irina Alekseevna Shkuratova ◽  
Marzena Rola-Łuszczak ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Russian Federation ◽  
Causative Agent ◽  
Bovine Leukemia Virus ◽  
Leukemia Virus ◽  
Molecular Genetic ◽  
The Russian Federation

scholarly journals Review of the Current Epidemiological Situation on the Incidence of Hemorrhagic Fever with Renal Syndrome in the World and Forecast of the Incidence for the Territory of the Russian Federation in 2019

2019 ◽  
pp. 30-36 ◽  
Author(s):  
T. A. Savitskaya ◽  
V. A. Trifonov ◽  
G. Sh. Isaeva ◽  
I. D. Reshetnikova ◽  
N. D. Pakskina ◽  
...  
Keyword(s):  
Russian Federation ◽  
Hemorrhagic Fever ◽  
Federal District ◽  
Incidence Rates ◽  
Downward Trend ◽  
Average Level ◽  
The World ◽  
The Russian Federation ◽  
Autonomous Regions ◽  
Epidemiological Situation

The paper presents analysis of epidemiological situation on hemorrhagic fever with renal syndrome around the world and in the Russian Federation over the period of 2009–2018. 5855 cases of hemorrhagic fever with renal syndrome were registered in Russia in 2018 (3.99 per one hundred thousand of the population). Downward trend is observed as compared to 2017 (by 29.6 %). Cases of cluster infection were not reported. It is established that the highest level of morbidity, exceeding the average level across Russia 3.9 times, was noted in the Volga Federal District, where 77.5% of the total cases occurred. The territory of the Russian Federation was differentiated by the HFRS incidence rates. The areas with high levels of morbidity included the entities of the Russian Federation with intensive index range between 9.08 and 41.39 per one hundred thousand of the population, among them Republics of Bashkortostan, Mari El, Tatarstan, and Mordovia, Udmurt and Chuvashi Republics, Kirov, Nizhny Novgorod, Penza, Samara, Ulyanovsk, Kostroma, Yaroslavl, and Jewish Autonomous Regions. The forecast for preservation of tense epidemiological situation on HFRS incidence in the territory of the Volga Federal District was substantiated.

scholarly journals The incidence of skin melanoma in the Russian Federation and federal districts

2018 ◽  
pp. 161-165 ◽  
Author(s):  
N. P. Malishevskaya ◽  
A. V. Sokolova ◽  
L. V. Demidov
Keyword(s):  
Russian Federation ◽  
Incidence Rates ◽  
Annual Rate ◽  
First Year ◽  
Visual Localization ◽  
Skin Melanoma ◽  
Average Annual Rate ◽  
Male Population ◽  
Rate Of Increase ◽  
The Russian Federation

Over the past 40 years, the incidence of skin melanoma in the world has increased approximately 3-fold.To study the current epidemiological situation of skin melanoma in the Russian Federation, data on the absolute, coarse and standardized incidence rates of melanoma (S43) in the male and female populations were analyzed. The specific gravity of the melanoma patients detected actively was analyzed at different stages of the tumor process who died within the first year since the diagnosis was established between 2006–2016.The incidence of skin melanoma in the Russian population is characterized by a constant increase of indexes, the average annual rate of increase in the incidence of the Russian Federation’s population of melanoma is 2 times higher than that of the general oncological morbidity. A higher average annual rate and a general increase in the incidence of SM is recorded in the male population. Only every 4th patient in the RF is detected actively, despite the fact that melanoma is a tumor of visual localization. In general, only one third of patients with skin melanoma (32.8%) are diagnosed in the first stage of the tumor process in the Russian Federation. Over the period from 2006 to 2016 in Russia, the indicators of neglect on skin melanoma significantly decreased by 40.6%, however they remain at an unacceptably high level. The index of the first-year lethality from skin melanoma in Russia for the period from 2006 to 2016 decreased by 26.01%.To improve the index of active detection of patients with SM, especially in the early stages, it is necessary to create a system for interaction of primary contact physicians with the patient (dermatovenerologists, cosmetologists, therapists) with the oncological service, the formation of on-alertness among physicians of all specialties, and among the population.

scholarly journals FEATURES OF THE IMPLEMENTATION OF THE POLICY OF GOVERNMENTAL SUPPORT OF SMALL AND MEDIUM ENTREPRENEURSHIP IN THE RUSSIAN FEDERATION

2019 ◽  
pp. 20-25
Author(s):  
N. N. Musinova ◽  
R. Zh. Sirazhdinov
Keyword(s):  
Development Strategy ◽  
Russian Federation ◽  
Necessary Conditions ◽  
Special Kind ◽  
Successful Implementation ◽  
Small Enterprises ◽  
Innovative Development ◽  
Positive Experience ◽  
Governmental Support ◽  
The Russian Federation

The features of the functioning of small enterprises and their special kind – innovative have been considered. The problems, arising in the process of their functioning, and their manifestation in Russia have been identified and examined in the paper. As a positive experience in the paper, the experience of Moscow has been analyzed, having the most comfortable conditions for the functioning of small innovative enterprises, all necessary infrastructure. However, even with all its financial, scientific and technical capabilities, Moscow cannot provide all the necessary conditions for the successful implementation of the country’s innovative development strategy.

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