COMORBIDITIES OF ISCHEMIC HEART DISEASE WITH OTHER NON-COMMUNICABLE DISEASES IN ADULT POPULATION: AGE AND RISK FACTORS ASSOCIATION

Background: The geriatric population is defined as population aged 60 years and above. The mixed profile of communicable and non-communicable diseases among the elderly population in developing countries places a huge burden on the existing health care delivery system. Present hospital based cross-sectional study was focused on the morbidity profile of the elderly and improve the health care services so as to enable them to lead a productive life. Material and Methods: Present study was single centre, descriptive observational study, conducted in subjects above 60 years and both gender, visiting to OPD and IPD, willing to participate in study after written consent. Results: We included total 200 geriatric population in our study. Majority of them were from 60-70 years age group (50 %) followed by 71-80 years (37%) and 81-90 years age group (13%). Mean age was 70.75±7.25 years. Males were 56.5% and females were 43.5%. Males were predominant in our study with male to female ratio 1.29:1. Most common addiction seen among the patients are tobacco chewing (49.5%) followed by smoking (27%), followed by pan (24.5%), nut (21.5%) and alcohol (10.5%). Family history of diabetes and hypertension was present in 63.5% and 72% cases respectively. Prevalence of cataract as commonest observed morbidity in our study was 60%, DM 37%, hypertension 34%, IHD 33.5%, anemia 21%, hearing loss 11.5% and cancer was 4%. Out of 45 deaths, 44.4% deaths occurred in patients with IHD as risk factor, 26.6% deaths occurred in patients with COPD as risk factor, 22.2% deaths occurred in patients with CVA/stroke as risk factor and 17.8% deaths occurred in patients with AKI as risk factor. So IHD, COPD, CVA and AKI were significantly associated with mortality. Conclusion: Commonly observed morbidities were cataract (60%), diabetes mellitus (37%), hypertension (34%), ischemic heart disease (33.5%) Significant association of mortality was seen with ischemic heart disease, chronic obstructive pulmonary disease, cerebrovascular accident and acute kidney injury.

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Tomato Role on Seven Deadliest Non-Communicable Disease

Jurnal Indonesia Sosial Sains ◽

10.36418/jiss.v2i8.385 ◽

2021 ◽

Vol 2 (8) ◽

pp. 1295-1308

Author(s):

Lathifah Dzakiyyah Zulfa ◽

Dessyani Salim ◽

Abigail Tirza Melia Silalahi ◽

Sharon Levita Hutapea ◽

Margaretha Maria Odilia Natasha

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Communicable Disease ◽

Communicable Diseases ◽

Chronic Obstructive ◽

Non Communicable Diseases ◽

Non Communicable Disease ◽

Inflammatory Effect

Non-communicable diseases such as ischemic heart disease, stroke, chronic obstructive pulmonary disease, lung cancer, Alzheimer, diabetes melitus, and kidney disease are leading causes of death in the world. There are many risk factors which can contribute to non-communicable diseases such as dietary. Vegetable consumption such as tomato may lower risk factors to non-communicable diseases because of its active ingredient, lycopene, retinol, alpha tomatine, and tomatidine. In this study, authors aim to explain the mechanism of tomato’s active compound in lowering risk factors of non-communicable disease based on biomarker found on each disease collected from recent epidemiological, in silico, in vitro, and in vivo researches. Lycopene and retinol have proven in reducing ischemic heart disease and stroke because of its anti-atherogenic properties and anti-inflammatory effect. Anti-oxidative and anti-inflammatory effect of lycopene also proven in lowering risk factors of chronic obstructive pulmonary diseases by modulate reverse cholesterol transport, so cholesterol homeostasis is created. In lung cancer, lycopene and other bioactive compound such as α-tomatine and tomatidine also have an anti-proliferative effect by interacting with Epidermal growth factor receptor (EGFR). Its ability to reduce the final product of lipid peroxidation level makes lycopene lower Alzheimer risk factor. There is much more function of tomato’s active coumpound although pure tomato has contradictive effect on some disease.

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Ischemic Heart Disease Risk Factors in Black Americans

PsycEXTRA Dataset ◽

10.1037/e375702004-001 ◽

1986 ◽

Cited By ~ 1

Author(s):

Shiriki K. Kumanyika ◽

Daniel D. Savage

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Disease Risk ◽

Black Americans ◽

Ischemic Heart ◽

Ischemic Heart Disease Risk ◽

Heart Disease Risk Factors ◽

Heart Disease Risk

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IMPACT OF RISK FACTORS OF ISCHEMIC HEART DISEASE ON THE DEVELOPMENT OF ACUTE CORONARY SYNDROME, PLATELET ULTRASTRUCTURE, AND ASPIRIN RESISTANCE

Wiadomości Lekarskie ◽

10.36740/wiadlek201911107 ◽

2019 ◽

Vol 72 (11) ◽

Author(s):

Yulian H. Kyyak ◽

Olga Yu. Barnett ◽

Marta P. Halkevych ◽

Olha Ye. Labinska ◽

Hryhoriy Yu. Kyyak ◽

...

Keyword(s):

Risk Factors ◽

Acute Coronary Syndrome ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Aspirin Resistance ◽

Ischemic Heart ◽

Coronary Syndrome

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IMPACT OF RISK FACTORS OF ISCHEMIC HEART DISEASE ON THE DEVELOPMENT OF ACUTE CORONARY SYNDROME, PLATELET ULTRASTRUCTURE, AND ASPIRIN RESISTANCE

Wiadomości Lekarskie ◽

10.36740/wlek201911107 ◽

2019 ◽

Vol 72 (11) ◽

Author(s):

Yulian H. Kyyak ◽

Olga Yu. Barnett ◽

Marta P. Halkevych ◽

Olha Ye. Labinska ◽

Hryhoriy Yu. Kyyak ◽

...

Keyword(s):

Risk Factors ◽

Acute Coronary Syndrome ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Aspirin Resistance ◽

Ischemic Heart ◽

Coronary Syndrome

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Gender difference in risk factors associated with ischemic heart disease in Lahore

Journal of Fatima Jinnah Medical University ◽

10.37018/hjie6482 ◽

2020 ◽

Vol 14 (2) ◽

pp. 72-77

Author(s):

Muhammad Salman Tariq ◽

Iram Manzoor ◽

Qurat Ul Ain Zulfi ◽

Naeem Hussain ◽

Nimra Saleem ◽

...

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Gender Difference ◽

Ischemic Heart Disease ◽

Ischemic Heart ◽

Public Health Issue ◽

Stressful Event ◽

Female Population ◽

High Tendency ◽

Factors Associated

Background: Ischemic heart disease (IHD) is one of the leading causes of mortality in Pakistan. With advancement in research, multiple causes have contributed in development of web of causation of this public health issue. The objective of this study was to assess gender differences in risk factors associated with ischemic heart disease in patients presenting at the biggest cardiology hospital of Lahore. Patients and methods: A comparative cross-sectional study was carried out in Punjab Institute of Cardiology, Lahore from January to August, 2018 on a sample of 296 diagnosed patients of IHD, through non-probability consecutive sampling technique. Data was collected on pretested questionnaire. The data was analyzed using SPSS version 22. Chi-Square test of significance was applied and a p-value ≤0.05 was considered statistically significant. Results: The mean age of participants was 45±12 years with predominance of male patients (71.3%). Frequency of risk factors for IHD included increase body mass index (83.8%), hypertension (61%), insufficient physical activity (43%), diabetes (38.5%) and smoking (23%). Increase serum cholesterol was reported in 95% and triglycerides in 99% of the participants. Gender difference was significant with females residing in urban population (p=0.054) and exercise routine (p=0.034). Males showed high tendency of IHD with smoking pattern (p<0.001) contrary to presence of diabetes in females (p=0.05), hypertension (p=0.054), BMI (p=0.0379) and stressful event in life (p=0.002). Males showed regular intake of medicines (p =0.045) after diagnosis as compared to female population. Conclusion: There is more frequency of ischemic heart disease in males as compared to females. Significant association was observed with residence in urban area, presence of diabetes, hypertension, high BMI and stressful event in life in occurrence of ischemic heart disease in female population.

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Major Left Bundle Branch Block and Coronary Heart Disease—Are There Any Differences between the Sexes?

Journal of Clinical Medicine ◽

10.3390/jcm10112284 ◽

2021 ◽

Vol 10 (11) ◽

pp. 2284

Author(s):

Diana Gurzău ◽

Alexandra Dădârlat-Pop ◽

Bogdan Caloian ◽

Gabriel Cismaru ◽

Horaţiu Comşa ◽

...

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Left Bundle Branch Block ◽

Left Ventricular ◽

Ischemic Heart ◽

Left Ventricular Ejection ◽

Bundle Branch Block ◽

Microvascular Angina ◽

Ventricular Ejection Fraction

Left bundle branch block is not a benign pathology, and its presence requires the identification of a pathological substrate, such as ischemic heart disease. Left bundle branch block appears to be more commonly associated with normal coronary arteries, especially in women. The objectives of our study were to describe the particularities of left bundle branch block in women compared to men with ischemic heart disease. Result: We included seventy patients with left bundle branch block and ischemic heart disease, with a mean age of 67.01 ± 8.89 years. There were no differences in the profile of risk factors, except for smoking and uric acid. The ventricular depolarization (QRS) duration was longer in men than women (136.86 ± 8.32 vs. 132.57 ± 9.19 msec; p = 0.018) and also men were observed to have larger left ventricular diameters. Left bundle branch block duration was directly associated with ventricular diameters and indirectly associated with left ventricular ejection fraction value, especially in women (R = −0.52, p = 0.0012 vs. R = −0.50, p = 0.002). In angiography, 80% of women had normal epicardial arteries compared with 65.7% of men; all these patients presented with microvascular dysfunction. Conclusion: The differences between the sexes were not so obvious in terms of the presence of risk factors; instead, there were differences in electrocardiographic, echocardiographic, and angiographic aspects. Left bundle branch block appears to be a marker of microvascular angina and systolic dysfunction, especially in women.

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Hemodialysis patients with better coronary flow reserve and nutrition status have surprising prognosis

European Heart Journal ◽

10.1093/ehjci/ehaa946.1269 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

T Imaoka ◽

N Umemoto ◽

S Oshima

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Coronary Flow Reserve ◽

Coronary Flow ◽

Ischemic Heart ◽

Nutrition Status ◽

Flow Reserve ◽

All Cause Mortality ◽

Conventional Risk Factors

Abstract Background In clinical setting, ischemic heart disease is a challenging problem in hemodialysis (HD) population. Coronary flow reserve (CFR) measured by 13 ammonia positron emitting tomography (13NH3PET) is an established and reliable modality for detecting coronary artery disease. Furthermore, some prior studies show CFR is an important and independent predictor for cardiovascular event and mortality. On the other hand, HD patients with malnutrition status have poor prognosis. We have reported about the relationship between cardiovascular events and geriatric nutrition risk index (GNRI). Now, we wonder the predictability of combination of CFR and GNRI. Methods and result We collected 438 consecutive HD patients who received 13NH3PET in our hospital suspected for ischemic heart disease. 29 patients were excluded due to undergoing coronary revascularization within 60 days, 103 patients were excluded due to incomplete database. In total, 306 HD patients were classified into 4 group according the median value of CFR (1.99) and GNRI (97.73); Low CFR Low GNRI group (n=77), High CFR and Low GNRI group (n=76), Low CFR High GNRI group (n=78) and High CFR High GNRI group (n=75). We collected their follow up data up to 1544 days (median 833 days) about all-cause mortality and cardiovascular (CV) mortality. Surprisingly, there is no mortality event in High CFR High GNRI group. We analyzed about all-cause mortality, CV mortality. Kaplan-Meyer analysis shows there are statistically intergroup differences in each (all-cause mortality; log rank p<0.01, CV mortality; log rank p=0.02). Furthermore, we calculated area under the curve (AUC) analysis, net reclassification improvement (NRI) and integrated discrimination improvement (IDI)m adding GNRI and CFR on conventional risk factors. There are intergroup differences for all-cause mortality in AUC [conventional risk factors, +GNRI, +GNRI+CFR; 0.70, 0.72 (p=0.29), 0.79 (p<0.01)], NRI [+GNRI; 0.32 (p=0.04), +GNRI+CFR 0.82 (p<0.01)] and IDI [+GNRI; 0.01 (p=0.05), +GNRI+CFR 0.09 (p<0.01)]. Conclusion HD patients with low CFR and malnutrition status has statistically significant poorer prognosis comparing HD patients with high CFR and without malnutrition status. Adding combination of GNRI and CFR on conventional risk factors improves the predictability of HD population's prognosis. Funding Acknowledgement Type of funding source: None

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