scholarly journals Correlation between Anemia and Malaria Infection Severity in Patients with Type 2 Diabetes Mellitus in Nigeria

2020 ◽  
Vol 7 (4) ◽  
Author(s):  
Adedeji David Atere ◽  
Henry Chijindu Okpoli ◽  
Kelvin Aimuemwosa Uwumarogie ◽  
Adebimpe Iyanuoluwa Moronkeji

Background: Malaria and diabetes mellitus are still a significant global public health problem despite the phenomenal progresses in clinical sciences related to the diseases. Both anemia and malaria parasitemia are common in developing countries. It is therefore important to diagnose and determine the correlation between anemia level and malaria infection severity in diabetic patients for better management. Methods: Patients with diabetes mellitus (DM) infected with malaria were recruited (n=50) as subjects and non-diabetic patients were used as control in this study, who were further divided into two sub-group: non-DM infected with malaria (n=25) and non-DM without malaria parasitemia (n=25). Blood sample were collected to examine the fasting blood sugar (FBS) level, packed cell volume (PCV), hemoglobin (Hb) level, and malaria parasitemia. Statistical analysis was then performed using ANOVA with a p value of less than or equal to 0.05 considered statistically significant. Results: The parasite density in DM with malaria was significantly lower (p<0.05) than in the non-DM with malaria. Interestingly, there was a higher PCV and hemoglobin level (p<0.05) in DM with malaria when compared with non-DM with malaria. Conclusion: DM patients infected with plasmodium have low parasite density but higher hemoglobin level and PCV compared to the control group. There is no correlation between the severity of anemia and malaria parasitemia in DM patients infected with malaria when compared to non-diabetic subjects infected with malaria. Further studies are needed to explore the correlation between hemoglobin level in DM and plasmodium infection

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e040305
Author(s):  
Chao Li ◽  
Ping Zhou ◽  
Yixi Cai ◽  
Bin Peng ◽  
Yongfang Liu ◽  
...  

IntroductionGestational diabetes mellitus (GDM) is a common gestational disease and an important global public health problem. GDM may affect the short-term and long-term health of offspring, but the associations between GDM and the neurodevelopment of offspring of mothers with GDM (OGDM) are still unclear, and studies based on the Chinese population are lacking. We aim to determine the associations between GDM and the neurodevelopment of OGDM by studying a cohort of OGDM and offspring of non-GDM mothers.Methods and analysisThe single-centre prospective cohort study is being conducted in China over 7 years. A total of 490 OGDM (GDM group) and 490 fromof healthy mothers (control group) will be enrolled during the same period. Baseline characteristics, neuropsychological development scores and clinical data at specific time points (at 0, 1, 3, 6, 12, 24, 36, 48, 60 and 72 months old) will be collected from the children in both groups until the age of 6 years. The associations between GDM and the neurodevelopment of OGDM from infancy to preschool age will be analysed using a multiple linear regression model adjusted for confounders. In addition, we will compare longitudinal data to further assess the effects of GDM on neurodevelopmental trajectories.Ethics and disseminationThe study has been approved by the Ethics Committee of the Children’s Hospital of Chongqing Medical University (Approval Number: (2019) Institutional Review Board (IRB) (STUDY) No. 85). The findings of this study will be disseminated through open access journals, peer-reviewed journals and scientific meetings.Trial registration numberNCT03997396.


2017 ◽  
Vol 2 (1) ◽  
pp. 8
Author(s):  
Siswanto Siswanto ◽  
Ismail Kamba ◽  
Siti Aminah

Diabetes mellitus is one of the communicable diseases that have become a public health problem, not only in Indonesia but also the world. Currently morbidity of diabetes mellitus is increasing every year, where in 2006 there were 14 million people in 2011 and ranks fourth with 773 cases. DM is also a cause of disease mortality by 5.8%. And Samarinda own particular Islamic Hospital years 2009, there were 449 patients with DM, and 2011 an increase in the 1931 patients with diabetes mellitus. To increase patients’ knowledge about diabetes and diabetic patients be directing attitudes that support or positive attitude towards keeping blood glucose levels to remain normal. Methode to use pra eksperiment with one group pretest posttest. individual conseling withAudiovisual media. There is increased knowledge about diabetes diabetic patients before and after intervention with increasing value of 3.77 (p value = 0.000) and increase in attitudes regarding diabetes mellitus diabetic patients with an increase in the value of 5,35 (p value = 0.003). There was an increase in knowledge and attitudes of patients hospitalized with diabetes mellitus hospital after islam samarinda given nutritional counseling using audio-visual media


2018 ◽  
Vol 3 (2) ◽  
pp. 72
Author(s):  
Setyoadi Setyoadi ◽  
Heri Kristianto ◽  
Siti Nur Afifah

Diabetes mellitus is a disease that required good self-management. Noncompliance in diet and meal plans cause the instability of blood glucose levels. Nutrition education calendar method can improve knowledge and ability to consume food that matches the number, hours and types with dietary adjustments listed in the calendar diet. This study aimed to determine the effect of nutrition education calendar method on blood glucose levels of patients with type 2 diabetes mellitus in Community Health Center Pakis Malang. Pre-experimental design one group pretest-posttest with purposive sampling was conducted in this study and sample obtained as many as 21 people. Blood glucose levels were measured before and after the nutrition education calendar methods. Compliance in using calendar method with the observation sheet. Statistical analysis values obtained by Wilcoxon, the p-value of 0.007 (p <0.05). The results of the analysis, 16 respondents showed a decrease in blood glucose levels and 5 respondents experienced an increase in blood glucose levels after the given intervention. It can be concluded that there are differences between blood glucose levels before and after nutrition education calendar method. Differences in blood glucose levels can be influenced by controlling diet respondent in accordance with the calendar method in education, but also antidiabetic drugs, and sports. Should be added to the control group to determine objectively the effect of nutrition education on the calendar method.


2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Birhanu Ayelign ◽  
Markos Negash ◽  
Meaza Genetu ◽  
Tadelo Wondmagegn ◽  
Tewodros Shibabaw

The interaction between diabetes and major world infections like TB is a major public health concern because of rapidly rising levels of diabetes. The dual burden of tuberculosis (TB) and diabetes mellitus (DM) has become a major global public health problem. Diabetes mellitus is a major risk factor for the development of active and latent tuberculosis. Immune mechanisms contributing to the increased susceptibility of diabetic patients to TB are due to the defects in bacterial recognition, phagocytic activity, and cellular activation which results in impaired production of chemokines and cytokines. The initiation of adaptive immunity is delayed by impaired antigen-presenting cell (APC) recruitment and function in hyperglycemic host, which results in reduced frequencies of Th1, Th2, and Th17 cells and its secretion of cytokines having a great role in activation of macrophage and inflammatory response of tuberculosis. In addition, impaired immune response and killing of intracellular bacteria potentially increase bacterial load, chronic inflammation, and central necrosis that facilitate bacterial dissemination and miliary tuberculosis. Understanding of the immunological and biochemical basis of TB susceptibility in diabetic patients will tell us the rational development of implementation and therapeutic strategies to alleviate the dual burden of the diseases. Therefore, the aim of this review was focused on the association between diabetes and tuberculosis, focusing on epidemiology, pathogenesis, and immune dysfunction in diabetes mellitus, and its association with susceptibility, severity, and treatment outcome failure to tuberculosis.


2018 ◽  
Vol 3 (3) ◽  
pp. 2473011418S0046
Author(s):  
Kelly Stéfani ◽  
Vinicius Borges ◽  
Aldo Barbachan

Category: Diabetes Introduction/Purpose: Diabetes mellitus has become a global public health problem. Not only has its incidence remained high in developed countries such as Japan and the United States, but, also, the number of cases has been growing alarmingly in developing countries such as Brazil. The concept of detection and management of diabetes mellitus in primary care centers is widely practiced in Brazil by the general physician. The purpose of this study was to evaluate the efficacy of our educational diabetics program for patients with diabetes mellitus and to determine the predictors of compliance. Since our patient orientation protocols and the insensitive footwear we provide reduce our hospital admission costs. Methods: A prospective study (2005-2017) was performed in a quaternary hospital where patients with diabetes were referred to the outpatient clinic of the diabetic foot group. The epidemiological profile of these patients under treatment in a specialized multidisciplinary outpatient unit was evaluated. A specific protocol included notes on the age, body mass index, length of disease, use of insulin, degree of sensation as evaluated by the Semmes-Weinstein monofilament test, deformity in feet, palpation of peripheral pulses, cigarette smoking, and previous operative procedure in foot an ankle.The same specialist orthopedic doctors in foot and ankle completed the protocol and performed the specific physical examination (reports were made on deformities regarded as risky for the incursion of ulcers such as plantar callosities, alterations of the hallux and lesser toes, loss of the longitudinal plantar arch, and all those related to Charcot arthropathy) and performed the same a guidelines for foot care. Results: Out of the 578 diabetic patients, the mean age of was 67 years, 69% being of the female gender. There was 53% made use of insulin, the time of disease was 14 years, and 85% patients were obese. Evaluation of protective sensibility showed that 68% were significantly decreased (from the 4.0 g monofilament). The ulcers was found in 64 patients, 57% had degree 1 in the Wagner classification, and 63% was affected in the forefoot. Charcot neuroarthropathy was diagnosed in 54 patients, 52% had the phase 3 in the Eichenholz classification, and 61% was affected in the midfoot. Fifty-three patients had amputations at the time of their first appointment, 66% on toes. 127 patients required surgery resulted from clinical complications: ulcers, osteomyelitis, and Charcot arthropathy. Conclusion: The costs related to the disease increase greatly with the appearance of the complications, especially if there is need of hospitalization and surgical treatment. The prevention of injuries, with adequate glycemic control and supply of protective shoes is essential.


2021 ◽  
Vol 5 (1) ◽  
pp. 32
Author(s):  
Febry Mutiariami Dahlan ◽  
Qomariah Ardhi

Anemia is a nutritional problem with a high prevalence in the world. Basic Health Reseacrch in 2018, around 48,9% of pregnant women in Indonesia experience anemia. This shows that anemia in pregnant women  is still a public health problem because the proportion  is quite high compared to the results of the 2013 Basic Health Research, which amounted to 37,1%. This research aims to identify the effect of Fe tablet and date palm on improving hemoglobin level among pregnant women in the third semester  at the Rita Marningsih Clinic 2020. This study was quasy-experiment by using two group pre-test and post-test and used dependent t test with control group. There were 30 respondents and purposive sampling was conducted, and an independent t-test was used to data analyzed.The Result  revealed that the experimental group the number of pregnant women whose Hb levels increased by 14 people (93,33%) and which decreased by 1 respondent (6,67%) and in the control group 13 respondents experienced an increase (86,67%) and 2 respondents (13,33%) decreased Hb levels. The bivariate result showed that the p value was 0,044<0,05, which means that there was an effect of giving Fe tablets and dates to the hemoglobin levels of pregnant women. Conclusion and recommendation : Fe tablets and dates affect the increase in hemoglobin levels. For pregnant women it is recommended to consume Fe tablets regularly and maintain the nutrition of their food, one of which adds dates to food consumed.


2019 ◽  
Vol 13 (Supl 1) ◽  
pp. S31
Author(s):  
Kelly Cristina Stéfani ◽  
Aldo Barbachan Rodrigues ◽  
Vinicius Quadros Borges ◽  
Gabriel Ferraz Ferreira ◽  
Leonardo Vinícius De Matos Moraes

Introduction: Diabetes mellitus (DM) has become a global public health problem. The concept of detection and management of diabetes mellitus in primary care centers is widely practiced in Brazil by the general practitioner. The aim of this study was to evaluate the efficacy of our educational program for diabetics for patients with diabetes mellitus and to determine the predictors of compliance. Methods: A cross-sectional prospective study was performed in a quaternary hospital where patients with diabetes were referred to the outpatient clinic of the diabetic foot group so that they were part of a multidisciplinary group (medical orthopedists specialists in foot and ankle, medical endocrinologists, physiotherapist and nurse) with a specific protocol for guidelines for foot care. Specialist orthopedic doctors of the foot and ankle completed the protocol and performed the specific physical examination. Results: Of the 578 diabetic patients, the mean age was 67 years, 69% were female, 53% used insulin to control the disease and the disease duration was 14 years. Obesity was diagnosed by calculation of the body mass index (BMI), and 85% patients were overweight. Evaluation of protective sensibility showed that 68% were significantly decreased, with sensation from the 4.0 g monofilament. One hundred and twenty seven patients required surgery resulting from clinical complications of the disease: 64 ulcers (Wagner classification 57% ulcers had a degree 1 Wagner classification, 63% affected forefoots), 54 Charcot arthropathies (52% Eichenholz in phase 3, 61% located in the mid-foot), and 9 cases of osteomyelitis. Fifty-three patients had one or more prior amputations at the time of their first appointment, mostly of the toes (66%). Conclusion: The costs related to the disease increased greatly with the appearance of complications, especially if there was a need for hospitalization and surgical treatment. The prevention of injuries with adequate glycemic control and the provision of protective shoes is essential.  


F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1030
Author(s):  
Chudchawal Juntarawijit ◽  
Yuwayong Juntarawijit

Background: Type 2 diabetes mellitus (T2DM) is a global public health problem. To avoid disease complications, diabetic patients have to control their blood glucose and maintain a healthy lifestyle including a healthy diet, weight control, moderate exercise and smoking cessation. Methods: This study aimed to survey sleep, eating and exercise behaviors of diabetic patients in Bang Rakam district, a rural community in Phitsanulok province, Thailand. The data on sleep and other health behaviors were taken from 1,385 T2DM patients and 1,394 non-T2DM controls, who were aged 30 - 85 years and were free from other chronic diseases. The data were collected using a structured questionnaire. Results: Compared to the control group, the diabetic group had a significantly higher body mass index (BMI).  However, fewer of them were found to smoke cigarettes and drink alcohol. Most of the participants were ‘morning people’ who slept 7-9 hours per day. It was found that sleep ≥8 hours increased the risk of diabetes among women (OR = 1.27, 95% CI 1.03 - 1.56). The diabetic group reported eating chicken and vegetables more than the control group. They also avoided eating beef and eating more than a cup of rice per meal. However, the T2DM group did fewer physical activities, such as walking, biking or playing sports, during their leisure time. Conclusions: Compared to the control group, diabetic patients in a rural community of Thailand had healthier sleep, lifestyle and eating behaviors but not healthier exercise behaviors, especially among obese women. Diabetic prevention programs should emphasize and promote weight control and increasing levels of exercise.


Author(s):  
Angeliki Stamatopoulou ◽  
Tonia Vasilakou

Background: Diabetes mellitus is a global public health problem. The purposes of this study were: development of healthy eating habits, excellent glycemic control, maintenance ideal body weight, smoking cessation, regular physical exercise, prevention of complications.Methods: A sample of 100 diabetic patients (57% males and 43% females, aged 39-89 years old) was monitored in the Hospital of Tripolis. Patients completed a questionnaire about their eating habits. Body weight, height, waist circumference, body mass index (BMI) calculation and glycosylated hemoglobin were measured. Follow lifestyle intervention included dietary guidelines.Results: After the intervention significant differences were observed: increases in physical activity (58.95% from 41.0%, p-value = 0.002), duration of exercise (Q1 = 1.0 from 0.5, p-value = 0.023), consumption of breakfast (94.74% from 86.0%, p-value = 0.013 ), daily number of meals (median = 5 from 4, p-value = 0.002), average score of frequency in fats / oils / olive consumption (median = 2.8 from 2.5, p-value <0.001) average score of frequency in fruit consumption (median = 4.0 from 2.5, p-value <0.001), and decreases in weight (Q1 = 73.0 from 74.5, p-value = 0.002), BMI (median = 31.7 from 32.4, p-value = 0.002), waist circumference (median = 106 from 108, p-value <0.001), average score of frequency in grain / starchy / legumes consumption (Q1 = 2.6 from 2.8, p-value = 0.050).Conclusions: This study shows that even small interventions can have the desired results. But it needs perseverance and adaptation of programs to the specific characteristics and cultural beliefs of patients.


2019 ◽  
Vol 32 (1) ◽  
pp. 46-53
Author(s):  
Nazmul Hoque Munna ◽  
Md Mohiuddin Ahmed ◽  
Mohammad Imtiaj Mahbub

Background: Tuberculosis (TB) is the one of the leading cause of death globally, more marked in developing countries like Bangladesh. The prevalence of Diabetes Mellitus (DM) is increasing globally fueled by obesity endemic. The study is designed to get an idea about prevalence and clinical impact of DM among pulmonary TB patients. Objective: The aim of the study is to find out the rate and effect of Diabetes mellitus in patients with pulmonary Tuberculosis. Material and Methods: This was a cross sectional study conducted in DOTS (directly observed therapy, short course) corner, outpatient department (OPD), Dhaka Medical College & Hospital, Dhaka from July to December 2012. 125 patients of pulmonary Tuberculosis were included in this study as case. 125 age and sex matched controls who were not suffering from pulmonary Tuberculosis were taken from the attendant of the patients who had given the consent. Prevalence and clinical impact of diabetes mellitus was sort out in both case and control group and compared with each other. Results: The study shows the prevalence of DM among pulmonary TB patients is 26.4% and among normal population (non TB patients) is 20.8%. The relative risk (odds ratio) of DM among pulmonary TB patients is 1.27 times more than non TB person with p-value - 0.02, which is significant. In symptoms analysis, diabetic patients have got more haemoptysis (45%), in contrast to non-diabetic group (13%), with p-value-0.001. In non-diabetic patients Fever are more common, 88% in contrast to diabetic group 57%, p-value-0.001. Sputum positivity is more common (69%) among diabetic pulmonary TB patients than non diabetic pulmonary TB patients (58%). On chest X ray findings this study reveals that pulmonary TB patient with DM having cavitary lesion is 33% while it is only 9.76% in non-diabetic persons. Conclusion: This study found that there was greater prevalence of DM among pulmonary TB patients (26.4%) than non pulmonary TB persons (20.4%). This findings provides the information that health care provider should intensively search presence of DM in pulmonary TB patients. TAJ 2019; 32(1): 46-53


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