Dental anomalies in the deciduous dentition of non-syndromic oral clefts patients

Abstract Objectives: to investigate the prevalence of dental anomalies in complete deciduous dentition of children with NSCL/P. Methods: this study included 75 children with NSCL/P and 286 healthy control. In both groups the children had deciduous dentition with ages varying from 4 to 6 years. Clinical examination, panoramic and periapical radiographies were performed and dental anomalies of number and shape were considered. Results: there was a higher prevalence of dental anomalies in the case group, compared to the control group. In all, 42 dental anomalies were identified, 25.33% in the case group and 8.04% in control group (p<0.001). Therewas a higher frequency of dental anomalies in NSCL/P (47.36%), followed by non-syndromic cleft lip (31.57%) and non-syndromic cleft palate (21.05%). The occurrence of agenesis (p= 0.005) and twinning (p = 0.029) were higher in the case group. Conclusions: the occurrence of agenesis and dental twinning was more frequent in the case group and may contribute to the definition of oral cleft subphenotype.

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Tooth malposition in patients with cleft lip and/or palate in a Brazilian population

Dentistry 3000 ◽

10.5195/d3000.2015.38 ◽

2015 ◽

Vol 3 (1) ◽

pp. 32-37 ◽

Cited By ~ 1

Author(s):

Mario Rodrigues Melo Filho ◽

Verônica Oliveira Dias ◽

Daniella Reis Martelli ◽

Lívia Ribeiro Paranaíba ◽

Mário Sérgio Oliveira Swerts ◽

...

Keyword(s):

Cleft Palate ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Statistical Significance ◽

Dental Anomalies ◽

Chi Square ◽

Oral Clefts ◽

Chi Square Test ◽

Cross Tabulation ◽

Definition Of

The purpose of the present study was to evaluate the prevalence of teeth malposition (rotated) in Brazilian patients with oral clefts and to contribute to the definition of subphenotypes. This study included 317 patients with nonsyndromic cleft lip with or without cleft palate. Tooth malposition was assessed clinically, through radiographs, and medical history records for each individual. Only teeth malpositions outside the area of the clefts were included. Comparisons were assessed by cross-tabulation and standard chi-square test, and statistical significance was set at p≤0.05. Cleft lip and palate was more prevalent in males, while cleft palate was more common in females. Regarding the presence of tooth malposition, of the 317 patients, 92 (29.02%) had at least one tooth with the dental anomaly. Tooth malposition was more common in patients with cleft lip and palate (16.1%), followed by, respectively, cleft palate (6.9%) and cleft lip (6%) (p=0.112). The highest occurrence of tooth malposition was in the mandible and involved the canines (p<0.01). Few studies have investigated the prevalence of tooth malposition in individuals with nonsyndromic cleft lip with or without cleft palate. Our results confirmed the highest occurrence of dental anomalies, particularly tooth malposition, in patients with oral clefts. Our findings also highlight that there was a higher occurrence of this condition in the mandible and not the maxilla.

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Oral Clefts and Academic Performance in Adolescence: The Impact of Anesthesia-Related Neurotoxicity, Timing of Surgery, and Type of Oral Clefts

The Cleft Palate-Craniofacial Journal ◽

10.1597/15-185 ◽

2017 ◽

Vol 54 (4) ◽

pp. 371-380 ◽

Cited By ~ 21

Author(s):

Nicola G. Clausen ◽

Dorthe A. Pedersen ◽

Jacob K. Pedersen ◽

Susanne E. Møller ◽

Dorthe Grosen ◽

...

Keyword(s):

Academic Performance ◽

Cleft Palate ◽

Birth Cohort ◽

Cleft Lip ◽

Ninth Grade ◽

Mean Difference ◽

Control Group ◽

Oral Clefts ◽

Oral Cleft ◽

The Impact

Objective Early life exposure to anesthesia and surgery is suspected to associate with cognitive impairment later in life. We compared academic achievement among adolescents with cleft lip only (CL), cleft palate only (CP), and cleft lip and cleft palate (CLP) with a noncleft control group to investigate whether outcome depends on timing and number of operations during childhood and/or type of oral cleft. Design Nationwide register-based follow-up study. Setting Danish birth cohort 1986 to 1990. Participants Five hundred fifty-eight children with isolated CL (n = 171), CLP (n =222), or CP (n = 195), of which 509 children had been exposed to anesthesia and one or more cleft operation(s), and a 5% sample of the birth cohort (n = 14,677). Main Outcome Measure(s) Test score in the Danish standardized ninth-grade exam and proportion of nonattainment, defined as “results for ninth-grade exam unavailable.” Data adjusted for sex, birth weight, parental age, and parental level of education. Results Compared to controls, children with CL achieved higher scores (mean difference 0.12, 95% CI –0.05; 0.29) and children with CLP presented with lower scores (mean difference –0.06, 95% CI –0.21; 0.09), albeit both statistically insignificant. Children with CP achieved significantly lower scores, mean difference –0.20 (95% CI –0.38; –0.03). Odds ratios for nonattainment at final exam were: CL 0.79 (95% CI 0.46; 1.35), CLP 1.07 (95% CI 0.71; 1.61), CP 2.59 (95% CI 1.78; 3.76). Conclusions Oral cleft type rather than number and timing of anesthesia and operations associate to poorer academic performance. Although a potential neurotoxic effect due to anesthetic agents is not reflected in the data, it cannot be completely excluded.

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Dental Anomalies as Part of the Cleft Spectrum

The Cleft Palate-Craniofacial Journal ◽

10.1597/07-064.1 ◽

2008 ◽

Vol 45 (4) ◽

pp. 414-419 ◽

Cited By ~ 68

Author(s):

Renato Menezes ◽

Alexandre Rezende Vieira

Keyword(s):

Cleft Palate ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Tooth Development ◽

Dental Anomalies ◽

Future Studies ◽

High Incidence ◽

Dental Records ◽

Definition Of ◽

Clinical Records

Objective: The aim of this study was to determine subphenotypes of clefts based on tooth development. Dental phenotypes (tooth agenesis, supernumerary and impacted teeth, transposition, and structural anomalies) outside the cleft area in the permanent dentition of oral cleft individuals were investigated. Design: Evaluation of dental records of cleft patients. Setting: National Museum of Health and Medicine, Washington, D.C. Patients, Participants: A collection of dental casts, radiographic and clinical records of 146 patients with oral clefts was evaluated. Main Outcome Measure: Association of dental anomalies with preferential subtypes of clefts. Results: Forty-seven individuals (32.19%) presented at least one dental anomaly outside the cleft area. Individuals with complete cleft lip and palate (CLP) presented more dental anomalies than individuals with incomplete CLP (p = .04). Cleft palate individuals presented more dental anomalies than CLP individuals (p = .048). Maxillary lateral incisors and premolars were the most affected teeth. High incidence of maxillary second premolar agenesis was observed in individuals with bilateral CLP (p = .04). In cases with unilateral CLP, 12.5% presented dental anomalies of the maxillary lateral incisors on the noncleft side. Cleft palate individuals presented a high incidence of mandibular premolar anomalies (p = .004). Conclusion: Future studies should consider the inclusion of a complete dental description to aid in the definition of cleft subphenotypes to be studied.

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Family Environment of Individuals with Oral Clefts in Argentina

The Cleft Palate-Craniofacial Journal ◽

10.1597/03-118.1 ◽

2005 ◽

Vol 42 (2) ◽

pp. 185-191 ◽

Cited By ~ 3

Author(s):

Diego F. Wyszynski ◽

Claudia Perandones ◽

Patricia Yannibelli ◽

Ricardo D. Bennun

Keyword(s):

Cleft Palate ◽

Social Environment ◽

Family Environment ◽

Cleft Lip ◽

Family Relationship ◽

Control Group ◽

Oral Clefts ◽

Recreational Activities ◽

The Social ◽

Different Types

Objective The purpose of this investigation was to study the social environment of families of children with different types of nonsyndromic oral clefts (OC) and to compare these groups with a control population of families of children without clefts. Design The study compared three nonsyndromic oral cleft groups and the control group using the Moos Family Environment Scale, which examines cohesion, expressiveness, conflict, independence, achievement-orientation, intellectual-cultural orientation, active-recreational orientation, moral-religious emphasis, organization, and control. Setting All parents of children with nonsyndromic oral clefts from a large craniofacial clinic in Buenos Aires, Argentina, were identified and were enrolled in this study between June 2000 and August 2001. Control families were ascertained from the pediatrics service of a hospital located in the vicinity of the craniofacial clinic. Participants One hundred and sixty-five parents were selected, based on having a child with nonsyndromic unilateral cleft lip with or without cleft palate (UCL/P), bilateral cleft lip with or without cleft palate (BCL/P), or isolated cleft palate (ICP). One hundred and eighty control parents with no family history of congenital anomalies were selected, as well. Results There was no major difference in the social environment of families of children with different types of nonsyndromic oral clefts. When compared with families in the control group, families of children with nonsyndromic oral clefts scored better in all three subdimensions of family relationship, revealed a high level of independence, and showed better structure and organization than control families did; however, families of children with nonsyndromic oral clefts reported participating in fewer recreational activities. Conclusions Overall, families of children with nonsyndromic oral clefts displayed a good social environment. Efforts should be focused to involve them in recreational activities.

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An Epidemiologic Study of Oral Clefts in Iran: Analysis of 1669 Cases

The Cleft Palate-Craniofacial Journal ◽

10.1597/1545-1569_2000_037_0191_aesooc_2.3.co_2 ◽

2000 ◽

Vol 37 (2) ◽

pp. 191-196 ◽

Cited By ~ 18

Author(s):

Mohammad Hossain Rajabian ◽

Mehdi Sherkat

Keyword(s):

Cleft Palate ◽

Cleft Lip ◽

Epidemiologic Study ◽

Maternity Hospital ◽

Control Group ◽

Normal Children ◽

Cross Sectional ◽

Oral Clefts ◽

Genetic Features ◽

Associated Malformations

Objective The objective of this study was to assess the epidemiology and some genetic aspects of oral clefting in Iran. Design The study was a 15-year cross-sectional (prevalence) study from August 1976 to September 1991. Setting The setting for the study was two plastic surgery departments, both mostly referral centers, and a maternity hospital in Iran. Participants The participants were 1669 consecutive surgical cases with oral clefts (79% between 1 day and 18 months of age), registered in two centers. In a parallel study, 19,369 livebirths born in a maternity hospital within the same period were surveyed to ascertain prevalence of clefting at birth. Normal children of this population were used as the control group. Samples were analyzed by prevalence of clefting at birth, type of oral cleft, side of clefting, sex ratio, associated malformations, clefts in relatives, and parental consanguinity. Results The prevalence of clefts was 1.03 per 1000 births. Cleft lip (without cleft palate) had a higher (34.9%) and cleft palate alone had a significantly lower prevalence (17.4%) than expected. Cleft lip (without cleft palate) was more common in females (53.6%) than in males (46.4%). The rate of associated malformations in cleft patients (7.73%) was higher than in controls (0.093%). Association between clefting and consanguinity was significant (45.8% in cases versus 43.1% in controls). Occurrence of noncleft congenital malformations among first-degree relatives of our cases (2.77%) was nearly two times that of controls (1.55%). Conclusion Our study reveals that the population incidence of oral clefts in Iran is much closer to Europian than Arab-African or South East Asian countries. However, significant variations in other epidemiologic and some genetic features were observed.

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Analysis of the candidate genes responsible for non-syndromic cleft lip and palate in Japanese people

Clinical Science ◽

10.1042/cs0990105 ◽

2000 ◽

Vol 99 (2) ◽

pp. 105-111 ◽

Cited By ~ 26

Author(s):

Atsuko TANABE ◽

Shigeru TAKETANI ◽

Yoko ENDO-ICHIKAWA ◽

Rikio TOKUNAGA ◽

Yutaka OGAWA ◽

...

Keyword(s):

Cleft Palate ◽

Candidate Genes ◽

Cleft Lip ◽

Transforming Growth Factor ◽

Cleft Lip And Palate ◽

Control Group ◽

Case Group ◽

Coding Region ◽

Transforming Growth Factor Α ◽

Significant Difference

In order to assess the association of alleles for candidate genes with non-syndromic cleft lip and palate, DNA samples from 43 Japanese patients were compared with those from 73 control subjects with respect to the genes encoding transforming growth factor α (TGFα), TGFβ and γ-aminobutyric acid type A receptor β3 (GABRB3). The restriction fragment length polymorphisms of the 3′-non-coding region of the TGFα gene K-primer region were observed after digestion with NcoI and HinfI. Allele 4 was the most common among cases of cleft lip with or without cleft palate, whereas allele 2 was the most common among controls. A significant difference was found in this region between groups with cleft lip (with or without cleft palate) and controls (χ2 = 10.190; P = 0.017). Three alleles of the TGFβ2 gene were tested, and allele 2 was the most common in both cases and controls. The proportion of allele 2 in the case group was greater than that in the control group, showing a significant difference between cases of cleft lip (with or without cleft palate) and controls (χ2 = 19.208; P < 0.0001). No significant differences in variants of TGFβ3 or GABRB3 between case and control populations were observed. Thus it is concluded that TGF genes play a role in craniofacial development, and that alleles of TGFα or/and TGFβ2 are associated with cleft lip and cleft palate in Japanese populations.

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Perceptual Speech Outcomes After Early Primary Palatal Repair in Ugandan Patients With Cleft Palate

The Cleft Palate-Craniofacial Journal ◽

10.1177/1055665620980249 ◽

2020 ◽

pp. 105566562098024

Author(s):

Kim Bettens ◽

Laura Bruneel ◽

Cassandra Alighieri ◽

Daniel Sseremba ◽

Duncan Musasizib ◽

...

Keyword(s):

Cleft Palate ◽

Cleft Lip ◽

Speech Therapy ◽

Cleft Lip And Palate ◽

Control Group ◽

English Speaking ◽

And Gender ◽

Early Primary ◽

Velopharyngeal Function ◽

Normal Speech

Objective: To provide speech outcomes of English-speaking Ugandan patients with a cleft palate with or without cleft lip (CP±L). Design: Prospective case–control study. Setting: Referral hospital for patients with cleft lip and palate in Uganda. Participants: Twenty-four English-speaking Ugandan children with a CP±L (15 boys, 9 girls, mean 8.4 years) who received palatal closure prior to 6 months of age and an age- and gender-matched control group of Ugandan children without cleft palate. Interventions: Comparison of speech outcomes of the patient and control group. Main Outcome Measures: Perceptual speech outcomes including articulation, resonance, speech understandability and acceptability, and velopharyngeal composite score (VPC-sum). Information regarding speech therapy, fistula rate, and secondary surgery. Results: Normal speech understandability was observed in 42% of the patients, and 38% were judged with normal speech acceptability. Only 16% showed compensatory articulation. Acceptable resonance was found in 71%, and 75% of the patients were judged perceptually to present with competent velopharyngeal function based on the VPC-sum. Additional speech intervention was recommended in 25% of the patients. Statistically significant differences for all these variables were still observed with the control children ( P < .05). Conclusions: Overall, acceptable speech outcomes were found after early primary palatal closure. Comparable or even better results were found in comparison with international benchmarks, especially regarding the presence of compensatory articulation. Whether this approach is transferable to Western countries is the subject for further research.

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The SNP rs560426 Within ABCA4-ARHGAP29 Locus and the Risk of Nonsyndromic Oral Clefts

The Cleft Palate-Craniofacial Journal ◽

10.1177/1055665619899764 ◽

2020 ◽

Vol 57 (6) ◽

pp. 671-677 ◽

Cited By ~ 1

Author(s):

Yah-Huei Wu-Chou ◽

Kuo-Ting Philip Chen ◽

Yi-Chieh Lu ◽

Yin-Ting Lin ◽

Hsien-Fang Chang ◽

...

Keyword(s):

Cleft Palate ◽

Cleft Lip ◽

Strong Association ◽

Nucleotide Polymorphisms ◽

Test Analysis ◽

Oral Clefts ◽

The Family ◽

Abca4 Gene ◽

Family Based ◽

New Evidence

Objective: Nonsyndromic oral clefts are common birth defect with complex etiology. In the present study, we attempt to further validate the possible role for ABCA4 and ARHGAP29 in the susceptibility to nonsyndromic oral clefts. Design: We performed allelic transmission disequilibrium test analysis, on 10 eligible single nucleotide polymorphisms (SNPs) and SNP haplotypes using the Family-Based Association Test. Participants: The study sample consisted of 334 case–parent trios of nonsyndromic oral clefts from Taiwanese population, separated into nonsyndromic cleft lip with or without cleft palate (NSCL/P) and nonsyndromic cleft palate only (NSCPO) groups. Results: We found only the SNP rs560426 within the ABCA4 gene showed strong association with NSCPO ( P = .03498; Permuted P = .05382). No association between other 9 selected SNPs in ABCA4-ARHGAP29 region and the risk of nonsyndromic oral clefts was found. For the haplotype analyses, we found only haplotype T-C (rs570926 and rs3789431) in ABCA4 block 2 showed significant association with nonsyndromic NSCL/P in these Taiwanese trios. Conclusions: We used a family-based analysis in 334 Taiwanese case–parent trios to validate the possible role for ABCA4 and ARHGAP29 in the susceptibility to nonsyndromic oral clefts. This study provides a new evidence for an association between the intron variant rs560426 within ABCA4 and nonsyndromic cleft palate which may contribute their regulatory role in craniofacial development.

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USE OF THE SPEECH PASSPORT IN REHABILITATION OF CHILDREN WITH CONGENITAL MAXILLOFACIAL MALFORMATIONS

The actual problems in dentistry ◽

10.18481/2077-7566-2019-15-2-79-83 ◽

2019 ◽

Vol 15 (2) ◽

pp. 79-83

Author(s):

Павел Токарев ◽

Pavel Tokarev ◽

Алексей Шулаев ◽

Aleksey Shulaev ◽

Ринат Салеев ◽

...

Keyword(s):

Cleft Lip ◽

Speech Therapy ◽

Cleft Lip And Palate ◽

Main Group ◽

Speech Development ◽

Control Group ◽

Speech Activity ◽

Speech Therapist ◽

Rehabilitation Measures ◽

Definition Of

Subject. The article describes the child's speech passport, as one of the important mechanisms of the rehabilitation and speech recovery in children with congenital cleft lip and palate. Purpose of the study ― evaluation of the treatment outcome in children with cleft palate with the use of a speech passport at the stage of rehabilitation. Materials and methods. The article presents the experience of the rehabilitation of more than 2,000 patients with congenital maxillofacial defects from 1998 to 2017. Results. The features of speech development were studied in 93 patients divided into two groups. The main group consisted of 56 people, in whom the definition of the algorithm of medical and logopedic aid was carried out using a speech passport, then the rehabilitation measures complex developed by us for restoring and correcting the speech function was applied. The control group included 37 people: patients who did not receive medical and speech therapy in the postoperative period, and patients who underwent rehabilitation measures in outpatient clinic at the place of residence. The speech activity indicators in patients of the compared groups had significant differences (p = 0,026), due to a more pronounced positive dynamics of speech activity recovery in the main group - the percentage of patients increased 3,6 times ― from 17,9 to 64,3 %, while in the control group the rate increased only 1,9 times ― from 21,6 up to 40,5 %. Conclusion. The developed speech passport involves a multidisciplinary approach to the child, early detection, treatment and rehabilitation. It is also can be defined as a link between health care, speech therapy and pedagogy. The child's speech passport data can be filled by a pediatrician, neurologist, maxillofacial surgeon, orthodontist, speech therapist and speech therapist defectologist at various stages of treatment and rehabilitation.

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Three-dimensional Evaluation of Mandibular Volume in Patients with Cleft Lip and Palate During the Deciduous Dentition Period

The Angle Orthodontist ◽

10.2319/112618-831.1 ◽

2019 ◽

Vol 90 (1) ◽

pp. 85-91 ◽

Cited By ~ 1

Author(s):

Abhishekhi Shrestha ◽

Masahiro Takahashi ◽

Tetsutaro Yamaguchi ◽

Mohamed Adel ◽

Mayu Furuhata ◽

...

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Three Dimensional ◽

Pairwise Comparison ◽

Craniofacial Morphology ◽

Analysis Of Covariance ◽

Control Group ◽

Deciduous Dentition ◽

Post Hoc ◽

And Control

ABSTRACT Objectives To examine the relationship between mandibular volume and craniofacial morphology in patients with cleft lip and palate using cone beam computed tomography (CBCT) and to compare these findings with control (noncleft) patients undergoing CBCT for other purposes during the deciduous dentition period. Materials and Methods Eighty-four patients were categorized into the unilateral cleft lip and alveolus (UCLA) group (n = 25; mean age, 4.60 ± 0.40 years), unilateral cleft lip and palate (UCLP) group (n = 23; mean age, 4.52 ± 0.39 years), bilateral cleft lip and palate (BCLP) group (n = 22; mean age, 4.54 ± 0.37 years), and control group without cleft (n = 14; mean age, 5.19 ± 0.52 years). Mandibular volume and craniofacial cephalometric measurements were obtained using CBCT. All measurements were assessed by analysis of covariance (ANCOVA) using Bonferroni post hoc pairwise comparison tests. Results ANCOVA revealed no statistically significant differences in mandibular volume among the groups. SNA° and ANB° were significantly larger in the UCLA and BCLP groups than in the control group. SN-MP° was smallest in the UCLA group. Co-A in the UCLP group was shorter than in the UCLA and BCLP groups. Go-Gn was shortest in the UCLP and BCLP groups compared with the control group. Conclusions Three-dimensional evaluation of craniofacial morphology using CBCT can provide valuable information on malocclusion and other dentoskeletal problems among patients with CLP.

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