scholarly journals The therapeutic use of symbiotics

2014 ◽  
Vol 27 (3) ◽  
pp. 206-209 ◽  
Author(s):  
Aline Gamarra Taborda FLESCH ◽  
Aline Kirjner POZIOMYCK ◽  
Daniel De Carvalho DAMIN
Keyword(s):  
Immune System ◽  
Glycemic Control ◽  
Functional Foods ◽  
Intestinal Flora ◽  
Gastrointestinal Diseases ◽  
Blood Cholesterol ◽  
Multiplicative Factor ◽  
Individual Actions ◽  
Reduced Risk ◽  
Stimulation Of

INTRODUCTION: Functional foods are health promoters and their use is associated with reduced risk of chronic degenerative and non-transmissible diseases. Examples are symbiotic. The association of one (or more) probiotic with a one (or more) prebiotic is called symbiotic, being the prebiotics complementary and probiotics synergistic, thus presenting a multiplicative factor on their individual actions. OBJECTIVE: To assess the evidences on the benefits of the use of symbiotics in the treatment of clinical and surgical situations. METHODS: The headings symbiotic, probiotic and prebiotic were searched in Pubmed/Medline in the last 15 years, and were selected 25 articles, used for database. RESULTS: The use of symbiotic may promote an increase in the number of bifidobacteria, glycemic control, reduction of blood cholesterol, balancing the intestinal flora which aids in reducing constipation and/or diarrhea, improves intestinal permeability and stimulation of the immune system. Clinical indications for these products has been expanded, in order to maximize the individual's physiological functions to provide greater. So, with the high interest in the clinical and nutritional control of disease, many studies have been conducted demonstrating the effectiveness of using symbiotic in improving and/or preventing various and/or symptoms of gastrointestinal diseases. CONCLUSION: Symbiotic behave differently and positively in various pathological situations.

scholarly journals Study on the immuno stimulation of radiation degraded β-glucan in swiss mice

2015 ◽  
Vol 5 (4) ◽  
pp. 9-15
Author(s):  
Thanh Long Nguyen ◽  
Quang Luan Le
Keyword(s):  
Cell Wall ◽  
Immune System ◽  
Gamma Irradiation ◽  
Gamma Rays ◽  
Irradiation Dose ◽  
Functional Foods ◽  
Water Soluble ◽  
Molecular Weights ◽  
Swiss Mice ◽  
Stimulation Of

The mixtures β-glucan extracted from the yeast cell wall were irradiated under gamma rays from a Co-60 source at doses of 100, 200 and 300 kGy in order to prepare water-soluble β-glucan. Yields of the water soluble β-glucan produced are 25.9, 49.1, 66.71%, and their molecular weights (Mw) are 30.5, 24.9 and 10.8 kDa, respectively. There are no any new peak in the IR spectra of the irradiated β-glucan samples, but the intensity ratio between the peaks at wavenumber of 1156 cm-1 (assigned to C-O-C bond) and of 1040 cm-1 (assigned to C-C bond) in glycosidic linkages was reduced with irradiation dose. These results revealed that gamma irradiation did not cause any change in the β-glucan structure except the scissions of glycosidic linkages. In this study, immuno stimulation of the irradiated b-glucan was also investigated for the Swiss mice. After 28 days supplying with the irradiated b-glucan, not only cellular indexes (white blood cell, neutrophils and lymphocytes counts), but also humoral  immunity indexes (IgA and IgM) of the mice significantly increased and the highest effects was obtained for the mice supplied with the oligoβ-glucan prepared by gamma irradiation at 200 kGy. Thus, the water soluble oligoβ-glucan with Mw ~ 24.9 kDa prepared by gamma radiation much stimulated the natural immune system (non-specific immunity) in mice including both the cellular and humoral immunities. Particularly, the irradiated b-glucan is a very promising product for preparation of functional foods aiming at cancer prevention.

scholarly journals Functional Food for the Stimulation of the Immune System Against Malaria

2021 ◽  
Author(s):  
Timothy Bamgbose ◽  
Anupkumar R. Anvikar ◽  
Pilar Alberdi ◽  
Isa O. Abdullahi ◽  
Helen I. Inabo ◽  
...  
Keyword(s):  
Immune System ◽  
Functional Food ◽  
Stimulation Of

scholarly journals Effects of Selected Prebiotics or Synbiotics Administered in ovo on Lymphocyte Subsets in Bursa of the Fabricius, Thymus, and Spleen in Non-Immunized and Immunized Chicken Broilers

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 476
Author(s):  
Marianna Szczypka ◽  
Agnieszka Suszko-Pawłowska ◽  
Maciej Kuczkowski ◽  
Michał Gorczykowski ◽  
Magdalena Lis ◽  
...  
Keyword(s):  
Immune System ◽  
Lactococcus Lactis ◽  
Blood Cells ◽  
Broiler Chickens ◽  
Lymphocyte Subsets ◽  
Double Positive ◽  
In Ovo ◽  
Lactococcus Lactis Subsp ◽  
Egg Incubation ◽  
Stimulation Of

The effects of in ovo-delivered prebiotics and synbiotics on the lymphocyte subsets of the lymphoid organs in non-immunized 7-day-old broiler chickens and in non-immunized, sheep red blood cells (SRBC)-immunized, and dextran (DEX)-immunized 21- and 35-day-old birds were studied. The substances were injected on the 12th day of egg incubation: Prebiotic1 group (Pre1) with a solution of inulin, Prebiotic2 group (Pre2) with a solution of Bi2tos (non-digestive transgalacto-oligosaccharides), Synbiotic1 group (Syn1) with inulin and Lactococcus lactis subsp. lactis IBB SL1, and Synbiotic2 group (Syn2) with Bi2tos and Lactococcus lactis subsp. cremoris IBB SC1. In 7-day-old chicks, a decrease in T splenocytes was noticed in all groups. The most pronounced effect in 21- and 35-day-old birds was an increase in TCRγδ+ cells in Syn1 and Syn2 groups. A decrease in bursal B cells was observed in DEX-immunized Pre1 group (21-day-old birds), and in the Syn1 group in non-immunized and SRBC-immunized 35-day-old birds. An increase in double-positive lymphocytes was observed in Pre1 (35-day-old birds) and Pre2 (immunized 21-day-old birds) groups. In Pre1 and Syn1 groups (21- and 35-day-old), an increase in B splenocytes and a decrease in T splenocytes were observed. We concluded that Syn1 was the most effective in the stimulation of the chicken immune system.

scholarly journals The Effect of Thermo-Mechanical Processing on Physical Properties of Processed Amaranth and Oat Bran Composites

2017 ◽  
Vol 6 (2) ◽  
pp. 82
Author(s):  
Sean X. Liu ◽  
Diejun Chen ◽  
George E. Inglett ◽  
Jingyuan Xu
Keyword(s):  
Physical Properties ◽  
High Speed ◽  
Functional Foods ◽  
Cold Water ◽  
Essential Amino Acids ◽  
Hot Water ◽  
Blood Cholesterol ◽  
Gluten Free ◽  
Oat Bran ◽  
Amaranth Flour

Amaranth-oat composites were developed using gluten free amaranth flour containing essential amino acids and minerals with oat products containing β-glucan, known for lowering blood cholesterol. Amaranth flour and oat bran concentrate (OBC) composites (1:4) were processed using different technologies, including dry mixing, baking, steaming, cold wet blending, and high speed homogenizing (Polytron PT6000) with cold water or hot water. The results showed that water holding capacities, pasting, and rheological properties were dramatically increased by wet blending, Polytron with cold water, and Polytron with hot water followed by drum drying. The processing procedures created dissimilar physical properties that will enhance the application of ancient grains and oat for functional foods that are suitable for people who are gluten-intolerant. In addition, the dietary fiber contents of composites were increased by the incorporation of OBC. The composites can be inexpensively prepared and processed. The new healthful products will be affordable for people who suffer from celiac disease or gluten-intolerant. These innovative gluten-free functional food products will help millions of gluten sensitive consumers enjoy heart-healthy functional foods.

scholarly journals The effects of co-transplantation of bone marrow hematopoietic stem cell and thymic multipotent stromal cells on the immune system of mice during its regeneration after cyclophosphamide treatment

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
D. Demchenko ◽  
I. Nikolskiy
Keyword(s):  
Bone Marrow ◽  
Immune System ◽  
Lymph Nodes ◽  
Stromal Cells ◽  
Activity Level ◽  
Delayed Type Hypersensitivity ◽  
Blast Transformation ◽  
Multipotent Stromal Cells ◽  
Hematopoietic Stem ◽  
Stimulation Of

The multipotent stromal cells (MSCs) are considered as one of the most promising agents for regenerating the immune system due to its powerful secretion of reparative factors and immunomodulatory properties.The purpose of the study is to investigate the effect of co-transplantation of bone marrow hematopoietic stem cells (HSCs) and thymic multipotent stromal cells (MSCs) on regeneration of murine immune system damaged by cyclophosphamide.Materials and methods. MSCs were obtained from thymuses of C57BL mice using explant technique. Bone marrow cells (BMCs) were obtained by flushing out the femur with nutrient medium. The immune deficiency of mice was modelled by the treatment with cyclophosphamide. After that, the cells were co-transplanted and the parameters of the immune system was evaluated. We determined the total number of erythrocytes, hematocrit, and hemoglobin concentration in peripheral blood; phases of the cell cycle and apoptosis of the cells of the mesenteric lymph nodes; the number of antibody-producing cells in the spleen; delayed type hypersensitivity (DTH); proliferative and cytotoxic activity of natural killer lymphocytes; phagocytic activity, level of spontaneous and induced bactericidal activity of peritoneal macrophages.Results. It was shown that in contrast to BMCs, the use of MSCs alone or co-transplantation of these cells increased the spontaneous proliferative activity of lymphocytes with a significant decrease in the number of lymph node cells in G0/G1 phase by 9.2 % and an increase in the number of lymphocytes in G2-M+S phase by 35 %, as well as restoring cellularity of bone marrow, thymus and lymph nodes in mice treated with cyclophosphamide. Regeneration of erythropoiesis was stimulated by BMCs, which was manifested by the normalization of hematocrit and hemoglobin, and an increase in the number of reticulocytes in the blood by 2.2 times compared with the group of mice receiving cyclophosphamide. Co-transplantation had less pronounced, but similar effect. Transplantation of thymic MSCs stimulated the natural cytotoxicity of splenocytes by 2.7 times and substantially increased the number of antibody-producing cells in the spleen by 1.7 times compared with the group of mice receiving cyclophosphamide. Co-transplantation had a pronounced suppressive effect on the blast transformation reaction induced by phytohemagglutinin by 1.7 times, but showed a stimulating effect on DTH response by 1.46 times. Transplantation of BMCs did not affect the functional activity of the immune system.Conclusion. The effects of co-transplantation of BMCs and thymic MSCs are realized in the several parts: stimulation of hematological parameters recovery (like under the effect of BMCs separately), normalization of cell number of lymphoid organs (as under the impact of thymic MSCs); inhibition of blast transformation activity and stimulation of DTH are the effects of co-transplantation.

scholarly journals Electrical Stimulation for Immune Modulation in Cancer Treatments

2022 ◽  
Vol 9 ◽  
Author(s):  
Ritopa Das ◽  
Sofia Langou ◽  
Thinh T. Le ◽  
Pooja Prasad ◽  
Feng Lin ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Immune System ◽  
Immune Modulation ◽  
Cancer Treatments ◽  
Different Types ◽  
Specific Antigens ◽  
High Doses ◽  
T Cell Transfer ◽  
Deficient Mice ◽  
Stimulation Of

Immunotherapy is becoming a very common treatment for cancer, using approaches like checkpoint inhibition, T cell transfer therapy, monoclonal antibodies and cancer vaccination. However, these approaches involve high doses of immune therapeutics with problematic side effects. A promising approach to reducing the dose of immunotherapeutic agents given to a cancer patient is to combine it with electrical stimulation, which can act in two ways; it can either modulate the immune system to produce the immune cytokines and agents in the patient’s body or it can increase the cellular uptake of these immune agents via electroporation. Electrical stimulation in form of direct current has been shown to reduce tumor sizes in immune-competent mice while having no effect on tumor sizes in immune-deficient mice. Several studies have used nano-pulsed electrical stimulations to activate the immune system and drive it against tumor cells. This approach has been utilized for different types of cancers, like fibrosarcoma, hepatocellular carcinoma, human papillomavirus etc. Another common approach is to combine electrochemotherapy with immune modulation, either by inducing immunogenic cell death or injecting immunostimulants that increase the effectiveness of the treatments. Several therapies utilize electroporation to deliver immunostimulants (like genes encoded with cytokine producing sequences, cancer specific antigens or fragments of anti-tumor toxins) more effectively. Lastly, electrical stimulation of the vagus nerve can trigger production and activation of anti-tumor immune cells and immune reactions. Hence, the use of electrical stimulation to modulate the immune system in different ways can be a promising approach to treat cancer.

scholarly journals A review on the influence of dietary immunobiotics on the performance, intestinal morphology and immune-related gene expression in post-hatched broiler chicks

2020 ◽  
Vol 5 (1) ◽  
pp. 57-67 ◽  
Author(s):  
Asad A. Khaskheli ◽  
Muhammad I. Khaskheli ◽  
Allah J. Khaskheli ◽  
Arshad A. Khaskheli
Keyword(s):  
Gene Expression ◽  
Immune System ◽  
Functional Foods ◽  
Molecular Mechanisms ◽  
Intestinal Morphology ◽  
Lymphoid Tissues ◽  
Broiler Chicks ◽  
Related Gene ◽  
Current Review ◽  
Immune Related Gene

The use of antibiotics in the broiler industry is continuously increasing for promoting growth performance, improving the edible meat yield, and preventing microbial infections in the chicks. Due to the extreme misuse of antibiotics, antimicrobial resistance is developing among the broilers and simultaneously to their consumers. Keeping in view these facts current review was planned to understand the effect of different dietary immunobiotics on the performance, intestinal morphology, and immune-related gene expression in post-hatched broiler chicks. The review of the literature indicated that the application of immunobiotics as functional foods and its biological value have been reported by many scientists worldwide. In addition, to develop immunologically functional foods, immunobiotics also help in regulating intestinal immunity. The current review further explored that the immunobiotics regulate intestinal immune homeostasis, cellular and molecular mechanisms. It was also interesting to note that immunobiotics concerning microorganisms stimulate the activation of mucosal immunity in the Gut Associated Lymphoid Tissues (GALT). In vitro studies on the toll-like receptor (TLR) 2-transfected cells showed that immunobiotics can potentially be used to enhance the immune system in the GALT. Keeping in view reviewed studies on immunobiotics it could be concluded that immunobiotics positively influence the performance, intestinal morphology, and immune-related gene expression in post-hatch chicks. They could be used as the best alternative to antibiotics. Keywords: Gut Associated Lymphoid Tissues; Immune system; Prebiotics; Receptors. 

Sign in / Sign up

Export Citation Format

Share Document