scholarly journals Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats

2006 ◽  
Vol 17 (4) ◽  
pp. 267-273 ◽  
Author(s):  
Ana Lia Anbinder ◽  
Juliana Campos Junqueira ◽  
Maria Nadir G. Mancini ◽  
Ivan Balducci ◽  
Rosilene Fernandes da Rocha ◽  
...  
Keyword(s):  
Cholesterol Level ◽  
Bone Repair ◽  
Plasma Cholesterol ◽  
Subcutaneous Administration ◽  
Blood Cholesterol ◽  
Blood Cholesterol Level ◽  
Water Group ◽  
Routes Of Administration ◽  
Cholesterol Levels ◽  
Significant Difference

The purpose of this study was to evaluate the effects of simvastatin, by oral or subcutaneous administration, on tibial defects regeneration and blood cholesterol level in rats. A surgical defect was made on the right tibia of 40 male animals assigned to 4 groups (n=10), based on two routes of administration and on the use or not of simvastatin: subcutaneous injection of simvastatin (7 mg/kg) (group AT) or only the vehicle of drug suspension (group AC), above the defect area, for 5 days; and 20 mg/kg of simvastatin macerated on water (group BT) or only water (group BC), orally, daily, during the whole observation period. The animals were sacrificed after 15 or 30 days, when blood samples were analyzed to check plasma cholesterol levels. Tibiae were removed and, after decalcification and routine laboratorial processing, histological and histomorphometrical analyses were carried out. ANOVA was used for statistical analysis at 5% signficance level. The histological and histomorphometrical analyses showed significant differences only between the experimental periods (p<0.05). Animals sacrificed after 30 days showed better bone repair (p<0.05). There was no statistically significant difference (p>0.05) for blood cholesterol levels between the groups. In conclusion, simvastatin administration either orally or subcutaneously did not improve bone repair of experimental tibial defects and did not alter blood cholesterol levels in rats.

scholarly journals Pengaruh Pemberian Alpukat Terhadap Kadar Kolesterol Total Darah Pada Mahasiswa/i Obesitas Di Fakultas Kedokteran Universitas HKBP Nommensen Medan Tahun 2019

2021 ◽  
Vol 6 (2) ◽  
pp. 40-43
Author(s):  
Syupiarni Putri Waruwu ◽  
Joseph Partogi Sibarani ◽  
Saharnauli Janna Verawaty Simorangkir
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Density Lipoprotein ◽  
The Body ◽  
Blood Cholesterol ◽  
Ldl Oxidation ◽  
Blood Cholesterol Level ◽  
Total Blood ◽  
Cholesterol Levels ◽  
Total Blood Cholesterol

Background: Cholesterol is a fat that does not dissolve easily in the blood. Most of the cholesterol in the blood is attached to specific protein carriers in the plasma in the form of lipoprotein complexes, which are soluble in water. Lipoprotein which carries cholesterol throughout the body. namely LDL (Low Density Lipoprotein) and HDL (High Density Lipoprotein). An increase in LDL in the body tends to form atherosclerosis. In contrast HDL cholesterol inhibits LDL oxidation so that atherosclerotic plaque formation does not occur. Obesity is one of the risk factors for atherosclerosis with manifestations of coronary heart disease. Handling of obesity has been done by many researchers and implemented. One ingredient from nature that serves as an alternative ingredient to lower blood cholesterol levels is avocado. Objective: To determine the effect of avocado administration on total blood cholesterol levels in the obese college students at the Medical Faculty of Nommensen HKBP University in 2019. Methods :This research is a pre-experimental study with a pre-post test design in one group. The sample was selected by purposive sampling method and obtained 20 obese students. Subjects consumed avocado juice every day for 14 days. Total cholesterol levels were measured before (day 0) and after (day 14) treatment. Results: The mean total cholesterol level of the subject's blood on the pretest examination was 188.10 mg / dL and the posttest examination was 180.05 mg / dL. There was a decrease in the average total blood cholesterol level of 8.05 mg / dl. Paired T-test showed that there was a non-significant decrease in mean total blood cholesterol level with a value of p = 0.068 (p <0.05). Conclusion: In this study there was no effect of avocado administration on total blood cholesterol levels in obese students.

scholarly journals PERBEDAAN TINGKAT KONSUMSI DAN KADAR KOLESTEROL DARAH ANTARA PEROKOK DAN NON PEROKOK

2019 ◽  
Vol 14 (2) ◽  
pp. 243
Author(s):  
Dina Fahmawati
Keyword(s):  
Food Intake ◽  
Cholesterol Level ◽  
Smoking Habit ◽  
Harmful Effect ◽  
Blood Cholesterol ◽  
P Value ◽  
Blood Cholesterol Level ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Difference

Cigarette smoke contains nicotine which disturbs health. Nicotine is capable of reducing the taste of food, so  there is appetite suppressant. The ability of nicotine in increasing blood liposuction process can affect the increase in blood cholesterol level. The research aims to study the difference between food intake and blood cholesterol level between smokers and non-smokers. This study was a comparative observational analytic study using cross-sectional design. The data of particular  subjects and smoking habit were  obtained from the questionnaire. The food intake was obtained by interview using 2x24 hours food recall form while the blood cholesterol level was obtained by blood sampling which was then analyzed using laboratory test. The subjects were 13 smokers and 13 non-smokers, taken by simple random sampling. The data were analyzed by Independent t-Test. The results have suggested that the difference in the average  food intake and  blood cholesterol level between smokers and non-smokers were not significant. The substantial average difference was found in the level of cholesterol intake, so  the statistical test has showed a significant difference, p-value = 0.005 < α(0.05). Smoking has a harmful effect for health so  people must decrease its consumption or stay abstinent from it. The longer human get exposed to cigarette, the more susceptible they get the illness from it.

scholarly journals PENGARUH AIR REBUSAN DAUN MAMPELAS (Teteracera indica) TERHADAP KADAR KOLESTEROL DARAH MENCIT

2017 ◽  
Vol 4 (3) ◽  
pp. 197
Author(s):  
Dian Samitra ◽  
Zico Fakhrur Rozi
Keyword(s):  
Cholesterol Level ◽  
Blood Cholesterol ◽  
Blood Cholesterol Level ◽  
Cholesterol Levels ◽  
Traditional Remedies ◽  
Lower Blood Cholesterol ◽  
Lower Blood ◽  
Post Test ◽  
The Mean ◽  
The Difference

Tetracera indica Merr. locally known as Mampelas is commonly used in traditional remedies. It believed to have the potential to cure hypercholesterolemia. The potential use of this plant to lower blood cholesterol level was understudied; therefore this study aimed to determine the effect of the infusion of fresh leaves of Tetracera indica to the blood cholesterol levels of mice. This research was true experimental design, a post-test only design with nonequivalent (control) groups. This study used 25 male mice divided into five categories, i.e., P0 mice were administered with 0 g of infusion, P1 mice with 2 g infusion, P2 mice with 5 g infusion, P3 mice with 10 g infusion, and P4 mice without Tetracera indica infusion but 10 mg of simvastatin. The treatment in all categories were given continuously for seven days. The results showed the mean of the blood cholesterol levels were 169.4 ± 59.37 mg/dL in P0, 121.8 ± 7.62 mg/dL in P1, 136.2 ± 15.69 mg/dL in P2, 110.6 ± 37 , 01 mg/dL in P3 , and 179,0 ± 35,24 mg/dL in P4. Kruskal Wallis test was calculated to determine the difference of blood cholesterol level among all groups, and it reported p < 0.05. The results of this study showed that infusion of Tetracera indica leaf was significantly lowered the level of blood cholesterol in mice.

scholarly journals Pengaruh Pemberian Berbagai Olahan Telur terhadap Kadar Kolesterol Total Darah Mencit

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Putri Mira Magistri ◽  
Rismawati YaswiR ◽  
Yustini Alioes
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Cholesterol Content ◽  
Blood Cholesterol ◽  
Blood Cholesterol Level ◽  
Total Blood ◽  
Cholesterol Levels ◽  
Randomized Design ◽  
Total Blood Cholesterol

AbstrakMasyarakat menggunakan berbagai cara pengolahan sebelum mengonsumsi telur yang dapat berpengaruh terhadap kadar zat gizi yang terkandung didalamnya, termasuk kadar kolesterol dalam telur yang juga akan mempengaruhi kadar kolesterol dalam darah. Tujuan penelitian ini adalah menentukan pengaruh pemberian berbagai olahan telur terhadap kadar kolesterol total darah mencit. Penelitian menggunakan 24 ekor mencit (Mus musculus) jantan albino umur 3 – 4 bulan dengan berat badan sekitar 30 – 40 gram. Jenis kandang yang digunakan adalah kandang kotak (box) sebanyak 24 unit dengan ukuran 28x30x20 cm. Metode yang digunakan ialah eksperimen dengan Rancangan Acak Lengkap (RAL) terdiri dari 6 unit perlakuan, yaitu unit perlakuan K (Kontrol), unit perlakuan A (telur mentah), unit perlakuan B (telur goreng), unit perlakuan C (telur rebus), unit perlakuan D (telur setengah matang) dan unit perlakuan E (telur asin). Dosis perlakuan adalah 1,56ml/20gram berat badan/mencit dan masing-masing perlakuan diulang 4 kali. Parameter yang diukur adalah kadar kolesterol total darah mencit. Hasil analisis keragaman menunjukan bahwa pemberian berbagai olahan telur memberikan pengaruh berbeda sangat nyata (P<0.01) terhadap kadar kolesterol total darah mencit. Berdasarkan hasil penelitian dapat disimpulkan bahwa rerata kadar kolesterol total darah mencit setelah diberikan berbagai olahan telur adalah telur mentah 106.96 mg/dl, telur goreng 143.53 mg/dl, telur rebus 194.50 mg/dl, telur setengah matang 180.91 mg/dl, dan telur asin 158.27 mg/dl.Kata kunci: olahan telur, kadar kolesterol total darah, mencit AbstractPeople use various methods of processing before consumption eggs which can affect the levels of nutrients contained in, including cholesterol content which can also affect the levels of total cholesterol in blood. The objective of this study was to determine the effect of giving a variety of processed egg on total cholesterol levels of mice. The experiment used 24 male albino mice (Mus nusculus) age 3 – 4 months old with 30 – 40 grams of body weight. The den used was 24 units of box with size of 28x30x20 cm. The experiment used Completely Randomized Design (CRD) consist of 6 treatment units which was K (control), A (raw egg), B (fried egg), C (boiled egg), D (soft-boiled egg), and E (salted egg). The dosage was  1.56 ml/20 grams of body weight/mice and 4 replication for each treatment units. The parameter measured was total blood cholesterol level of mice.  Results of analysis of variance showed that giving of a variety of processed egg gave highly  significant  effect (P <0.01) on total blood cholesterol levels of mice. Based on the results of this study, it can be concluded that the average total blood cholesterol levels of mice after giving of various preparations of eggs is as follows: raw eggs 106.96 mg / dl, fried eggs 143.53 mg / dl, boiled eggs 194.50 mg / dl, soft-boiled eggs 180.91 mg / dl, and salted egg 158.27 mg / dl..Keywords: processed egg, total blood cholesterol level,  mice

scholarly journals The influence of aqueous extract of roselle (Hibiscus sabdariffa) calyx on blood cholesterol level and body weight in rats

2011 ◽  
Vol 9 (2) ◽  
pp. 43-49
Author(s):  
MEISA MARSALINA ◽  
SAMIGUN SAMIGUN ◽  
ENDANG SRI HARDJANTI
Keyword(s):  
Body Weight ◽  
Cholesterol Level ◽  
Aqueous Extract ◽  
Statistical Test ◽  
Blood Cholesterol ◽  
Average Weight ◽  
Hibiscus Sabdariffa ◽  
Blood Cholesterol Level ◽  
Significant Difference ◽  
One Way Anova

Marsalina M, Samigun, Hardjanti ES. 2011. The influence of aqueous extract of roselle (Hibiscus sabdariffa) calyx on blood cholesterol level and body weight in rats. Biofarmasi 9: 43-49. This study aimed to investigate the influence of aqueous extract of roselle calyx on blood cholesterol level and body weight in rats. This experimental research was arranged as a pre and post-test controlled group design. Thirty Sprague-Dawley rats, with 3 months of age and 250 g in average weight, were used as an animal model. Those rats were grouped equally into five groups, i.e. negative control (aquadest), positive control (0.26 mg lovastatin/200 g body weight of rats/2 mL), the first dose of aqueous extract of roselle calyx (65 mg/200 g/2 mL), the second dose of aqueous extract of roselle calyx (130 mg/200 g/2 mL), and the third dose of aqueous extract of roselle calyx (195 mg/200 g/2 mL). The measurement of rat blood cholesterol level was conducted before and after treatment, while the rat body weight was measured once a week. The result of this study was analyzed by using one-way ANOVA statistical test. The one-way ANOVA statistical test showed no significant difference on reducing blood cholesterol level with p=0.327 (p>0.05) and body weight in rat with p=0.154, p=0.214, and p=0.938 (p>0.05). This study concluded that the aqueous extract of roselle calyx has no influence on lowering blood cholesterol level and body weight in rats.

Pediatric Preventive Cardiology: Atherosclerosis and Coronary Heart Disease

1988 ◽  
Vol 9 (10) ◽  
pp. 303-314
Author(s):  
William B. Strong ◽  
Barbara A. Dennison
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cholesterol Level ◽  
Disease Risk ◽  
Diet Therapy ◽  
Blood Cholesterol ◽  
Elevated Blood ◽  
Blood Cholesterol Level ◽  
Preventive Cardiology ◽  
Cholesterol Levels

Pediatric preventive cardiology has as one of its goals, the reduction in incidence and severity of cardiovascular disease in adults by the promotion of prudent life-styles in children and adolescents. Few would find fault with this goal, yet the "best" approach and strategy to reduce atherosclerosis and coronary heart disease has been the source of controversy.1-4 The recently published National Institutes of Health Consensus Conference Statement on lowering blood cholesterol to prevent heart disease has summarized the literature relating blood cholesterol and heart disease.5 The strategies recommended include: (1) dietary changes to reduce total dietary fat, saturated fat, and dietary cholesterol consumption in everyone older than 2 years of age, (2) universal blood cholesterol screening for all adults older than 18 years of age, (3) more intensive diet therapy for those with a blood cholesterol level ≥75th percentile, (4) possible addition of drug therapy for individuals whose blood cholesterol levels remain ≥75th percentile despite diet therapy, and (5) in individuals with elevated blood cholesterol levels, emphasis on management of other coronary heart disease risk factors: hypertension, cigarette smoking, diabetes and physical inactivity. The European Atherosclerosis Society has also recently advocated screening the population to find those at high risk (eg, those with an elevated blood cholesterol level in conjunction with population strategies to improve nutrition, eradicate smoking, control hypertension, and promote suitable physical activity.6

scholarly journals Effect of Bandotan (Ageratum conyzoidez L) Leaf Extract on Total Blood Cholesterol Levels of Broiler

2014 ◽  
Vol 10 (2) ◽  
Author(s):  
Egi Supriyadi ◽  
Roslizawaty Roslizawaty ◽  
Zuhrawati Zuhrawati
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Leaf Extract ◽  
Total Cholesterol Level ◽  
Blood Cholesterol ◽  
Precipitation Method ◽  
Blood Cholesterol Level ◽  
Total Blood ◽  
Cholesterol Levels ◽  
Total Blood Cholesterol

This study aimed to determine the effect of bandotan (Ageratum conyzoides L) leaf extract on total blood cholesterol level of broiler. This study used 15 broiler aged of 25 days. This study was an experimental study using completely randomized design (CRD) unidirectional pattern with 3 treatment groups and 5replications each. Group 0 (P0) was not given bandotan leaf extract, group 1 (P1) was given 3 ml bandotan leaf extract, and group 2 (P 2) was given 5 ml bandotan leaf extract. The administration of Bandotan leaf extract was carried out once a day for 5 consecutive days. On day 6 after treatment, the blood was collected then examined for total blood cholesterol level by precipitation method. Data was analyzed using analysis of variance. The result showed that the average of total cholesterol level on group P0, P1, and P2 was 134.20+10.50, 125.15+8.20, and 113.34+7.50 mg/dl, respectively. In conclusion, bandotan leaf extract decrease blood cholesterol levels of broiler.Key words: broiler, bandotan leaf extract, total cholesterol level

scholarly journals EFFECT OF PROBIOTIC AND PREBIOTIC CONSUMPTION ON BLOOD CHOLESTEROL LEVEL IN THE ELDERLY IN POSYANDU MANISJANGAN YOGYAKARTA

2021 ◽  
Vol 10 (3) ◽  
pp. 227-232
Author(s):  
Diyan Yunanto Setyaji ◽  
Fransisca Anjar Rina Setyani
Keyword(s):  
Cholesterol Level ◽  
Mung Bean ◽  
Lactobacillus Casei ◽  
The Elderly ◽  
Fermented Milk ◽  
Blood Cholesterol ◽  
Control Group ◽  
Blood Cholesterol Level ◽  
Cholesterol Levels ◽  
Lactobacillus Casei Shirota

Background: With advanced age, an increase in lipid profile is associated with the incidence of cardiovascular disease. Previous studies showed that the administration of probiotic and/or prebiotic are effective in improving lipid profiles. However, other studies have also shown that probiotic and prebiotic had insignificant effects on lipid profiles.Objectives: Determined the effects of probiotic and prebiotic on blood cholesterol level in the elderly.Methods: A total of 64 elderly who did not take cholesterol-lowering drugs enrolled in the quasi-experiment pretest-posttest design and were assigned to three interventions and control groups. The subjects in PRE-group consumed 100 grams of mung bean porridge per day; the subjects in PRO-group consumed 65 ml of fermented milk enriched with Lactobacillus casei Shirota strain per day; the subjects in PREPRO-group consumed 100 grams of mung bean porridge and 65 ml of fermented milk enriched with Lactobacillus casei Shirota strain per day. All intervention groups received treatment for 4 weeks. The control group did not receive any treatment during the study. Before and after treatment, cholesterol data was collected. Paired t-test, ANOVA, Post-hoc LSD were used for statistical analysis.Results There was an increase in cholesterol levels in PRE, PRO, PREPRO-groups (12.93 mg/dL; 48.37 mg/dL; and 7.62 mg/dL). Among the three intervention groups, only the consumption of probiotic was significant for changes in blood cholesterol levels (p 0.023). The administration of various interventions did not have a significant effect on changes in cholesterol levels (p 0.246) when compared to the control group.Conclusion: Prebiotic and probiotic do not lower blood cholesterol level in the elderly in Posyandu Manisjangan Yogyakarta.

scholarly journals The intestinal microbiota regulates host cholesterol homeostasis

BMC Biology ◽  
2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Tiphaine Le Roy ◽  
Emelyne Lécuyer ◽  
Benoit Chassaing ◽  
Moez Rhimi ◽  
Marie Lhomme ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Cholesterol Level ◽  
Intestinal Microbiota ◽  
Cholesterol Synthesis ◽  
Plasma Cholesterol ◽  
Cholesterol Homeostasis ◽  
Blood Cholesterol ◽  
Hepatic Cholesterol ◽  
Hepatic Cholesterol Synthesis ◽  
Cholesterol Levels

Abstract Background Management of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale. Results We depleted the intestinal microbiota of hypercholesterolemic female Apoe−/− mice using broad-spectrum antibiotics. Measurement of plasma cholesterol levels as well as cholesterol synthesis and fluxes by complementary approaches showed that the intestinal microbiota strongly regulates plasma cholesterol level, hepatic cholesterol synthesis, and enterohepatic circulation. Moreover, transplant of the microbiota from humans harboring elevated plasma cholesterol levels to recipient mice induced a phenotype of high plasma cholesterol levels in association with a low hepatic cholesterol synthesis and high intestinal absorption pattern. Recipient mice phenotypes correlated with several specific bacterial phylotypes affiliated to Betaproteobacteria, Alistipes, Bacteroides, and Barnesiella taxa. Conclusions These results indicate that the intestinal microbiota determines the circulating cholesterol level and may thus represent a novel therapeutic target in the management of dyslipidemia and cardiovascular diseases.

Assessing Population-Based Programs to Reduce Blood Cholesterol Level and Saturated Fats

1991 ◽  
Vol 7 (3) ◽  
pp. 315-326 ◽  
Author(s):  
Erkki Vartiainen ◽  
Gregory Heath ◽  
Earl Ford
Keyword(s):  
Cholesterol Level ◽  
Intervention Group ◽  
Saturated Fat ◽  
Blood Cholesterol ◽  
Published Data ◽  
Blood Cholesterol Level ◽  
Reference Area ◽  
Cholesterol Levels ◽  
Saturated Fats ◽  
Intervention Area

AbstractThis article reviews seven community-based programs for prevention of cardiovascular disease and their effects on blood cholesterol levels and saturated fat intake. In two programs, cholesterol levels were reduced more in the intervention area than in the reference area. In two other programs, cholesterol increased less in the intervention area than in the reference area. In one program, cholesterol levels initially fell in the intervention group and increased in the reference group; after the first 4 years, the levels also started to increase in the intervention group. The final two programs reduced cholesterol equally in both groups. Only two programs reported on the intake of saturated fats; in both, intake of saturated fat was reduced more in the intervention area than in the reference populations. In one program area, total intake of fat was reduced more than in the reference area. Published data do not allow us to draw conclusions regarding which components of the programs were most important. These studies show that the average blood cholesterol level can be affected in a general population.

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