QUANTITATIVE STUDIES ON THE HORMONAL INDUCTION OF OESTRUS IN SPAYED EWES

1955 ◽  
Vol 12 (3) ◽  
pp. 163-173 ◽  
Author(s):  
T. J. ROBINSON
Keyword(s):  
Hormonal Control ◽  
Behaviour Pattern ◽  
Physiological Changes ◽  
Quantitative Studies ◽  
Oestradiol Benzoate ◽  
Endogenous Oestrogen ◽  
The Mean ◽  
The Difference ◽  
Response Line ◽  
Mean Time

SUMMARY Seven trials were conducted with sixty-nine ovariectomized Suffolk cross-bred ewes to determine the requirements of oestradiol benzoate (ODB), given alone or preceded by 75 mg progesterone (6 × 12·5 mg in oil over 3 days, followed 2 days later by oestrogen), for oestrous behaviour and characteristic vaginal changes. Progesterone pretreatment resulted in a marked increase of sensitivity to oestrogen. For oestrus, the respective values of the median effective dose (ED 50) for ODB preceded by progesterone and for ODB alone were 22 and 64 μg, the difference being significant (P<0·001). The 99% fiducial limits associated with these estimates were respectively 19 and 26 μg and 52 and 81 μg. For vaginal changes the corresponding values were 10-14-17 and 20-24-28 (P<0·001). Progesterone pretreatment resulted in an apparently steeper dose-response line for oestrus, and advanced the mean time of onset by about 12 hr. The behaviour pattern following progesterone—ODB appeared to differ from that following ODB alone. Oestrus in the ewe appears to be under dual hormonal control. Endogenous oestrogen production is insufficient to induce the full psychic and physiological changes associated with normal oestrus, unless the animal has been conditioned previously by progesterone.

scholarly journals Lateral Antebrachial Cutaneous Nerve as a Donor Source for Digital Nerve Grafting: A Concept Revisited

2017 ◽  
Vol 11 (1) ◽  
pp. 1041-1048 ◽  
Author(s):  
Mehmet Bekir Unal ◽  
Kemal Gokkus ◽  
Evrim Sirin ◽  
Eren Cansü
Keyword(s):  
Pearson Correlation ◽  
Mean Value ◽  
Cutaneous Nerve ◽  
Digital Nerve ◽  
Mean Values ◽  
Nerve Grafts ◽  
The Mean ◽  
The Difference ◽  
Mean Time

Objective: The main objective of this study is to evaluate the availability of lateral antebrachial cutaneous nerve (LACN) autograft for acute or delayed repair of segmented digital nerve injuries. Patients and Methods: 13 digital nerve defects of 11 patients; treated with interposition of LACN graft that harvested from ipsilateral extremity were included in the study. Mean follow up period was 35, 7 months. The mean time from injury to grafting is 53, 3 days. The results of the mean 2PDT and SWMT values of injured /uninjured finger at the end of follow up period were evaluated with Paired T test. The correlation between the defect length and the difference of 2PDT, SWMT values between the uninjured and injured finger at the end of follow up period; were evaluated with Pearson - correlation analysis. Results: The mean value of our 2PDT and SWMT results are ~5,923, ~3, 52, respectively in which can be interpreted between the normal and diminished light touch. The defect length and difference percentage of SWMT values is positively and significantly correlated statistically. Mean length of interposed nerve grafts was 18.5 mm. The age of the patient and the mean values of 2PDT and SWMT with the difference % of 2PDT and % of SWMT are not statistically correlated. Conclusion: Based on results regarding sensory regaining at recipient side and negligible sensory deficit at harvesting side, we suggest that lateral antebrachial cutaneous nerve might be a valuable graft option for digital nerve defects.

Analysis of reproducibility, evaluation, and preference of the new iC100 rebound tonometer versus iCare PRO and Perkins portable applanation tonometry

2019 ◽  
Vol 30 (6) ◽  
pp. 1349-1355 ◽  
Author(s):  
Mercedes Molero-Senosiaín ◽  
Laura Morales-Fernández ◽  
Federico Saenz-Francés ◽  
Julian García-Feijoo ◽  
Jose María Martínez-de-la-Casa
Keyword(s):  
Intraocular Pressure ◽  
Visual Analogue Scale ◽  
Analogue Scale ◽  
Normal Subjects ◽  
Applanation Tonometry ◽  
Rebound Tonometer ◽  
The Mean ◽  
The Difference ◽  
The Comparative Study ◽  
Mean Time

Objectives: To analyze the reproducibility of the new iC100 rebound tonometer, to compare its results with the applanation tonometry and iCare PRO and to evaluate the preference between them. Materials and methods: For the study of reproducibility, 15 eyes of 15 healthy Caucasian subjects were included. Three measurements were taken each day in three separate sessions. For the comparative study, 150 eyes of 150 Caucasian subjects were included (75 normal subjects and 75 patients with glaucoma). Three consecutive measurements were collected with each tonometer, randomizing the order of use. The discomfort caused by each tonometer was evaluated using the visual analogue scale. Results: No statistically significant differences were detected between sessions. In the comparison between tonometers, the measurements with iC100 were statistically lower than those of Perkins (−1.35 ± 0.417, p = 0.004) and that iCare PRO (−1.41 ± 0.417, p = 0.002). The difference between PRO and Perkins was not statistically significant ( p = 0.990). The mean time of measurement (in seconds) with iC100 was significantly lower than with Perkins (6.74 ± 1.46 vs 15.53 ± 2.01, p < 0.001) and that PRO (6.74 ± 1.46 vs 11.53 ± 1.85, p < 0.001). Visual analogue scale score with iC100 was lower than Perkins (1.33 ± 0.99 vs 1.73 ± 1.10, p < 0.05). In total, 61.7% preferred iC100 against Perkins. Conclusion: The reproducibility of this instrument has been proven good. iC100 underestimates intraocular pressure compared to applanation tonometry at normal values and tends to overestimate it in high intraocular pressure values. Most of the subjects preferred iC100 tonometer.

scholarly journals Which Surgical Method is More Effective in the Fifth Metatarsal Base Fracture?

2017 ◽  
Vol 2 (3) ◽  
pp. 2473011417S0002
Author(s):  
Jun-Beom Kim ◽  
Chi Ahn ◽  
Byeong-Seop Park
Keyword(s):  
Clinical Results ◽  
Plate Group ◽  
Group A ◽  
The Mean ◽  
The Difference ◽  
Group B ◽  
Clinical And Radiological Results ◽  
Mean Time ◽  
Screw Group

Category: Trauma Introduction/Purpose: The aim of this study was to evaluate and compare the clinical and radiological results of internal fixation with headless cannulated screw and locking compression distal ulna hook plate for the fracture at the base of fifth metatarsal bone, Zone 1. Methods: From April 2012 to April 2015, thirty cases (29 patients) were evaluated retrospectively. The mean follow up periods was 13 months. There were divided two groups based on use of the screw (group A, n=15) or the plate (group B, n=15).We measured the displacement to diastasis of the fracture on the foot oblique radiographs taken pre- and post-operatively in each group, checked the time to bone union and the difference of the reduction distance in each group. Clinical results were evaluated using American Orthopedic Foot and Ankle Society (AOFAS) midfoot score at 12 months postoperative. Results: In group A, the mean time to union was 54.2±9.3 days, the mean displacement to diastasis improved to 0.3±0.4 mm postoperatively (p<0.001), and the mean reduction distance was 2.9±1.0 mm. In group B, the mean time to union was 41.5±7.0 days, the mean displacement to diastasis improved to 0.06±0.2 mm postoperatively (p<0.001), and the mean reduction distance was 4.1±1.6 mm. AOFAS score was verified 97.7±3.4 in group A and 98.2±3.2 in group B. The time to union was significantly different between groups A and B (p=0.01).There were no complications. Conclusion: We suggest that the plate is more effective method for the shorter union time in surgical treatment of fifth metatarsal base fractures.

THE ASSAY OF CORTICOTROPHIN IN MICE

1963 ◽  
Vol 44 (2) ◽  
pp. 237-249 ◽  
Author(s):  
Claus Rerup ◽  
Pavo Hedner
Keyword(s):  
Subcutaneous Administration ◽  
Small Sample ◽  
Lower Body ◽  
Sample Analysis ◽  
Lower Body Weight ◽  
Increased Sensitivity ◽  
The Mean ◽  
The Difference ◽  
Response Line ◽  
Free Plasma

ABSTRACT The assay of corticotrophin was performed in mice by means of small sample analysis of free plasma corticosteroids. In this method hypophysectomy was replaced by dexamethasone pretreatment. The response was measured preferably in a single mouse weighing 20 g or more. When mice of a lower body weight were used the plasma of two randomly assigned mice was pooled. Corticosteroids (mainly corticosterone) were determined fluorometrically in 0.25 (0.20) ml samples of plasma from heparinized blood. The results show that valid corticotrophin assays can be performed in mice both by the intravenous and subcutaneous route. Compared with the adrenal ascorbic acid depletion method or the plasma corticosteroid method in the rat the assay in mice was found to be at least five times more sensitive. 40 micro-units of corticotrophin were consistently detectable. Precision was dependent on the route of administration, the mean index of precision (s/b) being 0.20 in the intravenous and 0.12 in the subcutaneous assay. The difference was due to a steeper slope of the logdose-response line after subcutaneous administration. Contrary to the findings in the rat, corticotrophin A (oxycel purified) did not differ significantly in potency estimates from subcutaneous and intravenous assays in mice, when crude corticotrophin (U. S. P. Corticotropin Reference Standard) was the basis of comparison. Accordingly results of subcutaneous assays of corticotrophin A samples in terms of the U. S. P. standard were lower in mice than in rats. The use of gelatine instead of saline as diluent in the subcutaneous assays yielded slightly but not significantly higher potency estimates (25 per cent). The interpretation of the results is that for intravenous corticotrophin assays the mouse method is comparable to the rat assay. For subcutaneous corticotrophin assays, however, the mouse method is not suitable, if crude corticotrophin (U. S. P. standard) is the basis of comparison, but if corticotrophin A (oxycel purified) is the standard of reference (e. g. the Third International Standard for Corticotrophin), the mouse method may justifiably be used. The advantages of the mouse method are increased sensitivity, precision, convenience, and economy.

Using discrete-event simulation to increase the efficiency of point of distribution sites

2018 ◽  
Vol 16 (5) ◽  
pp. 279
Author(s):  
Patrick Glass, MS, MPH ◽  
Eric Dietz, PhD ◽  
Pamela Aaltenon, PhD, RN
Keyword(s):  
Computer Simulation ◽  
Simulation Model ◽  
Discrete Event ◽  
T Test ◽  
Computer Simulation Model ◽  
Group A ◽  
The Mean ◽  
The Difference ◽  
Group B ◽  
Mean Time

Objective: The objective of this research was to develop a computer simulation model that will provide the most optimal allocation of resources for a point of distribution (POD) site.Design: A baseline assessment was conducted by participants establishing POD sections with no guidance from the investigator. A computer model was built with four stations: triage, registration, screening, and dispensing. The information from the computer simulation was used to design the allocation of volunteers for the experimental group. Once the data were collected, a two-sample t test was used to determine the significance of the difference between the average times of the two groups to complete the POD.Setting: The POD site was conducted indoors with volunteers acting as patients, and volunteer nursing students, and pharmacy students acting as POD workers. Volunteers were divided into two groups, group B, experimental and group A, control. Time was recorded using a digital time-stamp at the beginning and at the end of the POD.Interventions: The researcher inputted the total number of volunteers into the model, and the model generated the most applicable ratio for distribution of human capital: a one-to-one ratio of screeners to dispensers. Main outcome measures: The mean time for Group A was 4.55 minutes (95% CI: 4.27, 4.83). The mean time for group B was 3.05 minutes (95% CI: 2.79, 3.31). A two-sample t test and Analysis of Variance of these data show that the difference is meaningful (p < 0.001).Results: The results show that a discrete-event computer simulation can be used to identify the most efficient use of resources in order to decrease the amount of time that patients are required to participate.Conclusions: The discrete-event computer simulation model was found to be effective at identifying ways to increase efficiency and reduce the overall time required by patients to complete the POD.

Clinical signs and duration of cyanide toxicosis delivered by the M-44 ejector in wild dogs

2006 ◽  
Vol 33 (3) ◽  
pp. 181 ◽  
Author(s):  
Amber L. Hooke ◽  
Lee Allen ◽  
Luke K.-P. Leung
Keyword(s):  
Initial Phase ◽  
Clinical Signs ◽  
Sodium Cyanide ◽  
Cerebral Hypoxia ◽  
Ocular Reflex ◽  
Righting Reflex ◽  
The Mean ◽  
The Difference ◽  
Wild Dogs ◽  
Mean Time

Sodium cyanide poison is potentially a more humane method to control wild dogs than sodium fluoroacetate (1080) poison. This study quantified the clinical signs and duration of cyanide toxicosis delivered by the M-44 ejector. The device delivered a nominal 0.88 g of sodium cyanide, which caused the animal to loose the menace reflex in a mean of 43 s, and the animal was assumed to have undergone cerebral hypoxia after the last visible breath. The mean time to cerebral hypoxia was 156 s for a vertical pull and 434 s for a side pull. The difference was possibly because some cyanide may be lost in a side pull. There were three distinct phases of cyanide toxicosis: the initial phase was characterised by head shaking, panting and salivation; the immobilisation phase by incontinence, ataxia and loss of the righting reflex; and the cerebral hypoxia phase by a tetanic seizure. Clinical signs that were exhibited in more than one phase of cyanide toxicosis included retching, agonal breathing, vocalisation, vomiting, altered levels of ocular reflex, leg paddling, tonic muscular spasms, respiratory distress and muscle fasciculations of the muzzle.

scholarly journals Memoir on the rotation of crops, and on the quantity of inorganic matters abstracted from the soil by various plants under different circumstances

1851 ◽  
Vol 5 ◽  
pp. 551-554
Keyword(s):  
Botanic Garden ◽  
Chemical Examination ◽  
Agricultural College ◽  
Three Samples ◽  
Short Period ◽  
Chemical Constitution ◽  
University College London ◽  
The Mean ◽  
The Difference ◽  
Mean Time

The author was first led to undertake the researches of which an account is given in the present memoir, by the expectation of verifying the theory of De Candolle, in which the deterioration experienced by most crops on their repetition was attributed to the deleterious influence of their root-excretions. For this purpose he set apart, ten years ago, a number of plots of ground in the Botanic Garden at Oxford, uniform as to quality and richness, one-half of which was planted each year, up to the present time, with the same species of crop, and the other half with the same kinds, succeeding each other in such a manner that no one plot should receive the same crop twice during the time of the continuance of the experiments, or at least not within a short period of one another. The difference in the produce obtained in the two crops, under these circumstances, would, the author conceived, represent the degree of influence ascribable to the root-excretions. The results obtained during the first few years from these experiments, as well as from the researches which had, in the mean time, been communicated to the world by M. Braconnot and others on the same subject, led him in a great measure to abandon this theory, and to seek for some other mode of explaining the falling-off of crops on repetition. In order to clear up the matter, he determined to ascertain, for a series of years, not only the amount of crop which would be obtained from each of the plants tried under these two systems, but also the quantity of inorganic matters extracted in each case from the soil, and the chemical constitution of the latter, which had furnished these ingredients. The chemical examination of the crops, however, on account of the labour it involved, was confined to six out of the number of the plants cultivated; and of these, three samples were analysed; the first being the permanent one, viz. that cultivated for nine or ten successive years in the same plot of ground; the second, the shifting one, obtained from a plot which had borne different crops in the preceding years; and the third, the standard, derived from a sample of average quality, grown under natural circumstances, either in the Botanic Garden itself, or in the neighbourhood of Oxford. These analyses were performed by Mr. Way formerly assistant to Professor Graham, of University College, London, and now attached to the Agricultural College near Cirencester.

scholarly journals Religion, Radicalism and National Character: In Perspective of South Sulawesi Local Wisdom

2018 ◽  
Vol 18 (2) ◽  
pp. 201
Author(s):  
Mahmuddin Mahmuddin
Keyword(s):  
Social Issues ◽  
Daily Life ◽  
National Character ◽  
South Sulawesi ◽  
The Mean ◽  
The Difference ◽  
Social Capitals ◽  
Mean Time

It is widely believed that Indonesia is encountering an issue of disharmony due to a number of horizontal conflicts which are based on ethnics, religions, and races. In addition, there are many social issues also happen in recent years that stimulate the conflicts. For example, the rampant of drugs users across the country and the increase of significant number of terrorists in many regions in Indonesia. The writer believes that one of the main reasons of these conflicts is lacking of understanding nation charachter as well as local wisdoms that owned by certain community. In the mean time, Indonesia as country is rich of characters that can unite community under the flag of nation and diminish conflicts among them. In the context of South Sulawesi region, there are, at least, three different characters that can decrease the emergence of radicalism. Firstly, respect to the difference. Secondly, they are open-minded. Thirdly, maintaining tradition of ashame (siri) as a local genius. These characters are social capitals of South Sulawesi communities in tackling radicalism understanding. The writer come to conclude that if every single ethnics in Indonesia make their local genius as their philosophy in daily life, the radicalism movement might be tackled across the country.[Dipercaya secara luas bahwa Indonesia menghadapi masalah ketidakharmonisan karena sejumlah konflik horizontal yang didasarkan pada etnis, agama, dan ras. Selain itu, ada banyak masalah sosial juga terjadi dalam beberapa tahun terakhir yang merangsang konflik. Misalnya, merajalela pengguna narkoba di seluruh negeri dan meningkatnya jumlah teroris yang signifikan di banyak wilayah di Indonesia. Penulis percaya bahwa salah satu alasan utama dari konflik ini adalah kurangnya pemahaman tentang karakter bangsa dan juga kearifan lokal yang dimiliki oleh masyarakat tertentu. Sementara itu, Indonesia sebagai negara kaya akan karakter yang bisa menyatukan masyarakat di bawah bendera negara dan mengurangi konflik di antara mereka. Dalam konteks wilayah Sulawesi Selatan, setidaknya ada tiga karakter berbeda yang dapat menurunkan kemunculan radikalisme. Pertama, hargai perbedaannya. Kedua, mereka berpikiran terbuka. Ketiga, menjaga tradisi ashame (siri) sebagai jenius lokal. Karakter ini adalah ibu kota sosial masyarakat Sulawesi Selatan dalam mengatasi pemahaman radikalisme.  Penulis kemudian menyimpulkan bahwa jika setiap etnis di Indonesia membuat jenius lokal mereka sebagai filosofi mereka dalam kehidupan sehari-hari, gerakan radikalisme dapat ditangani di seluruh negeri.]

scholarly journals Efficacy of Intrathecal Neostigmine with Intrathecal Dexmedetomidine in Postoperative Analgesia

2020 ◽  
Vol 5 (2) ◽  
pp. 39-42
Author(s):  
Nischala Reddy G ◽  
Ajay Babu Ramakrishnan ◽  
S. Ankalagowri Sankardevar ◽  
Uthkala B Hegde
Keyword(s):  
Motor Block ◽  
Sensory Block ◽  
Sedation Score ◽  
Age Group ◽  
Group I ◽  
The Mean ◽  
Group Ii ◽  
The Difference ◽  
Hyperbaric Solution ◽  
Mean Time

Background: The present study was conducted to compare the efficacy of intrathecal neostigmine with intrathecal dexmedetomidine in postop- erative analgesia. Subjects and Methods: The present study was conducted in the department of Anesthesia involving 100 patients belonging to ASA grade I and II, posted for elective Sub umbilical surgeries, under spinal anaesthesia. Group I patients received 3.0ml of hyperbaric solution of 0.5% bupivacaine + 50mcg (0.5ml) of Neostigmine. Group II patients received 3.0ml of hyperbaric solution of 0.5% bupivacaine + 10mcg (0.5ml) of dexmedetomidine. Results: The maximum patients were seen in age group 18-30 years ie 10 in group I and 16 in group II and minimum in 41-50 years ie 6 in group I and 4 in group II. The mean time for onset of sensory block in group I was 1.43 0.53 min and in group II was 2.319   0.44 min. The mean time for onset of peak sensory block in group I was 5.48    0.43 min and Group II was 7.31    0.44 min.  Time for two segment regression was significantly higher in dexmedetomidine group as compared to neostigmine group, the mean time for two segment regression in group I was 124.98 21.48 min and group II was 165.24 14.45 min. The mean time for onset of motor block was 3.079 0.44 min in group I and 4.0454  0.38 min in group II. The mean duration of motor block in group I was 191.58  26.81 min and 324   36.8 min in group II. The difference was significant (P< 0.05). The mean sedation score in group I was 1.03 and in group II was 2.07. The difference was significant (P< 0.05). Conclusion: Authors recommend the use of dexmedetomidine as an adjuvant to bupivacaine in subarachnoid block

scholarly journals Reticulocyte rigidity and passage through endothelial-like pores

Blood ◽  
1991 ◽  
Vol 78 (11) ◽  
pp. 3037-3042 ◽  
Author(s):  
RE Waugh
Keyword(s):  
Mechanical Properties ◽  
Bone Marrow ◽  
In Vitro Model ◽  
Gradient Centrifugation ◽  
The Mean ◽  
The Difference ◽  
Vitro Model ◽  
Mean Time ◽  
Endothelial Pores

The importance of cell rigidity in regulating the release of reticulocytes from the bone marrow has been investigated in a model system. Reticulocytes were obtained from phlebotomized rabbits and separated from whole blood by discontinuous density gradient centrifugation. The mechanical properties of the cells were tested. Using single-cell micromechanical techniques, the membrane elastic rigidity and the viscoelastic response of reticulocyte and mature cell populations were measured. The reticulocyte membranes were more rigid than the mature membranes, but the reticulocyte properties were heterogeneous, and some cells exhibited behavior indistinguishable from the mature cells. The mean time constant for viscoelastic recovery was the same for reticulocytes as for mature cells, but the variability within the reticulocyte population was greater. The possible influence of this increased rigidity on cell egress from the bone marrow was tested using an in vitro model of the thin endothelial pores found within the marrow. A silicon wafer approximately 0.1 microns in thickness and containing a small (1.2-microns diameter) pore in its center was cemented over the tip of a large (15.0-microns ID) micropipette. The passage of cells through the pore was observed as a function of the pressure across the pore. Consistent with the difference in mechanical properties, the reticulocytes required greater pressures (as great as 4.0 mm Hg compared with less than 1.0 mm Hg) and took longer to traverse the pore. These measurements support the postulate that deformability is important in the regulation of the release of cells from bone marrow.

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