A LONGITUDINAL STUDY OF THE URINARY EXCRETION OF INDIVIDUAL STEROIDS IN CHILDREN FROM 8 TO 12 YEARS OLD

1968 ◽  
Vol 41 (2) ◽  
pp. 139-156 ◽  
Author(s):  
J. M. TANNER ◽  
D. GUPTA
Keyword(s):  
Longitudinal Study ◽  
Urinary Excretion ◽  
Skeletal Maturity ◽  
Skeletal Age ◽  
Chronological Age ◽  
Low Level ◽  
Maturity Score

SUMMARY A longitudinal study was made of the urinary excretion of a number of C19 and C21 steroids in 11 healthy boys and 9 healthy girls aged 8–12 yr. Urine collections were made every 6 months, over periods ranging from 1 to 2½ yr. in different children. The excretions of most substances showed surprisingly regular increments in individual children. Differences between individual children were marked and often consistent; some children excreted high amounts of one substance and low amounts of another, and other childen the reverse. The variation between individuals in the excretion of substances such as androsterone and aetiocholanolone was reduced when the results were plotted against skeletal rather than chronological age. DHA was excreted by all subjects, but at a very low level before the skeletal age of 10 yr. The glucuronide: sulphate ratio of the 11-deoxy-17-oxosteroids fell consistently from 8 to 12 yr. whereas the ratio of 5α-: 5β-11-deoxy-17-oxosteroids increased. Boys excreted more C19 steroids than girls with the same skeletal maturity score. This comparison is physiologically more meaningful than comparing boys and girls of the same chronological age.

A LONGITUDINAL STUDY OF THE URINARY EXCRETION OF INDIVIDUAL STEROIDS IN CHILDREN FROM 3 TO 7 YEARS OLD

1971 ◽  
Vol 68 (1) ◽  
pp. 141-163 ◽  
Author(s):  
D. Gupta ◽  
W. A. Marshall
Keyword(s):  
Sex Differences ◽  
Longitudinal Study ◽  
Urinary Excretion ◽  
Skeletal Maturity ◽  
Older Children ◽  
Significant Relationships ◽  
The Mean ◽  
Mean Trend ◽  
Steroid Excretion ◽  
Cortisol Metabolites

ABSTRACT A longitudinal study was made of the daily urinary excretion, on or near each birthday, of a number of C19 and C21 steroids in 9 healthy girls and 5 healthy boys aged 3 to 7 years. The amount of androsterone excreted by each individual increased slowly during the period of study but the absolute amounts varied greatly between individuals. The excretion of aetiocholanolone was greater than that of androsterone, contrary to reported findings in older children. Small amounts of DHA were found. Testosterone was found in only about 40% of samples; epitestosterone in 70 % and 11β-OH-androsterone in only 62 %. Cortisol metabolites were excreted in amounts which increased with age and all three metabolites of corticosterone were present in most specimens. 11-Deoxycortisol was found in about 50 % of the samples and THS in 63 %. The mean trend in the ratio of glucuronides to sulphates of the 11-deoxy-17-oxosteroids decreased with increasing age, but the 11-deoxy-11-oxy ratio of 17-oxosteroids increased as did the 5α/5β ratio of the C19 and C21 steroids. No sex differences were observed. The excretion of cortisol metabolites showed a positive correlation with height and weight. 11-Deoxy-17-oxosteroids were positively correlated with the weight. No significant relationships between steroid excretion and skeletal maturity were found.

scholarly journals Correlation between chronological age and skeletal age using CVMI and modified MP3 methods

2020 ◽  
Vol 16 (12) ◽  
pp. 1045-1050
Author(s):  
Ravindra Kumar Jain ◽  
Keyword(s):  
Skeletal Maturity ◽  
Cervical Vertebrae ◽  
Skeletal Age ◽  
Chronological Age ◽  
Accurate Estimation ◽  
P Value ◽  
Positive Correlation ◽  
Lateral Cephalograms ◽  
Rough Approximation ◽  
Method R

Chronological age conveys only a rough approximation of the maturational status of a person whereas skeletal maturity indicators give a more accurate estimation. Therefore, it is of interest to document the correlation between chronological and skeletal age using CVMI and modified MP3 methods. A total of 39 subjects between the age ranges of 9-16 years were selected for this study. Pre-treatment lateral cephalograms and hand-wrist radiographs of the subjects were used. The skeletal age was analyzed by the Cervical Vertebrae Maturity Index (CVMI) and modified MP3 methods. The data was analyzed with SPSS software version 23.00. Kendall’s Tau correlation test was performed to estimate the correlation between chronological age and skeletal age among the subjects and a linear regression test was also performed. Positive correlation was found between chronological age and skeletal age assessed by CVMI method (r= 0.398) and modified MP3 method (r=0.382) with p value <0.003. Thus it can be concluded that there was a positive correlation between chronological age and skeletal age among all the subjects.

Tryptophan-Niacin Metabolism in Rat with Puromycin Aminonucleoside-Induced Nephrosis

2006 ◽  
Vol 76 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Yukari Egashira ◽  
Shin Nagaki ◽  
Hiroo Sanada
Keyword(s):  
Body Weight ◽  
Urinary Excretion ◽  
Enzyme Activities ◽  
Treated Group ◽  
Control Group ◽  
Puromycin Aminonucleoside ◽  
Low Level ◽  
Key Enzyme

We investigated the change of tryptophan-niacin metabolism in rats with puromycin aminonucleoside PAN-induced nephrosis, the mechanisms responsible for their change of urinary excretion of nicotinamide and its metabolites, and the role of the kidney in tryptophan-niacin conversion. PAN-treated rats were intraperitoneally injected once with a 1.0% (w/v) solution of PAN at a dose of 100 mg/kg body weight. The collection of 24-hour urine was conducted 8 days after PAN injection. Daily urinary excretion of nicotinamide and its metabolites, liver and blood NAD, and key enzyme activities of tryptophan-niacin metabolism were determined. In PAN-treated rats, the sum of urinary excretion of nicotinamide and its metabolites was significantly lower compared with controls. The kidneyα-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) activity in the PAN-treated group was significantly decreased by 50%, compared with the control group. Although kidney ACMSD activity was reduced, the conversion of tryptophan to niacin tended to be lower in the PAN-treated rats. A decrease in urinary excretion of niacin and the conversion of tryptophan to niacin in nephrotic rats may contribute to a low level of blood tryptophan. The role of kidney ACMSD activity may be minimal concerning tryptophan-niacin conversion under this experimental condition.

COMPARISION OF DENTAL SCORING SYSTEM WITH RADIOGRAPHIC SKELETAL SYSTEM IN AGE ESTIMATION

JKCD ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 9-11
Author(s):  
Sadaf Ambreen
Keyword(s):  
Age Estimation ◽  
Scoring System ◽  
Skeletal Age ◽  
Chronological Age ◽  
Age Group ◽  
Dental Age ◽  
Scoring Method ◽  
Cross Sectional ◽  
Study Results ◽  
Male Subjects

Objectives: To compare Demirjian Dental scoring method with Greulich-Pyle (GP) Skeletal method of age estimation in pubertal children. Materials and Methods: Sample of the study included 267 male healthy subjects of 11-16 years of age group.. Demirjian Scoring system was utilized to evaluate the orthopantomograms to assess their Dental age and the Hand-Wrist radiographs were analyzed to calculate the skeletal age by utilizing GP atlas. Chronological age was obtained from the date of birth of the subject .Both methods were compared with one another and with the chronological age. It was a cross-sectional study and only healthy male subjects without any clinical abnormalities were included in the study. Results: A total of 267 male subjects of 11-16 years of age group were assessed by Demirjian and Greulich Pyle Methods. Both were compared with Chronological Age. Data obtained was statistically analyzed and the Student “t” test was applied in the study population. The mean difference between Chronolgical age and dental age was 0.69years and that of chronological age and skeletal age was 0.87 years. It was observed from dental age assessment that it does not differ much from the skeletal age. Conclusion: It was concluded that Demirjian method of Age Estimation is more precise than Greulich Pyle method of Age Estimation. Furthermore both methods can be used selectively in Medicolegal cases to access bone age which can be easily correlated to chronological age.

An Evaluation of the Effects of Elevated Body Mass Index on Skeletal Age

2021 ◽  
Author(s):  
Michael H. French ◽  
Michael S. Kung ◽  
W. Nathan Holmes ◽  
Hossein Aziz ◽  
Evelyn S. Thomas ◽  
...  
Keyword(s):  
Chart Review ◽  
Pediatric Patients ◽  
Intraclass Correlation ◽  
Retrospective Chart Review ◽  
Skeletal Age ◽  
Chronological Age ◽  
Age Group ◽  
Obese Children ◽  
Significant Difference ◽  
Hand Radiographs

Abstract BackgroundMany treatment decisions in children’s Orthopaedics are based on age. This study determined whether a discrepancy between chronological age (CA) and skeletal age (SA) is dependent on BMI and if overweight or obese children would have an advanced SA.Materials and Methods120 children between ages 8-17 with an adequate hand radiograph and a correlating BMI were enrolled by retrospective chart review. Stratification based on age, sex, ethnicity, and BMI percentile was performed. For each age group, 6 males and 6 females were selected with 50% of each group having an elevated BMI. Two blinded physicians independently evaluated hand radiographs and recorded the SA. Statistical analyses evaluated inter-rater reliability and any discrepancy between groups.ResultsThe final statistical analysis included 96 children. The Intraclass Correlation Coefficient for SA determined by the two reviewers was excellent at 0.95. A difference of 13 months was found between CA and SA in the elevated BMI cohort versus the non-elevated BMI cohort, (p<0.001). No significant difference was seen between CA and SA for the non-elevated cohort (p=0.72), while matching for age and sex. ConclusionChronological age and skeletal age are not always equivalent especially in pediatric patients who are overweight or obese.

scholarly journals Assessment of Skeletal and Dental Maturity Levels for a given Chronological Age among Indian Children

2012 ◽  
Vol 13 (3) ◽  
pp. 310-315 ◽  
Author(s):  
K Krishna Murthy ◽  
C Nagendra Srinivas ◽  
Varalakshmi LNU ◽  
C Vijay Kumar ◽  
M Krishnaveni
Keyword(s):  
Treatment Planning ◽  
Clinical Significance ◽  
Skeletal Age ◽  
Diagnosis And Treatment ◽  
Chronological Age ◽  
Dental Age ◽  
Indian Children ◽  
The Individual ◽  
Dental Maturity

ABSTRACT Aim The aim of this study was to evaluate the maturity levels of the individual by comparing the correlation between dental, skeletal and the chronological ages. Materials and methods Intraoral periapical radiographs of the complete right side of the dentition and posteroanterior radiographs of the hand and wrist were obtained from 260 subjects, ranged from 3 to 15 years of age. Evaluation of handwrist roentgenograms for skeletal age and intraoral roentgenograms for dental age was done. Results The findings of present study indicated that participated children were skeletally and dentally, retarded in maturation as compared with the standards except at 3 and 6 years of age. The girls were found to be skeletally more advanced than boys at all ages except 7 and 10 years of age. The dental maturity is more for girls than that of boys. Conclusion No significant correlation was found among skeletal age, dental age and chronological age. Dental age and skeletal age was found to be correlated at 6, 10 and 11 years in boys and 6 and 9 years of age in girls. Clinical significance The results of this study could enhance the diagnosis and treatment planning in orthodontics and other dental disciplines. How to cite this article Murthy KK, Srinivas CN, Varalakshmi, Kumar CV, Krishnaveni M. Assessment of Skeletal and Dental Maturity Levels for a given Chronological Age among Indian Children. J Contemp Dent Pract 2012;13(3):310-315.

scholarly journals Correlation and Correspondence between Skeletal Maturation Indicators in Hand-Wrist and Cervical Vertebra Analyses and Skeletal Maturity Score in Korean Adolescents

Children ◽  
2021 ◽  
Vol 8 (10) ◽  
pp. 910
Author(s):  
Ji Yoon Jeon ◽  
Cheol-Soon Kim ◽  
Jung-Suk Kim ◽  
Sung-Hwan Choi
Keyword(s):  
Multiple Correspondence Analysis ◽  
Rank Order ◽  
Skeletal Maturity ◽  
Age Determination ◽  
Cervical Vertebra ◽  
Skeletal Maturation ◽  
Lateral Cephalogram ◽  
Korean Adolescents ◽  
Maturity Score ◽  
Significant Difference

This retrospective observational study aimed to examine the correlation and correspondence between skeletal maturation indicators (SMI), cervical vertebral maturation indicators (CVMI), and radius-ulna-short bones (RUS) skeletal maturity scores in Korean adolescents, and to determine whether easily obtainable SMI or CVMI can replace the RUS skeletal maturity score. A total of 1017 participants were included with both hand-wrist radiograph and lateral cephalogram acquired concurrently. From the lateral cephalogram, CVMI was determined; through the hand-wrist radiograph, SMI was categorized, and the RUS skeletal maturity score was evaluated as well. Associations were examined using the Mann–Whitney U test, Spearman’s rank-order correlation analysis, and multiple correspondence analysis. There was no statistically significant difference in chronological age between males and females; however, the SMI, CVMI, and RUS skeletal maturity scores were significantly higher in females. The SMI, CVMI, and RUS skeletal maturity scores showed a statistically significant strong degree of both positive correlation and correspondence. However, a precisely corresponding RUS skeletal maturity score was difficult to obtain for a specific CVMI and SMI stage, implying the absence of a quantitative correlation. In conclusion, detailed evaluation should be conducted using the RUS skeletal maturity score, preferably in cases that require bone age determination or residual growth estimation.

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