Experience of creating and the first results of the prospective hospital registry of patients with suspected or confirmed coronavirus infection (COVID-19) and community-acquired pneumonia (TARGET-VIP)

2020 ◽  
Vol 123 (8) ◽  
pp. 6
Author(s):  
O.M. Drapkina ◽  
O.E. Karpov ◽  
M.M. Loukyanov ◽  
S.Yu. Martsevich ◽  
A.A. Pulin ◽  
...  
Keyword(s):  
Community Acquired Pneumonia ◽  
First Results ◽  
Coronavirus Infection ◽  
Hospital Registry

P2.45: Risk factors for recurrent community acquired pneumonia: first results of the CAP-Network

2004 ◽  
Vol 46 (S1) ◽  
pp. 144-144
Author(s):  
Andreas Walter ◽  
Miriam Schwartz ◽  
Y. Kohlhammer ◽  
Heiner Raspe ◽  
Torsten Schäfer
Keyword(s):  
Risk Factors ◽  
Community Acquired Pneumonia ◽  
First Results

scholarly journals Epidemiological risks and lessons from the first wave of new coronavirus infection (COVID-19) in medical organizations

2021 ◽  
Author(s):  
Yevgeniy I. Sisin Sisin
Keyword(s):  
Health Care Workers ◽  
Health Workers ◽  
Adult Population ◽  
Emergency Situation ◽  
Community Acquired Pneumonia ◽  
Parasitic Diseases ◽  
Protective Equipment ◽  
Epidemiological Investigation ◽  
Care Workers ◽  
Coronavirus Infection

The aim of the study is to study the epidemiological risks and features of the incidence of COVID-19 in medical organizations in order to develop proposals for optimizing preventive and anti-epidemic measures. Methods: we examined reporting forms "an overview of cases with positive COVID-19" (138 items), "an overview of cases of community-acquired pneumonia with positive COVID-19" (138 units), the card of epidemiological investigation of the disease COVID-19 health workers (386 units of information), copies of "Acts of epidemiological investigation of infectious (parasitic) diseases, establishing causal relationships" (47 units of information), copies of extraordinary reports about the emergency situation of sanitary-and-epidemiologic nature (47 items). We used epidemiological and statistical methods of information processing. Conclusion: the incidence of coronavirus infection in health care workers correlated with the incidence of adult population, had a higher indicator than among them, without differing in severity and outcomes of COVID-19. The prevalence of morbidity in medical organizations was the predominance among the affected employees of medical organizations. Conditions that contribute to infection were various violations of preventive and anti-epidemic measures, including the use of personal protective equipment.

scholarly journals Microbial landscape in hospital patients with new coronavirus disease (COVID-19), antibiotic resistance comparison vs. Pre-covid stage: a prospective study

2021 ◽  
Vol 28 (5) ◽  
pp. 14-28
Author(s):  
Marina G. Avdeeva ◽  
Makka I. Kulbuzheva ◽  
Sergey V. Zotov ◽  
Yelena V. Zhuravleva ◽  
Alina V. Yatsukova
Keyword(s):  
Antibiotic Resistance ◽  
Community Acquired Pneumonia ◽  
Patient Treatment ◽  
Hospital Treatment ◽  
Gram Positive ◽  
Gram Negative ◽  
Hospital Patients ◽  
Coronavirus Infection ◽  
Low Incidence ◽  
A Prospective Study

Background. The new coronavirus infection has manifested untypically compared to other acute respiratory agents, posing a major challenge to researchers worldwide. Despite low incidence of bacterial complications, microbial coinfection plays an important role in the onset and development of severe COVID-19 to hamper diagnosis, treatment and prognosis.Objectives. A study of microbial landscape in secondary complications of COVID-19 and prevailing microbial-agent antibiotic resistance dynamics in COVID-19 vs. patients with pre-COVID community-acquired pneumonia.Methods. We analysed 1,113 bacterial sputum cultures in COVID-19 patients from 21 hospital of Krasnodar Krai. The study sample comprised 524 strains isolated from COVID-19 patients in bacteriological assays. The comparison sample included 643 positive sputum strains isolated from community-acquired pneumonia patients developing disease in outcome of acute respiratory infection in 2015–2018. The microbial aetiology landscape and strain antibiotic resistance have been compared in COVID-19 vs. patients with community-acquired pneumonia.Results. Gram-negative bacteria predominated in COVID-19 cultures (58%), followed by Gram-positive bacteria (15%) and fungi (27%). Acinetobacter baumannii (35%) and Klebsiella pneumoniae (33%) were about equally represented in Gram-negative flora, Pseudomonas aeruginosa (19%) and other microorganisms were half as common. Streptococcus pneumonia and Staphylococcus aureus accounted for 48 and 15% Gram-positive strains, respectively. Sputum-isolated fungi were mainly identifi ed as Candida albicans (89%). The Streptoccocus pneumoniae detection rate dropped to 7% in 2020 relative of other flora, which is 10 times less vs. pre-COVID rates, whilst the fungal rate increased dramatically. Antibiotic resistance increased in most isolated microbial strains.Conclusion. A Gram-negative-dominated aetiology of lower respiratory tract lesions, as well as higher risk of fungal and other opportunistic coinfections should be taken into account in patient treatment for a complicated coronavirus infection. A higher antibiotic resistance is induced by active indication-ignorant use of antibiotics, including pre-hospital treatment. A suitable treatment regimen in COVID-19 should avoid undue antibiotic prescriptions in every patient.

scholarly journals Differential diagnosis of bilateral lungs opacities in the hospital for admission of community-acquired pneumonia – not only COVID-19

2020 ◽  
Vol 24 (2) ◽  
pp. 78-95
Author(s):  
A. S. Vinokurov ◽  
O. I. Belenkaya ◽  
E. A. Zolotova ◽  
S. V. Michurina ◽  
O. O. Vinokurova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Community Acquired Pneumonia ◽  
Lung Damage ◽  
Ground Glass ◽  
Small Areas ◽  
Radiological Data ◽  
Coronavirus Infection ◽  
To Receive

Due to the current epidemiological situation caused by the spread of the new SARS-CoV-2 coronavirus, in March 2020 several Moscow hospitals were completely or partially redesigned to receive patients with community- acquired pneumonia.Purpose. The aim of the survey is to analyze clinical, laboratory and radiological data in patients with coronavirus infection at the early stages of its spread in Russia, and to clarify diseases for differential diagnosis mainly based on CT evidence.Materials and methods. We studied data from 21 patients with verified coronavirus infection admitted to the hospital for community-acquired pneumonia. Clinical symptoms, laboratory and physical indicators, as well as typical lung changes on the CT were evaluated.Results. Major clinical symptoms in coronavirus patients are fever (100%), cough (90.5%), shortness of breath (76.1%). Laboratory indicators showed increases in CRP (85.7%), leukocytosis (66.6%), and LDG (84.6%). According to CT, 95.2% of lung changes involved both sides, and 66.7% occurred in all lung fields. The sign of “ground glass” was observed in a 100% of the cases, its combination with the “paving stone” – in 61,9%, “ground glass” coupled with small areas of consolidations were detected in 33,3% of the cases. Changes such as nodules, cavities and massive areas of consolidation were not identified.Conclusion. On the basis of our own data we confirmed the main trends of diagnostics and clinical features, which were identified by authors from Asia and Europe, who faced this infection earlier, and also considered important CT characteristics useful for differential diagnosis of coronavirus lung damage and other lung diseases.

EPIDEMIOLOGICAL FEATURES OF THE COURSE OF COMMUNITY-ACQUIRED PNEUMONIA IN PATIENTS OF THE CITY OF SARATOV AND SARATOV OBLAST

2020 ◽  
Author(s):  
Е.A. Chumachkova ◽  
◽  
S.A. Portenko ◽  
E.S. Kazakova ◽  
O.V. Kedrova ◽  
...  
Keyword(s):  
Outpatient Treatment ◽  
Medical Records ◽  
Community Acquired Pneumonia ◽  
Saratov Oblast ◽  
Patient Gender ◽  
Epidemiological Features ◽  
Coronavirus Infection ◽  
Etiological Agents ◽  
The Moment ◽  
The City

The aim of the study was to identify the epidemiological features of the course of community-acquired pneumonia among patients in the city of Saratov and the Saratov region during the epidemic of a new coronavirus infection. The medical records of 129 patients of various ages with a confirmed diagnosis of community-acquired pneumonia, who were on inpatient and outpatient treatment, were analyzed. The study established the predominance of pneumonia caused by COVID-19, compared to pneumonia caused by other etiological agents, and the pattern of identification of mild, moderate and severe forms of the disease from the moment the first signs of the disease appear. The computed tomography of the chest organs was proved to be the most informative diagnostic method. The severity of the inflammatory process in the lungs was analyzed depending on the age of the patient, gender, and the presence of concomitant chronic diseases.

scholarly journals Prehospital period in patients with COVID-19 and community acquired pneumonia: age characteristics, cardiovascular comorbidity and pharmacotherapy during epidemic wave (the data of hospital registry)

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
M Lukiyanov ◽  
S Y Martsevich ◽  
A A Pulin ◽  
N P Kutishenko ◽  
E Y Andreenko ◽  
...  
Keyword(s):  
Community Acquired Pneumonia ◽  
Polymerase Chain Reaction Test ◽  
Time Interval ◽  
Positive Polymerase Chain Reaction ◽  
Cardiovascular Pharmacotherapy ◽  
Significant Difference ◽  
History Of ◽  
The Mean ◽  
Hospital Registry ◽  
Epidemic Wave

Abstract Aim To estimate age characteristics, proportion of concomitant cardiovascular diseases (CVD), cardiovascular pharmacotherapy during prehospital period in patients with COVID-19 and community acquired pneumonia (CAP) according the data of hospital registry. Methods The registry included all patients admitted to the special COVID-19 center from April 6 to June 2, 2020 with suspected or confirmed COVID-19 and CAP. This enrollment period was corresponding to the main part of the first epidemic wave of COVID-19 in megapolis (the number of new cases on April 6 and July 2, 2020 was 591 and 662, respectively, the maximal number, 6703 cases, was registered on May 7). COVID-19 was diagnosed in cases of positive polymerase chain reaction test (60.7%) or according to computed tomography data. Results The registry included 1.130 patients (age 57.5±12.8 years, 51.2% men). CAP was diagnosed in 94% of cases, CVD - in 52.9%. Mean age values (from the 1-st up to the 11-th weeks of enrollment period) were, respectively, week by week: 52.8; 54.3; 57.3; 59.6; 56.9; 60.0; 57.2; 62.7; 59.3; 57.4 and 62.2 years (p<0.001; β-coefficient 0.78; 95% Confidential Interval, CI 0.50–1.07). The proportion of patients with CVD was for each of these weeks, respectively: 34.2%; 43.0%; 52.9%; 53.5%; 50.5%; 61.4%; 53.9%; 68.9; 63.1%; 54.8% and 66.7% (p<0.001; Odds Ratio 1.04; 95% CI 1.02–1.06). So, during enrollment period the mean age of patients increased significantly (on average by 0.78 years per week) as well as the proportion of CVD cases increased from 34.2% up to 66.7% (average 51.5%). The mean duration of period from the first day of clinical symptoms until the date of hospitalization was 8.3±5.9 days (median 7; with Q1-Q3 from 5 to 10). There were no significant difference for the length of this period between groups of patients with and without CVD: 8.4±6.2 and 8.3±5.7 days (median 7; with Q1-Q3 from 5 to 10 for both groups), p=0.82; between age groups of ≥65 years and <65 years: 8.8±7.2 and 8.1±5.3 days (median 7 with Q1-Q3 from 5 to 10, and 7 with Q1-Q3 from 4 to 10, respectively), p=0.07. Antihypertensive therapy during prehospital period was administered in 78.4% cases of hypertension, ACE inhibitors/sartans in patients with chronic heart failure (CHF) and history of myocardial infarction (MI) - in 64.6% and 52.3%, beta-blockers in CHF and history of MI – 54.4% and 42.2%, statins in coronary artery disease (CAD) – 28.9%, antiplatelets in CAD without atrial fibrillation (AF) – 50.4%, anticoagulants in AF – 57.5%. Conclusions Prehospital period in patients with COVID-19, community-acquired pneumonia enrolled into the hospital registry was characterized by rising of age and proportion of CVD cases during enrollment period. The correspondence of cardiovascular pharmacotherapy to clinical guidelines was insufficient that must be improved in clinical practice during time interval between first symptoms and hospitalization date. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Respiratory viral infections in the lower respiratory tract failure (Literature review)

2021 ◽  
Vol 13 (4) ◽  
pp. 5-13
Author(s):  
I. V. Babachenko ◽  
E. A. Kozyrev ◽  
E. V. Sharipova ◽  
E. D. Orlova ◽  
N. S. Tian
Keyword(s):  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Viral Infections ◽  
Community Acquired Pneumonia ◽  
Laboratory Diagnostics ◽  
Bacterial Strains ◽  
Lower Respiratory Tract Disease ◽  
Coronavirus Infection ◽  
Tract Disease

The sharp increase in viral pneumonia against the background of the pandemic of the new coronavirus infection SARS-CoV-2 requires more attention to the study of the role of viruses in damage to the lower respiratory tract, including their etiological significance in the development of community-acquired pneumonia. Modern possibilities of laboratory diagnostics make it possible not only to identify and study respiratory viruses, but also to help differentiate active viral infections as a cause of lower respiratory tract disease from virus carriers. The review describes the epidemiological and clinical features of the most relevant or less studied pneumotropic viral infections in children (respiratory syncytial, adenovirus, bocavirus, metapneumovirus), including their role in the etiology of pneumonia in children. Understanding the viral etiology of pneumonia in children will reduce the antibacterial load, which will help to reduce the side effects of chemotherapy and slow the emergence of antimicrobialresistant bacterial strains.

scholarly journals INFLUENCE OF ULTRAVIOLET BLOOD IRRADIATION ON COVID-19 ASSOCIATED COMMUNITY-ACQUIRED PNEUMONIA

2021 ◽  
Author(s):  
I. Khodza ◽  
P. Puzdryak ◽  
P Bondarenko ◽  
A. Degtyarev ◽  
A. Erofeev ◽  
...  
Keyword(s):  
Immune Response ◽  
Interleukin 6 ◽  
High Efficiency ◽  
Community Acquired Pneumonia ◽  
Medical Community ◽  
Dna Molecules ◽  
Coronavirus Infection ◽  
Blood Irradiation ◽  
Anti Inflammatory ◽  
Positive Effect

The pandemic of 21st century caused by the SARS-Cov-2 virus has posed a challenge for the global medical community. Community-acquired polysegmental pneumonia caused by the novel coronavirus infection (COVID-19) proceeds in a variety of types and may be complicated by a potentially lethal immune response - a cytokine storm. The latter is characterized by rapid proliferation and increased activity of T-cells, macrophages and natural killer cells releasing various inflammatory cytokines and chemical mediators by protective cells [5,8]. This pathological condition can be treated by recombinant humanized monoclonal antibody against monofunctional cytokine human interleukin-6 receptor. The effect of IL-6 blockers is to selectively bind and inhibit both soluble and membrane IL-6 receptors (sIL-6R and mIL-6R). There are studies demonstrating a positive effect and increased survival rate while using drugs that block the production of interleukin-6 [7,11]. The new coronavirus infection causes inflammation of the artery wall with intravascular thrombogenesis, which justifies the high efficiency of anticoagulant and hormone therapy [6,9,10].The standards of drug treatment of the studied infection include antiviral, anti-inflammatory, anticoagulant, mucolytic, symptomatic, intravenous infusion and oxygen therapy.Methodological recommendations for the diagnosis and treatment of a new coronavirus infection, issued by the Ministry of Health of the Russian Federation, are regularly updated in accordance with the accumulation of positive treatment results by global and local medical communities. In addition to drug therapy, there are other methods of body detoxification. One of the additional methods for treatment of community-acquired pneumonia along with viral "vasculitis" and correction of the immune response can be provided by ultraviolet blood irradiation (UBI).It is well known that ultraviolet radiation has a disinfecting effect. The wavelengths used in UVBI affect the efficiency of UV absorption by DNA molecules of the pathogen. Bactericidal UV radiation at certain wavelengths causes thymine dimerization in DNA molecules. The accumulation of such changes in the DNA of microorganisms leads to a slowdown in the rate of their reproduction and extinction. The photohemocorrection method is characterized by immunostimulatory, anti-inflammatory, anti-hypoxic, membrane stabilizing, antioxidant and detoxifying effects [1]. In the current study we obtained data on a significant decrease in the systemic inflammatory response, marked and fast decrease of the C-reactive protein in blood tests of patients while receiving ultraviolet blood irradiation. The relief of the systemic inflammatory reaction had a positive effect on the reduction of infiltrative changes in the lung tissue, as well as the timing of discharge from hospital.

scholarly journals Peculiarities of complete blood count indicators in patients with community-acquired pneumonia during the COVID-19 pandemic

2021 ◽  
Vol 9 (5-6) ◽  
pp. 33-41
Author(s):  
V.I. Trykhlib ◽  
K.P. Bieliaieva ◽  
N.R. Tsyurak ◽  
L.O. Palatna
Keyword(s):  
Hospital Stay ◽  
Blood Count ◽  
Complete Blood Count ◽  
Severe Form ◽  
Community Acquired Pneumonia ◽  
Hospital Treatment ◽  
Normal Range ◽  
Normal Platelet ◽  
Normal Number ◽  
Coronavirus Infection

The article presents the literature review data on the community-acquired pneumonia and the survey of patients with community-acquired pneumonia during the pandemic of the new coronavirus infection COVID-19. There are no changes in the rate of leukocytosis detection in patients with mild course of the di­sease within 10 days of hospital stay. There is a tendency to increase the proportion of people with a normal number of leukocytes and lymphocytes from day 4–6 of hospital treatment. Significantly, leukopenia was detected in 9.3 % of patients 1–3 days after hospitalization and was not observed in the future. Lymphopenia was registered in the first 1–6 days of hospital stay and was not observed from day 7–9. Granulocytosis was detected in 27.6 % of patients on day 1–3 in the hospital and in the following days their percentage decreased significantly; at the same time, the number of people with normal range of granulocytes increased significantly. Normal platelet counts were observed in most patients (93.8 %) on day 1–3 of hospital stay, and thrombocytopenia was recorded only in 6.3 % of individuals on day 1–3 after hospitalization. In moderate-to-severe form, 24.7 % of patients had leukocytosis on day 1–3 of hospital stay, and on day 7–9 of treatment, it was detected already in 28.8 % (p > 0.05). The majority of patients (66.7 %) had normocytosis in the first three days, and leukopenia was observed in 8.7 % of people on day 1–3. Significantly, the share of detected lymphocytosis increased, and lymphopenia — decreased from 4–6 days of hospital stay. Granulocytosis was registered in 23.2 % of patients on day 1–3 of hospital stay, followed by a significant decrease in the percentage of granulocytes from days 4–6. Band neutrophils were elevated in the first three days among 51.6 % of patients, and their percen­tage significantly decreased after the fourth day. Most individuals (77.3 %) had a normal platelet count on day 1–3 in the hospital, and thrombocytopenia at this time was found in 16.7 %. The majority of patients aged 20–30 years had a normal number of leukocytes (65.5 %), and 25.5 % had leukocytosis 1–3 days after hospitalization. Lymphocytosis in the first 3 days was registered among 9 % of people and then increased significantly, lymphopenia was observed in 31 % of patients on day 1–3 and subsequently decreased, granulocytosis — in 25 % of cases, elevated levels of band neutrophils — in 43.8 %, thrombocytosis — in 7.3 %, thrombocytopenia — in 10.9 %. Among patients aged 31–40 years in the first 3 days after hospitalization, leukocytosis was registered in 28 % of cases, leukocyte count was normal in 72 %, leukopenia was not detected, 48 % of patients had lymphopenia, 15.8 % — granulocytosis, levels of band neutrophils were elevated in 65.2 %, thrombocytosis was observed in 8 % of cases, thrombocytopenia — in 8 %. Most patients (66.7 %) aged 41–50 years on day 1–3 after hospitalization had normocytosis, 19 % — leukocytosis, 14.3 % — leukopenia, 14.3 % — lymphocytosis, 38.1 % — lymphopenia, 3 (25 %) people had granulocytosis, levels of band neutrophils were elevated in 65 % of cases, thrombocytosis was detected in 4.8 %, thrombocytopenia — in 28.5 %. Among patients aged 51–60 years in the first 3 days after hospitalization, the following indicators of complete blood count were found: 16.1 % of individuals had leukocytosis, number of leukocytes was normal in 83.9 % of cases, leukopenia was not detected, lymphocytosis was found in 16.1 % of people, lymphopenia — in 22.6 %, granulocytosis — in 20 %, elevated levels of band neutrophils — in 39.3 %, thrombocytosis — in 3.2 %, thrombocytopenia — in 16.2 %. Patients older than 60 years on days 1–3 after hospitalization had the following changes: 38.8 % — leukocytosis, white blood cell count was normal in 49 % of cases, 12.2 % of people had leukopenia, 12.2 % — lymphocytosis, 51.1 % — lymphopenia, granulocytosis was not observed, 25 % had granulocytopenia, 60 % — elevated levels of band neutrophils, 8.2 % — thrombocytosis, and 18.3 % — thrombocytopenia.

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