scholarly journals Aplicabilidade do digital smile design em reabilitações estéticas: revisão de literatura

2020 ◽  
Vol 11 (2) ◽  
pp. 139
Author(s):  
Natália Rivoli Rossi ◽  
Juliana De Freitas Gouveia Silva ◽  
Murilo Rocha Rodrigues ◽  
Elisa Camargo Kukulka ◽  
Manassés Tercio Vieira Grangeiro ◽  
...  
Keyword(s):  
Meta Analysis ◽  
In Vivo Studies ◽  
Restorative Dentistry ◽  
Treatment Protocols ◽  
Search Terms ◽  
Facial Proportions ◽  
The Aesthetic ◽  
The Many ◽  
Aesthetic Dentistry

OBJECTIVE: To review the literature on the digital planning and diagnosis protocol known as "Digital Smile Design", highlighting its main advantages concerning aesthetic rehabilitation in restorative dentistry. MATERIAL AND METHOD: 60 articles were searched in Pubmed, Scielo, and Bireme databases, using the search terms Dental photography, cosmetic dentistry, treatment protocols. Inclusion criteria were: In vivo studies, systematic reviews and meta-analysis, literature addressing variables under study, language in Portuguese and English, and articles published from 1990 to 2020. Exclusion criteria were: letter to the editor, literature review, and clinical case. RESULTS: DSD is a treatment planning tool used in interdisciplinary aesthetic dentistry to strengthen the diagnostic vision, improve communication between specialists and patient guidance. Smile design refers to the many scientific and artistic principles that, collectively, can create a beautiful smile. These principles are established through data collected from patients as diagnostic models, anamnesis, and measurement of facial proportions. In turn, the aesthetic composition of the smile depends on many points of reference and anatomical parameters for the formation of a harmonious and beautiful set. FINAL CONSIDERATIONS: the DSD is an important tool to be used for aesthetics rehabilitations in restorative dentistry, since it is an instrument that facilitates the diagnosis, improves communication between the multidisciplinary team and assists in the orientation and motivation of the patient, increasing the predictability of treatments.

scholarly journals Does systemic oral administration of curcumin effectively reduce alveolar bone loss associated with periodontal disease? A systematic review and meta-analysis of preclinical in vivo studies

2020 ◽  
Vol 75 ◽  
pp. 104226
Author(s):  
Juliana Simeão Borges ◽  
Luiz Renato Paranhos ◽  
Gabriela Leite de Souza ◽  
Felipe de Souza Matos ◽  
Ítalo de Macedo Bernardino ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Loss ◽  
Periodontal Disease ◽  
Oral Administration ◽  
Alveolar Bone ◽  
Meta Analysis ◽  
Alveolar Bone Loss ◽  
In Vivo Studies

scholarly journals Welding Fumes, a Risk Factor for Lung Diseases

2020 ◽  
Vol 17 (7) ◽  
pp. 2552 ◽  
Author(s):  
Maria Grazia Riccelli ◽  
Matteo Goldoni ◽  
Diana Poli ◽  
Paola Mozzoni ◽  
Delia Cavallo ◽  
...  
Keyword(s):  
Risk Factor ◽  
Ultrafine Particles ◽  
Lung Diseases ◽  
Occupational Safety ◽  
Meta Analysis ◽  
Technical Information ◽  
In Vivo Studies ◽  
Welding Fumes

(1) Background: Welding fumes (WFs) are composed of fine and ultrafine particles, which may reach the distal airways and represent a risk factor for respiratory diseases. (2) Methods: In vitro and in vivo studies to understand WFs pathogenesis were selected. Epidemiological studies, original articles, review, and meta-analysis to examine solely respiratory disease in welders were included. A systematic literature search, using PubMed, National Institute for Occupational Safety and Health Technical Information Center (NIOSHTIC), and Web of Science databases, was performed. (3) Results: Dose, time of exposure, and composition of WFs affect lung injury. Inflammation, lung defense suppression, oxidative stress, DNA damage, and genotoxic effects were observed after exposure both to mild and stainless steel WFs. (4) Conclusions: The detection of lung diseases associated with specific occupational exposure is crucial as complete avoidance or reduction of the exposure is difficult to achieve. Further studies in the area of particle research may aid the understanding of mechanisms involved in welding-related lung disease and to expand knowledge in welding-related cardiovascular diseases.

scholarly journals The Influence of Eggshell on Bone Regeneration in Preclinical In Vivo Studies

Biology ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 476
Author(s):  
Horia Opris ◽  
Cristian Dinu ◽  
Mihaela Baciut ◽  
Grigore Baciut ◽  
Ileana Mitre ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Animal Studies ◽  
Meta Analysis ◽  
Bone Matrix ◽  
In Vivo Studies ◽  
Defect Model ◽  
Exclusion Criteria ◽  
Freeze Dried ◽  
Grafting Materials

The aim of this study is to systemically review the available evidence on the in vivo behavior of eggshell as a guided bone regeneration substitute material. Five databases (PubMed, Cochrane, Web of Science, Scopus, EMBASE) were searched up to October 2020. In vivo animal studies with a bone defect model using eggshell as a grafting material were included. Risk of bias was assessed using SYRCLE tool and the quality assessment using the ARRIVE guidelines. Overall, a total of 581 studies were included in the study, 187 after duplicate removal. Using the inclusion and exclusion criteria 167 records were further excluded. The full text of the remaining 20 articles was assessed for eligibility and included in the qualitative and quantitative assessment synthesis. There were different methods of obtaining eggshell grafting materials. Eggshell is a biocompatible grafting material, with osteoconduction proprieties. It forms new bone similar to Bio-Oss and demineralized freeze-dried bone matrix. It can be combined with other materials to enhance its proprieties. Due to the high variability of the procedures, animals, production and assessment methods, no meta-analysis could be performed. Eggshell might be considered a promising biomaterial to be used in bone grafting procedures, though further research is needed.

Association of Phytol with Toxic and Cytotoxic Activities in an Antitumoral Perspective: A Meta-Analysis and Systemic Review

2019 ◽  
Vol 18 (13) ◽  
pp. 1828-1837 ◽  
Author(s):  
Marcus V.O.B. Alencar ◽  
Muhammad T. Islam ◽  
Eunus S. Ali ◽  
José V.O. Santos ◽  
Márcia F.C.J. Paz ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Meta Analysis ◽  
Reactive Oxygen Species Generation ◽  
In Vivo Studies ◽  
Lipid Lowering ◽  
Systemic Review ◽  
Cytotoxic Activities ◽  
Apoptosis And Necrosis

Background: Phytol have various pharmacological activities such as antimicrobial, cytotoxic, antitumoral, antimutagenic, anti-atherogenic, antidiabetic, lipid-lowering, antispasmodic, antiepileptic, antinociceptive, antioxidant, anti-inflammatory, anxiolytic, antidepressant and immunoadjuvant. Several studies point to an association of phytol with implications for apoptosis and necrosis at cellular levels in cancer, yet no clear conclusions were drawn. Method: To clarify this, we conducted a meta-analysis of non-clinical studies of phytol and its associations with toxicity and cytotoxicity emphasizing the mechanisms of apoptosis and necrosis induction and its importance in tumor therapy. Relevant studies were systematically searched in PubMed and Web of Science. The association between phytol and cyto-/toxicity was assessed by odds ratio (ORs) and 95% confidence intervals (CI). Twentythree studies were finally included in the meta-analysis. A significant association between phytol and toxicity (OR: 1.47; 95% CI = 0.86–2.48) was found among in vivo studies and cytotoxicity (OR: 1.81; 95% CI = 1.12– 2.65, p<0.05) in in vitro and ex vivo studies. In in vitro studies, 24% of them indicate that phytol at high doses induces apoptosis by several mechanisms; while about 40% of ex vivo studies indicate that phytol induces reactive oxygen species generation. But, Phytol does not act as a direct oxidant, unlike its metabolite phytanic acid. The 24% of in vivo studies also highlighted the mechanisms for apoptosis-like including expression of Bcl2 protein or mutations in pro-apoptotic protein Bax. Of them, 8% studies show necrosis and hepatotoxicity. However, in 24% of the articles, the mechanisms of toxicity and cytotoxicity are still not well elucidated. Conclusion: This study confirms that the association between phytol and cyto-/toxicity depends on the dose/concentration used in the given experimental conditions. Thus, there are still great prospects for new research aimed at the use of phytol and its metabolite as anticancer agents.

scholarly journals Comparison of the Use of Titanium–Zirconium Alloy and Titanium Alloy in Dental Implants: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 44 (4) ◽  
pp. 305-312 ◽  
Author(s):  
Ronaldo Silva Cruz ◽  
Cleidiel Aparecido Araujo Lemos ◽  
Hiskell Francine Fernandes Oliveira ◽  
Victor Eduardo de Souza Batista ◽  
Eduardo Piza Pellizzer ◽  
...  
Keyword(s):  
Dental Implants ◽  
Animal Studies ◽  
Meta Analysis ◽  
In Vivo Studies ◽  
Cochrane Library ◽  
Eligibility Criteria ◽  
Ti Alloys ◽  
Significant Difference ◽  
Titanium Zirconium

The aim of this study was to compare the values of bone-implant contact (BIC) and removal torque (RTQ) reported in different animal studies for titanium–zirconium (TiZr) and titanium (Ti) dental implants. This review has been registered at PROSPERO under number CRD42016047745. We undertook an electronic search for data published up until November 2017 using the PubMed/Medline, Embase, and The Cochrane Library databases. Eligibility criteria included in vivo studies, comparisons between Ti and TiZr implants in the same study, and studies published in English that evaluated BIC and RTQ. After inclusion criteria, 8 studies were assessed for eligibility. Of the 8 studies, 7 analyzed BIC outcome and 3 analyzed RTQ outcome. Among such studies, 6 studies were considered for meta-analysis of quantitative for BIC and 2 studies for RTQ. There was no significant difference for BIC analysis (P = .89; random ration [RR]: −0.21; 95% confidence interval [CI]: −3.14 to 2.72). The heterogeneity of the primary outcome studies was considered low (7.19; P = .21; I2: 30%). However, the RTQ analysis showed different results favoring the TiZr dental implants (P = .001; RR: 23.62; 95%CI: 9.15 to 38.10). Low heterogeneity was observed for RTQ (χ2: 1.25; P = .26; I2: 20%). Within the limitations of this study, there was no difference between TiZr and Ti alloys implants in terms of BIC. However, TiZr implants had higher RTQ than Ti alloys.

scholarly journals Microleakage of Direct Restorations. Comparisonbetween Bulk-Fill and Traditional Composite Resins:Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Francesca Zotti ◽  
Edoardo Falavigna ◽  
Giorgia Capocasale ◽  
Daniele De Santis ◽  
Massimo Albanese
Keyword(s):  
Systematic Review ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Adhesive System ◽  
Risk Of Bias ◽  
Composite Resins ◽  
In Vivo Studies ◽  
Marginal Adaptation ◽  
Posterior Teeth

AbstractSince the bulk-fill composites were produced, there was a progressive diffusion of their use for direct conservative treatment in posterior teeth. Their chemical structure increases the depth of cure and decreases the polymerization contraction; in this manner, bulk-fill composites can be placed in 4 mm single layers and the treatment times are considerably reduced. However, aesthetic and mechanical properties and impact on microleakage of bulk-fill resins are still unclear.This systematic review and meta-analysis aimed to assess the risk of microleakage of direct posterior restorations made of bulk-fill versus conventional composite resins.Researches were performed on PubMed and Scopus databases. Eligible in vivo studies, published since 2006, were reviewed. Outcomes of marginal discoloration, marginal adaptation, and recurrent caries were considered to conduct the systematic review and meta-analysis. Secondary data were examined to implement additional analysis and assess the risk of bias.Eight randomized clinical trials were analyzed, involving 778 direct restorations. The summary of RCTs led to significant but inconsistent results; the marginal discoloration and recurrent caries were found to be improved respectively by 5.1 and 1.4%, whereas the marginal adaptation was reduced of 6.5%. Secondary analyses revealed that follow-up periods, the adhesive system used and the class of carious lesions evaluated are confounding factors, and they result in a risk of bias across studies.Bulk-fill composites are innovative materials for conservative dentistry and they can be used to reduce treatment steps and duration of operative times. There are insufficient data to explore the relationship between bulk-fill composites and microleakage and further investigations are needed.

scholarly journals Meta-analysis of in vitro and in vivo studies of the biological effects of low-level millimetre waves

2021 ◽  
Author(s):  
Andrew Wood ◽  
Rohan Mate ◽  
Ken Karipidis
Keyword(s):  
Power Density ◽  
Negative Correlation ◽  
Effect Size ◽  
Biological Effects ◽  
Meta Analysis ◽  
Quality Score ◽  
In Vivo Studies ◽  
Low Level

Abstract Background With the roll-out of new technologies such as 5G, there has been renewed community concern regarding the adequacy of research on possible health effects from associated radiofrequency radiation, mainly in the millimetre wave (MMW) band. Objective We conducted a meta-analysis of in vitro and in vivo studies investigating bioeffects of MMWs at low exposure levels. Methods We identified 107 in vitro and in vivo studies investigating MMWs and biological effects in which the power density employed has been below 100 W/m2, which is below the current standards for occupational local exposures. Where possible, we estimated the magnitude of the principal effect reported or set this magnitude to zero in studies reporting no significant effects. We also estimated the quality of the studies, based on a methodology used in previous analyses. Results We show a negative correlation between effect size and both power density and specific absorption rate. There was also a significant negative correlation between effect size and quality score. A multivariate analysis revealed that there is an increase in the effect size for certain biological systems being investigated and laboratories in which the work was carried out whilst the quality score for some of these tends to be low. We note that many of the studies were motivated by a desire to elucidate the possible mechanisms in therapeutic devices rather than assessing the safety of telecommunications systems. Finally, it appears that the presence or absence of modulation does not influence the reported effect size. Significance Many of the findings of this meta-analysis have not been reported before and have important implications for overall interpretation of in vitro and in vivo data. Overall, the results of this study do not confirm an association between low-level MMWs and biological effects.

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