scholarly journals MODIFICATION OF THE MINIMAL BERGMAN MODEL OF THE "INSULIN-GLUCOSE" SYSTEM AND ITS IMPLEMENTATION IN MATLAB/SIMULINK

2021 ◽  
Vol 2 ◽  
pp. 28-37
Author(s):  
Vladimir Belov ◽  
Mark Procofiev ◽  
Tatyana Komandresova ◽  
Alexander Samarkin
Keyword(s):  
Insulin Pump ◽  
Automatic Regulation ◽  
Type I ◽  
Specific Patient ◽  
Matlab Simulink ◽  
Insulin Producing Cells ◽  
Fundamental Possibility ◽  
Glucose System ◽  
Effects Of Aging ◽  
Implementation In Matlab

The article discusses a modification of Bergman's minimal mathematical model of the "insulin-glucose" system, which allows simulating controlled exogenous sources of glucose and insulin into the patient's blood on the model and investigating the dynamics of changes in their concentrations in normal conditions, in type I DM and type II DM. A modeling scheme is presented in graphic notations of the MatLab / Simulink computer mathematics system and a number of computational experiments on it are described to determine the type of glycemic profiles of glucose and insulin concentration in the patient's blood in the noted situations. The fundamental possibility of using model mappings in the MatLab/Simulink environment for the study and tuning of the loop for automatic regulation of the "insulin-glucose" balance in the patient's blood using a controlled insulin pump is demonstrated. It was also found that the modified minimal model can be customized for a specific patient with diabetes, which makes it possible to use it to solve the problems of individual prediction of the development of a diabetic disease in a specific patient. In addition, the described model makes it possible to recreate and virtually investigate various conditions and cases on it that affect the dynamics of insulin and glucose concentrations in the patient's blood, for example, when he performs physically stressed activities, in the presence of the effects of “aging” of insulin-producing cells in the pancreas. iron, etc. 

Effects of aging on actin sliding speed on myosin from single skeletal muscle cells of mice, rats, and humans

2001 ◽  
Vol 280 (4) ◽  
pp. C782-C788 ◽  
Author(s):  
Peter Höök ◽  
Vidyasagar Sriramoju ◽  
Lars Larsson
Keyword(s):  
Posttranslational Modifications ◽  
Actin Filaments ◽  
Mammalian Species ◽  
Type I ◽  
In Vitro Motility Assay ◽  
Sliding Speed ◽  
Myosin Heavy Chain Isoform ◽  
In Vitro Motility ◽  
Effects Of Aging

The effects of aging on the mechanical properties of myosin were measured in 87 fibers from muscles of humans ( n = 40), rats ( n = 21), and mice ( n = 26) using a single fiber in vitro motility assay. Irrespective of species, an 18–25% aging-related slowing in the speed of actin filaments was observed from 62 single fibers expressing the slow (type I) β-myosin heavy chain isoform. The mechanisms underlying the aging-related slowing of motility speed remain unknown, but it is suggested that posttranslational modifications of myosin by oxidative stress, glycation, or nitration play an important role. The aging-related slowing in the speed of actin filaments propelled by the type I myosin was confirmed in three mammalian species with an ∼3,400-fold difference in body size. Motility speed from human myosin was 3-fold slower than from myosin of the ∼3,400-fold smaller mouse and approximately twofold slower when compared with the ∼130-fold smaller rat, irrespective of age. A strong correlation was observed between the log values of actin sliding speed and body mass, suggesting that the effects of scaling is, at least in part, due to altered functional properties of the motor protein itself.

NUMERICAL MODELING OF ATHEROSCLEROSIS LESION EVOLUTION IN TIME I. INITIAL STAGE OF THE DISEASE

2016 ◽  
Vol 16 (05) ◽  
pp. 1650068
Author(s):  
SAFOORA KARIMI ◽  
MITRA DADVAR ◽  
BAHRAM DABIR
Keyword(s):  
Inflammatory Responses ◽  
Foam Cell ◽  
Cell Formation ◽  
Ldl Oxidation ◽  
Foam Cell Formation ◽  
Type I ◽  
Specific Patient ◽  
Disease Evolution ◽  
Endothelium Dysfunction ◽  
Initial Stage

Atherosclerosis is one of the main causes of death in the developed world. The disease, which is an inflammatory disease, has been the focus of many studies. A few studies attempted to model atherosclerosis lesion development mathematically while no attention has been paid to the multistage nature of the disease. The present study provides a mathematical model for atherosclerosis evolution by focusing on the inflammatory responses of the initial stage of the disease. In the model, the inflammatory response in type I lesion, which includes endothelium dysfunction, LDL oxidation, monocytes entry, foam cell formation and intima property changes, are coupled with the transport equations of blood and LDL in lumen and arterial wall. The innovation of the model is determination of the duration of the initial stage of lesion propagation for a specific patient while the presence of leaky junction in endothelial layer and LDL oxidation in the intima layer are considered. The greatest advantage of the study in comparison with previous studies is to provide a model for the initiating stage of the atherosclerosis development so that a more precise result of the disease evolution is obtained.

Patterns of failure in the treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells

2005 ◽  
Vol 201 (3) ◽  
pp. S90-S91
Author(s):  
Takahisa Fujikawa ◽  
Seh-Hoon Oh ◽  
Liya Pi ◽  
Tom Shupe ◽  
Bryon Petersen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Type I Diabetes ◽  
Embryonic Stem ◽  
Type I ◽  
Patterns Of Failure ◽  
Insulin Producing Cells

scholarly journals Estimation of Semiconductor Switching Losses under Hard Switching using Matlab/Simulink Subsystem

2013 ◽  
Vol 2 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Volodymyr Ivakhno ◽  
Volodymyr V. Zamaruiev ◽  
Olga Ilina
Keyword(s):  
Semiconductor Devices ◽  
Average Power ◽  
Power Converter ◽  
System Level ◽  
Automatic Regulation ◽  
Regulation System ◽  
Matlab Simulink ◽  
Turn On ◽  
System Level Simulation ◽  
Power Switch

AbstractThe conventional tools for the system level simulation of the switch-mode power converters (for example, MATLAB/SIMILINK) allow simulating the behavior of a power converter jointly operating with the control system in a closed automatic regulation system. This simulation tools either represent semiconductor devices as ideal switches or implement the simplest models based on volt-ampere characteristics of standard types of semiconductor devices for conducting loss estimation. This fact makes direct calculation of dynamic power losses in the semiconductor devices impossible. The MATLAB/SIMILINK subsystem that calculates the average power dissipated in the power switch during turn-on and turn-off transition is proposed in this paper. The represented approach used in the subsystem estimates by the means of MATLAB/SIMILINK the values of turn-on and turn-off energies at power switch commutation instances on the base of switching current and voltage measurements and the values of commutation energies given in datasheet on power switch. The simulation results of step-down converter with IGBT and proposed subsystem in MATLAB/SIMULINK were compared with the calculation results obtained in Semisel

scholarly journals miR-375 induces human decidua basalis-derived stromal cells to become insulin-producing cells

2014 ◽  
Vol 19 (3) ◽  
Author(s):  
Anahita Shaer ◽  
Negar Azarpira ◽  
Akbar Vahdati ◽  
Mohammad Karimi ◽  
Mehrdad Shariati
Keyword(s):  
Type I Diabetes ◽  
Morphological Changes ◽  
Placental Tissue ◽  
Micro Rna ◽  
Type I ◽  
Isolated Cells ◽  
Decidua Basalis ◽  
Insulin Producing Cells ◽  
Glucose Challenge ◽  
Promising Source

AbstractThis paper focuses on the development of renewable sources of isletreplacement tissue for the treatment of type I diabetes mellitus. Placental tissue-derived mesenchymal stem cells (MSCs) are a promising source for regenerative medicine due to their plasticity and easy availability. They have the potential to differentiate into insulin-producing cells. miR-375 is a micro RNA that is expressed in the pancreas and involved in islet development. Human placental decidua basalis MSCs (PDB-MSCs) were cultured from full-term human placenta. The immunophenotype of the isolated cells was checked for CD90, CD105, CD44, CD133 and CD34 markers. The MSCs (P3) were chemically transfected with hsa-miR-375. Total RNA was extracted 4 and 6 days after transfection. The expressions of insulin, NGN3, GLUT2, PAX4, PAX6, KIR6.2, NKX6.1, PDX1, and glucagon genes were evaluated using real-time qPCR. On day 6, we tested the potency of the clusters in response to the high glucose challenge and assessed the presence of insulin and NGN3 proteins via immunocytochemistry. Flow cytometry analysis confirmed that more than 90% of the cells were positive for CD90, CD105 and CD44 and negative for CD133 and CD34. Morphological changes were followed from day 2. Cell clusters formed during day 6. Insulin-producing clusters showed a deep red color with DTZ. The expression of pancreatic-specific transcription factors increased remarkably during the four days after transfection and significantly increased on day 7. The clusters were positive for insulin and NGN3 proteins, and C-peptide and insulin secretion increased in response to changes in the glucose concentration (2.8 mM and 16.7 mM). In conclusion, the MSCs could be programmed into functional insulin-producing cells by transfection of miR-375.

scholarly journals Assessment of type i diabetes mellitus compensation degree in children and adolescents of Perm Krai

2020 ◽  
Vol 36 (6) ◽  
pp. 57-63
Author(s):  
O. M. Khudorozhkova ◽  
E. N. Smirnova
Keyword(s):  
Children And Adolescents ◽  
Insulin Pump ◽  
Type I Diabetes ◽  
Insulin Pump Therapy ◽  
Type I ◽  
Chronic Complications ◽  
Pump Therapy ◽  
Perm Krai ◽  
Type 1 Dm

Aim. To assess the dependence of carbohydrate metabolism state in children and adolescents with type I diabetes mellitus (DM) in Perm Krai on patients age, disease duration, way of insulin administration (regimen of multiple insulin injections or insulin pump therapy), complications available. Materials and methods. The study enclosed 451 children and adolescents, living in Perm Krai, who were hospitalized for type 1 DM to Endocrine Unit of Regional Childrens Clinical Hospital during 2016-2017. Glycated hemoglobin level (HbA1c), daily insulin requirement, availability and character of complications were assessed in these patients. Conclusions. The state of decompensation more often is connected with the disease duration for more than 5 years and adolescent age. There was detected a feedback between the physical development level and the duration of disease and number of chronic complications. The period of development of type 1 DM chronic complications depends on patients age, sex and compensation of disease. The degree of compensation of the disease is higher when using insulin pump therapy or regimen of multiple injections of ultrashort analogs of insulin in combination with basal analogs.

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