Successful Restoration of Severely Mutilated Primary Incisors Using a Novel Method to Retain Zirconia Crowns – Two Year Results

2016 ◽  
Vol 40 (6) ◽  
pp. 425-430 ◽  
Author(s):  
Osama Ibrahim El Shahawy ◽  
Anne C O'Connell
Keyword(s):  
Survival Time ◽  
Healthy Children ◽  
Glass Ionomer ◽  
Reliable Technique ◽  
Mean Survival Time ◽  
Anterior Teeth ◽  
Kaplan Meier ◽  
Zirconia Crowns ◽  
Novel Method

Aim: This manuscript describes a simple reliable technique for restoring severely mutilated primary anterior teeth. A rigid glass ionomer post is created over which zirconia crowns can be fitted to achieve a long-term stable esthetic restoration for primary anterior teeth. Study design: Children aged 2–5 years with two up to six extensively decayed upper primary incisors were included. Fuji IX was condensed into an intracanal space created to a depth of 3mm, to provide a core which also extended 3mm supragingivally. Crown preparations were completed upon these cores. Zirconia crowns (Nusmile, Houston Texas USA) were fitted and cemented over the prepared cores. All patients were recalled at regular intervals. Results: Twenty-three healthy children with 86 restorations participated in the study. The overall survival of the restorations was 95.3% after 12 months and 80.2% after 24 months. According to Kaplan-Meier survival analysis, the median survival time was not reached while the estimated mean survival time was 22.9 months. Conclusions: This newly described clinical technique is simple and reliable to use for restoration of extensively decayed primary incisors. Use of zirconia crowns retained using this technique offers superior esthetic, durable restorations with remarkable gingival response up to 24 months.

scholarly journals Factors Influencing the Survival of Preformed Zirconia Crowns in Children Treated under General Anesthesia

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Abdurahman S. Alhissan ◽  
Sharat Chandra Pani
Keyword(s):  
Confidence Interval ◽  
General Anesthesia ◽  
Survival Time ◽  
Mean Survival Time ◽  
Pulp Therapy ◽  
Anterior Teeth ◽  
Kaplan Meier ◽  
Zirconia Crowns ◽  
Rate Of Failure ◽  
The Impact

Aim. This study aimed to retrospectively evaluate the success of zirconia crowns placed in the anterior teeth of children and evaluate the impact of pulp therapy of the tooth on the rate of failure. Materials and Methods. A total of 70 anterior teeth of 20 children aged between 3 and 5 years who had undergone the placement of zirconia crowns under general anesthesia were followed up for 24 months. Kaplan–Meier Survival curves were plotted for the estimation of two-year survival time. The outcomes for teeth that had received pulp therapy were compared to those that had not received pulp therapy. Results. Kaplan–Meier survival analysis of 70 crowns observed over a two-year period showed that mean survival time for the crowns was 38.7 months with a confidence interval ranging from 38.1 months to 39.3 months. When the survival of the crowns was observed based on the presence or absence of symptoms, it was observed that only 4 out of the 70 crowns were symptomatic (with or without crown loss) at the end of two years, giving a success rate of 94.3%. The mean survival time was also increased to 39.5 months (confidence interval 39.15–39.98 months). Conclusion. Zirconia crowns provide an acceptable level of success and longevity. Crowns placed on teeth after pulp therapy are more likely to fail than those placed on teeth without pulp therapy.

scholarly journals The Survival Of All Ceramic Crowns With A Zirconia Core (Lava™)

2019 ◽  
Vol 2 (1) ◽  
pp. 01-04
Author(s):  
Gang wei ◽  
Jiang Dai ◽  
Ling Xiao ◽  
Chen Dong ◽  
Fei Liu
Keyword(s):  
Survival Time ◽  
Hospital Setting ◽  
Clinical Situation ◽  
Convenience Sample ◽  
Mean Survival Time ◽  
Anterior Teeth ◽  
Kaplan Meier ◽  
Increased Risk ◽  
The Mean ◽  
Survival Plot

Background: Few studies have assessed the survival of restorations and particularly zirconia based crowns in the restoration of the severely worn dentition. This study aimed to determine survival and factors associated with failure in anterior teeth worn through to dentine restored with Lava™ crowns. Methods: A convenience sample of 30 participants (27 male, 3 female) had 161 Lava™ crowns placed by one specialist clinician in a hospital setting. Follow-up was over a median 72 month period. Results: Of the 161 Lava™ crowns only 25 failed (15.5%) in 15 individuals up to 84 months for the longest case. Major failures were total debond (N=7) or minor delamination chips within the veneer ceramic layer (N=18). The mean time to first failure was 25.23 months. The Kaplan Meier survival plot estimated the Mean Survival Time for the crowns to be 74 months (95%CI 70.4, 77.3). Failures by subject were not associated with an increase in Occlusal Vertical Dimension using a Dahl approach but were associated with an edge-to-edge incisal relation (p<0.05), attrition (p<0.05) and bruxism (p<0.005). Conclusion: The Kaplan Meier survival plot estimated the Mean Survival Time for the crowns to be 74 months. The high loads in bruxism result in increased risk of fracture or debond. Clinical relevance: A protective bi-laminar splint is thus advisable. Nonetheless, application of zirconia based crowns in a difficult clinical situation such as bruxism can be a successful treatment modality.

scholarly journals A Preliminary Study of microRNA-208b after Acute Myocardial Infarction: Impact on 6-Month Survival

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Mostafa Alavi-Moghaddam ◽  
Mohammad Chehrazi ◽  
Shamila D. Alipoor ◽  
Maryam Mohammadi ◽  
Alireza Baratloo ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Survival Time ◽  
Term Survival ◽  
Relative Expression ◽  
Kaplan Meier ◽  
Healthy Control ◽  
And Gender

Introduction. miRNAs contribute to a variety of essential biological processes including development, proliferation, differentiation, and apoptosis. Circulating microRNAs are very stable and have shown potential as biomarkers of cardiovascular disease. microRNA-208b expression was increased in the blood of patients with acute myocardial infarction (AMI) and has been proposed as a biomarker for early diagnosis. In this pilot study, we investigate the potential of circulating miR-208b as a prognostic biomarker of 6-month survival in AMI patients. Methods. Plasma samples from 21 patients and 8 age- and gender-matched healthy adults were collected, and circulating levels of miR-208b were detected using quantitative real-time PCR. Results. miR-208b levels were higher in healthy control subjects (9.6-fold; P≤0.05). Within the AMI patients, the levels of miR-208b were significantly lower in the survivor versus nonsurvivor group (fold change = 6.51 and 14.1, resp.; P≤0.05). The Kaplan-Meier curve revealed that the 6-month survival time was significantly higher among AMI patients with a relative expression of miR-208b lower than 12.38. The hazard ratio (HR) for the relative expression of miR-208b (<12.38 was the reference) was 5.08 (95% CI: 1.13–22.82; P=0.03). Conclusion. Our results showed that elevated miR-208b expression was associated with reduced long-term survival in AMI patients. These pilot data indicate the need for a large follow-up study to confirm whether miR-208b can be used as a predictor of 6-month survival time after AMI.

Characteristics and Survival of 29 Patients with Sezary Syndrome.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 5587-5587
Author(s):  
Francesca Sampogna ◽  
Marina Frontani ◽  
Giannandrea Baliva ◽  
Damiano Abeni ◽  
Giuseppe A. Lombardo ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Survival Time ◽  
White Blood Cells ◽  
Clinical History ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Term Survival ◽  
Kaplan Meier

Abstract We created a relational database of patients with cutaneous T-cell lymphoma (CTCL) to collect in a standardised fashion, anagraphic variables, clinical history, clinical, histological, haematological, and immunological information on CTCL patients hospitalised at IDI-IRCCS, Rome, Italy. At present, there are data on 424 patients, hospitalised from 1983 to July 2005. Active follow-up is performed yearly to ensure a standardised ascertainment of survival time. For deceased patients, the actual date of death (for all causes) is recorded, while surviving patients are censored at the date of last contact. The database includes 29 patients with Sezary syndrome (SS). Follow-up times ranged from 0 to 105 months. At first hospitalisation the median values of cells/mL were: white blood cells (WBC) 8750, neutrophils 4250, eosinophils 140, basophils 120, lymphocytes 2760, monocytes 500, CD3+ 2780, CD4+ 2431, CD8+ 192, CD19+ 96. Seventeen patients were deceased. We included in the Kaplan-Meier survival analysis only patients who were diagnosed before July 2004 (n=26). Median survival time from diagnosis was 52 months. No significant differences were observed in mortality for WBC (cutoff 9000 cells/uL), neutrophils (cutoff 4500 cells/uL), basophils (cutoff 200 cells/uL), lymphocytes (cutoff 3000 cells/uL), monocytes (cutoff 500 cells/uL), CD3+ (cutoff 2000 cells/uL), CD4+ (cutoff 2000 cells/uL), CD8+ (cutoff 200 cells/uL), CD19+ (cutoff 70 cells/uL). A lower survival was observed for patients with eosinophils &lt;200 cells/uL (p=.08). Survival in patients with SS does not seem to be influenced by haemathologic parameters. However, patients with long-term survival (&gt;90 months) are observed, and their characteristics should be further investigated. Survival analysis of 26 patients with Sézary syndrome, Rome, Italy, 1991–2004. Survival analysis of 26 patients with Sézary syndrome, Rome, Italy, 1991–2004.

Vascularized Ulnar Bone Grafts for Limb-Sparing Surgery for the Treatment of Distal Radial OsteosarcomaS

2011 ◽  
Vol 47 (2) ◽  
pp. 98-111 ◽  
Author(s):  
Susan C. Hodge ◽  
Daniel Degner ◽  
Richard Walshaw ◽  
Brian Teunissen
Keyword(s):  
Retrospective Study ◽  
Survival Time ◽  
Bone Grafts ◽  
Implant Loosening ◽  
Mean Survival Time ◽  
Free Interval ◽  
Cortical Allograft ◽  
The Mean ◽  
Radial Bone

The objective of this retrospective study was to compare vascularized free or roll-in ulnar bone grafts for limb-sparing surgery in dogs with radial osteosarcoma with the cortical allograft, metal endoprosthesis, or distraction osteogenesis techniques. Overall, the ulnar graft techniques used in this study demonstrated excellent healing properties. Complications included recurrence of the tumor in 25% (2/8) of the dogs, metastasis in 50% (4/8) of the dogs, implant loosening in 37.5% (3/8) of the dogs, implant failure in 12.5% (1/8) of the dogs, and infection in 62.5% (5/8) of the dogs. Mean survival time was 29.3 mo (range, 9 to 61 mo). The mean metastasis-free interval was 33.67 mo (range, 8 to 54 mo). Tumors recurred locally in two dogs at 10 mo and 20 mo postoperatively. This study yielded similar long-term complications as other limb-sparing options (such as cortical allografts and metal endoprostheses) and allowed dogs to bear weight on the operated limb with acceptable limb function. More research is needed regarding specific healing times for ulnar vascularized grafts, time until implant removal, and the extent of radial bone that could ultimately be replaced by the ulna.

scholarly journals Hyponatremia—Long-Term Prognostic Factor for Nonfatal Pulmonary Embolism

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 214
Author(s):  
Anca Ouatu ◽  
Madalina Stefana Mihai ◽  
Daniela Maria Tanase ◽  
Cristina Gena Dascalu ◽  
Nicoleta Dima ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Prognostic Factor ◽  
Survival Time ◽  
Recurrence Rate ◽  
Serum Sodium ◽  
Cost Effective ◽  
Continuous Variable ◽  
Coronary Syndrome ◽  
Mean Survival Time

Over recent years, studies have shown that in patients with left-sided heart failure, arterial hypertension, and acute coronary syndrome, hyponatremia is a negative prognostic factor. In this context, there is raising interest in the association between hyponatremia and pulmonary embolism (PE). This retrospective cohort study includes 404 consecutive patients with confirmed acute nonfatal pulmonary embolism divided into four groups according to their sodium fluctuation pattern. The primary outcome was all-cause mortality and determining the recurrence rate among patients with nonfatal PE using serum sodium levels as a continuous variable. Patients with acquired and persistent hyponatremia had a significantly higher rate of mortality rate than those in the normonatremia group (12.8% and 40.4%, OR- 7.206, CI: 2.383–21.791, p = 0.000 and OR-33.250, CI: 11.521–95.960, p = 0.000 vs. 2%, p < 0.001, respectively). Mean survival time decreases from 23.624 months (95% CI: (23.295–23.953)) in the normonatremia group to 16.426 months (95% CI: (13.17–19.134)) in the persistent hyponatremia group, statistically significant (p = 0.000). The mean survival time for all patients was 22.441 months (95% CI: (21.930–22.951)). The highest recurrence rate was recorded at 12 and 24 months in the acquired hyponatremia group (16.7% and 14.1%, respectively). Serum sodium determination is a simple and cost-effective approach in evaluating the short and long-term prognosis in patients with acute PE.

scholarly journals Life weariness, suicidal thoughts and mortality: a sixteen-year longitudinal study among men and women older than 60 years

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Cecilia Fagerström ◽  
Anna-Karin Welmer ◽  
Sölve Elmståhl ◽  
Hanna Tuvesson
Keyword(s):  
Survival Time ◽  
Hazard Ratio ◽  
Adjusted Hazard Ratio ◽  
National Study ◽  
Suicidal Thoughts ◽  
Term Survival ◽  
Men And Women ◽  
Mean Survival Time ◽  
Long Term Mortality

Abstract Background Suicide in old age is a significant contributor to mortality. However, the extent to which life weariness and suicidal thoughts impact on mortality in a long-term perspective is unknown. The aim of this study was to investigate the effect of life weariness and suicidal thoughts on long-term survival (16 years) in an older Swedish population, controlling for demographic and social network factors and depression. A further aim was to investigate differences in sex and age interactions in relation to mortality among individuals with and without life weariness and suicidal thoughts. Methods A longitudinal cohort study on a national, representative sample of individuals aged 60+ years was conducted within the Swedish National Study of Aging and Care study. The sample included 7213 individuals, who provided information about life weariness and suicidal thoughts through an item derived from the Montgomery-Åsberg Depression Rating Scale. Data were analysed with multivariate Cox proportional hazards models, adjusted for potential confounders. Results At baseline, 12.5% of the participants (14.6% of females and 9.5% of males) reported life weariness and suicidal thoughts. During the 16-year follow-up, a mean survival time was 11.5 years (standard deviation (SD) 5.6), and 3804 individuals died (59.5% females and 40.5% males). Individuals with life weariness and suicidal thoughts had half the survival rate compared with those without such thoughts (24.5% vs. 50.6%), with a mean survival time of 8.4 years (SD 5.7) versus 12.0 years (SD 5.4). The multi-adjusted hazard ratio of mortality for those reporting life weariness and suicidal thoughts was 1.44 (95% confidence interval, 1.30–1.59), with the population attributable risk at 11.1%. In the models, being male or female 80+ years showed the highest multi-adjusted hazard ratio of long-term mortality (ref. female 60–69 years). Conclusions The findings suggested that life weariness and suicidal thoughts were risk factors for long-term mortality, when controlled for sex and age interactions that were found to strongly predict long-term mortality. These findings have practical implications in prevention of mortality, emphasising the importance of screening, identifying, and intercepting older men and women with signs of life weariness and suicidal thoughts. Trial registration Not applicable.

scholarly journals Radiomic analysis of lung cancer for the assessment of patient prognosis and intratumor heterogeneity

2021 ◽  
Vol 54 (2) ◽  
pp. 87-93 ◽  
Author(s):  
José Raniery Ferreira Junior ◽  
Marcel Koenigkam-Santos ◽  
Camila Vilas Boas Machado ◽  
Matheus Calil Faleiros ◽  
Natália Santana Chiari Correia ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Overall Survival ◽  
Fourier Transform ◽  
Survival Time ◽  
Risk Group ◽  
Mean Survival Time ◽  
Kaplan Meier ◽  
The Mean ◽  
The Fourier Transform

Abstract Objective: To determine whether the radiomic features of lung lesions on computed tomography correlate with overall survival in lung cancer patients. Materials and Methods: This was a retrospective study involving 101 consecutive patients with malignant neoplasms confirmed by biopsy or surgery. On computed tomography images, the lesions were submitted to semi-automated segmentation and were characterized on the basis of 2,465 radiomic variables. The prognostic assessment was based on Kaplan-Meier analysis and log-rank tests, according to the median value of the radiomic variables. Results: Of the 101 patients evaluated, 28 died (16 dying from lung cancer), and 73 were censored, with a mean overall survival time of 1,819.4 days (95% confidence interval [95% CI]: 1,481.2-2,157.5). One radiomic feature (the mean of the Fourier transform) presented a difference on Kaplan-Meier curves (p < 0.05). A high-risk group of patients was identified on the basis of high values for the mean of the Fourier transform. In that group, the mean survival time was 1,465.4 days (95% CI: 985.2-1,945.6), with a hazard ratio of 2.12 (95% CI: 1.01-4.48). We also identified a low-risk group, in which the mean of the Fourier transform was low (mean survival time of 2,164.8 days; 95% CI: 1,745.4-2,584.1). Conclusion: A radiomic signature based on the Fourier transform correlates with overall survival, representing a prognostic biomarker for risk stratification in patients with lung cancer.

scholarly journals Are restricted mean survival time methods especially useful for noninferiority trials?

2021 ◽  
pp. 174077452097657
Author(s):  
Boris Freidlin ◽  
Chen Hu ◽  
Edward L Korn
Keyword(s):  
Survival Time ◽  
Proportional Hazards ◽  
Small Sample ◽  
Operating Characteristics ◽  
Mean Survival Time ◽  
Kaplan Meier ◽  
Noninferiority Trials ◽  
Restricted Mean Survival Time ◽  
Experimental Treatments ◽  
Event Rates

Background: Restricted mean survival time methods compare the areas under the Kaplan–Meier curves up to a time [Formula: see text] for the control and experimental treatments. Extraordinary claims have been made about the benefits (in terms of dramatically smaller required sample sizes) when using restricted mean survival time methods as compared to proportional hazards methods for analyzing noninferiority trials, even when the true survival distributions satisfy proportional hazardss. Methods: Through some limited simulations and asymptotic power calculations, the authors compare the operating characteristics of restricted mean survival time and proportional hazards methods for analyzing both noninferiority and superiority trials under proportional hazardss to understand what relative power benefits there are when using restricted mean survival time methods for noninferiority testing. Results: In the setting of low-event rates, very large targeted noninferiority margins, and limited follow-up past [Formula: see text], restricted mean survival time methods have more power than proportional hazards methods. For superiority testing, proportional hazards methods have more power. This is not a small-sample phenomenon but requires a low-event rate and a large noninferiority margin. Conclusion: Although there are special settings where restricted mean survival time methods have a power advantage over proportional hazards methods for testing noninferiority, the larger issue in these settings is defining appropriate noninferiority margins. We find the restricted mean survival time methods lacking in these regards.

scholarly journals Risk Evaluation and Molecular Biomarkers Identification of Firefighter Suffering Lung Cancer Via the TCGA Database

2020 ◽  
Author(s):  
Bin Bai ◽  
Qinghao Meng
Keyword(s):  
Lung Cancer ◽  
Survival Time ◽  
Cancer Patients ◽  
Risk Evaluation ◽  
Differentially Expressed ◽  
Flame Resistance ◽  
Lung Cancer Patients ◽  
Kaplan Meier ◽  
Main Component

Abstract To evaluate the risk of firefighters suffering lung cancer after a long-term career and identify novel molecule biomarkers for evaluation, we tested the composition of flame-resistance door combustion byproducts. The results showed that the main component of combustion byproducts was PAHs and VOCs. The ceRNAs network showed that 26 mRNAs, 18 miRNAs, and 141 lncRNAs were involved in the lung cancer process. Most of the ceRNAs in our study could be affected by PAHs and VOCs. The Kaplan-Meier plots of differentially expressed RNAs in the ceRNA network showed that 3 mRNAs, 4 miRNAs, and 13lncRNAs have a relationship with the survival time of lung cancer patients. We recommended that mRNA COL1A1, CCBN1, and PFKP; miRNA hsa-miR-143, hsa-miR-183, hsa-miR-144, hsa-miR-372 and hsa-miR-373; lncRNA UCA1, TTTY16, LSAMP-AS1, LINC00337 and LNX1-AS1 as a biomarker to evaluate the risk of a firefighter suffering lung cancer and other cancers.

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