Hormonal contraception with progestagen desogestrel in women with diffuse non-toxic goiter аnd autoimmune thyroiditis

The article represents influence of gestagen desogestrel on size and function of thyroid gland in women of reproductive age. Into the study we included 70 women who were prescribed gestagen desogestrel in a daily dose of 75 mg for a period of 12 months. All the patients were devided into two groups. The first group consisted of 20 women with diffuse nontoxic goiter, the second consisted of 30 women with autoimmune thyroiditis. Control group consisted of 20 women without thyroid gland pathology. Prior to therapy with desogestrel and after 12 month of treatment, serum levels of free triiodothyronine, free thyroxine and thyrotropin releasing hormone, thyroperoxidase antibodies were determined and thyroid gland sonigraphy was performed in all the patients. Obtained data show that gestagen desogestrel doesn’t influence the size and function of thyroid gland in healthy women and in patients with diffuse non-toxic goiter. In women with autoimmune thyroiditis implication of desogestrel significantly decreases blood levels of thyroperoxidase autoantibodies.

Download Full-text

Hormonal contraception in women with diffuse nontoxic goiter and autoimmune thyroiditis

Journal of obstetrics and women s diseases ◽

10.17816/jowd62545-51 ◽

2013 ◽

Vol 62 (5) ◽

pp. 45-51

Author(s):

Galina Petrovna Pologoyko

Keyword(s):

Thyroid Gland ◽

Oral Contraceptives ◽

Autoimmune Thyroiditis ◽

Reproductive Age ◽

Control Group ◽

Blood Levels ◽

Thyroid Peroxidase ◽

Combined Oral Contraceptives ◽

Nontoxic Goiter ◽

And Function

The article considers the influence of combined oral contraceptives on size and function of thyroid gland in women of reproductive age. We examined 215 women, taking low dose and microdose combined oral contraceptives for 12 months as monotherapy or in combination with potassium iodide. The first group consisted of 75 women with diffuse nontoxic goiter, second – of 70 women with autoimmune thyroiditis. Control group consisted of 70 women without pathology of thyroid gland. Prior to therapy with combined contraceptives and after 12 months of treatment, we determined serum levels of free triiodothyronine, free thyroxine, and thyrotropin releasing hormone, antibodies to thyroid peroxidase and antibodies to thyroglobulin (ELISA) and performed sonography of thyroid gland. Results of our study suggest that combined oral contraceptives may increase the size of thyroid gland among women with diffuse nontoxic goiter without changing its function. In women with autoimmune thyroiditis, application of combined oral contraceptive significantly decreases blood levels of autoantibodies to thyroid peroxidase and thyroglobulin. Application of combined oral contraceptives in healthy women doesn’t influence the size and function of thyroid gland.

Download Full-text

Features of reproductive function in infertile women with hyperthyroidism

Perm Medical Journal ◽

10.17816/pmj38164-71 ◽

2021 ◽

Vol 38 (1) ◽

pp. 64-71

Author(s):

L. M. Rzakulieva ◽

A. E. Hajizade

Keyword(s):

Thyroid Gland ◽

Reproductive Function ◽

Reproductive Age ◽

Control Group ◽

Women Of Reproductive Age ◽

Early Menopause ◽

Ovarian Volume ◽

Infertile Women ◽

Group I ◽

Toxic Goiter

Objective. The aim was to study the characteristics of reproductive function in women of fertile age with infertility and hyperfunction of the thyroid gland. Materials and methods. The object of the study was 148 women of fertile age. To compare the indicators obtained by special methods, the control group included the indicators of laboratory and instrumental examination of 30 non-pregnant women of reproductive age. Reproductive function was evaluated in 118 women with hyperthyroidism: 58 retrospectively (group I) and 60 prospectively (group II); the control group consisted of 30 healthy women of reproductive age. Hormonal studies were performed by radioimmune and enzyme immunoassay methods using the automatic analyzer "Cobb" ("Hoffmann La Roche", Switzerland), as well as DPS test systems the analyzer Immulite (USA). Ultrasound of the thyroid gland was performed by a linear sensor with a frequency of 7.5 MHz. The volume of the thyroid gland was calculated according to the Bruno formula. Results. For women of fertile age with hyperthyroidism, a decrease in ovarian reserve is characteristic that is manifested by a significant increase in FSH level (14.1 3.1 IU / L, p 0.05), and a decrease in inhibin B level (35.9 12,7 pg / ml, p 0.05). In 47.7 % of women of fertile age with hyperthyroidism, there is a decrease in ovarian volume and a significant reduction in the average number of antral follicles of normal size (4.34 1.56, p 0.05). Conclusions. Based on the results obtained, it can be assumed that in diffuse toxic goiter there are not only functional disorders (metabolism of hormones of the reproductive system), but also deep organic changes in the structure of the ovaries that leads to a rapid suppression of their functions. In cases of thyroid diseases, the clinical manifestation of these changes is premature and early menopause.

Download Full-text

Diffuse non-toxic goiter and pregnancy

Journal of obstetrics and women s diseases ◽

10.17816/jowd81454 ◽

2005 ◽

Vol 54 (1) ◽

pp. 29-34

Author(s):

V. V. Potine ◽

А. В. Loginov ◽

N. N. Tkathenko

Keyword(s):

Thyroid Gland ◽

Pregnant Women ◽

Autoimmune Thyroiditis ◽

Thyroid Volume ◽

Percentage Increase ◽

Free T4 ◽

Healthy Women ◽

Toxic Goiter ◽

And Function ◽

Second Degree

The aim of this study was to investigate of effect of pregnancy on the thyroid sizes and function at the patients with diffuse non-toxic goiter in a region of marginal iodine deficiency. Materials and methods: 132 pregnant women in the age of 18-39 years, including 110 with diffuse non- toxic goiter and 22 pregnant women with a normal thyroid gland, were examined. 30 patients with diffuse non-toxic goiter of the first degree received 200 мкг per day of KI (iodid- 200), 40 patients with diffuse non-toxic goiter of the second degree received a 25-75 micrograms/day thyroxine (euthyrox). 25 patients with diffuse non-toxic goiter had not received regular therapy. The autoimmune thyroiditis is revealed for 15 women with diffuse non-toxic goiter. They received a 75-100 micrograms/day euthyrox. We estimated volume of the thyroid gland by ultrasound, serum TSH and serum thyroid hormone in each trimester of pregnancy. Results: At the healthy women during pregnancy the percentage increase of volume of a thyroid gland has constituted 24,30,2%. At the patients with diffuse non-toxic goiter, not receiving therapy, the thyroid gland was authentically increased at 37,11,1%. At the pregnant women receiving iodidum the percentage increase of volume of a thyroid gland has constituted 12,30,7%. After of a euthyrox therapy there was a relative decrease of the thyroid volume by 13,70,5%. In the group of healthy women a TSH level has increased inconsiderable from l,30,6mU/l to l,60,2mU/l to the end of pregnancy. During pregnancy in the group of women with diffuse non-toxic goiter without treatment rising the TSH values in a blood from l,40,3mU/I to 2,30,2 mU/l was revealed. The mean TSH levels of the goitrous pregnant group, receiving iodidum, essentially did not vary during pregnancy. In the goitrous pregnant group, receiving euthyrox, a TSH level has decreased considerably from l,80,5mU/l to 0,60,2 mU/l to the end of pregnancy. TSH values and free T4 in all the pregnant women were within the reference range in a blood of the healthy nonpregnant women. Was not observed of differences of pregnancy course and term delivery in compared groups. The high frequency of complications of pregnancy is connected to availability of the not diagnosed autoimmune thyroiditis. Conclusion: These results recommend to usage of iodine at the women with a not enlarged thyroid gland and with diffuse non-toxic goiter of the first degree and nonsupressic doses of thyroxine at the women with diffuse non-toxic goiter of the second degree during pregnancy.

Download Full-text

The influence of I, Se, S citrate on biochemical processes in chicken broiler organism

Scientific Messenger of LNU of Veterinary Medicine and Biotechnology ◽

10.32718/nvlvet9607 ◽

2019 ◽

Vol 21 (96) ◽

pp. 41-46

Author(s):

U. I. Tesarivska ◽

R. S. Fedoruk ◽

I. I. Kovalchuk ◽

O. I. Koleshchuk ◽

M. M. Tsap ◽

...

Keyword(s):

Thyroid Gland ◽

Blood Serum ◽

Serum Levels ◽

Control Group ◽

Blood Levels ◽

Urea Level ◽

Blood Indices ◽

Biochemical Processes ◽

Experimental Group ◽

Alt Activity

The manuscript describes the analysis of the influence of the I, Se, S citrate on the chicken broiler organism in high and low concentrations which was synthesized цитрату with the help of the electropulse nanotechnology method. Chicken broilers of the experimental groups of cross ROSS-308 from the day old I, Se, S citrate were drunk in the ration I – 3 : Se – 1 : S – 5 parts from the rate, first experimental group 10 mcg I/l, second – 40 I/l of drinking water. The use of both doses of I, Se, S citrate till 35 day of technological cycle had no probable effect in the biochemical processes of the poultry blood, however was a tendency to decrease the creatinine levels by 6%, urea by 21%, triacylglycerols by 13.3%, inorganic phosphor by 14.3% and АсАТ activity on 8% in chicken broiler of the first experimental group as increase in the content of cholesterol by 11.4%, albumin by 4.8% and ALT activity on 28.3% compared with the poultry of the control group. Chicken broilers which were drunk higher concentration of I, Se, S citrate with water, revealed the same amount of creatinine, cholesterol in blood serum and ALT activity as the poultry of control group, but the urea level has the tendency to decrease on 15.8%, АсАТ activity on – 8%, and triacylglycerols content – 1.9 times. There is a tendency to increase of albumin and inorganic phosphor levels respectively by 10.2 and 14.3% in the blood of these chicken. The use of the I, Se, S citrate in the dose of 10 mcg I/l till 48 day of technological period of growth and development caused a corresponding effect on the lipid metabolism in poultry organism, which indicates a likely decrease in blood levels of triacylglycerolsна in 1.6 times on the background of increase the cholesterol level by 27.3%. There is also a downward trend of levels of Calcium by 14.8; Phosphor by 22.2%, albumin by 12.3%, creatinine by 3.2% and aminotransferase activity: ALT – by 10.5 and АсАТ – by 3.4%. Urea level tended to increase by 15.4% in relation to the indices of the control group. It is probable that, in comparison with the control poultry group, an increase in chicken broilers blood serum levels of urea by 2.4 times, cholesterol and inorganic phosphor by 1.9 times when drinking I, Se, S citrate with water in the dose 40 mcg I/l till 48 day indicates the possibility of protein, lipid and mineral intensity. There was marked a tendency to increase the levels of creatinine on 10.2%, triacylglycerols – by 7.7%, and decrease the content of Calcium by 14.8% and АLТ and АсАТ activity by 11.4 and 7.2%, respectively, which given likely with other blood indices differences may be due to kidney, liver and thyroid gland functions changes. The investigation of the individual organs status of chicken broilers of both experimental groups by determination their mass coefficients indicates the absence in changes in liver functions the thymus and the fabric bag, and a probable increase in heart mass control on 23.5%, the mass coefficient of the spleen – by 1.7 times. In the future, it is advisable to study the influence of different concentrations of I, Se, S citrate on the hormone-synthesizing thyroid gland function.

Download Full-text

Clinical-pathological Changes in Reproductive Age Women With Autoimmune Thyroiditis

Bulletin of Science and Practice ◽

10.33619/2414-2948/70/31 ◽

2021 ◽

Vol 7 (9) ◽

pp. 354-359

Author(s):

N. Mazhitova ◽

R. Kalmatov ◽

G. Abdykaimova ◽

Zh. Abdullaeva

Keyword(s):

Thyroid Gland ◽

Autoimmune Thyroiditis ◽

Thyroid Stimulating Hormone ◽

Diagnostic Methods ◽

Reproductive Age ◽

Thyroid Peroxidase ◽

Kyrgyz Republic ◽

Free Triiodothyronine ◽

Autoimmune Thyroid Diseases ◽

Autoimmune Pathology

Research relevance: Autoimmune pathology of the thyroid gland is one of the urgent problems of modern endocrinology, and this is due to the lack of clarity of pathogenetic mechanisms and the lack of objective and reliable diagnostic methods, including immunological. The mechanisms of autoimmune thyroid diseases have not yet been fully elucidated, although about a hundred years have passed since the first description of autoimmune thyroiditis. According to world statistics, thyroid disease occurs in almost 30% of the world’s population. According to the latest data, in Kyrgyzstan, they are found in 10–30 percent of the population. Objectives of the study: Clinical and pathological substantiation of ways to optimize the diagnosis of autoimmune thyroiditis in residents of the southern region of the Kyrgyz Republic. Research methods: clinical and immunological (determination of the titer of antibodies to thyroid peroxidase (AT TPO); cytokines); static method; laboratory (content of free thyroxine (T4); thyroid-stimulating hormone (TSH); free triiodothyronine (T3); hematological, biochemical blood test; ultrasound of the thyroid gland. Conclusions: Lack of iodine causes irreparable harm to absolutely every person: child and adult, men and women. Iodine deficiency is most common in women who are in late pregnancy.

Download Full-text

IL-10-592 A/C Gene Polymorphism and Cytokine Levels are Associated with Susceptibility to Drug Resistance in Tuberculosis

Turkish Journal of Immunology ◽

10.25002/tji.2020.1235 ◽

2020 ◽

Vol 8 (3) ◽

pp. 103-112

Author(s):

Atefeh SADEGHI SHERMEH ◽

Majid KHOSHMIRSAFA ◽

Ali-Akbar DELBANDI ◽

Payam TABARSI ◽

Esmaeil MORTAZ ◽

...

Keyword(s):

Serum Levels ◽

World Health ◽

Control Group ◽

Drug Resistant ◽

Nucleotide Polymorphisms ◽

Genotype Frequencies ◽

Cytokine Levels ◽

Ifn Γ ◽

Health Organization ◽

And Function

Introduction: Tuberculosis (TB) and especially resistant forms of it have a substantial economic burden on the community health system for diagnosis and treatment each year. Thus, investigation of this field is a priority for the world health organization (WHO). Cytokines play important roles in the relationship between the immune system and tuberculosis. Genetic variations especially single nucleotide polymorphisms (SNPs) impact cytokine levels and function against TB. Material and Methods: In this research SNPs in IFN-γ (+874 T/A) and IL-10 (-592 A/C) genes, and the effects of these SNPs on cytokine levels in a total of 87 tuberculosis patients and 100 healthy controls (HCs) were studied. TB patients divided into two groups: 1) 67 drug-sensitive (DS-TB) and 2) 20 drug-resistant (DR-TB) according to drug sensitivity test using polymerase chain reaction (PCR). For the genotyping of two SNPs, the PCR-based method was used and IFN-γ and IL-10 levels were measured by ELISA in pulmonary tuberculosis (PTB) and control group. Results: In -592A/C SNP, only two genotypes (AA, AC) were observed and both genotypes showed statistically significant differences between DR-TB and HCs (p=0.011). IL-10 serum levels in PTB patients were higher than HCs (p=0.02). The serum levels of IFN-γ were significantly higher in DS-TB patients than that of the other two groups (p<0.001); however, no significant differences were observed for allele and genotype frequencies in IFN-γ +874. Conclusions: Our results suggest that the SNP at -592 position of IL-10 gene may be associated with the susceptibility to DR-TB. However, further investigation is necessary. Keywords: Polymorphism, IFN-γ, IL-10, tuberculosis, drug-resistant tuberculosis

Download Full-text

Features of the ovarian reserve of women of reproductive age suffering from autoimmune diseases

GYNECOLOGY ◽

10.26442/20795696.2020.5.200416 ◽

2020 ◽

Vol 22 (5) ◽

pp. 27-30

Author(s):

Elena N. Andreeva ◽

Olga R. Grigoryan ◽

Yulia S. Absatarova ◽

Irina S. Yarovaya ◽

Robert K. Mikheev

Keyword(s):

Type 1 Diabetes ◽

Thyroid Gland ◽

Autoimmune Diseases ◽

Ovarian Reserve ◽

Reproductive Potential ◽

Reproductive Age ◽

Control Group ◽

Antithyroid Antibodies ◽

Healthy Women

The reproductive potential of a woman depends on indicators of the ovarian reserve, such as the anti-Muller hormone (AMH) and the number of antral follicles (NAF). Autoimmune diseases have a significant effect on fertility and contribute to the development of premature ovarian failure. Aim.To evaluate the parameters of the ovarian reserve in patients with type 1 diabetes mellitus, carriers of antibodies to the thyroid gland in a state of euthyroidism and compare them with similar parameters in healthy women. Materials and methods.In the first block of the study, the level of AMH, follicle-stimulating hormone, luteinizing hormone, NAF was studied among 224 women with diabetes and 230 healthy women in the control group. In block II, the level of the above hormonal indices was studied in 35 carriers of antithyroid antibodies in the state of euthyroidism and 35 healthy women. Results.In patients with type 1 diabetes, the level of AMH, NAF was statistically significantly lower when compared with the control group. Among carriers of antithyroid antibodies and healthy women, no difference in AMH and NAF was found. Conclusion.The autoimmune processes accompanying diabetes are more influenced by the ovarian reserve indices than autoimmune aggression to the tissues of the thyroid gland.

Download Full-text

HHV-6 Infection and Chemokine RANTES Signaling Pathway Disturbance in Patients with Autoimmune Thyroiditis

Viruses ◽

10.3390/v12060689 ◽

2020 ◽

Vol 12 (6) ◽

pp. 689 ◽

Cited By ~ 1

Author(s):

Alina Sultanova ◽

Maksims Cistjakovs ◽

Liba Sokolovska ◽

Katerina Todorova ◽

Egils Cunskis ◽

...

Keyword(s):

Thyroid Gland ◽

Autoimmune Thyroiditis ◽

Genomic Sequence ◽

Thyroid Tissue ◽

Human Herpesvirus ◽

Control Group ◽

Nested Polymerase Chain Reaction ◽

Tissue Samples ◽

Reverse Transcription Pcr ◽

Visual Confirmation

The aim of this study was to investigate the role of human herpesvirus-6 (HHV-6) in autoimmune thyroiditis (AIT) development. We examined the possible involvement of HHV-6 gene expression encoding immunomodulating proteins U12 and U51 in AIT development and their role in the modulation of chemokine signaling. One hundred patients with autoimmune thyroiditis following thyroidectomy were enrolled in this study. Nested polymerase chain reaction (nPCR) was used to detect the HHV-6 sequence in DNA samples. Reverse transcription PCR (RT-PCR) with three different HHV-6 gene targets (U79/80, U51 and U12) was to detect active infection markers. HHV-6 load was identified using a commercial real-time PCR kit. Immunohistochemistry was performed to investigate the expression of the HHV-6 antigen and RANTES (Regulated upon Activation, Normal T Cell Expressed and Secreted) in thyroid gland tissue. Different commercial immunosorbent assay kits were used for the detection of RANTES, IFNγ, IL-6, and TNFα levels in the AIT patient group and controls. We detected 98% presence of the HHV-6 genomic sequence in AIT patients’ thyroid gland tissues. Markers of active HHV-6 infection (HHV-6 U79/80, U12 and/or U51 mRNA) were predominant in AIT patients’ thyroid tissue samples in comparison with the control group (56% vs. 6%). Evidence from immunofluorescence microscopy showed that HHV-6 can persist in thyrocytes and can interact with RANTES. Visual confirmation of the intense immunofluorescence signal of RANTES detected in thyroid tissues could indicate high expression of this chemokine in the thyroid gland. On the other hand, immunosorbent assays showed very low RANTES levels in AIT patients’ peripheral plasma. These results indicate that RANTES level in AIT patients could be influenced by HHV-6 activation, which in turn may aid AIT development.

Download Full-text

189 THE EFFECT OF VITAMIN D SUPPLEMENTATION ON ANTI-MULLERIAN HORMONE LEVELS IN REPRODUCTIVE-AGE WOMEN

Reproduction Fertility and Development ◽

10.1071/rdv27n1ab189 ◽

2015 ◽

Vol 27 (1) ◽

pp. 185 ◽

Cited By ~ 2

Author(s):

M. Taheri ◽

M. Modarres ◽

A. Abdollahi

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Intervention Group ◽

Serum Levels ◽

Vitamin D Supplementation ◽

T Test ◽

Reproductive Age ◽

Control Group ◽

Post Intervention ◽

Reproductive Age Women

Vitamin D deficiency has been correlated with the infertility and lower clinical pregnancy following IVF. Anti-Mullerian hormone (AMH) plays a key role during follicle development; it has been recognised as a predictor of regular ovulation and probably IVF success. Considering the critical need for experimental human study to investigate the impact of vitamin D supplementation on ovulatory function, the aim of this study was to demonstrate the effectiveness of the vitamin D supplementation on AMH serum levels among reproductive-age women with vitamin D deficiency. 195 reproductive women (18–35 year-old) with confirmed vitamin D deficiency [serum 25(OH)D <75 nmol L–1] and without diagnosed polycystic ovary syndrome (PCOS) were enrolled to this controlled clinical trial. Participants were randomly assigned to a control group (n = 96) or an intervention group (n = 99). Women in the intervention group used 2000 IU day–1 vitamin D drops for 15 weeks. 19 participants were missed during the follow-up; finally the numbers of women in the intervention and control groups were 91 and 85, respectively. At the beginning of the study and after the intervention, 25-hydroxyvitamin D and AMH serum levels were quantified using enzyme immunoassay (EIA; Immunodiagnostic Systems, Boldon, UK) and ELISA (Beckman-Coulter Inc., Fullerton, CA, USA) methods respectively. The post-intervention AMH measurement was performed after 2–5 weeks in the same day-of-cycle on which basal AMH measurement was done. Paired t-test, independent t-test, and Pearson correlation were used as appropriate and a P-value of less than 0.05 was considered significant. Significantly low AMH levels were seen in the vitamin D deficient women of this study (14.46 ± 11.92 pmol L–1 in control group and 14.09 ± 11.52 pmol L–1 in intervention group). After the intake of vitamin D supplementation in intervention group, AMH levels were increased to 24.89 ± 12.47 pmol L–1, which were significantly different from the 15.43 ± 13.03 pmol L–1 in control group (P < 0.001). Correlation coefficients for AMH with pre-intervention and post-intervention vitamin D were r = 0.489 and r = 0.599 respectively (P < 0.001). Treatment of vitamin D deficiency increases AMH to the optimum levels. Vitamin D deficient women had low levels of AMH. These findings support other studies which found a correlation of poor IVF outcomes with low vitamin D levels. Vitamin D supplementation could be useful in the improvement of controlled ovarian hyper-stimulation/IVF outcomes in case of vitamin D deficiency.

Download Full-text

Peculiarities of sonoelastographic imaging of thyroid papillary cancer in presence of autoimmune thyroiditis

Terapevticheskii arkhiv ◽

10.26442/00403660.2021.04.200675 ◽

2021 ◽

Vol 93 (4) ◽

pp. 369-375

Author(s):

Anna R. Khachatryan ◽

Goar J. Vardanyan ◽

Garnik A. Avetisyan ◽

Aram S. Chomoyan ◽

Satenik E. Baghdasaryan ◽

...

Keyword(s):

Thyroid Gland ◽

Autoimmune Thyroiditis ◽

Ultrasound Image ◽

Shear Wave Elastography ◽

Qualitative Assessment ◽

Control Group ◽

Thyroid Papillary ◽

Degree Of Confidence ◽

Thyroid Papillary Cancer ◽

High Degree

Aim. To determine the features of visualization of papillar thyroid cancer (PTC) in presence of autoimmune thyroiditis (AIT) according to sonoelastography data. Materials and methods. 155 patients were examined (75 PTC, 30 AIT, 20 PTC in presence of AIT and 30 with diffuse parenchymal changes) and 30 patients of the control group. Among patients with PTC 68 (90.7%) were represented by female (mean age 46.713.12 years) and 7 (9.3%) by male (average age 48.14.05 years) patients, PTC in presence of AIT by 19 female (average age 46.916.98 years) and 1 male (22 years) patients. Ultrasound investigation was performed with devices Toshiba Aplio-400 and Toshiba Aplio-500 (Japan) by the standard method and using elastography. A surface transducer with a frequency of 1014 MHz was used. An analysis of the thyroid ultrasound image was performed in correspondence with TI-RADS. For a qualitative assessment of the elastographic picture of thyroid foci, the TsukubaUeno assessment visual standardized system was implemented. Results. According to the TI-RADS scale, most nodular formations are assigned to category 4. With TPC with an unchanged thyroid gland, category 4 was determined in 52 patients (69.3%), and with PR in presence of AIT 15 patients (75%). When determining the qualitative criteria for Tsukuba Ueno, the majority of tumors were assigned to types 3b and 4: cancers in presence of AIT 95% and cancers with no changes to thyroid gland 81.3%. Sonoelastographic criteria for thyroid parenchyma with AIT with a high degree of confidence are significantly higher than in the control group (p0.000). In a comparative analysis of thyroid sonoelastography in PTC with unchanged parenchyma and AIT, changes according to compression elastography are statistically unreliable. In shear wave elastography, sonoelastographic criteria for PTC are significantly higher in patients with AIT (p0.02 when measured in kPa, p0.01 when measured in m/s). Conclusion. Sonoelastography data can be used as additional criteria in the differential diagnosis of focal thyroid formations.

Download Full-text