scholarly journals Betadin (EGIS) in treatment of inflammatory diseases and dysbiotic state of external female genital organs

2021 ◽  
Vol 50 (1) ◽  
pp. 61-63
Author(s):  
S. S. Popova
Keyword(s):  
Inflammatory Diseases ◽  
Wide Spectrum ◽  
Effective Therapy ◽  
High Tolerance ◽  
Female Genital

The special research of clinicalproperties of Betadin EGIS showed its efficiency in 85% cases. The analysis of the data made it possible to conclude that for today Betadin EGIS is a preferable preparation in treating vulvo-vaginitis and other pathological states andprocesses in externalfemale genital organs. The main advantage of the preparation is its wide spectrum of action. It enables to begin adequate and effective therapy in due time without waiting for the results offinal bacteriological diagnostics. The research showed that Betadin EGIS has high tolerance, if necessary it can be used in combination with others antibacteriological drugs.

Antibacterial treatment and hirudotherapy in hormono— dependent and inflammatory diseases of female genital organs

1998 ◽  
Vol 79 (4) ◽  
pp. 280-281
Author(s):  
R. I. Zhivoglyad
Keyword(s):  
Antibacterial Therapy ◽  
Inflammatory Diseases ◽  
Hirudo Medicinalis ◽  
Antibacterial Treatment ◽  
Pathologic Process ◽  
Combined Use ◽  
Biochemical Indices ◽  
Positive Effect ◽  
Female Genital

The results of the influence of the Hirudo medicinalis leeches and antibacterial therapy on homeostasis indices in patients with hormono dependent and inflammatory diseases of genital organs are analyzed. The positive effect of hirudotherapy courses on general and biochemical indices of blood changed as a result of the pathologic process progression is shown. The combined use of hirudotherapy and antibacterial treatment is recommended.

Treatment of inflammatory diseases of the female genitalia with iontophoresis

1927 ◽  
Vol 23 (4) ◽  
pp. 425-429
Author(s):  
N. S. Utochnikova
Keyword(s):  
Young Women ◽  
Surgical Intervention ◽  
Inflammatory Diseases ◽  
The Other ◽  
Female Genitalia ◽  
Physical Methods ◽  
Surgical Methods ◽  
The One ◽  
Methods Of Treatment ◽  
Female Genital

The treatment of inflammatory diseases of the female genitalia has long been one of the most important tasks of the gynecologist. With the development of surgery, surgical methods of treatment began to be applied: exudates were removed, the uterus and inflamed appendages were extirpated, etc.; but the danger of surgical intervention on the one hand, and on the other - the severe consequences of removal of organs such as ovaries, especially in young women - forced gynecologists to spend much effort in discovering and improving non-operative methods of treatment of inflammatory diseases of the female genital parts. Among these methods, physical methods such as water, mud, light baths, massage, etc., as well as those related to electricity have long been prominent.

scholarly journals Inhaled antibiotics to improve efficacy and safety in the treatment of upper airway and lung inflammatory diseases

2021 ◽  
pp. 84-92
Author(s):  
Vladimir N. Drozdov ◽  
Konstantin I. Arefev ◽  
Svetlana Y. Serebrova ◽  
Irina A. Komissarenko ◽  
Evgenia V. Shikh ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Targeted Delivery ◽  
Whooping Cough ◽  
Inflammatory Diseases ◽  
Wide Spectrum ◽  
Chronic Obstructive ◽  
Combination Drug ◽  
Antibacterial Drugs ◽  
Systemic Antibiotic Therapy ◽  
Inhaled Antibiotics

Inhaled antibacterial drugs have been used since the 1940s with greater or lesser effectiveness, due to the possibility of targeted delivery of drugs directly to the infection site at concentrations higher than MICs. High local concentrations of antibacterial agents expand the possibilities of treating infections caused by multiresistant strains and reduces antibiotic resistance in the population. The inhaled delivery method is characterized by a high level of safety due to the absence of systemic toxic effects, which reduces the risk of pseudomembranous colitis and other complications of antibiotic therapy. Thiamphenicol glycinate acetylcysteinate is a combined drug that includes thiamphenicol and N-acetylcysteine, which causes its antibacterial and mucolytic activity. The results of clinical studies have demonstrated the effectiveness of TGA in the treatment of acute and chronic bronchitis, chronic obstructive pulmonary disease, community-acquired pneumonia, laryngotracheitis, rhinosinusitis and other infections of the upper and lower respiratory tract. In pediatrics, the drug is used to treat bronchitis and pneumonia, especially those that cannot be treated with other antibacterial drugs, bronchiolitis, whooping cough, and cystic fibrosis. The article presents data on the effectiveness and safety of containing TGA. A wide spectrum of antibacterial actions, the ability to form high local concentrations of antibacterial and mucolytic components in the focus of infection, a low risk of serious side effects in both adults and children are noted. The topical use of the combination drug has proven to be effective not only in bringing about a pronounced clinical improvement, but also in reducing the frequency of use of systemic antibiotic therapy. The efficacy of thiamphenicol glycinate acetylcysteinate is not inferior to macrolide antibiotics.

scholarly journals Host-Directed Therapies for Cutaneous Leishmaniasis

2021 ◽  
Vol 12 ◽  
Author(s):  
Fernanda O. Novais ◽  
Camila Farias Amorim ◽  
Phillip Scott
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Inflammatory Diseases ◽  
Wide Spectrum ◽  
Substantial Evidence ◽  
Novel Approach ◽  
Clinical Presentations ◽  
Wide Range ◽  
Parasite Replication ◽  
Inflammatory Drugs ◽  
Improve Clinical Outcome

Cutaneous leishmaniasis exhibits a wide spectrum of clinical presentations from self-resolving infections to severe chronic disease. Anti-parasitic drugs are often ineffective in the most severe forms of the disease, and in some cases the magnitude of the disease can result from an uncontrolled inflammatory response rather than unrestrained parasite replication. In these patients, host-directed therapies offer a novel approach to improve clinical outcome. Importantly, there are many anti-inflammatory drugs with known safety and efficacy profiles that are currently used for other inflammatory diseases and are readily available to be used for leishmaniasis. However, since leishmaniasis consists of a wide range of clinical entities, mediated by a diverse group of leishmanial species, host-directed therapies will need to be tailored for specific types of leishmaniasis. There is now substantial evidence that host-directed therapies are likely to be beneficial beyond autoimmune diseases and cancer and thus should be an important component in the armamentarium to modulate the severity of cutaneous leishmaniasis.

Radiographic Characterization of Enlarged Sternal Lymph Nodes in 71 Dogs and 13 Cats

2012 ◽  
Vol 48 (3) ◽  
pp. 176-181 ◽  
Author(s):  
Kelli Smith ◽  
Robert O'Brien
Keyword(s):  
Retrospective Study ◽  
Lymph Nodes ◽  
Statistical Difference ◽  
Inflammatory Diseases ◽  
Wide Spectrum ◽  
Etiologic Agent ◽  
Neoplastic Disease ◽  
Clinical Diagnoses ◽  
Average Size

In this retrospective study, radiographically enlarged sternal lymph nodes (LNs) were evaluated in 71 dogs and 13 cats for average size, location, and most representative radiographic view. Concurrent clinical diagnoses were also noted and grouped into one of three following categories: neoplastic, inflammatory, or hematologic. There were no statistically significant differences in LN size between lateral views within each species. Enlarged sternal LNs were more cranially positioned in dogs than cats. No statistical difference was noted between right and left laterals, as to on which projection the enlarged sterna lymph nodes was seen best. Neoplastic disease (78.9%) was the most prevalent condition seen in association with LN enlargement in dogs, followed by primary infectious or inflammatory diseases (14.1%) and various hematologic conditions (7.0%). In cats, neoplasia was also most common (69.2%), followed by inflammatory diseases (30.8%). No hematologic conditions were noted in cats. The most common etiologic agent seen concurrently with enlarged sternal LNs in both dogs (33.8%) and cats (38.5%) was malignant lymphoma. The results of this study provide a clinically useful representation of the average size and location of radiographically enlarged sternal LNs for dogs and cats. The diseases represented demonstrate the wide spectrum of potential causes of sternal lymphadenopathy.

scholarly journals Terpikhin for chronic inflammatory diseases of the female genital area Schwarz (Deut. Med. Woch., 1921, No. 52)

2021 ◽  
Vol 18 (3) ◽  
pp. 105-105
Author(s):  
V. G.
Keyword(s):  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases ◽  
Genital Area ◽  
Female Genital

This remedy, offered by Oestgeich-Som, contains 15% ol. terebinthini, 0.5% quinine and anesthesin each, 84% ol. olivarum. Having applied it in 22 cases of perimetritis, salpingitis, oophoritis, infiltrates in the posterior Dоnglasen, etc., Schwarz (Deut. Med. Woch., 1921, No. 52) was very pleased with the results.

scholarly journals Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment

Biomolecules ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 687 ◽  
Author(s):  
Eun Seong Hwang ◽  
Seon Beom Song
Keyword(s):  
Adverse Effects ◽  
Inflammatory Diseases ◽  
Wide Spectrum ◽  
Public Awareness ◽  
High Dose ◽  
Negative Effects ◽  
Methylation Of Dna ◽  
Multiple Routes ◽  
Underlying Mechanisms ◽  
High Level

Nicotinamide (NAM) at doses far above those recommended for vitamins is suggested to be effective against a wide spectrum of diseases and conditions, including neurological dysfunctions, depression and other psychological disorders, and inflammatory diseases. Recent increases in public awareness on possible pro-longevity effects of nicotinamide adenine dinucleotide (NAD+) precursors have caused further growth of NAM consumption not only for clinical treatments, but also as a dietary supplement, raising concerns on the safety of its long-term use. However, possible adverse effects and their mechanisms are poorly understood. High-level NAM administration can exert negative effects through multiple routes. For example, NAM by itself inhibits poly(ADP-ribose) polymerases (PARPs), which protect genome integrity. Elevation of the NAD+ pool alters cellular energy metabolism. Meanwhile, high-level NAM alters cellular methyl metabolism and affects methylation of DNA and proteins, leading to changes in cellular transcriptome and proteome. Also, methyl metabolites of NAM, namely methylnicotinamide, are predicted to play roles in certain diseases and conditions. In this review, a collective literature search was performed to provide a comprehensive list of possible adverse effects of NAM and to provide understanding of their underlying mechanisms and assessment of the raised safety concerns. Our review assures safety in current usage level of NAM, but also finds potential risks for epigenetic alterations associated with chronic use of NAM at high doses. It also suggests directions of the future studies to ensure safer application of NAM.

Immunomodulators use in a treatment of lower urogenital tract infections in women

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (1) ◽  
pp. 69-74
Author(s):  
Galina B Dikke ◽  
Vladimir V Ostromensky
Keyword(s):  
Inflammatory Diseases ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Supportive Therapy ◽  
The Body ◽  
Comprehensive Treatment ◽  
Lower Genital Tract ◽  
Increased Risk ◽  
Window Of Vulnerability ◽  
Tract Infections

Relevance. Women’ immune system indexes are dependent on cyclic hormonal influences. They decrease in the ovulation and in luteal phase of the menstrual cycle forming a “window of vulnerability” when there is an increased risk of infection with pathogenic and opportunistic microorganisms. Infected tissues inflammatory reaction in its turn aggravates these disorders. For these reasons, one should not only use empirical regimens of antimicrobial therapy covering wide spectrum of pathogens, but also to consider the possibility and need of a comprehensive approach with use of adjuvant treatment methods (detoxification, immunomodulatory, supportive therapy). Aim. To determine immunological changes in the body of women with lower genital tract infectious and inflammatory diseases and to justify a role of immunomodulators in increasing of treatment and relapse prevention efficacy. Materials and methods. In order to write this review domestic and foreign publications were searched in Russian and international search systems (PubMed, eLIBRARY, etc.) for the last 2-22 years. The review included articles from peer-reviewed literature. Results. Due to its immunomodulatory, anti-inflammatory and detoxifying effects azoximer bromide contributes to an increase in treatment efficacy: elimination of pathogenic flora increases by 30%, clinical manifestations resolution occurs 2 times faster, a relapse risk reduces. Conclusion. To activate anti-infective immunity a comprehensive treatment with immunomodulators use is advisable.

Truncated and Microparticle Free Soluble Tissue Factor Bound to Peripheral Monocytes Preferentially Activate Factor VII.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 2232-2232 ◽  
Author(s):  
Mohammad Khan ◽  
Takashi Hattori ◽  
Stefan Niewiarowski ◽  
L. Henry Edmunds ◽  
Robert W. Colman
Keyword(s):  
Tissue Factor ◽  
Blood Cells ◽  
Mononuclear Cells ◽  
Inflammatory Diseases ◽  
Wide Spectrum ◽  
Factor Vii ◽  
Activate Factor ◽  
Healthy Individuals ◽  
Prothrombotic State ◽  
Low Concentrations

Abstract Soluble plasma tissue factor (TF) circulates in picomolar concentrations in healthy individuals and increases in a wide spectrum of diseases. This study tests the hypothesis that both truncated or long length TF antigens in low concentrations combine with monocytes or platelets to convert factor VII (fVII) to fVIIa. Both recombinant truncated TF (rsTF, kDa 33) and long length (47 kDa) plasma TF (pTF), obtained from pericardial wounds of patients having cardiac surgery using cardiopulmonary bypass, were studied in association with blood cells and TF bearing microparticles. Tissue factor was measured by ELISA. RsTF binds to erythrocytes, platelets, mononuclear cells and neutrophils. The rate of fVII conversion with rsTF (1.0 – 103nmoles/L) is fastest with mononuclear cells, less with platelets, minimal with neutrophils and undetectable with erythrocytes. Both unstimulated and stimulated mononuclear cells or platelets in the presence of 3.5 pmoles/L rsTF or pTF convert fVII (10 nmoles/L) to fVIIa, but the amounts of fVIIa produced is greater in mononuclear cells. When leukocytes or platelets are absent, microparticles associated with 3.5 pmoles/L TF antigen, derived from pericardial wound plasma, do not activate fVII. Stimulated mononuclear cells convert nearly all available fVII (10 nmoles/L) to fVIIa with 3.5 pmoles/L pTF. Unstimulated mononuclear cells convert small amounts of fVII with as little as 1 pmole/L rsTF but no VIIa is produced by platelets, neutrophils or erythrocytes under these conditions. At all concentrations (0.001 to 1m moles/L) mononuclear cells more efficiently convert fVII to fVIIa than platelets. This study shows that stimulated mononuclear cells provide the most efficient phospholipid platform for activation of truncated or long length molecules of soluble TF at low concentrations of TF antigen. The results suggest a new mechanism by which soluble TF, which is increased in clinical inflammatory diseases, may lead to a prothrombotic state.

scholarly journals Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action

2008 ◽  
Vol 30 (3) ◽  
pp. 271-280 ◽  
Author(s):  
Antonio Waldo Zuardi
Keyword(s):  
Chemical Structure ◽  
Web Of Science ◽  
Inflammatory Diseases ◽  
Wide Spectrum ◽  
Therapeutic Effects ◽  
Neuroprotective Effects ◽  
Wide Range ◽  
Sedative Effects ◽  
Therapeutic Properties ◽  
Number Of Publications

OBJECTIVE: The aim of this review is to describe the historical development of research on cannabidiol. METHOD: This review was carried out on reports drawn from Medline, Web of Science and SciELO. DISCUSSION: After the elucidation of the chemical structure of cannabidiol in 1963, the initial studies showed that cannabidiol was unable to mimic the effects of Cannabis. In the 1970's the number of publications on cannabidiol reached a first peak, having the research focused mainly on the interaction with delta9-THC and its antiepileptic and sedative effects. The following two decades showed lower degree of interest, and the potential therapeutic properties of cannabidiol investigated were mainly the anxiolytic, antipsychotic and on motor diseases effects. The last five years have shown a remarkable increase in publications on cannabidiol mainly stimulated by the discovery of its anti-inflammatory, anti-oxidative and neuroprotective effects. These studies have suggested a wide range of possible therapeutic effects of cannabidiol on several conditions, including Parkinson's disease, Alzheimer's disease, cerebral ischemia, diabetes, rheumatoid arthritis, other inflammatory diseases, nausea and cancer. CONCLUSION: In the last 45 years it has been possible to demonstrate that CBD has a wide range of pharmacological effects, many of which being of great therapeutic interest, but still waiting to be confirmed by clinical trials.

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