scholarly journals Treatment of Dental Caries with Diamine Silver Fluoride: Literature Review

2018 ◽  
Vol 20 (3) ◽  
pp. 152
Author(s):  
Marília Franco Punhagui ◽  
Jaqueline Costa Favaro ◽  
Beatriz Brandão Sacarpelli ◽  
Ricardo Danil Guiraldo ◽  
Murilo Baena Lopes ◽  
...  
Keyword(s):  
Literature Review ◽  
Data Extraction ◽  
Caries Prevention ◽  
In Vivo Studies ◽  
Permanent Teeth ◽  
Cochrane Library ◽  
Silver Diamine Fluoride ◽  
Non Invasive

AbstractBrazilian health care programs recommend the use of cariostatic solutions of silver diamine fluoride (SDF) or sodium fluoride varnishes for children 0 to 3 years old with high or moderate caries activity for the control of caries lesions. SDF is a safe, economical, efficient and non-invasive coadjuvant agent, exerting an antibacterial action capable of reducing superficial mineral loss of the enamel and can be used in the treatment of deciduous and permanent teeth. The objective of this literature review was to gather current information on describing the mechanism of SDF action’ and its clinical application in young children in caries prevention and paralysis. The PubMed / Medline and Cochrane Library databases were accessed by identifying the relevant studies published in English from 1960 to May 2017. The search strategy employed the keywords: “Silver diamine fluoride” and “Children “or “Infant” and “Caries prevention”. Data extraction was performed in: 19 in vitro studies; 10 review articles and 8 in vivo studies. It was possible to conclude that SDF is almost twice as effective compared to fluoride varnish in caries paralysis. However, the contact time of the solution and the optimal frequency of application of the SDF are still undefined, inducing new projects and clinical studies in the search for an adequate clinical protocol of this cariostatic.Keywords: Preventive Dentistry. Children. Dental Caries.Resumo Os programas de assistência à saúde brasileiros recomendam para o controle das lesões de cárie a utilização de soluções cariostáticas de diamino fluoreto de prata - DFP ou vernizes de fluoreto de sódio para crianças de 0 a 3 anos com atividade de cárie alta ou moderada. O DFP é agente coadjuvante seguro, econômico, eficiente e não invasivo, exercendo ação antibacteriana capaz de reduzir a perda mineral superficial do esmalte e, pode ser utilizado no tratamento de dentes decíduos e permanentes. O objetivo desta revisão de literatura foi reunir informações atuais sobre descrever o mecanismo de ação do DFP e sua aplicação clínica em crianças de pouca idade na prevenção e paralisação da cárie. As bases de dados PubMed/Medline e Cochane Library foram acessadas identificando os estudos relevantes publicados em inglês, no período de 1960 a maio de 2017. A estratégia de busca empregou as palavras-chave: “Silver diamine fluoride” and “Children” or “Infant” and “Caries prevention”. A extração dos dados foi realizada em: 19 estudos in vitro; 10 artigos de revisão e 8 estudos in vivo. Foi possível concluir que o DFP apresenta-se quase duas vezes tão eficaz comparado ao verniz fluoretado na paralização de cárie. Porém, o tempo de contato da solução e a frequência ótima de aplicação do DFP ainda estão indefinidos, suscitando novos projetos e estudos clínicos na busca de adequado protocolo clínico deste cariostático.Palavra-chave: Odontologia Preventiva. Criança. Carie Dentária. 

scholarly journals Pharmacological and Therapeutic Potential of Myristicin: A Literature Review

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5914
Author(s):  
Elisa Frederico Seneme ◽  
Daiane Carla dos Santos ◽  
Evelyn Marcela Rodrigues Silva ◽  
Yollanda Edwirges Moreira Franco ◽  
Giovanna Barbarini Longato
Keyword(s):  
Literature Review ◽  
Therapeutic Potential ◽  
Review Article ◽  
In Vivo Studies ◽  
Exclusion Criteria ◽  
Asian Continent ◽  
Natural Origin ◽  
Beneficial Effects

Natural products have been used by humanity for many centuries to treat various illnesses and with the advancement of technology, it became possible to isolate the substances responsible for the beneficial effects of these products, as well as to understand their mechanisms. In this context, myristicin, a substance of natural origin, has shown several promising activities in a large number of in vitro and in vivo studies carried out. This molecule is found in plants such as nutmeg, parsley, carrots, peppers, and several species endemic to the Asian continent. The purpose of this review article is to discuss data published in the last 10 years at Pubmed, Lilacs and Scielo databases, reporting beneficial effects, toxicity and promising data of myristicin for its future use in medicine. From 94 articles found in the literature, 68 were included. Exclusion criteria took into account articles whose tested extracts did not have myristicin as one of the major compounds.

The use of L-glucose in cancer diagnosis: Results from In Vitro and In Vivo Studies

2021 ◽  
Vol 28 ◽  
Author(s):  
Ioanna A. Anastasiou ◽  
Ioanna Eleftheriadou ◽  
Anastasios Tentolouris ◽  
Iordanis Mourouzis ◽  
Constantinos Pantos ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Diagnosis ◽  
English Language ◽  
Research Work ◽  
Tumor Development ◽  
Mirror Image ◽  
In Vivo Studies ◽  
Cochrane Library

Background:: Cancer cells are characterized by metabolic heterogeneity. Although many research groups make efforts to analyze this heterogeneity, little attention has been paid to the scenario that cancer cells may utilize otherwise unusable substrates as fuel for tumor development. Of the two stereoisomers of glucose, D-glucose but not L-glucose, the mirror image isomer of D-glucose, is abundantly found in nature. D-glucose is the human body's key source of energy, through aerobic respiration. However, data from in vitro and in vivo studies examining the ability of cancer cells to take up L-glucose are scarce. Objectives: The present mini-review aims to present current literature data on the role of L-glucose in cancer diagnosis based on in vitro and in vivo studies. Methods: The MEDLINE, EMBASE, and the Cochrane Library with restrictions to articles in English language databases were searched to retrieve available data. Results: There are limited data in literature regarding in vitro and in vivo studies that examined the ability of cancer cells to take up L-glucose. Research work so far has shown that that the binding of a fluorescent detector to L-glucose molecule produced a fluorescent probe that was specifically taken up by malignant cancer cells, thus providing a unique method for their detection. Conclusion: Given that L-glucose is taken up by cancer cells, L-glucose fluorescent probes can be a useful tool for visualization and characterization of cancer cells. More research on the potential biologic effects of L-glucose in cancer is necessary.

scholarly journals Efficiency of Teeth Bleaching after Regenerative Endodontic Treatment: A Systematic Review

2021 ◽  
Vol 10 (2) ◽  
pp. 316
Author(s):  
Irini Fagogeni ◽  
Tomasz Falgowski ◽  
Joanna Metlerska ◽  
Mariusz Lipski ◽  
Maciej Górski ◽  
...  
Keyword(s):  
Web Of Science ◽  
In Vivo Studies ◽  
Cochrane Library ◽  
Barrier Materials ◽  
The Cochrane Library ◽  
Regenerative Endodontic Treatment

The aim of this review is to evaluate of effectiveness of bleaching procedures used to treat discolored teeth subsequent to regenerative endodontic procedures (REPs) based on the review of in vitro and in vivo studies. This literature review was carried out according to the PRISMA guidelines. Four databases (PubMed, Scopus, the Cochrane Library, and Web of Science databases) were searched electronically, until 30 January 2020 without a year limit. The quality of studies was assessed using a modified methodological index for non-randomized studies. After analyzing 1405 studies, 6 in vitro and 9 in vivo studies were eligible for this review. In in vitro studies, effectiveness of bleaching was assessed in teeth discolored by antibiotic pastes, blood, and barrier materials in various combinations. In all analyzed studies, bleaching was effective in teeth discolored by antibiotic pastes as well as by blood and barrier materials. Of 26 treated teeth in the in vivo studies, 17 teeth were bleached successfully. In six cases, there was improvement of the shade. In three cases, bleaching was not sufficient. Bleaching material, techniques, and times differed between studies. Whitening of discolored teeth after REPs is achievable. However, to establish precise guidelines, further long-term clinical studies should be performed.

scholarly journals Laser Photobiomodulation (PBM)—A Possible New Frontier for the Treatment of Oral Cancer: A Review of In Vitro and In Vivo Studies

Healthcare ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 134
Author(s):  
Alessandro Del Vecchio ◽  
Gianluca Tenore ◽  
Maria Clotilde Luzi ◽  
Gaspare Palaia ◽  
Ahmed Mohsen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Data Extraction ◽  
In Vivo Studies ◽  
Clinical Use ◽  
Inclusion Criteria ◽  
Beneficial Effects ◽  
New Frontier

The treatment of oral squamous cell carcinoma (OSCC) is particularly complex due to its aggressive behavior, location, the patient’s age, and its spread at diagnosis. In recent years, photobiomodulation (PBM) has been introduced in different medical fields; however, its application, in patients suffering from OSCC for palliative support or to induce analgesia, has been hotly debated due to the possibility that the cell growth stimuli induced by PBM could lead to a worsening of the lesions. The aim of this study is to review the literature to observe the available data investigating the effect of PBM on cancer cells in vitro and in vivo. A review was conducted on the PubMed and Scopus databases. A total of twelve studies met the inclusion criteria and were therefore included for quality assessment and data extraction. The analysis showed that the clinical use of PBM is still only partially understood and is, therefore, controversial. Some authors stated that it could be contraindicated for clinical use in patients suffering from SCC, while others noted that it could have beneficial effects. According to the data that emerged from this review, it is possible to hypothesize that there are possibilities for PBM to play a beneficial role in treating cancer patients, but further evidence about its clinical efficacy and the identification of protocols and correct dosages is still needed.

scholarly journals Antibacterial and antifungal activities herbácia Zingiber Officinale in dentistry: a literature review

2020 ◽  
Vol 9 (10) ◽  
pp. e6689109141
Author(s):  
Natália Franco Brum ◽  
Mariana Sobreira Bezerra ◽  
Aline Sobreira Bezerra ◽  
Gabriela Scortegagna de Souza ◽  
Patricia Kolling Marquezan
Keyword(s):  
Literature Review ◽  
Zingiber Officinale ◽  
Cochrane Library ◽  
Antibiofilm Activity ◽  
Bacterial Strains ◽  
Dental Biofilm ◽  
Antibacterial And Antifungal Activities ◽  
Technological Advances

The pathogenic dental biofilm formed by species presents itself as a serious problem, since it contributes to the development of oral and bodily diseases. In this sense, Dentistry stands out for expanding knowledge about the oral ecosystem and performing procedures aimed at reducing its pathogenicity and improving oral health. Thus, technological advances and indiscriminate application of antibiotics have made bacterial strains resistant, with a great search for safer, more natural and effective methods. Therefore, the use of plants for healthy treatments is an area of great study in Dentistry. In the present literature review, we sought to analyze the species Zingiber officinali with its antimicrobial and antibiofilm activity. For this study, materials were searched at the BIREME, CINAHL, Cochrane Library, Embase, Google Schoolar, PubMed, Science Direct, published until August 2020. The search for the articles was carried out in August 2020, of the 3,401 studies were refined in 18. The findings showed that the plant Zingiber officinale has the capacity to inhibit certain bacteria in vitro, such as Bacillus sp., Escherichia coli, Pseudomonas aeruginosa, Streptococcus mutans and fungi, like Candida albicans. Thus, studies in the area are still needed in order to prove its effectiveness in vivo, to analyze the toxicity, drug interactions and side effects of the plant.

scholarly journals Biocompatibility of Root Canal Sealers: A Systematic Review of In Vitro and In Vivo Studies

Materials ◽  
2019 ◽  
Vol 12 (24) ◽  
pp. 4113 ◽  
Author(s):  
Diogo Afonso Fonseca ◽  
Anabela Baptista Paula ◽  
Carlos Miguel Marto ◽  
Ana Coelho ◽  
Siri Paulo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Root Canal ◽  
Biological Effects ◽  
Tissue Response ◽  
In Vivo Studies ◽  
Cochrane Library ◽  
Toxic Potential ◽  
Root Canal Sealers

(1) Aim: To perform a systematic review of the literature on the biocompatibility of root canal sealers that encompasses the various types of sealers that are commercially available as well as both in vitro and in vivo evidence. (2) Methods: This systematic review has been registered in PROSPERO (ID 140445) and was carried out according to PRISMA guidelines using the following databases: PubMed, Cochrane Library, ClinicalTrials.gov, Science Direct, and Web of Science Core Collection. Studies published between 2000 and 11 June 2019 that evaluated cytotoxicity (cell viability/proliferation) and biocompatibility (tissue response) of root canal sealers were included. (3) Results: From a total of 1249 studies, 73 in vitro and 21 in vivo studies were included. In general, studies suggest that root canal sealers elicit mild to severe toxic effects and that several factors may influence biocompatibility, e.g., material setting condition and time, material concentration, and type of exposure. Bioactive endodontic sealers seem to exhibit a lower toxic potential in vitro. (4) Conclusions: The available evidence shows that root canal sealers exhibit variable toxic potential at the cellular and tissue level. However, the methodological heterogeneity among studies included in this systematic review and the somewhat conflicting results do not allow a conclusion on which type of sealer presents higher biocompatibility. Further research is crucial to achieve a better understanding of the biological effects of root canal sealers.

scholarly journals A Review of Complementary and Alternative Medicine Therapies on Muscular Atrophy: A Literature Review of In Vivo/In Vitro Studies

2018 ◽  
Vol 2018 ◽  
pp. 1-27 ◽  
Author(s):  
Seong-Mok Jeong ◽  
Byung-Kwan Seo ◽  
Yeon-Cheol Park ◽  
Yong-Hyeon Baek
Keyword(s):  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Muscular Atrophy ◽  
In Vitro Studies ◽  
Hindlimb Suspension ◽  
In Vivo Studies ◽  
Cochrane Library ◽  
Complementary And Alternative

Objective. The objective of this review is to evaluate the recent treatment and study trends of complementary and alternative medicine (CAM) treatments on muscular atrophy by reviewing in vivo/in vitro studies.Materials and Methods. The searches were conducted via electronic databases including PubMed, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang MED, and five Korean databases. Only in vivo and in vitro studies were included in this study.Results. A total of 44 studies (27 in vivo studies, 8 in vitro studies, and 9 in vivo with in vitro) were included. No serious maternal or fetal complications occurred. There were various animal models induced with muscular atrophy through “hindlimb suspension”, “nerve damage”, ‘alcohol or dexamethasone treatment’, “diabetes”, “CKD”, “stroke”, “cancer”, “genetic modification”, etc. In 28 of 36 articles measuring muscle mass, CAM significantly increased the mass. Additionally, 10 of them showed significant improvement in muscle function. In most in vitro studies, significant increases in both the diameter of myotubes and muscle cell numbers were reported. The mechanisms of action of protein synthesis, degradation, autophagy, and apoptotic markers were also investigated.Conclusions. These results demonstrate that CAM could prevent muscular atrophy. Further studies about CAM on muscular atrophy are needed.

scholarly journals Role of Mesenchymal Stem Cell-Conditioned Medium (MSC-CM) in ligament or tendon healing: A Systematic Review from 1998-2018

2020 ◽  
Vol 8 (5_suppl5) ◽  
pp. 2325967120S0010
Author(s):  
Sholahuddin Rhatomy ◽  
Tito Sumarwoto ◽  
Andhi Prijosedjati ◽  
Romaniyanto ◽  
Thomas Edison Prasetyo
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Conditioned Medium ◽  
Tendon Healing ◽  
In Vitro Studies ◽  
In Vivo Studies ◽  
Cochrane Library

Background: The therapeutic value of mesenchymal stem cells (MSCs) in tissue engineering and regenerative medicine is attributable in part to paracrine pathways triggered by several secreted factors secreted into culture media. The secreted factor here is known as the conditioned medium (CM) or secretome. Objectives: This review is aimed to investigate and summarise the in-vitro, pre-clinical in-vivo studies regarding the role of CM-MSC in ligament or tendon healing from 1998 until 2018. Data Sources: A systematic literature search on PubMed, MEDLINE, OVID, Scopus, Google scholar, and Cochrane library was carried out by using search terms: Secretome, conditioned medium, mesenchymal stem cell, ligament, tendon and healing. Methods: A total of 904 articles were reviewed. Five articles were identified as relevant for this systematic literature review. Results: One tables of studies were constructed for in vitro studies and in-vivo studies. Conclusion: All of the included in-vitro studies and in-vivo studies have shown a promoting effect of ligament or tendon healing at various stages in vitro or in vivo. Although there are no clinical studies regarding the use of CM- MSC in the human ligament or tendon healing that have been conducted, transplantation of secretome has shown a promising result in the acceleration of ligament or tendon healing process.

Regenerative potential of stem cells derived from human exfoliated deciduous (SHED) teeth during engineering of human body tissues

2020 ◽  
Vol 16 ◽  
Author(s):  
Shivkanya Fuloria ◽  
Ajay Jain ◽  
Sameep Singh ◽  
Iswar Hazarika ◽  
Samson Salile ◽  
...  
Keyword(s):  
Stem Cells ◽  
Human Body ◽  
In Vivo Studies ◽  
Permanent Teeth ◽  
Deciduous Teeth ◽  
Pulp Tissue ◽  
Human Teeth ◽  
Body Tissues

Abstract:: Current decade witnesses the regenerative potential of stem cells (SCs) based life-saving therapies for the treatment of various disease and conditions. Human teeth act as reservoir for SCs that exist with high abundance in baby, wisdom, and permanent teeth. The collection of stem cells from human exfoliated deciduous teeth (SHED) is considered as a simple process as it offers the convenience of little or no pain. In comparison to the SCs from dental or bone marrow or other tissues, the SHED offers the benefit of higher cellular differentiation and proliferation. Massive in vitro and in vivo studies reveal the regenerative potential of SHED in the engineering of dental pulp tissue, neuronal tissue, root, bio root, cardiovascular tissues, lymphatic tissues, renal tissues, dermal tissues, hepatic tissues, and bone tissues. Current review describes the methods of collection/isolation/storage, various biomarkers, and types of SHED. This review highlights the regenerative potential of SHED in the engineering of different tissues of human body. As per the available research evidences present study supports that SHED may differentiate into the endothelial cells, neurons, odontoblasts, pancreatic

scholarly journals Antiviral Activity of Ivermectin Against SARS-CoV-2: An Old-Fashioned Dog with a New Trick—A Literature Review

2020 ◽  
Vol 88 (3) ◽  
pp. 36 ◽  
Author(s):  
Mudatsir Mudatsir ◽  
Amanda Yufika ◽  
Firzan Nainu ◽  
Andri Frediansyah ◽  
Dewi Megawati ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Severe Acute Respiratory Syndrome ◽  
Literature Review ◽  
Antiviral Activity ◽  
In Vivo Studies ◽  
Investigational Drug ◽  
Modeling Analysis ◽  
Global Threat

The coronavirus disease 2019 (COVID-19) pandemic is a major global threat. With no effective antiviral drugs, the repurposing of many currently available drugs has been considered. One such drug is ivermectin, an FDA-approved antiparasitic agent that has been shown to exhibit antiviral activity against a broad range of viruses. Recent studies have suggested that ivermectin inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus suggesting its potential for use against COVID-19. This review has summarized the evidence derived from docking and modeling analysis, in vitro and in vivo studies, and results from new investigational drug protocols, as well as clinical trials, if available, which will be effective in supporting the prospective use of ivermectin as an alternative treatment for COVID-19.

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